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profileChristopher H Gibbons, M.D.

TitleAssociate Professor of Neurology
InstitutionBeth Israel Deaconess Medical Center
DepartmentNeurology
AddressBeth Israel Deaconess Med Ctr
Palmer 111 West
One Deaconess Rd
Boston MA 02215
Phone617/632-8454
Fax617/632-0852
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Collapse Biography 
Collapse awards and honors
1996 - 1997American Heart Association Research Fellowship
1999MD with Distinction in Immunologic Research
2002 - 2003Chief Resident in Neurology, Johns Hopkins Hospital
2007Fellowship Award, Peripheral Nerve Society
2007 - 2010Council Member, Autonomic Section of the American Academy of Neurology
2007 - 2008JDRF Career Development Award
2010Board of Directors, American Autonomic Society
2011PJ Dyck Award
2010 - 2013Chair Elect, Autonomic Section of the American Academy of Neurology
2013Chair, Autonomic Section of the American Academy of Neurology
2013 - 2014President Elect, American Autonomic Society
2014 - 2015President, American Autonomic Society

Collapse Overview 
Collapse overview
Dr. Gibbons is an Associate Professor of Neurology at Harvard Medical School and on staff at Beth Israel Deaconess Medical Center and Joslin Diabetes Center in Boston, Massachusetts.

Dr. Gibbons is director of the Joslin Diabetes Center Neuropathy Clinic. He is the director of the Neurocutaneous skin biopsy lab at Beth Israel Deaconess Medical Center. Dr. Gibbons is currently the Chair for the Autonomic Section of the American Academy of Neurology and President of the American Autonomic Society.

Dr. Gibbons is actively engaged in clinical/translational research and has published extensively on peripheral and autonomic neuropathies. His current areas of research include 1) defining the mechanisms and pathophysiology underlying the development of neuropathy in diabetes and 2) investigating the presence of cutaneous alpha-synuclein in neurodegenerative disorders. Dr. Gibbons has received research funding through the NIH (NINDS), the Goldberg Foundation and the Juvenile Diabetes Research Foundation.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K23NS050209     (GIBBONS, CHRISTOPHER H)May 1, 2008 - Oct 30, 2013
NIH/NINDS
Structure &Function in Diabetic Small Fiber Neuropathy
Role: Principal Investigator

F32NS049899     (GIBBONS, CHRISTOPHER H)Jul 1, 2004 - Jun 30, 2007
NIH/NINDS
Structure and Function: Diabetic Small Fiber Neuropathy
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 2; 87(5):505-12. PMID: 27385742.
    View in: PubMed
  2. Sinn DI, Gibbons CH. Pathophysiology and Treatment of Orthostatic Hypotension in Parkinsonian Disorders. Curr Treat Options Neurol. 2016 Jun; 18(6):28. PMID: 27138287.
    View in: PubMed
  3. Provitera V, Gibbons CH, Wendelschafer-Crabb G, Donadio V, Vitale DF, Stancanelli A, Caporaso G, Liguori R, Wang N, Santoro L, Kennedy WR, Nolano M. A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg. Eur J Neurol. 2016 Feb; 23(2):333-8. PMID: 26493160.
    View in: PubMed
  4. Fedorowski A, Gibbons C. Orthostatic hypotension and diabetes are dangerous companions. J Diabetes Complications. 2016 Jan-Feb; 30(1):5-6. PMID: 26601788.
    View in: PubMed
  5. Gibbons CH, Freeman R. Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study. Neurology. 2015 Oct 20; 85(16):1362-7. PMID: 26400576; PMCID: PMC4626242 [Available on 10/20/16].
  6. Jones PK, Gibbons CH. Autonomic function testing: an important diagnostic test for patients with syncope. Pract Neurol. 2015 Oct; 15(5):346-51. PMID: 26109586.
    View in: PubMed
  7. Gibbons C. Postural tachycardia syndrome, the debate continues…. Clin Auton Res. 2014 Dec; 24(6):245-6. PMID: 25391988.
    View in: PubMed
  8. Gibbons CH, Freeman R. Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan; 138(Pt 1):43-52. PMID: 25392197; PMCID: PMC4285188 [Available on 01/01/16].
  9. Gibbons CH. Small fiber neuropathies. Continuum (Minneap Minn). 2014 Oct; 20(5 Peripheral Nervous System Disorders):1398-412. PMID: 25299289.
    View in: PubMed
  10. Jones PK, Gibbons CH. The role of autonomic testing in syncope. Auton Neurosci. 2014 Sep; 184:40-5. PMID: 24948113.
    View in: PubMed
  11. Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R. Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome. PLoS One. 2013; 8(12):e84716. PMID: 24386408; PMCID: PMC3874039.
  12. Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T. Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014 Feb; 24(1):1-2. PMID: 24178965; PMCID: PMC3948189.
  13. Wang N, Gibbons CH, Lafo J, Freeman R. a-Synuclein in cutaneous autonomic nerves. Neurology. 2013 Oct 29; 81(18):1604-10. PMID: 24089386; PMCID: PMC3806913.
  14. Boruchow SA, Gibbons CH. Utility of skin biopsy in management of small fiber neuropathy. Muscle Nerve. 2013 Dec; 48(6):877-82. PMID: 23553795.
    View in: PubMed
  15. Illigens BM, Siepmann T, Roofeh J, Gibbons CH. Laser Doppler imaging in the detection of peripheral neuropathy. Auton Neurosci. 2013 Oct; 177(2):286-90. PMID: 23850386; PMCID: PMC3778150.
  16. Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A. The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013 Jun; 18(2):153-61. PMID: 23781962; PMCID: PMC3694741.
  17. Illigens BM, Gibbons CH. A human model of small fiber neuropathy to study wound healing. PLoS One. 2013; 8(1):e54760. PMID: 23382960; PMCID: PMC3561391.
  18. Wang N, Gibbons CH. Skin biopsies in the assessment of the autonomic nervous system. Handb Clin Neurol. 2013; 117:371-8. PMID: 24095140.
    View in: PubMed
  19. Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92. PMID: 22868966; PMCID: PMC3563419.
  20. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-9. PMID: 22921261; PMCID: PMC3563397.
  21. Muppidi S, Scribner M, Gibbons CH, Adams-Huet B, Spaeth EB, Vernino S. A Unique Manifestation of Pupillary Fatigue in Autoimmune Autonomic Ganglionopathy. Arch Neurol. 2012 May; 69(5):644-8. PMID: 22232207; PMCID: PMC3433577.
  22. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6. PMID: 22158721; PMCID: PMC3359761.
  23. Hovaguimian A, Gibbons CH. Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep. 2011 Jun; 15(3):193-200. PMID: 21286866; PMCID: PMC3086960.
  24. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr; 21(2):69-72. PMID: 21431947.
    View in: PubMed
  25. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8. PMID: 21393070.
    View in: PubMed
  26. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90. PMID: 21411809; PMCID: PMC3201146.
  27. Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98. PMID: 21061393; PMCID: PMC3057686.
  28. Gibbons CH, Freeman R, Veves A. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34. PMID: 20805259; PMCID: PMC2992203.
  29. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9. PMID: 20544913; PMCID: PMC3048308.
  30. Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41. PMID: 20437589; PMCID: PMC3057039.
  31. Kasselman LJ, Veves A, Gibbons CH, Rutkove SB. Cold exposure exacerbates the development of diabetic polyneuropathy in the rat. Exp Diabetes Res. 2009; 2009:827943. PMID: 20130819; PMCID: PMC2814234.
  32. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86. PMID: 19398703; PMCID: PMC2677479.
  33. Gibbons CH, Freeman R. Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12. PMID: 19144572.
    View in: PubMed
  34. Illigens BM, Gibbons CH. Sweat testing to evaluate autonomic function. Clin Auton Res. 2009 Apr; 19(2):79-87. PMID: 18989618; PMCID: PMC3046462.
  35. Lair L, Gibbons C, Freeman R. Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4. PMID: 18850064.
    View in: PubMed
  36. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304. PMID: 18541883; PMCID: PMC3046813.
  37. Gibbons CH, Vernino SA, Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7. PMID: 18268189.
    View in: PubMed
  38. Ebenezer GJ, Hauer P, Gibbons C, McArthur JC, Polydefkis M. Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies. J Neuropathol Exp Neurol. 2007 Dec; 66(12):1059-73. PMID: 18090915.
    View in: PubMed
  39. Christopher Gibbons, Ningshan Wang, Ben Illigens, Justin Centi, Roy Freeman. The Cutaneous Architecture of Autonomic Nerve Fiber Innervation. Clinical Autonomic Research. 2007; 17(5):319.
  40. Christopher Gibbons, Justin Centi, Anh Thu Nguyen, Roy Freeman. Peripheral Autonomic Dysfunction Precedes Structural Abnormalities in Diabetic Small Fiber Neuropathy. Clinical Autonomic Research. 2007; 17(5):306.
  41. Wang Z, Low PA, Jordan J, Freeman R, Gibbons CH, Schroeder C, Sandroni P, Vernino S. Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current. Neurology. 2007 May 29; 68(22):1917-21. PMID: 17536048; PMCID: PMC2615674.
  42. Gibbons C, Illigens B, Centi J, Freeman R. Modeling the Role of Peripheral Neuropathy on Wound Healing. Neurology. 2007.
  43. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32. PMID: 16832073.
    View in: PubMed
  44. Gibbons C, Centi J, DeZure A, Freeman R. A Capsaicin Model of Autonomic Nerve Fiber Degeneration and Regeneration. Neurology. 2006; 66(5 S2):A258-9.
  45. Gibbons CH, Freeman R. Treatment options for autonomic neuropathies. Curr Treat Options Neurol. 2006 Mar; 8(2):119-32. PMID: 16464408.
    View in: PubMed
  46. Gibbons CH, Griffin JW, Polydefkis M, Bonyhay I, Brown A, Hauer PE, McArthur JC. The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy. Neurology. 2006 Jan 24; 66(2):256-8. PMID: 16434668.
    View in: PubMed
  47. Freeman R, Gibbons C. Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517. PMID: 16304717.
    View in: PubMed
  48. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology. 2005 Oct 11; 65(7):1104-6. PMID: 16217067.
    View in: PubMed
  49. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81. PMID: 15774451; PMCID: PMC1739586.
  50. Gibbons CH, Freeman R. Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4. PMID: 15768201.
    View in: PubMed
  51. Gibbons C, Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii. PMID: 15207880.
    View in: PubMed
  52. Gibbons C, Llinas R. Case 1: a woman with headache and dizziness. MedGenMed. 2003 Feb 13; 5(1):35. PMID: 12827096.
    View in: PubMed
  53. Gibbons CH, McArthur JC. Case 8: A Young Man With Painful Inability To Walk. MedGenMed. 2002.
  54. Gibbons C, Kollmann TR, Pettoello-Mantovani M, Kim A, Goldstein H. Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV. AIDS Res Hum Retroviruses. 1997 Nov 20; 13(17):1453-60. PMID: 9390744.
    View in: PubMed
  55. Clark AS, Lindenfeld RC, Gibbons CH. Anabolic-androgenic steroids and brain reward. Pharmacol Biochem Behav. 1996 Mar; 53(3):741-5. PMID: 8866980.
    View in: PubMed
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