Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Marco Luciano Loggia, Ph.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DA047088 (LOGGIA, MARCO LUCIANO) Jul 15, 2018 - Mar 31, 2023
    NIH/NIDA
    Imaging neuroglial mechanisms of neuropathic pain-opioid interaction in HIV
    Role: Principal Investigator
  2. R01NS095937 (LOGGIA, MARCO LUCIANO) Sep 1, 2016 - Jun 30, 2021
    NIH/NINDS
    In-vivo imaging of spinal and brain glial activation in low back pain patients
    Role: Principal Investigator
  3. R01NS094306 (LOGGIA, MARCO LUCIANO) Apr 15, 2016 - Mar 31, 2021
    NIH/NINDS
    The Role of Brain Glial Activation in knee Ostoarthritis
    Role: Principal Investigator
  4. R21NS087472 (LOGGIA, MARCO LUCIANO) Sep 15, 2014 - Aug 31, 2016
    NIH/NINDS
    The Role of Neuroimmune Activation in Chronic Pain and Negative Affect
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 Jan 02; 129(1):364-372. PMID: 30530989.
    View in: PubMed
  2. Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, Bendotti C, Bonetto V, De Marchi F, Rosen B, Hooker J, Cudkowicz M, Atassi N. A pilot trial of RNS60 in amyotrophic lateral sclerosis. Muscle Nerve. 2018 Nov 20. PMID: 30458059.
    View in: PubMed
  3. Loggia ML, Edwards RR. Brain Structural Alterations in Chronic Knee Osteoarthritis: What Can Treatment Effects Teach Us? Pain Med. 2018 Nov 01; 19(11):2099-2100. PMID: 30137638.
    View in: PubMed
  4. Lee J, Mawla I, Kim J, Loggia ML, Ortiz A, Jung C, Chan ST, Gerber J, Schmithorst VJ, Edwards RR, Wasan AD, Berna C, Kong J, Kaptchuk TJ, Gollub RL, Rosen BR, Napadow V. Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics. Pain. 2018 Oct 17. PMID: 30540621.
    View in: PubMed
  5. Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML. Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation. Brain Behav Immun. 2019 Jan; 75:72-83. PMID: 30223011.
    View in: PubMed
  6. Loggia ML. Chronic pain and opioid receptor availability: disentangling the molecular contributions and the "chicken or the egg" dilemma. Pain. 2018 Sep; 159(9):1679-1680. PMID: 29794615.
    View in: PubMed
  7. Ratai EM, Alshikho MJ, Zürcher NR, Loggia ML, Cebulla CL, Cernasov P, Reynolds B, Fish J, Seth R, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis. Neuroimage Clin. 2018; 20:357-364. PMID: 30112276.
    View in: PubMed
  8. Ellingsen DM, Napadow V, Protsenko E, Mawla I, Kowalski MH, Swensen D, O'Dwyer-Swensen D, Edwards RR, Kettner N, Loggia ML. Brain Mechanisms of Anticipated Painful Movements and Their Modulation by Manual Therapy in Chronic Low Back Pain. J Pain. 2018 Nov; 19(11):1352-1365. PMID: 30392530.
    View in: PubMed
  9. Lee J, Protsenko E, Lazaridou A, Franceschelli O, Ellingsen DM, Mawla I, Isenburg K, Berry MP, Galenkamp L, Loggia ML, Wasan AD, Edwards RR, Napadow V. Encoding of Self-Referential Pain Catastrophizing in the Posterior Cingulate Cortex in Fibromyalgia. Arthritis Rheumatol. 2018 Aug; 70(8):1308-1318. PMID: 29579370.
    View in: PubMed
  10. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, Chonde DB, Izquierdo Garcia D, Mainero C, Catana C, Chan J, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated magnetic resonance imaging and [11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis. Ann Neurol. 2018 Jun; 83(6):1186-1197. PMID: 29740862.
    View in: PubMed
  11. Lee YC, Fine A, Protsenko E, Massarotti E, Edwards RR, Mawla I, Napadow V, Loggia ML. Brain Correlates of Continuous Pain in Rheumatoid Arthritis as Measured by Pulsed Arterial Spin Labeling. Arthritis Care Res (Hoboken). 2018 May 21. PMID: 29781581.
    View in: PubMed
  12. Lois C, González I, Izquierdo-García D, Zürcher NR, Wilkens P, Loggia ML, Hooker JM, Rosas HD. Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI. ACS Chem Neurosci. 2018 Nov 21; 9(11):2563-2571. PMID: 29719953.
    View in: PubMed
  13. Lee YC, Napadow V, Loggia ML. Editorial: Functional Connectivity: Dissecting the Relationship Between the Brain and "Pain Centralization" in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 Jul; 70(7):977-980. PMID: 29761844.
    View in: PubMed
  14. Albrecht DS, Ahmed SU, Kettner NW, Borra RJH, Cohen-Adad J, Deng H, Houle TT, Opalacz A, Roth SA, Melo MFV, Chen L, Mao J, Hooker JM, Loggia ML, Zhang Y. Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Pain. 2018 May; 159(5):968-977. PMID: 29419657.
    View in: PubMed
  15. Albrecht DS, Granziera C, Hooker JM, Loggia ML. Correction to In Vivo Imaging of Human Neuroinflammation. ACS Chem Neurosci. 2018 Jun 20; 9(6):1515. PMID: 29708334.
    View in: PubMed
  16. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    View in: PubMed
  17. Ran C, Albrecht DS, Bredella MA, Yang J, Yang J, Liang SH, Cypess AM, Loggia ML, Atassi N, Moore A. PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28. Mol Imaging Biol. 2018 04; 20(2):188-193. PMID: 28983743.
    View in: PubMed
  18. Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, Chan J, Chonde DB, Garcia DI, Catana C, Mainero C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage Clin. 2018; 17:347-353. PMID: 29159046.
    View in: PubMed
  19. Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. J Nucl Med. 2018 Jan; 59(1):107-114. PMID: 28818984.
    View in: PubMed
  20. Nijs J, Loggia ML, Polli A, Moens M, Huysmans E, Goudman L, Meeus M, Vanderweeën L, Ickmans K, Clauw D. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert Opin Ther Targets. 2017 08; 21(8):817-826. PMID: 28685641.
    View in: PubMed
  21. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 07 19; 37(29):6938-6945. PMID: 28626012.
    View in: PubMed
  22. Schreiber KL, Loggia ML, Kim J, Cahalan CM, Napadow V, Edwards RR. Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe. J Pain. 2017 Jul; 18(7):855-867. PMID: 28300650.
    View in: PubMed
  23. Lazaridou A, Kim J, Cahalan CM, Loggia ML, Franceschelli O, Berna C, Schur P, Napadow V, Edwards RR. Effects of Cognitive-Behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia. Clin J Pain. 2017 03; 33(3):215-221. PMID: 27518491.
    View in: PubMed
  24. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    View in: PubMed
  25. Herranz E, Hooker JM, Izquierdo-Garcia D, Loggia ML, Mainero C. Reply. Ann Neurol. 2017 Feb; 81(2):324-325. PMID: 28032651.
    View in: PubMed
  26. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. 2016 Dec 13; 87(24):2554-2561. PMID: 27837005.
    View in: PubMed
  27. Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563.
    View in: PubMed
  28. Lee J, Lin RL, Garcia RG, Kim J, Kim H, Loggia ML, Mawla I, Wasan AD, Edwards RR, Rosen BR, Hadjikhani N, Napadow V. Reduced insula habituation associated with amplification of trigeminal brainstem input in migraine. Cephalalgia. 2017 Oct; 37(11):1026-1038. PMID: 27521844.
    View in: PubMed
  29. Albrecht DS, Granziera C, Hooker JM, Loggia ML. In Vivo Imaging of Human Neuroinflammation. ACS Chem Neurosci. 2016 Apr 20; 7(4):470-83. PMID: 26985861.
    View in: PubMed
  30. Mawla I, Loggia M, Schmithorst V, Ortiz A, Gerber J, Protsenko E, Lee J, Kim J, Kim H, Berna C, Kaptchuk T, Kong J, Gollub R, Rosen B, Edwards R, Wasan A, Napadow V. (336) Investigating the neural circuitry supporting clinical pain perception in chronic low back pain - the importance of cardiorespiratory artifact correction with arterial spin labeling fMRI. J Pain. 2016 Apr; 17(4S):S59-S60. PMID: 28162572.
    View in: PubMed
  31. Garcia R, Lin R, Lee J, Loggia M, Kim J, Kim H, Wasan A, Edwards R, Hadjikhani N, Napadow V. (395) Brainstem activity and connectivity is modulated by respiratory-gated auricular vagus afferent nerve stimulation (RAVANS) in migraine patients - an fMRI study. J Pain. 2016 Apr; 17(4S):S73-S74. PMID: 28162639.
    View in: PubMed
  32. Napadow V, Li A, Loggia ML, Kim J, Mawla I, Desbordes G, Schalock PC, Lerner EA, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients. Allergy. 2015 Nov; 70(11):1485-92. PMID: 26280659; PMCID: PMC4609272 [Available on 11/01/16].
  33. Lai TH, Protsenko E, Cheng YC, Loggia ML, Coppola G, Chen WT. Neural Plasticity in Common Forms of Chronic Headaches. Neural Plast. 2015; 2015:205985. PMID: 26366304; PMCID: PMC4558449.
  34. Ibinson JW, Vogt KM, Taylor KB, Dua SB, Becker CJ, Loggia M, Wasan AD. Optimizing and Interpreting Insular Functional Connectivity Maps Obtained During Acute Experimental Pain: The Effects of Global Signal and Task Paradigm Regression. Brain Connect. 2015 Dec; 5(10):649-57. PMID: 26061382; PMCID: PMC4684650 [Available on 12/01/16].
  35. Kim J, Loggia ML, Cahalan CM, Harris RE, Beissner F, Garcia RG, Kim H, Wasan AD, Edwards RR, Napadow V. The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction. Arthritis Rheumatol. 2015 May; 67(5):1395-1405. PMID: 25622796; PMCID: PMC4414820.
  36. Loggia ML, Berna C, Kim J, Cahalan CM, Martel MO, Gollub RL, Wasan AD, Napadow V, Edwards RR. The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients. J Pain. 2015 Aug; 16(8):692-9. PMID: 25937162.
    View in: PubMed
  37. Kim H, Kim J, Loggia ML, Cahalan C, Garcia RG, Vangel MG, Wasan AD, Edwards RR, Napadow V. Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks. Neuroimage Clin. 2015; 7:667-77. PMID: 25844321; PMCID: PMC4379388.
  38. Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage Clin. 2015; 7:409-14. PMID: 25685708; PMCID: PMC4310932.
  39. Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM. Evidence for brain glial activation in chronic pain patients. Brain. 2015 Mar; 138(Pt 3):604-15. PMID: 25582579.
    View in: PubMed
  40. Desbordes G, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F, Napadow V. Evoked itch perception is associated with changes in functional brain connectivity. Neuroimage Clin. 2015; 7:213-21. PMID: 25610783; PMCID: PMC4300003.
  41. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022; PMCID: PMC4280551.
  42. Dolman AJ, Loggia ML, Edwards RR, Gollub RL, Kong J, Napadow V, Wasan AD. Phenotype matters: the absence of a positive association between cortical thinning and chronic low back pain when controlling for salient clinical variables. Clin J Pain. 2014 Oct; 30(10):839-45. PMID: 24135900; PMCID: PMC4103969.
  43. Loggia ML, Edwards RR, Harris RE, Napadow V. Reply: To PMID 24449585. Arthritis Rheumatol. 2014 Jun; 66(6):1684-5. PMID: 24515749; PMCID: PMC4195441.
  44. Coombs G, Loggia ML, Greve DN, Holt DJ. Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect. PLoS One. 2014; 9(5):e97466. PMID: 24816735; PMCID: PMC4016310.
  45. Loggia ML, Berna C, Kim J, Cahalan CM, Gollub RL, Wasan AD, Harris RE, Edwards RR, Napadow V. Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia. Arthritis Rheumatol. 2014 Jan; 66(1):203-12. PMID: 24449585; PMCID: PMC4516215.
  46. Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen K, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan AD, Gollub RL. S1 is associated with chronic low back pain: a functional and structural MRI study. Mol Pain. 2013 Aug 21; 9:43. PMID: 23965184.
    View in: PubMed
  47. Kim J, Loggia ML, Edwards RR, Wasan AD, Gollub RL, Napadow V. Sustained deep-tissue pain alters functional brain connectivity. Pain. 2013 Aug; 154(8):1343-51. PMID: 23718988; PMCID: PMC3700646.
  48. Napadow V, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The brain circuitry mediating antipruritic effects of acupuncture. Cereb Cortex. 2014 Apr; 24(4):873-82. PMID: 23222890; PMCID: PMC3948489.
  49. Loggia ML, Kim J, Gollub RL, Vangel MG, Kirsch I, Kong J, Wasan AD, Napadow V. Default mode network connectivity encodes clinical pain: an arterial spin labeling study. Pain. 2013 Jan; 154(1):24-33. PMID: 23111164; PMCID: PMC3534957.
  50. Loggia ML, Edwards RR, Kim J, Vangel MG, Wasan AD, Gollub RL, Harris RE, Park K, Napadow V. Disentangling linear and nonlinear brain responses to evoked deep tissue pain. Pain. 2012 Oct; 153(10):2140-51. PMID: 22883925; PMCID: PMC3445769.
  51. Loggia ML, Napadow V. Multi-parameter autonomic-based pain assessment: more is more? Pain. 2012 Sep; 153(9):1779-80. PMID: 22633682.
    View in: PubMed
  52. Jensen KB, Berna C, Loggia ML, Wasan AD, Edwards RR, Gollub RL. The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain. Neurosci Lett. 2012 Jun 29; 520(2):156-64. PMID: 22445888; PMCID: PMC3810294.
  53. Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS One. 2011; 6(11):e27764. PMID: 22132136.
    View in: PubMed
  54. Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural correlates of chronic low back pain measured by arterial spin labeling. Anesthesiology. 2011 Aug; 115(2):364-74. PMID: 21720241; PMCID: PMC3286828.
  55. Loggia ML, Juneau M, Bushnell MC. Autonomic responses to heat pain: Heart rate, skin conductance, and their relation to verbal ratings and stimulus intensity. Pain. 2011 Mar; 152(3):592-8. PMID: 21215519.
    View in: PubMed
  56. Campbell CM, Witmer K, Simango M, Carteret A, Loggia ML, Campbell JN, Haythornthwaite JA, Edwards RR. Catastrophizing delays the analgesic effect of distraction. Pain. 2010 May; 149(2):202-7. PMID: 20188470; PMCID: PMC2860661.
  57. Kong J, Loggia ML, Zyloney C, Tu P, Laviolette P, Gollub RL. Exploring the brain in pain: activations, deactivations and their relation. Pain. 2010 Feb; 148(2):257-67. PMID: 20005043; PMCID: PMC2815185.
  58. Loggia ML, Bushnell MC, Tétreault M, Thiffault I, Bhérer C, Mohammed NK, Kuchinad AA, Laferrière A, Dicaire MJ, Loisel L, Mogil JS, Brais B. Carriers of recessive WNK1/HSN2 mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli. J Neurosci. 2009 Feb 18; 29(7):2162-6. PMID: 19228968; PMCID: PMC2749662.
  59. Loggia ML, Schweinhardt P, Villemure C, Bushnell MC. Effects of psychological state on pain perception in the dental environment. J Can Dent Assoc. 2008 Sep; 74(7):651-6. PMID: 18789200.
    View in: PubMed
  60. Loggia ML, Mogil JS, Bushnell MC. Experimentally induced mood changes preferentially affect pain unpleasantness. J Pain. 2008 Sep; 9(9):784-91. PMID: 18538637.
    View in: PubMed
  61. Loggia ML, Mogil JS, Bushnell MC. Empathy hurts: compassion for another increases both sensory and affective components of pain perception. Pain. 2008 May; 136(1-2):168-76. PMID: 17822850.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Loggia's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (179)
Explore
_
Co-Authors (70)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.