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Cristina Aguayo-Mazzucato, Ph.D., M.D.

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Mentoring
Available: 12/02/19, Expires: 10/30/21

The risk of type 2 diabetes (T2D) increases with age and given the importance of beta cell loss/dysfunction in the development of the disease we would like to further our understanding of the effects of beta cell aging in the development of T2D. We have identified markers to evaluate the age of individual beta cells and have mouse models that allow us to specifically delete old beta cells and evaluate the effects of this intervention in the disease. The role of beta cell aging in type 1 diabetes will also be evaluated, specifically the effect of the senescence-associated secretory phenotype (SASP) on the function and proliferative capacity of neighbouring cells. In person projects would allow students to work using rodent models with techniques that range from immunohistochemstry, basic molecular biology, cell culture, islet isolation, evaluation of insulin secretion, ELISA, FACS to animal work with interventions such as high fat diet or implants. Remote projects will be based on data analysis using different statistical packages and accessing publicly available databases.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Midha A, Pan H, Abarca C, Andle J, Carapeto P, Bonner-Weir S, Aguayo-Mazzucato C. Unique human and mouse ß-cell senescence-associated secretory phenotype (SASP) reveal conserved signaling pathways and heterogeneous factors. Diabetes. 2021 Mar 05. PMID: 33674410.
    Citations:    Fields:    
  2. Aguayo-Mazzucato C. Functional changes in beta cells during ageing and senescence. Diabetologia. 2020 10; 63(10):2022-2029. PMID: 32894312.
    Citations: 2     Fields:    
  3. Aguayo-Mazzucato C, Midha A. ß-cell senescence in type 2 diabetes. Aging (Albany NY). 2019 11 25; 11(22):9967-9968. PMID: 31767811.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Aguayo-Mazzucato C, Andle J, Lee TB, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir S. Acceleration of ß Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell Metab. 2019 07 02; 30(1):129-142.e4. PMID: 31155496.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  5. Aguayo-Mazzucato C, Diaque P, Hernandez S, Rosas S, Kostic A, Caballero AE. Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States. Diabetes Metab Res Rev. 2019 02; 35(2):e3097. PMID: 30445663.
    Citations: 5     Fields:    Translation:Humans
  6. Aguayo-Mazzucato C, Lee TB, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S. T3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells. Diabetes. 2018 07; 67(7):1322-1331. PMID: 29625991.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  7. Aguayo-Mazzucato C, Bonner-Weir S. Pancreatic ß Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab. 2018 01 09; 27(1):57-67. PMID: 28889951.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  8. Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S. ß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 04; 25(4):898-910.e5. PMID: 28380379.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  9. Bonner-Weir S, Aguayo-Mazzucato C. Physiology: Pancreatic ß-cell heterogeneity revisited. Nature. 2016 07 21; 535(7612):365-6. PMID: 27398615.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Bonner-Weir S, Aguayo-Mazzucato C, Weir GC. Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci. 2016 May; 121(2):155-8. PMID: 26998806.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  11. Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S. MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. J Clin Endocrinol Metab. 2015 Oct; 100(10):3651-9. PMID: 26207953.
    Citations: 17     Fields:    Translation:HumansCells
  12. Weir GC, Aguayo-Mazzucato C, Bonner-Weir S. ß-cell dedifferentiation in diabetes is important, but what is it? Islets. 2013 Sep-Dec; 5(5):233-7. PMID: 24356710.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  13. Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs ß-cell function. Diabetes. 2013 Dec; 62(12):4201-7. PMID: 24009256.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes. 2013 Oct; 62(10):3459-68. PMID: 23775765.
    Citations: 13     Fields:    Translation:AnimalsCells
  15. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S. Thyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013 May; 62(5):1569-80. PMID: 23305647.
    Citations: 51     Fields:    Translation:AnimalsCells
  16. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion. Endocrinology. 2012 Nov; 153(11):5180-7. PMID: 22919061.
    Citations: 25     Fields:    Translation:AnimalsCells
  17. Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832. PMID: 21698184.
    Citations: 42     Fields:    Translation:Animals
  18. Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604. PMID: 21240476.
    Citations: 50     Fields:    Translation:AnimalsCells
  19. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93. PMID: 21190012.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  20. Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit F. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res. 2011 Jan; 21(1):95-105. PMID: 21088282.
    Citations: 82     Fields:    Translation:Animals
  21. Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010 Mar; 6(3):139-48. PMID: 20173775.
    Citations: 60     Fields:    Translation:HumansCells
  22. Aguayo-Mazzucato C, Sanchez-Soto C, Godinez-Puig V, Gutiérrez-Ospina G, Hiriart M. Restructuring of pancreatic islets and insulin secretion in a postnatal critical window. PLoS One. 2006 Dec 20; 1:e35. PMID: 17183663.
    Citations: 28     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.