Harvard Catalyst Profiles

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Charles J. Weitz, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM129275 (WEITZ, CHARLES J) Jun 5, 2020 - Mar 31, 2024
    Transcriptional Activator Complex of the Mammalian Circadian Clock
    Role: Principal Investigator
  2. R01NS095977 (WEITZ, CHARLES J) Sep 1, 2016 - Jun 30, 2021
    Mammalian circadian clock: genetics of PERIOD complex composition and structure.
    Role: Principal Investigator
  3. R01GM095945 (WEITZ, CHARLES J) Aug 1, 2011 - Apr 30, 2016
    BMAL1 Complexes of the Circadian Clock
    Role: Principal Investigator
  4. R01NS060860 (WEITZ, CHARLES J) May 15, 2008 - Apr 30, 2014
    Circadian Clock of the Paraventricular Nucleus
    Role: Principal Investigator
  5. R21EY017924 (WEITZ, CHARLES J) Sep 1, 2007 - Aug 31, 2009
    Diurnal Rhythms Gene Expression in the Anterior Eye
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sinturel F, Gos P, Petrenko V, Hagedorn C, Kreppel F, Storch KF, Knutti D, Liani A, Weitz C, Emmenegger Y, Franken P, Bonacina L, Dibner C, Schibler U. Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks. Genes Dev. 2021 Mar 01; 35(5-6):329-334. PMID: 33602874.
    Citations: 2     Fields:    
  2. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptácek LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 2017 Oct; 32(5):380-393. PMID: 29098954.
    Citations: 45     Fields:    Translation:Humans
  3. Aryal RP, Kwak PB, Tamayo AG, Gebert M, Chiu PL, Walz T, Weitz CJ. Macromolecular Assemblies of the Mammalian Circadian Clock. Mol Cell. 2017 Sep 07; 67(5):770-782.e6. PMID: 28886335.
    Citations: 50     Fields:    Translation:AnimalsCells
  4. Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nat Struct Mol Biol. 2015 Oct; 22(10):759-66. PMID: 26323038.
    Citations: 21     Fields:    Translation:AnimalsCells
  5. Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G. Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell. 2015 Nov 05; 26(22):3940-5. PMID: 26269583.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Kim JY, Kwak PB, Gebert M, Duong HA, Weitz CJ. Purification and analysis of PERIOD protein complexes of the mammalian circadian clock. Methods Enzymol. 2015; 551:197-210. PMID: 25662458.
    Citations: 8     Fields:    Translation:HumansAnimals
  7. Kim JY, Kwak PB, Weitz CJ. Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. Mol Cell. 2014 Dec 18; 56(6):738-48. PMID: 25453762.
    Citations: 34     Fields:    Translation:AnimalsCells
  8. Duong HA, Weitz CJ. Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb; 21(2):126-32. PMID: 24413057.
    Citations: 43     Fields:    Translation:AnimalsCells
  9. Lande-Diner L, Boyault C, Kim JY, Weitz CJ. A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16021-6. PMID: 24043798.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  10. Padmanabhan K, Robles MS, Westerling T, Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 03; 337(6094):599-602. PMID: 22767893.
    Citations: 67     Fields:    Translation:AnimalsCells
  11. Duong HA, Robles MS, Knutti D, Weitz CJ. A molecular mechanism for circadian clock negative feedback. Science. 2011 Jun 17; 332(6036):1436-9. PMID: 21680841.
    Citations: 100     Fields:    Translation:AnimalsCells
  12. Sadacca LA, Lamia KA, deLemos AS, Blum B, Weitz CJ. An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia. 2011 Jan; 54(1):120-4. PMID: 20890745.
    Citations: 113     Fields:    Translation:Animals
  13. Robles MS, Boyault C, Knutti D, Padmanabhan K, Weitz CJ. Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010 Jan 22; 327(5964):463-6. PMID: 20093473.
    Citations: 56     Fields:    Translation:AnimalsCells
  14. Storch KF, Weitz CJ. Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6808-13. PMID: 19366674.
    Citations: 87     Fields:    Translation:Animals
  15. Lamia KA, Storch KF, Weitz CJ. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15172-7. PMID: 18779586.
    Citations: 400     Fields:    Translation:Animals
  16. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24; 130(4):730-741. PMID: 17719549.
    Citations: 166     Fields:    Translation:Animals
  17. Zhao WN, Malinin N, Yang FC, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ. CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar; 9(3):268-75. PMID: 17310242.
    Citations: 29     Fields:    Translation:AnimalsCells
  18. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol. 2007; 72:307-18. PMID: 18419288.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron. 2006 Oct 19; 52(2):255-69. PMID: 17046689.
    Citations: 386     Fields:    Translation:AnimalsCells
  20. Kraves S, Weitz CJ. A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nat Neurosci. 2006 Feb; 9(2):212-9. PMID: 16429135.
    Citations: 50     Fields:    Translation:AnimalsCells
  21. Kramer A, Yang FC, Kraves S, Weitz CJ. A screen for secreted factors of the suprachiasmatic nucleus. Methods Enzymol. 2005; 393:645-63. PMID: 15817317.
    Citations: 9     Fields:    Translation:AnimalsCells
  22. Zhong S, Storch KF, Lipan O, Kao MC, Weitz CJ, Wong WH. GoSurfer: a graphical interactive tool for comparative analysis of large gene sets in Gene Ontology space. Appl Bioinformatics. 2004; 3(4):261-4. PMID: 15702958.
    Citations: 30     Fields:    Translation:Cells
  23. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling. Novartis Found Symp. 2003; 253:250-62; discussion 102-9, 263-6, 281-4. PMID: 14712926.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ. Extensive and divergent circadian gene expression in liver and heart. Nature. 2002 May 02; 417(6884):78-83. PMID: 11967526.
    Citations: 528     Fields:    Translation:Animals
  25. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science. 2001 Dec 21; 294(5551):2511-5. PMID: 11752569.
    Citations: 140     Fields:    Translation:AnimalsCells
  26. Griffin EA, Staknis D, Weitz CJ. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science. 1999 Oct 22; 286(5440):768-71. PMID: 10531061.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  27. Ceriani MF, Darlington TK, Staknis D, Más P, Petti AA, Weitz CJ, Kay SA. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 1999 Jul 23; 285(5427):553-6. PMID: 10417378.
    Citations: 147     Fields:    Translation:AnimalsCells
  28. Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov; 21(5):1101-13. PMID: 9856465.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  29. Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TD, Weitz CJ, Takahashi JS, Kay SA. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science. 1998 Jun 05; 280(5369):1599-603. PMID: 9616122.
    Citations: 237     Fields:    Translation:AnimalsCells
  30. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 1998 Jun 05; 280(5369):1564-9. PMID: 9616112.
    Citations: 565     Fields:    Translation:AnimalsCells
  31. Morris ME, Viswanathan N, Kuhlman S, Davis FC, Weitz CJ. A screen for genes induced in the suprachiasmatic nucleus by light. Science. 1998 Mar 06; 279(5356):1544-7. PMID: 9488654.
    Citations: 25     Fields:    Translation:Animals
  32. Weitz CJ. Circadian timekeeping: loops and layers of transcriptional control. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14308-9. PMID: 8962044.
    Citations: 1     Fields:    Translation:HumansAnimals
  33. Gekakis N, Saez L, Delahaye-Brown AM, Myers MP, Sehgal A, Young MW, Weitz CJ. Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science. 1995 Nov 03; 270(5237):811-5. PMID: 7481773.
    Citations: 78     Fields:    Translation:AnimalsCells
  34. Weitz CJ, Miyake Y, Shinzato K, Montag E, Zrenner E, Went LN, Nathans J. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. Am J Hum Genet. 1992 Mar; 50(3):498-507. PMID: 1531728.
    Citations: 24     Fields:    Translation:HumansCells
  35. Weitz CJ, Nathans J. Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II. Neuron. 1992 Mar; 8(3):465-72. PMID: 1532320.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Nathans J, Weitz CJ, Agarwal N, Nir I, Papermaster DS. Production of bovine rhodopsin by mammalian cell lines expressing cloned cDNA: spectrophotometry and subcellular localization. Vision Res. 1989; 29(8):907-14. PMID: 2629206.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  37. Weitz CJ, Faull KF, Goldstein A. Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature. 1987 Dec 17-23; 330(6149):674-7. PMID: 3683586.
    Citations: 14     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.