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Christopher H Gibbons, M.D.

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1996 - 1997
American Heart Association Research Fellowship
MD with Distinction in Immunologic Research
2002 - 2003
Chief Resident in Neurology, Johns Hopkins Hospital
Fellowship Award, Peripheral Nerve Society
2007 - 2010
Council Member, Autonomic Section of the American Academy of Neurology
2007 - 2008
JDRF Career Development Award
Board of Directors, American Autonomic Society
PJ Dyck Award
2010 - 2013
Chair Elect, Autonomic Section of the American Academy of Neurology
Chair, Autonomic Section of the American Academy of Neurology
2013 - 2014
President Elect, American Autonomic Society
2014 - 2015
President, American Autonomic Society
2020 - 2021
Irwin Schatz Award for Autonomic Disorders

Dr. Gibbons is an Associate Professor of Neurology at Harvard Medical School and on staff at Beth Israel Deaconess Medical Center and Joslin Diabetes Center in Boston, Massachusetts.

Dr. Gibbons is director of the Joslin Diabetes Center Neuropathy Clinic. He is the director of the Neurocutaneous skin biopsy lab at Beth Israel Deaconess Medical Center. Dr. Gibbons is currently the Chair for the Autonomic Section of the American Academy of Neurology and President of the American Autonomic Society.

Dr. Gibbons is actively engaged in clinical/translational research and has published extensively on peripheral and autonomic neuropathies. His current areas of research include 1) defining the mechanisms and pathophysiology underlying the development of neuropathy in diabetes and 2) investigating the presence of cutaneous alpha-synuclein in neurodegenerative disorders. Dr. Gibbons has received research funding through the NIH (NINDS), the Goldberg Foundation and the Juvenile Diabetes Research Foundation.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R44NS117214 (Levine) Oct 1, 2020 - Sep 30, 2022
    The detection of cutaneous phosphorylated alpha-synuclein across the synucleinopathies.
    Role Description: The goal of this small business grant is to validate skin biopsy detection of phosphorylated alpha-synuclein as a clinical diagnostic marker of synucleinopathy. This is a collaborative project between CND Life Sciences and BIDMC.
    Role: Academic Principal Investigator
  2. (Gibbons) Jan 1, 2017 - Sep 30, 2021
    Grifols Inc
    A double-blind, placebo controlled trial of Gamunex-C in Patients with Small Fiber Neuropathy Associated with Autoantibodies to TS-HDS and FGFR3.
    Role Description: This is a pilot treatment trial of IVIG for autoimmune mediated small fiber neuropathy.
    Role: Principal Investigator
  3. (Gibbons) Jan 1, 2016 - Sep 30, 2021
    Grifols Inc
    A double-blind placebo controlled trial of IVIG in the treatment induced neuropathy of diabetes.
    Role Description: This is a treatment trial of IVIG to prevent or reverse the neuropathic complications caused by an abrupt improvement in glycemic control.
    Role: Principal Investigator
  4. U54NS065736 (Roberstson) May 1, 2009
    Autonomic Rare Diseases Clinical Research Consortiu
    Role Description: The goal of this grant is to develop a research consortium to study several rare autonomic disorders with a combination of pilot grants, natural history studies and randomized controlled trials of clinical treatments.
    Role: Co-Investigator
  5. K23NS050209 (GIBBONS, CHRISTOPHER H) May 1, 2008 - Oct 30, 2013
    Structure & Function in Diabetic Small Fiber Neuropathy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gibbons CH, Rajan S, Senechal K, Hendry E, McCallister B, Levine TD. A double-blind placebo-controlled pilot study of immunoglobulin for small fiber neuropathy associated with TS-HDS and FGFR-3 autoantibodies. Muscle Nerve. 2022 Nov 11. PMID: 36367813.
    Citations:    Fields:    
  2. Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills AM, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping. Cerebellum. 2022 Oct 03. PMID: 36190676; PMCID: PMC9527378.
    Citations:    Fields:    
  3. Mayuga KA, Fedorowski A, Ricci F, Gopinathannair R, Dukes JW, Gibbons C, Hanna P, Sorajja D, Chung M, Benditt D, Sheldon R, Ayache MB, AbouAssi H, Shivkumar K, Grubb BP, Hamdan MH, Stavrakis S, Singh T, Goldberger JJ, Muldowney JAS, Belham M, Kem DC, Akin C, Bruce BK, Zahka NE, Fu Q, Van Iterson EH, Raj SR, Fouad-Tarazi F, Goldstein DS, Stewart J, Olshansky B. Sinus Tachycardia: a Multidisciplinary Expert Focused Review. Circ Arrhythm Electrophysiol. 2022 09; 15(9):e007960. PMID: 36074973; PMCID: PMC9523592.
    Citations:    Fields:    Translation:Humans
  4. Freeman R, Gonzalez-Duarte A, Barroso F, Campagnolo M, Rajan S, Garcia J, Kim JY, Wang N, Orellana L, Gibbons C. Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages. Ann Clin Transl Neurol. 2022 09; 9(9):1370-1383. PMID: 35945901; PMCID: PMC9463946.
    Citations:    Fields:    Translation:Humans
  5. Miglis MG, Seliger J, Shaik R, Gibbons CH. A case series of cutaneous phosphorylated a-synuclein in Long-COVID POTS. Clin Auton Res. 2022 06; 32(3):209-212. PMID: 35570247; PMCID: PMC9108014.
    Citations:    Fields:    Translation:Humans
  6. Gibbons CH, Freeman R, Bellaire B, Adler CH, Moore D, Levine T. Synuclein-One study: skin biopsy detection of phosphorylated a-synuclein for diagnosis of synucleinopathies. Biomark Med. 2022 05; 16(7):499-509. PMID: 35272481; PMCID: PMC9169016.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  7. Miglis MG, Zitser J, Schneider L, During E, Jaradeh S, Freeman R, Gibbons CH. Cutaneous a-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder. Sleep. 2021 12 10; 44(12). PMID: 34244806; PMCID: PMC8664580.
    Citations: 2     Fields:    Translation:Humans
  8. Evidente VGH, Evidente DH, Ortega SC, Levine TD, Freeman R, Gibbons CH. X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy. Mov Disord. 2022 01; 37(1):130-136. PMID: 34582053.
    Citations:    Fields:    Translation:Humans
  9. Sohn EH, Gibbons CH, Freeman R, Lee AY, Jung MS, Kim S. Validation of the Korean version of the Boston Autonomic Symptom Questionnaire. J Clin Neurol. 2021 Jul; 17(3):463-469. PMID: 34184455.
  10. Gibbons CH, Zhu J, Zhang X, Habboubi N, Hariri R, Veves A. Phase 2a randomized controlled study investigating the safety and efficacy of PDA-002 in diabetic peripheral neuropathy. J Peripher Nerv Syst. 2021 09; 26(3):276-289. PMID: 34169613.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  11. Gibbons C, Donadio V, Sommer C, Liguori R, Lauria Pinter G, Lombardi R, Doppler K, Freeman R. Reader Response: In Vivo Distribution of a-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease. Neurology. 2021 05 18; 96(20):964-965. PMID: 34001543.
    Citations: 1     Fields:    Translation:Humans
  12. Veazie S, Peterson K, Ansari Y, Chung KA, Gibbons CH, Raj SR, Helfand M. Fludrocortisone for orthostatic hypotension. Cochrane Database Syst Rev. 2021 05 17; 5:CD012868. PMID: 34000076; PMCID: PMC8128337.
    Citations:    Fields:    Translation:Humans
  13. Levine TD, Bellaire B, Gibbons C, Freeman R. Cutaneous alpha-synuclein deposition in postural tachycardia patients. Ann Clin Transl Neurol. 2021 04; 8(4):908-917. PMID: 33764697.
    Citations: 4     Fields:    Translation:HumansCells
  14. Gibbons CH, Klein C. IVIG and Small Fiber Neuropathy: The Ongoing Search for Evidence. Neurology. 2021 05 18; 96(20):929-930. PMID: 33766998.
    Citations: 1     Fields:    Translation:Humans
  15. Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano T, Kim HA, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Corrigendum to "Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology" [Clin. Neurophysiol. 132(2) (2021) 666-682]. Clin Neurophysiol. 2021 May; 132(5):1194. PMID: 33685802.
    Citations:    Fields:    
  16. Gibbons CH, Silva G, Freeman R. Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. Heart Rhythm. 2021 08; 18(8):1361-1368. PMID: 33482385.
    Citations: 2     Fields:    Translation:Humans
  17. Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol. 2021 02; 132(2):666-682. PMID: 33419664.
    Citations: 11     Fields:    Translation:Humans
  18. Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020 12 01; 95(22):1005-1014. PMID: 33055271.
    Citations: 10     Fields:    Translation:HumansCells
  19. Gibbons CH. Diabetes and Metabolic Disorders and the Peripheral Nervous System. Continuum (Minneap Minn). 2020 10; 26(5):1161-1183. PMID: 33002997.
    Citations: 1     Fields:    Translation:Humans
  20. Koulouris AE, Edwards RR, Dorado K, Schreiber KL, Lazaridou A, Rajan S, White J, Garcia J, Gibbons C, Freeman R. Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain. Pain Med. 2020 10 01; 21(10):2336-2347. PMID: 32895703.
    Citations: 7     Fields:    Translation:Humans
  21. Wang N, Garcia J, Freeman R, Gibbons CH. Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results. J Histochem Cytochem. 2020 10; 68(10):669-678. PMID: 32921251.
    Citations: 7     Fields:    Translation:HumansCells
  22. Gibbons CH, Freeman R. Delayed orthostatic hypotension. Auton Neurosci. 2020 12; 229:102724. PMID: 32942225.
    Citations: 1     Fields:    Translation:Humans
  23. Sohn E, Suh BC, Wang N, Freeman R, Gibbons CH. A novel method to quantify cutaneous vascular innervation. Muscle Nerve. 2020 10; 62(4):492-501. PMID: 32270499.
    Citations: 1     Fields:    Translation:Humans
  24. Freeman R, Illigens BMW, Lapusca R, Campagnolo M, Abuzinadah AR, Bonyhay I, Sinn DI, Miglis M, White J, Gibbons CH. Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension. Hypertension. 2020 05; 75(5):1325-1332. PMID: 32223377.
    Citations: 14     Fields:    Translation:Humans
  25. Olshansky B, Cannom D, Fedorowski A, Stewart J, Gibbons C, Sutton R, Shen WK, Muldowney J, Chung TH, Feigofsky S, Nayak H, Calkins H, Benditt DG. Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment. Prog Cardiovasc Dis. 2020 May - Jun; 63(3):263-270. PMID: 32222376; PMCID: PMC9012474.
    Citations: 11     Fields:    Translation:Humans
  26. Gibbons CH. Treatment induced neuropathy of diabetes. Auton Neurosci. 2020 07; 226:102668. PMID: 32247944.
    Citations: 6     Fields:    Translation:Humans
  27. Gibbons CH, Wang N, Kim JY, Campagnolo M, Freeman R. Skin Biopsy in Evaluation of Autonomic Disorders. Continuum (Minneap Minn). 2020 Feb; 26(1):200-212. PMID: 31996629.
    Citations: 1     Fields:    Translation:Humans
  28. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci. 2020 01; 223:102550. PMID: 31928708.
    Citations: 4     Fields:    Translation:Humans
  29. Barboi A, Gibbons CH, Bennaroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions. Clin Auton Res. 2020 04; 30(2):183-184. PMID: 31802304.
    Citations:    Fields:    Translation:HumansCells
  30. Isonaka R, Gibbons CH, Wang N, Freeman R, Goldstein DS. Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies. Clin Auton Res. 2019 12; 29(6):587-593. PMID: 31673840.
    Citations: 5     Fields:    Translation:HumansCells
  31. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res. 2020 02; 30(1):13-18. PMID: 31475305.
    Citations: 7     Fields:    Translation:Humans
  32. Gewandter JS, Gibbons CH, Campagnolo M, Lee J, Chaudari J, Ward N, Burke L, Cavaletti G, Herrmann DN, McArthur JC, Russell JW, Smith AG, Smith SM, Turk DC, Dworkin RH, Freeman R. Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review. Neurology. 2019 08 20; 93(8):346-360. PMID: 31320471.
    Citations: 9     Fields:    Translation:Humans
  33. Kim JY, Illigens BM, McCormick MP, Wang N, Gibbons CH. Alpha-Synuclein in Skin Nerve Fibers as a Biomarker for Alpha-Synucleinopathies. J Clin Neurol. 2019 Apr; 15(2):135-142. PMID: 30938106; PMCID: PMC6444158.
    Citations: 18     
  34. Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG, Höke A. Peripheral Neuropathy Research Registry: A prospective cohort. J Peripher Nerv Syst. 2019 03; 24(1):39-47. PMID: 30629307.
    Citations: 4     Fields:    Translation:Humans
  35. González-Duarte A, Cárdenas-Soto K, Fueyo O, Bañuelos CE, Gibbons C, Freeman R. Small fibre neuropathy assessments in early stages of hATTR amyloidosis. Amyloid. 2019; 26(sup1):55-56. PMID: 31343296.
    Citations:    Fields:    Translation:Humans
  36. Illigens BMW, Gibbons CH. Autonomic testing, methods and techniques. Handb Clin Neurol. 2019; 160:419-433. PMID: 31277866.
    Citations: 3     Fields:    Translation:Humans
  37. Gibbons CH. Basics of autonomic nervous system function. Handb Clin Neurol. 2019; 160:407-418. PMID: 31277865.
    Citations: 18     Fields:    Translation:HumansAnimals
  38. Evans JP, Smith A, Gibbons C, Alonso J, Valderas JM. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS): a view from the UK. Patient Relat Outcome Meas. 2018; 9:345-352. PMID: 30498382; PMCID: PMC6207259.
    Citations: 18     
  39. Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI. Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 09 11; 72(11):1294-1309. PMID: 30190008.
    Citations: 50     Fields:    Translation:Humans
  40. Claassen DO, Adler CH, Hewitt LA, Gibbons C. Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers. BMC Neurol. 2018 Aug 25; 18(1):125. PMID: 30144800.
    Citations: 16     Fields:    Translation:Humans
  41. Rajan S, Campagnolo M, Callaghan B, Gibbons CH. Sudomotor function testing by electrochemical skin conductance: does it really measure sudomotor function? Clin Auton Res. 2019 02; 29(1):31-39. PMID: 29956008.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  42. Provitera V, Gibbons CH, Wendelschafer-Crabb G, Donadio V, Vitale DF, Loavenbruck A, Stancanelli A, Caporaso G, Liguori R, Wang N, Santoro L, Kennedy WR, Nolano M. The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy. Eur J Neurol. 2018 06; 25(6):848-853. PMID: 29493845.
    Citations: 5     Fields:    Translation:HumansCells
  43. Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D. Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol. 2018 03; 83(3):522-531. PMID: 29405350; PMCID: PMC5867255.
    Citations: 50     Fields:    Translation:Humans
  44. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Author response: Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 11 14; 89(20):2122. PMID: 29133613.
    Citations:    Fields:    Translation:Humans
  45. Gibbons CH. Treatment-Induced Neuropathy of Diabetes. Curr Diab Rep. 2017 Oct 24; 17(12):127. PMID: 29064042.
    Citations: 14     Fields:    Translation:Humans
  46. Gibbons CH, Goebel-Fabbri A. Microvascular Complications Associated With Rapid Improvements in Glycemic Control in Diabetes. Curr Diab Rep. 2017 07; 17(7):48. PMID: 28526993.
    Citations: 4     Fields:    Translation:Humans
  47. Gibbons CH, Simon DK, Huang M, Tilley B, Aminoff MJ, Bainbridge JL, Brodsky M, Freeman R, Goudreau J, Hamill RW, Luo ST, Singer C, Videnovic A, Bodis-Wollner I, Wong PS. Autonomic and electrocardiographic findings in Parkinson's disease. Auton Neurosci. 2017 07; 205:93-98. PMID: 28506500.
    Citations: 8     Fields:    Translation:Humans
  48. Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D. Natural history of pure autonomic failure: A United States prospective cohort. Ann Neurol. 2017 Feb; 81(2):287-297. PMID: 28093795; PMCID: PMC5323269.
    Citations: 97     Fields:    Translation:Humans
  49. Gibbons CH. Treatment induced neuropathy of diabetes-Long term implications in type 1 diabetes. J Diabetes Complications. 2017 Apr; 31(4):715-720. PMID: 28159476.
    Citations: 10     Fields:    Translation:Humans
  50. Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S, Karabin B, Kuritzky L, Lew M, Low P, Mehdirad A, Raj SR, Vernino S, Kaufmann H. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017 Aug; 264(8):1567-1582. PMID: 28050656; PMCID: PMC5533816.
    Citations: 94     Fields:    Translation:Humans
  51. Gibbons CH, Wang N, Freeman R. Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease. J Parkinsons Dis. 2017; 7(3):503-509. PMID: 28582870.
    Citations: 6     Fields:    Translation:HumansCells
  52. Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Mcarthur JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy. Muscle Nerve. 2017 03; 55(3):366-372. PMID: 27447116; PMCID: PMC5528159.
    Citations: 7     Fields:    Translation:Humans
  53. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 Jan 03; 88(1):17-24. PMID: 27903817.
    Citations: 27     Fields:    Translation:Humans
  54. Abuzinadah AR, Sinn DI, Freeman R, Gibbons CH. Blood pressure oscillations in baroreflex failure. Clin Auton Res. 2016 12; 26(6):465-466. PMID: 27541037.
    Citations: 1     Fields:    Translation:Humans
  55. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 02; 87(5):505-12. PMID: 27385742.
    Citations: 37     Fields:    Translation:Humans
  56. Sinn DI, Gibbons CH. Pathophysiology and Treatment of Orthostatic Hypotension in Parkinsonian Disorders. Curr Treat Options Neurol. 2016 Jun; 18(6):28. PMID: 27138287.
    Citations: 2     
  57. Provitera V, Gibbons CH, Wendelschafer-Crabb G, Donadio V, Vitale DF, Stancanelli A, Caporaso G, Liguori R, Wang N, Santoro L, Kennedy WR, Nolano M. A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg. Eur J Neurol. 2016 Feb; 23(2):333-8. PMID: 26493160.
    Citations: 29     Fields:    Translation:HumansCells
  58. Fedorowski A, Gibbons C. Orthostatic hypotension and diabetes are dangerous companions. J Diabetes Complications. 2016 Jan-Feb; 30(1):5-6. PMID: 26601788.
    Citations: 4     Fields:    Translation:Humans
  59. Gibbons CH, Freeman R. Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study. Neurology. 2015 Oct 20; 85(16):1362-7. PMID: 26400576; PMCID: PMC4626242.
    Citations: 39     Fields:    Translation:Humans
  60. Jones PK, Gibbons CH. Autonomic function testing: an important diagnostic test for patients with syncope. Pract Neurol. 2015 Oct; 15(5):346-51. PMID: 26109586.
    Citations: 2     Fields:    Translation:Humans
  61. Gibbons C. Postural tachycardia syndrome, the debate continues…. Clin Auton Res. 2014 Dec; 24(6):245-6. PMID: 25391988.
    Citations:    Fields:    Translation:Humans
  62. Gibbons CH, Freeman R. Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan; 138(Pt 1):43-52. PMID: 25392197; PMCID: PMC4285188.
    Citations: 48     Fields:    Translation:Humans
  63. Gibbons CH. Small fiber neuropathies. Continuum (Minneap Minn). 2014 Oct; 20(5 Peripheral Nervous System Disorders):1398-412. PMID: 25299289.
    Citations: 7     Fields:    Translation:Humans
  64. Jones PK, Gibbons CH. The role of autonomic testing in syncope. Auton Neurosci. 2014 Sep; 184:40-5. PMID: 24948113.
    Citations: 4     Fields:    Translation:Humans
  65. Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R. Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome. PLoS One. 2013; 8(12):e84716. PMID: 24386408.
    Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
  66. Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T. Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014 Feb; 24(1):1-2. PMID: 24178965.
    Citations:    Fields:    Translation:Humans
  67. Wang N, Gibbons CH, Lafo J, Freeman R. a-Synuclein in cutaneous autonomic nerves. Neurology. 2013 Oct 29; 81(18):1604-10. PMID: 24089386; PMCID: PMC3806913.
    Citations: 84     Fields:    Translation:HumansCells
  68. Boruchow SA, Gibbons CH. Utility of skin biopsy in management of small fiber neuropathy. Muscle Nerve. 2013 Dec; 48(6):877-82. PMID: 23553795.
    Citations: 4     Fields:    Translation:Humans
  69. Illigens BM, Siepmann T, Roofeh J, Gibbons CH. Laser Doppler imaging in the detection of peripheral neuropathy. Auton Neurosci. 2013 Oct; 177(2):286-90. PMID: 23850386.
    Citations: 11     Fields:    Translation:Humans
  70. Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A. The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013 Jun; 18(2):153-61. PMID: 23781962.
    Citations: 9     Fields:    Translation:Humans
  71. Illigens BM, Gibbons CH. A human model of small fiber neuropathy to study wound healing. PLoS One. 2013; 8(1):e54760. PMID: 23382960.
    Citations: 6     Fields:    Translation:HumansCells
  72. Wang N, Gibbons CH. Skin biopsies in the assessment of the autonomic nervous system. Handb Clin Neurol. 2013; 117:371-8. PMID: 24095140.
    Citations: 9     Fields:    Translation:HumansAnimals
  73. Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92. PMID: 22868966; PMCID: PMC3563419.
    Citations: 10     Fields:    Translation:HumansCells
  74. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-2209. PMID: 22921261.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  75. Muppidi S, Scribner M, Gibbons CH, Adams-Huet B, Spaeth EB, Vernino S. A Unique Manifestation of Pupillary Fatigue in Autoimmune Autonomic Ganglionopathy. Arch Neurol. 2012 May; 69(5):644-8. PMID: 22232207; PMCID: PMC3433577.
    Citations: 5     Fields:    Translation:Humans
  76. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6. PMID: 22158721; PMCID: PMC3359761.
    Citations: 13     Fields:    Translation:Humans
  77. Hovaguimian A, Gibbons CH. Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep. 2011 Jun; 15(3):193-200. PMID: 21286866.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  78. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr; 21(2):69-72. PMID: 21431947.
    Citations: 434     Fields:    Translation:Humans
  79. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8. PMID: 21393070.
    Citations: 134     Fields:    Translation:Humans
  80. Hovaguimian A, Gibbons CH. Clinical Approach to the Treatment of Painful Diabetic Neuropathy. Ther Adv Endocrinol Metab. 2011 Feb; 2(1):27-38. PMID: 21709806.
    Citations: 9     
  81. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90. PMID: 21411809.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  82. Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98. PMID: 21061393.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
  83. Gibbons CH, Freeman R, Veves A. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34. PMID: 20805259.
    Citations: 22     Fields:    Translation:Humans
  84. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9. PMID: 20544913.
    Citations: 18     Fields:    Translation:HumansCells
  85. Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41. PMID: 20437589.
    Citations: 53     Fields:    Translation:HumansCells
  86. Kasselman LJ, Veves A, Gibbons CH, Rutkove SB. Cold exposure exacerbates the development of diabetic polyneuropathy in the rat. Exp Diabetes Res. 2009; 2009:827943. PMID: 20130819.
    Citations: 2     Fields:    Translation:AnimalsCells
  87. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86. PMID: 19398703; PMCID: PMC2677479.
    Citations: 48     Fields:    Translation:HumansCells
  88. Gibbons CH, Freeman R. Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12. PMID: 19144572.
    Citations: 20     Fields:    Translation:Humans
  89. Illigens BM, Gibbons CH. Sweat testing to evaluate autonomic function. Clin Auton Res. 2009 Apr; 19(2):79-87. PMID: 18989618; PMCID: PMC3046462.
    Citations: 47     Fields:    Translation:Humans
  90. Lair L, Gibbons C, Freeman R. Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4. PMID: 18850064.
    Citations:    Fields:    Translation:Humans
  91. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304. PMID: 18541883; PMCID: PMC3046813.
    Citations: 20     Fields:    Translation:HumansCells
  92. Gibbons CH, Vernino SA, Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7. PMID: 18268189.
    Citations: 20     Fields:    Translation:Humans
  93. Ebenezer GJ, Hauer P, Gibbons C, McArthur JC, Polydefkis M. Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies. J Neuropathol Exp Neurol. 2007 Dec; 66(12):1059-73. PMID: 18090915.
    Citations: 45     Fields:    Translation:HumansCells
  94. Christopher Gibbons, Justin Centi, Anh Thu Nguyen, Roy Freeman. Peripheral Autonomic Dysfunction Precedes Structural Abnormalities in Diabetic Small Fiber Neuropathy. Clinical Autonomic Research. 2007; 17(5):306.
  95. Christopher Gibbons, Ningshan Wang, Ben Illigens, Justin Centi, Roy Freeman. The Cutaneous Architecture of Autonomic Nerve Fiber Innervation. Clinical Autonomic Research. 2007; 17(5):319.
  96. Wang Z, Low PA, Jordan J, Freeman R, Gibbons CH, Schroeder C, Sandroni P, Vernino S. Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current. Neurology. 2007 May 29; 68(22):1917-21. PMID: 17536048; PMCID: PMC2615674.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  97. Gibbons C, Illigens B, Centi J, Freeman R. Modeling the Role of Peripheral Neuropathy on Wound Healing. Neurology. 2007.
  98. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32. PMID: 16832073.
    Citations: 67     Fields:    Translation:Humans
  99. Gibbons C, Centi J, DeZure A, Freeman R. A Capsaicin Model of Autonomic Nerve Fiber Degeneration and Regeneration. Neurology. 2006; 66(5 S2):A258-9.
  100. Gibbons CH, Freeman R. Treatment options for autonomic neuropathies. Curr Treat Options Neurol. 2006 Mar; 8(2):119-32. PMID: 16464408.
    Citations: 3     
  101. Gibbons CH, Griffin JW, Polydefkis M, Bonyhay I, Brown A, Hauer PE, McArthur JC. The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy. Neurology. 2006 Jan 24; 66(2):256-8. PMID: 16434668.
    Citations: 37     Fields:    Translation:HumansCells
  102. Freeman R, Gibbons C. Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517. PMID: 16304717.
    Citations:    Fields:    Translation:HumansCells
  103. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology. 2005 Oct 11; 65(7):1104-6. PMID: 16217067.
    Citations: 8     Fields:    Translation:Humans
  104. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81. PMID: 15774451; PMCID: PMC1739586.
    Citations: 11     Fields:    Translation:Humans
  105. Gibbons CH, Freeman R. Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4. PMID: 15768201.
    Citations: 17     Fields:    Translation:Humans
  106. Gibbons C, Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii. PMID: 15207880.
    Citations: 12     Fields:    Translation:HumansCells
  107. Gibbons C, Llinas R. Case 1: a woman with headache and dizziness. MedGenMed. 2003 Feb 13; 5(1):35. PMID: 12827096.
    Citations:    Fields:    Translation:Humans
  108. Gibbons CH, McArthur JC. Case 8: A Young Man With Painful Inability To Walk. MedGenMed. 2002.
  109. Gibbons C, Kollmann TR, Pettoello-Mantovani M, Kim A, Goldstein H. Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV. AIDS Res Hum Retroviruses. 1997 Nov 20; 13(17):1453-60. PMID: 9390744.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  110. Clark AS, Lindenfeld RC, Gibbons CH. Anabolic-androgenic steroids and brain reward. Pharmacol Biochem Behav. 1996 Mar; 53(3):741-5. PMID: 8866980.
    Citations: 13     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.