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Cristina Aguayo-Mazzucato, Ph.D., M.D.

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Mentoring
Available: 11/01/18, Expires: 10/31/19

The risk of type 2 diabetes (T2D) increases with age and given the importance of beta cell loss/dysfunction in the development of the disease we would like to further our understanding of the effects of beta cell aging in the development of T2D. We have identified markers to evaluate the age of individual beta cells and have mouse models that allow us to specifically delete old beta cells and evaluate the effects of this intervention in the disease. Students would mainly work using rodent models with techniques that range from immunohistochemstry, basic molecular biology, cell culture, islet isolation, evaluation of insulin secretion, ELISA, FACS sorting to animal work with interventions such as high fat diet or implants. Some translational work using pancreatic samples from donors is also available. The role of beta cell aging in type 1 diabetes will also be evaluated.


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  1. Aguayo-Mazzucato C, Diaque P, Hernandez S, Rosas S, Kostic A, Caballero AE. Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States. Diabetes Metab Res Rev. 2019 Feb; 35(2):e3097. PMID: 30445663.
    Citations:    Fields:    
  2. Aguayo-Mazzucato C, Lee TB, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S. T3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells. Diabetes. 2018 07; 67(7):1322-1331. PMID: 29625991.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Aguayo-Mazzucato C, Bonner-Weir S. Pancreatic ß Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab. 2018 01 09; 27(1):57-67. PMID: 28889951.
    Citations: 2     Fields:    
  4. Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S. ß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 04; 25(4):898-910.e5. PMID: 28380379.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  5. Bonner-Weir S, Aguayo-Mazzucato C. Physiology: Pancreatic ß-cell heterogeneity revisited. Nature. 2016 07 21; 535(7612):365-6. PMID: 27398615.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  6. Bonner-Weir S, Aguayo-Mazzucato C, Weir GC. Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci. 2016 May; 121(2):155-8. PMID: 26998806.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S. MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. J Clin Endocrinol Metab. 2015 Oct; 100(10):3651-9. PMID: 26207953; PMCID: PMC4596039.
    Citations: 6     Fields:    Translation:HumansCells
  8. Weir GC, Aguayo-Mazzucato C, Bonner-Weir S. ß-cell dedifferentiation in diabetes is important, but what is it? Islets. 2013 Sep-Dec; 5(5):233-7. PMID: 24356710.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  9. Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs ß-cell function. Diabetes. 2013 Dec; 62(12):4201-7. PMID: 24009256.
    Citations: 10     Fields:    Translation:AnimalsCells
  10. Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes. 2013 Oct; 62(10):3459-68. PMID: 23775765.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S. Thyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013 May; 62(5):1569-80. PMID: 23305647.
    Citations: 31     Fields:    Translation:AnimalsCells
  12. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion. Endocrinology. 2012 Nov; 153(11):5180-7. PMID: 22919061.
    Citations: 13     Fields:    Translation:AnimalsCells
  13. Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832. PMID: 21698184; PMCID: PMC3116839.
    Citations: 33     Fields:    Translation:Animals
  14. Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604. PMID: 21240476; PMCID: PMC3045081.
    Citations: 22     Fields:    Translation:AnimalsCells
  15. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93. PMID: 21190012; PMCID: PMC3047400.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  16. Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit F. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res. 2011 Jan; 21(1):95-105. PMID: 21088282; PMCID: PMC3012930.
    Citations: 49     Fields:    Translation:Animals
  17. Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010 Mar; 6(3):139-48. PMID: 20173775.
    Citations: 41     Fields:    Translation:HumansCells
  18. Aguayo-Mazzucato C, Sanchez-Soto C, Godinez-Puig V, Gutiérrez-Ospina G, Hiriart M. Restructuring of pancreatic islets and insulin secretion in a postnatal critical window. PLoS One. 2006 Dec 20; 1:e35. PMID: 17183663.
    Citations: 16     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.