Cristina Aguayo-Mazzucato, Ph.D., M.D.
|Title||Instructor in Medicine|
|Institution||Joslin Diabetes Center|
|Address||Joslin Diabetes Center|
Research - 5th Floor
One Joslin Place
Boston MA 02215
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Available: 07/25/17, Expires: 09/03/18
The risk of type 2 diabetes (T2D) increases with age and given the importance of beta cell loss/dysfunction in the development of the disease we would like to further our understanding of the effects of beta cell aging in the development of T2D.
We have identified markers to evaluate the age of individual beta cells and have mouse models that allow us to specifically delete old beta cells and evaluate the effects of this intervention in the disease.
Students would mainly work using rodent models with techniques that range from immunohistochemstry, basic molecular biology, cell culture, islet isolation, evaluation of insulin secretion, ELISA, FACS sorting to animal work with interventions such as high fat diet or implants. . Some translational work using pancreatic samples from donors is also available.
The role of beta cell aging in type 1 diabetes will also be evaluated.
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