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Phillip Jason White, Ph.D.

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Mentoring
Available: 08/01/18, Expires: 07/31/22

The transmission of ultrasound (US) through the skull bone has been investigated for therapeutic and imaging applications. One of the primary obstacles to the effective application of transcranial US is bone-induced phase aberration due to geometric variations both within a subject and between subjects. The predictability of the transmitted US wavefield within the cranial vault is paramount to the development of clinically useful US-based procedures ranging from intracranial tumor ablation and drug delivery to intraoperative monitoring and hemorrhage detection. The present gold standard for assessing skull thickness for US phase aberration correction is x-ray computed tomography (CT). Because CT has several inherent limitations as compared to US (e.g., safety, cost, and convenience), there is an interest in US-based methods for skull thickness prediction.

The proposed study will investigate the potential for using US-derived data to perform aberration correction for the transcranial propagation of US. Specific details pertaining to human skull geometry will be statistically analyzed to formulate a framework by which US-based measurements will yield comparable aberration correction as CT measurements.

This study will involve benchtop experimentation with US transducers and specialized instrumentation; computer-based image processing (US and CT); and the use of human ex vivo calvarium specimens.

Available: 08/11/18, Expires: 07/31/22

Rapid developments in brain imaging within the past few decades have yielded numerous modalities and tools for enhancing our understanding of normal and pathological brain anatomy. Some of these modalities include x-ray computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US). As these tools have become more readily available for clinicians and researchers, it has been suggested that the combined use of multiple radiological modalities, whether in situ or synergized post-procedurally, can yield tremendous benefits in both research and clinical settings.

The development of radiological tools requires the use of phantom materials that mimic the behavior of human tissues in response to the specific radiological modality being studied. Our lab, as a highly interdisciplinary research environment, incorporates numerous imaging modalities into our investigations and as such, is interested in the development of an anatomically-accurate human brain phantom that can respond in a brain tissue-like fashion to x-ray irradiation, MRI imaging, and ultrasound. In addition, as part of a larger study to investigate the use of ultrasound for thermal ablation of intracranial tumors, the multiple-modality brain phantom should also absorb and dissipate thermal energy in a fashion similar to the human brain.

This study will involve benchtop experimentation (including measurements with CT scanners, MRI scanners, US transducers, and other specialized instrumentation) and computer-based image processing (CT, MRI, and US).


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  1. Meral FC, Naing ZZ, Meyer FA, Jafferji MA, Power C, Clement GT, White PJ. Transcranial ultrasound-optical transmission correlation. J Acoust Soc Am. 2014 Apr; 135(4):2209. PMID: 25235270.
    Citations:    
  2. Meral FC, Persaud MA, Silva AE, Mundra A, Clement GT, Vosburgh KG, White PJ. A novel device for guiding ventriculostomy with transcranial ultrasound. J Acoust Soc Am. 2014 Apr; 135(4):2211. PMID: 25235277.
    Citations:    
  3. Meral FC, Bennoui AB, Ferro JV, Maneval CD, Jafferji MA, Giordano NJ, Clement GT, White PJ. Transcranial ultrasound hemorrhage detector. J Acoust Soc Am. 2014 Apr; 135(4):2209. PMID: 25235272.
    Citations:    
  4. Madore B, White PJ, Thomenius K, Clement GT. Accelerated focused ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Dec; 56(12):2612-23. PMID: 20040398.
    Citations: 3     Fields:    
  5. White PJ, Whalen S, Tang SC, Clement GT, Jolesz F, Golby AJ. An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med. 2009 Feb; 28(2):191-203. PMID: 19168769.
    Citations: 6     Fields:    Translation:Humans
  6. White PJ, Clement GT. Two-dimensional localization with a single diffuse ultrasound field excitation. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov; 54(11):2309-17. PMID: 18051165.
    Citations: 2     Fields:    
  7. White PJ, Palchaudhuri S, Hynynen K, Clement GT. The effects of desiccation on skull bone sound speed in porcine models. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Aug; 54(8):1708-10. PMID: 17703676.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. White PJ, Clement GT, Hynynen K. Longitudinal and shear mode ultrasound propagation in human skull bone. Ultrasound Med Biol. 2006 Jul; 32(7):1085-96. PMID: 16829322.
    Citations: 39     Fields:    Translation:Humans
  9. White PJ. Transcranial focused ultrasound surgery. Top Magn Reson Imaging. 2006 Jun; 17(3):165-72. PMID: 17414073.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. White PJ, Clement GT, Hynynen K. Local frequency dependence in transcranial ultrasound transmission. Phys Med Biol. 2006 May 07; 51(9):2293-305. PMID: 16625043.
    Citations: 9     Fields:    Translation:HumansCells
  11. White PJ, Clement GT. A single-channel low-frequency method for ultrasound imaging. Journal of the Acoustical Society of America. 2006; 119(5):3320 (A).
  12. White PJ, Palchaudhuri S, Clement GT, Hynynen K. The effects of desiccation on skull bone sound speed. 6th International Symposium on Therapeutic Ultrasound. 2006.
  13. White PJ, Clement GT, Hynynen K. Transcranial longitudinal and shear sound speeds in animal models. Journal of the Acoustical Society of America. 2006; 119(5):3319(A).
  14. White J, Clement GT, Hynynen K. Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Sep; 52(9):1518-22. PMID: 16285450.
    Citations: 14     Fields:    Translation:Humans
  15. Clement GT, White PJ, King RL, McDannold N, Hynynen K. A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy. J Ultrasound Med. 2005 Aug; 24(8):1117-25. PMID: 16040827.
    Citations: 19     Fields:    Translation:Humans
  16. Huttunen T, Malinen M, Kaipio JP, White PJ, Hynynen K. A full-wave Helmholtz model for continuous-wave ultrasound transmission. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):397-409. PMID: 15857048.
    Citations:    Fields:    
  17. White PJ, Clement GT. Nonlinear restoring behavior of therapeutic ultrasound transducers. 5th International Symposium on Therapeutic Ultrasound. 2005.
  18. White PJ, Hynynen K, Clement GT. Longitudinal and shear mode ultrasound propagation in human skull bone. 5th International Symposium on Therapeutic Ultrasound. 2005.
  19. Hynynen K, McDannold N, Clement GT, White PJ, Treat L, Yin X, Jolesz F, Sheikov N, Vykhodtseva N. Feasibility of noninvasive ultrasound delivery for tumor ablation and targeted drug delivery in the brain. Journal of the Acoustical Society of America. 2005; 117(4):2411(S).
  20. White PJ, Clement GT, Hynynen K. Frequency-dependent ultrasound transmission through the human skull. Journal of the Acoustical Society of America. 2005; 117(4):2412(A).
  21. Clement GT, White PJ, Hynynen K. Feasibility of shear-mode transcranial ultrasound imaging. Journal of the Acoustical Society of America. 2005; 117(4):2588(A).
  22. White PJ, Clement GT, Hynynen K. Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2005; 52(9):1518-1522.
  23. White PJ, Clement GT, Hynynen K. Frequency-dependent ultrasound transmission through the human skull. 5th International Symposium on Therapeutic Ultrasound. 2005.
  24. White PJ. Modalities for the optimization of ultrasound transmission through the human skull. 2005.
  25. Hynynen K, Clement GT, McDannold N, Vykhodtseva N, King R, White PJ, Vitek S, Jolesz FA. 500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magn Reson Med. 2004 Jul; 52(1):100-7. PMID: 15236372.
    Citations: 63     Fields:    Translation:HumansAnimals
  26. Clement GT, White PJ, Hynynen K. Enhanced ultrasound transmission through the human skull using shear mode conversion. J Acoust Soc Am. 2004 Mar; 115(3):1356-64. PMID: 15058357.
    Citations: 30     Fields:    Translation:HumansCells
  27. Hynynen K, Clement GT, McDannold N, Vykhodtseva N, White PJ, Jolesz F, Sheikov N. The feasibility of noninvasive image-guided treatments of brain disorders by focused ultrasound. Journal of the Acoustical Society of America. 2004; 115(5):2246(A).
  28. Clement GT, White PJ, Hynynen K. Optimizing noninvasive transcranial therapy: Beyond amplitude and phase compensation. 4th International Symposium on Therapeutic Ultrasound. 2004.
  29. White PJ, Clement GT, Hynynen K. Transcrainal Focus Reconstruction with Amplitude Correction. 2004 IEEE Ultrasonics Symposium. 2004.
  30. Clement GT, White PJ, Hynynen K. Ultrasonic Shear (SH) Mode in the Human Skull. 2003 IEEE Ultrasonics Symposium. 2003.
  31. Hynynen K, Clement GT, McDannold N, Vykhodtseva N, King R, White PJ, Vitek S, Jolesz F. A 500 Element Ultrasound Phased Array System For Noninvasive Focal Surgery of the Brain- A Preliminary Rabbit Study With Ex Vivo Human Skulls. 2003 IEEE Ultrasonics Symposium. 2003.
  32. Clement GT, McDannold N, White PJ, Vykhodtseva N, Martin H, Hynynen K. MRI-guided focused ultrasound through the human skull. Proc. International Soc. Mag. Res in Med. 2002.
  33. White PJ, Clement GT, Hynynen K. Investigation of a large area phased array for focused ultrasound surgery through the skull. Physics in Medicine and Biology. 2000; 45(4):1071-1083.
  34. White PJ, Gilbert KE, Goodman RR. Laboratory measurements of variability in high-frequency bottom backscatter due to thermal fluctuations. Journal of the Acoustical Society of America. 1994; 96(5):3286(A).
  35. Gilbert KE, Kulbago TJ, White PJ. A structure function constraint for stable least-squares inversion of reflected data. Journal of the Acoustical Society of America. 1994; 96(5):3224(A).
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.