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Eric Alan Osborn, M.D.

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Duke University, Durham, NCBSE06/1998Biomedical Engineering
Massachusetts Institute of Technology, Cambridge, MASM06/2000Mechanical Engineering
Massachusetts Institute of Technology, Cambridge, MAPhD06/2004Medical Engineering and Medical Physics
Harvard Medical School, Boston, MAMD06/2006
Beth Israel Deaconess Medical Center, Boston, MA06/2009Residency, Internal Medicine
Beth Israel Deaconess Medical Center, Boston, MA06/2012Fellowship, Cardiovascular Disease
Beth Israel Deaconess Medical Center, Boston, MA06/2013Fellowship, Interventional Cardiology
Massachusetts General Hospital, Boston, MA12/2014Fellowship, Post-Doctoral Research


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL130465 (OSBORN, ERIC A) Jan 1, 2017 - Dec 31, 2020
    Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Osborn EA, Johnson M, Maksoud A, Spoon D, Zidar FJ, Korngold EC, Buccola J, Garcia Cabrera H, Rapoza RJ, West NEJ, Rauch J. Safety and efficiency of percutaneous coronary intervention using a standardised optical coherence tomography workflow. EuroIntervention. 2022 Nov 08. PMID: 36373421.
    Citations:    Fields:    
  2. Osborn EA, Houstis NE, Jaffer FA. Synergizing Light and Machine Learning to Comprehensively Reveal Coronary Plaque Composition. JACC Basic Transl Sci. 2021 Dec; 6(12):961-963. PMID: 35024501; PMCID: PMC8733742.
  3. Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA. Highly Selective PPARa (Peroxisome Proliferator-Activated Receptor a) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging. J Am Heart Assoc. 2021 10 19; 10(20):e020834. PMID: 34632804; PMCID: PMC8751880.
    Citations:    Fields:    Translation:Animals
  4. Osborn EA, Ughi GJ, Verjans JW, Piao Z, Gerbaud E, Albaghdadi M, Khraishah H, Kassab MB, Takx RAP, Cui J, Mauskapf A, Shen C, Yeh RW, Klimas MT, Tawakol A, Tearney GJ, Jaffer FA. Intravascular Molecular-Structural Assessment of Arterial Inflammation in Preclinical Atherosclerosis Progression. JACC Cardiovasc Imaging. 2021 11; 14(11):2265-2267. PMID: 34419392; PMCID: PMC8571057.
    Citations: 1     Fields:    Translation:Humans
  5. Chowdhury MM, Singh K, Albaghdadi MS, Khraishah H, Mauskapf A, Kessinger CW, Osborn EA, Kellnberger S, Piao Z, Lino Cardenas CL, Grau MS, Jaff MR, Rosenfield K, Libby P, Edelman ER, Lindsay ME, Tearney GJ, Jaffer FA. Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits. JACC Basic Transl Sci. 2020 Jul; 5(7):685-695. PMID: 32760856; PMCID: PMC7393431.
    Citations: 4     
  6. Darmoch F, Alraies MC, Al-Khadra Y, Moussa Pacha H, Pinto DS, Osborn EA. Intravascular Ultrasound Imaging-Guided Versus Coronary Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2020 03 03; 9(5):e013678. PMID: 32075491.
    Citations: 17     Fields:    Translation:Humans
  7. Chowdhury M, Osborn EA. Physiological Assessment of Coronary Lesions in 2020. Curr Treat Options Cardiovasc Med. 2020 Jan 15; 22(1):2. PMID: 31938934.
    Citations: 4     
  8. Seguy B, Osborn EA, Pernot M, Gerbaud E. A giant coronary artery aneurysm and recurrent ST-segment elevation myocardial infarction: A management dilemna. Cardiol J. 2019; 26(2):212-214. PMID: 31032877; PMCID: PMC6712981.
    Citations: 2     Fields:    Translation:Humans
  9. Yang-Giuliano X, Osborn EA. Paradoxically simple: A new nutritional index for predicting coronary risk. Int J Cardiol. 2018 07 01; 262:106-107. PMID: 29706386; PMCID: PMC5945199.
    Citations: 1     Fields:    
  10. Mukhopadhyay A, Faridi KF, Asnani A, Osborn EA, Yang JX, Phillips CT, York M. Chest Pain During Chemotherapy: A Case of Severe Myocardial Bridging. J Invasive Cardiol. 2018 Jul; 30(7):E61. PMID: 29958181.
    Citations:    Fields:    Translation:Humans
  11. Bozhko D, Osborn EA, Rosenthal A, Verjans JW, Hara T, Kellnberger S, Wissmeyer G, Ovsepian SV, McCarthy JR, Mauskapf A, Stein AF, Jaffer FA, Ntziachristos V. Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo. Eur Heart J Cardiovasc Imaging. 2017 Nov 01; 18(11):1253-1261. PMID: 28031233; PMCID: PMC5837649.
    Citations: 11     Fields:    Translation:Animals
  12. Osborn EA, Kessinger CW, Tawakol A, Jaffer FA. Metabolic and Molecular Imaging of Atherosclerosis and Venous Thromboembolism. J Nucl Med. 2017 06; 58(6):871-877. PMID: 28450558; PMCID: PMC5450364.
    Citations: 6     Fields:    Translation:Humans
  13. Okai I, Iwata H, Osborn EA, Fukuda K, Shiozaki M, Kimura Y, Chikata Y, Inoue K, Fujiwara Y, Jaffer FA, Daida H, Sumiyoshi M. Sequential Acute Coronary Syndrome 4 Days Apart: A Missed Opportunity? Circ J. 2017 Jul 25; 81(8):1231-1233. PMID: 28190858; PMCID: PMC5673484.
    Citations:    Fields:    Translation:Humans
  14. Verjans JW, Osborn EA, Ughi GJ, Calfon Press MA, Hamidi E, Antoniadis AP, Papafaklis MI, Conrad MF, Libby P, Stone PH, Cambria RP, Tearney GJ, Jaffer FA. Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis: Clinical and Intracoronary Evaluation of Indocyanine Green. JACC Cardiovasc Imaging. 2016 09; 9(9):1087-1095. PMID: 27544892.
    Citations: 33     Fields:    Translation:HumansAnimals
  15. Chikata Y, Iwata H, Osborn EA, Fukuda K, Okai I, Shiozaki M, Kimura Y, Inoue K, Fujiwara Y, Sumiyoshi M. Simultaneous subacute coronary artery stent thrombosis in a carrier of two CYP2C19 loss-of function polymorphisms (*2/*3). Int J Cardiol. 2016 Jun 01; 212:148-50. PMID: 27038722; PMCID: PMC4842144.
    Citations: 1     Fields:    Translation:Humans
  16. Osborn EA, Jaffer FA. Imaging inflammation and neovascularization in atherosclerosis: clinical and translational molecular and structural imaging targets. Curr Opin Cardiol. 2015 Nov; 30(6):671-80. PMID: 26398413; PMCID: PMC4632070.
    Citations: 7     Fields:    Translation:Humans
  17. Osborn EA, Cutlip DE. Do you see what I see? Time for a standardized approach to angiography-based decision making. Circ Cardiovasc Interv. 2014 Dec; 7(6):736-8. PMID: 25516757.
    Citations:    Fields:    Translation:Humans
  18. Ughi GJ, Verjans J, Fard AM, Wang H, Osborn E, Hara T, Mauskapf A, Jaffer FA, Tearney GJ. Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging. Int J Cardiovasc Imaging. 2015 Feb; 31(2):259-68. PMID: 25341407.
    Citations: 23     Fields:    Translation:HumansAnimals
  19. Osborn EA, Jaffer FA. The advancing clinical impact of molecular imaging in CVD. JACC Cardiovasc Imaging. 2013 Dec; 6(12):1327-41. PMID: 24332285.
    Citations: 39     Fields:    Translation:Humans
  20. Osborn EA, Jaffer FA. Imaging atherosclerosis and risk of plaque rupture. Curr Atheroscler Rep. 2013 Oct; 15(10):359. PMID: 23982263.
    Citations: 20     Fields:    Translation:HumansAnimals
  21. Osborn EA, Jaffer FA. The year in molecular imaging. JACC Cardiovasc Imaging. 2012 Mar; 5(3):317-28. PMID: 22421179.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Osborn EA, Jaffer FA. The year in molecular imaging. JACC Cardiovasc Imaging. 2010 Nov; 3(11):1181-95. PMID: 21071007.
    Citations: 6     Fields:    Translation:HumansAnimals
  23. Han Y, Osborn EA, Maron MS, Manning WJ, Yeon SB. Impact of papillary and trabecular muscles on quantitative analyses of cardiac function in hypertrophic cardiomyopathy. J Magn Reson Imaging. 2009 Nov; 30(5):1197-202. PMID: 19856455.
    Citations: 12     Fields:    Translation:Humans
  24. Osborn EA, Jaffer FA. The year in molecular imaging. JACC Cardiovasc Imaging. 2009 Jan; 2(1):97-113. PMID: 19356541.
    Citations: 1     Fields:    Translation:HumansAnimals
  25. Osborn EA, Jaffer FA. Advances in molecular imaging of atherosclerotic vascular disease. Curr Opin Cardiol. 2008 Nov; 23(6):620-8. PMID: 18830079; PMCID: PMC3984946.
    Citations: 11     Fields:    Translation:Humans
  26. Osborn EA, Rabodzey A, Dewey CF, Hartwig JH. Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C444-52. PMID: 16176968.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  27. Bindschadler M, Osborn EA, Dewey CF, McGrath JL. A mechanistic model of the actin cycle. Biophys J. 2004 May; 86(5):2720-39. PMID: 15111391; PMCID: PMC1304143.
    Citations: 25     Fields:    Translation:Cells
  28. Nakamura F, Osborn E, Janmey PA, Stossel TP. Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments. J Biol Chem. 2002 Mar 15; 277(11):9148-54. PMID: 11786548.
    Citations: 31     Fields:    Translation:Cells
  29. McGrath JL, Osborn EA, Tardy YS, Dewey CF, Hartwig JH. Regulation of the actin cycle in vivo by actin filament severing. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6532-7. PMID: 10823888; PMCID: PMC18648.
    Citations: 25     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.