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Last Name

profileSarah J Lessard, PH.D.

TitleAssistant Professor of Medicine
InstitutionJoslin Diabetes Center
AddressJoslin Diabetes Center
Research -5th Floor
One Joslin Place
Boston MA 02215
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Margolis LM, Lessard SJ, Ezzyat Y, Fielding RA, Rivas DA. Circulating MicroRNA Are Predictive of Aging and Acute Adaptive Response to Resistance Exercise in Men. J Gerontol A Biol Sci Med Sci. 2017 Oct 01; 72(10):1319-1326. PMID: 27927764.
    View in: PubMed
  2. Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, Goodyear LJ. The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. J Clin Invest. 2016 Feb; 126(2):560-70. PMID: 26690705; PMCID: PMC4731174.
  3. Rivas DA, Lessard SJ, Rice NP, Lustgarten MS, So K, Goodyear LJ, Parnell LD, Fielding RA. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. FASEB J. 2014 Sep; 28(9):4133-47. PMID: 24928197.
    View in: PubMed
  4. An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, Goodyear LJ. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15; 306(12):R925-33. PMID: 24740654; PMCID: PMC4159733.
  5. Stephenson EJ, Lessard SJ, Rivas DA, Watt MJ, Yaspelkis BB, Koch LG, Britton SL, Hawley JA. Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab. 2013 Aug 01; 305(3):E429-38. PMID: 23757406; PMCID: PMC4073983.
  6. Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013 Aug; 62(8):2717-27. PMID: 23610057; PMCID: PMC3717870.
  7. Ritchie RH, Leo CH, Qin C, Stephenson EJ, Bowden MA, Buxton KD, Lessard SJ, Rivas DA, Koch LG, Britton SL, Hawley JA, Woodman OL. Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. Am J Physiol Heart Circ Physiol. 2013 Mar 01; 304(5):H729-39. PMID: 23262135; PMCID: PMC3833993.
  8. Rivas DA, Lessard SJ, Saito M, Friedhuber AM, Koch LG, Britton SL, Yaspelkis BB, Hawley JA. Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2011 Apr; 300(4):R835-43. PMID: 21270346; PMCID: PMC3075075.
  9. Lessard SJ, Rivas DA, Stephenson EJ, Yaspelkis BB, Koch LG, Britton SL, Hawley JA. Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. Am J Physiol Regul Integr Comp Physiol. 2011 Jan; 300(1):R175-82. PMID: 21048074; PMCID: PMC3023282.
  10. Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15541-6. PMID: 20713714; PMCID: PMC2932588.
  11. Yaspelkis BB, Kvasha IA, Lessard SJ, Rivas DA, Hawley JA. Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. Eur J Appl Physiol. 2010 Nov; 110(4):779-88. PMID: 20596724.
    View in: PubMed
  12. Lessard SJ, Rivas DA, Chen ZP, van Denderen BJ, Watt MJ, Koch LG, Britton SL, Kemp BE, Hawley JA. Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 2009 Nov; 150(11):4883-91. PMID: 19819977; PMCID: PMC2775978.
  13. Rivas DA, Lessard SJ, Coffey VG. mTOR function in skeletal muscle: a focal point for overnutrition and exercise. Appl Physiol Nutr Metab. 2009 Oct; 34(5):807-16. PMID: 19935842.
    View in: PubMed
  14. Rivas DA, Yaspelkis BB, Hawley JA, Lessard SJ. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Endocrinol. 2009 Sep; 202(3):441-51. PMID: 19574345.
    View in: PubMed
  15. Yeo WK, Lessard SJ, Chen ZP, Garnham AP, Burke LM, Rivas DA, Kemp BE, Hawley JA. Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. J Appl Physiol (1985). 2008 Nov; 105(5):1519-26. PMID: 18801964.
    View in: PubMed
  16. Saito M, Lessard SJ, Rivas DA, Reeder DW, Hawley JA, Yaspelkis BB. Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism. 2008 Sep; 57(9):1173-80. PMID: 18702941; PMCID: PMC2597576.
  17. Pedersen DJ, Lessard SJ, Coffey VG, Churchley EG, Wootton AM, Ng T, Watt MJ, Hawley JA. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol (1985). 2008 Jul; 105(1):7-13. PMID: 18467543.
    View in: PubMed
  18. Hawley JA, Lessard SJ. Exercise training-induced improvements in insulin action. Acta Physiol (Oxf). 2008 Jan; 192(1):127-35. PMID: 18171435.
    View in: PubMed
  19. Yaspelkis BB, Lessard SJ, Reeder DW, Limon JJ, Saito M, Rivas DA, Kvasha I, Hawley JA. Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E941-9. PMID: 17623749.
    View in: PubMed
  20. Lessard SJ, Rivas DA, Chen ZP, Bonen A, Febbraio MA, Reeder DW, Kemp BE, Yaspelkis BB, Hawley JA. Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes. 2007 Jul; 56(7):1856-64. PMID: 17440174.
    View in: PubMed
  21. Hawley JA, Lessard SJ. Mitochondrial function: use it or lose it. Diabetologia. 2007 Apr; 50(4):699-702. PMID: 17279353.
    View in: PubMed
  22. Lessard S, DeYoung J, Vazzana N. Medication discrepancies affecting senior patients at hospital admission. Am J Health Syst Pharm. 2006 Apr 15; 63(8):740-3. PMID: 16595814.
    View in: PubMed
  23. Lessard SJ, Chen ZP, Watt MJ, Hashem M, Reid JJ, Febbraio MA, Kemp BE, Hawley JA. Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Feb; 290(2):E251-7. PMID: 16118254.
    View in: PubMed
  24. McInerney P, Lessard SJ, Burke LM, Coffey VG, Lo Giudice SL, Southgate RJ, Hawley JA. Failure to repeatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc. 2005 Mar; 37(3):404-11. PMID: 15741838.
    View in: PubMed
  25. Lessard SJ, Lo Giudice SL, Lau W, Reid JJ, Turner N, Febbraio MA, Hawley JA, Watt MJ. Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle. Endocrinology. 2004 Dec; 145(12):5665-70. PMID: 15375026.
    View in: PubMed
  26. Hawke TJ, Lessard S, Vickery L, Lipskie SL, Lindinger MI. Ouabain stimulates unidirectional and net potassium efflux in resting mammalian skeletal muscle. Can J Physiol Pharmacol. 2001 Nov; 79(11):932-41. PMID: 11760095.
    View in: PubMed
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