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Sarah J Lessard, PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Scheiman J, Luber JM, Chavkin TA, MacDonald T, Tung A, Pham LD, Wibowo MC, Wurth RC, Punthambaker S, Tierney BT, Yang Z, Hattab MW, Avila-Pacheco J, Clish CB, Lessard S, Church GM, Kostic AD. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat Med. 2019 Jul; 25(7):1104-1109. PMID: 31235964.
    Citations:    
  2. Sun XL, Lessard SJ, An D, Koh HJ, Esumi H, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart. J Cell Biochem. 2019 Jan; 120(1):685-696. PMID: 30256437.
    Citations:    Fields:    
  3. Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018 08 02; 9(1):3030. PMID: 30072727.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Margolis LM, Lessard SJ, Ezzyat Y, Fielding RA, Rivas DA. Circulating MicroRNA Are Predictive of Aging and Acute Adaptive Response to Resistance Exercise in Men. J Gerontol A Biol Sci Med Sci. 2017 Oct 01; 72(10):1319-1326. PMID: 27927764.
    Citations: 6     Fields:    Translation:Humans
  5. Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, Goodyear LJ. The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. J Clin Invest. 2016 Feb; 126(2):560-70. PMID: 26690705.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Rivas DA, Lessard SJ, Rice NP, Lustgarten MS, So K, Goodyear LJ, Parnell LD, Fielding RA. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. FASEB J. 2014 Sep; 28(9):4133-47. PMID: 24928197.
    Citations: 29     Fields:    Translation:HumansCells
  7. An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, Goodyear LJ. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15; 306(12):R925-33. PMID: 24740654.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Stephenson EJ, Lessard SJ, Rivas DA, Watt MJ, Yaspelkis BB, Koch LG, Britton SL, Hawley JA. Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab. 2013 Aug 01; 305(3):E429-38. PMID: 23757406.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013 Aug; 62(8):2717-27. PMID: 23610057.
    Citations: 16     Fields:    Translation:AnimalsCells
  10. Ritchie RH, Leo CH, Qin C, Stephenson EJ, Bowden MA, Buxton KD, Lessard SJ, Rivas DA, Koch LG, Britton SL, Hawley JA, Woodman OL. Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. Am J Physiol Heart Circ Physiol. 2013 Mar 01; 304(5):H729-39. PMID: 23262135.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Rivas DA, Lessard SJ, Saito M, Friedhuber AM, Koch LG, Britton SL, Yaspelkis BB, Hawley JA. Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2011 Apr; 300(4):R835-43. PMID: 21270346.
    Citations: 26     Fields:    Translation:AnimalsCells
  12. Lessard SJ, Rivas DA, Stephenson EJ, Yaspelkis BB, Koch LG, Britton SL, Hawley JA. Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. Am J Physiol Regul Integr Comp Physiol. 2011 Jan; 300(1):R175-82. PMID: 21048074.
    Citations: 18     Fields:    Translation:AnimalsCells
  13. Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15541-6. PMID: 20713714.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  14. Yaspelkis BB, Kvasha IA, Lessard SJ, Rivas DA, Hawley JA. Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. Eur J Appl Physiol. 2010 Nov; 110(4):779-88. PMID: 20596724.
    Citations:    Fields:    Translation:AnimalsCells
  15. Lessard SJ, Rivas DA, Chen ZP, van Denderen BJ, Watt MJ, Koch LG, Britton SL, Kemp BE, Hawley JA. Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 2009 Nov; 150(11):4883-91. PMID: 19819977.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  16. Rivas DA, Lessard SJ, Coffey VG. mTOR function in skeletal muscle: a focal point for overnutrition and exercise. Appl Physiol Nutr Metab. 2009 Oct; 34(5):807-16. PMID: 19935842.
    Citations: 10     Fields:    Translation:HumansAnimals
  17. Rivas DA, Yaspelkis BB, Hawley JA, Lessard SJ. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Endocrinol. 2009 Sep; 202(3):441-51. PMID: 19574345.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Yeo WK, Lessard SJ, Chen ZP, Garnham AP, Burke LM, Rivas DA, Kemp BE, Hawley JA. Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. J Appl Physiol (1985). 2008 Nov; 105(5):1519-26. PMID: 18801964.
    Citations: 10     Fields:    Translation:HumansCells
  19. Saito M, Lessard SJ, Rivas DA, Reeder DW, Hawley JA, Yaspelkis BB. Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism. 2008 Sep; 57(9):1173-80. PMID: 18702941.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Pedersen DJ, Lessard SJ, Coffey VG, Churchley EG, Wootton AM, Ng T, Watt MJ, Hawley JA. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol (1985). 2008 Jul; 105(1):7-13. PMID: 18467543.
    Citations: 14     Fields:    Translation:HumansCells
  21. Hawley JA, Lessard SJ. Exercise training-induced improvements in insulin action. Acta Physiol (Oxf). 2008 Jan; 192(1):127-35. PMID: 18171435.
    Citations: 81     Fields:    Translation:HumansCells
  22. Yaspelkis BB, Lessard SJ, Reeder DW, Limon JJ, Saito M, Rivas DA, Kvasha I, Hawley JA. Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E941-9. PMID: 17623749.
    Citations: 14     Fields:    Translation:AnimalsCells
  23. Lessard SJ, Rivas DA, Chen ZP, Bonen A, Febbraio MA, Reeder DW, Kemp BE, Yaspelkis BB, Hawley JA. Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes. 2007 Jul; 56(7):1856-64. PMID: 17440174.
    Citations: 42     Fields:    Translation:Animals
  24. Hawley JA, Lessard SJ. Mitochondrial function: use it or lose it. Diabetologia. 2007 Apr; 50(4):699-702. PMID: 17279353.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Lessard S, DeYoung J, Vazzana N. Medication discrepancies affecting senior patients at hospital admission. Am J Health Syst Pharm. 2006 Apr 15; 63(8):740-3. PMID: 16595814.
    Citations: 10     Fields:    Translation:Humans
  26. Lessard SJ, Chen ZP, Watt MJ, Hashem M, Reid JJ, Febbraio MA, Kemp BE, Hawley JA. Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Feb; 290(2):E251-7. PMID: 16118254.
    Citations: 16     Fields:    Translation:AnimalsCells
  27. McInerney P, Lessard SJ, Burke LM, Coffey VG, Lo Giudice SL, Southgate RJ, Hawley JA. Failure to repeatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc. 2005 Mar; 37(3):404-11. PMID: 15741838.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  28. Lessard SJ, Lo Giudice SL, Lau W, Reid JJ, Turner N, Febbraio MA, Hawley JA, Watt MJ. Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle. Endocrinology. 2004 Dec; 145(12):5665-70. PMID: 15375026.
    Citations: 11     Fields:    Translation:Animals
  29. Hawke TJ, Lessard S, Vickery L, Lipskie SL, Lindinger MI. Ouabain stimulates unidirectional and net potassium efflux in resting mammalian skeletal muscle. Can J Physiol Pharmacol. 2001 Nov; 79(11):932-41. PMID: 11760095.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.