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Jonathan Abraham, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI141940 (COEN, DONALD M) Nov 9, 2018 - Oct 31, 2021
    NIH
    Structural studies of herpesvirus DNA polymerases
    Role: Co-Principal Investigator
  2. DP5OD023084 (ABRAHAM, JONATHAN) Sep 22, 2016 - Aug 31, 2021
    NIH
    Antibody therapeutics for human viral hemorrhagic fevers and prevention of late neurological syndromes
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ferrero S, Flores MD, Short C, Vazquez CA, Clark LE, Ziegenbein J, Zink S, Fuentes D, Payes C, Batto MV, Collazo M, García CC, Abraham J, Cordo SM, Rodriguez JA, Helguera G. Antibody-based inhibition of pathogenic New World Hemorrhagic Fever mammarenaviruses by steric occlusion of the human transferrin receptor 1 apical domain. J Virol. 2021 Jun 16; JVI0186820. PMID: 34132574.
    Citations:    Fields:    
  2. Sahtoe DD, Coscia A, Mustafaoglu N, Miller LM, Olal D, Vulovic I, Yu TY, Goreshnik I, Lin YR, Clark L, Busch F, Stewart L, Wysocki VH, Ingber DE, Abraham J, Baker D. Transferrin receptor targeting by de novo sheet extension. Proc Natl Acad Sci U S A. 2021 Apr 27; 118(17). PMID: 33879614.
    Citations: 1     Fields:    
  3. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021 05 13; 184(10):2605-2617.e18. PMID: 33831372.
    Citations: 6     Fields:    Translation:HumansCells
  4. Rubin EJ, Baden LR, Abraham J, Morrissey S. Audio Interview: The Implications of Changes in the Structural Biology of SARS-CoV-2. N Engl J Med. 2021 03 11; 384(10):e48. PMID: 33704945.
    Citations:    Fields:    Translation:Humans
  5. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Griffiths A, Abraham J. Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. bioRxiv. 2020 Nov 13. PMID: 33200128.
    Citations:    
  6. Abraham J. Passive antibody therapy in COVID-19. Nat Rev Immunol. 2020 07; 20(7):401-403. PMID: 32533109.
    Citations: 27     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  7. Clark LE, Mahmutovic S, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA, Wucherpfennig KW, Paessler S, Abraham J. Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun. 2018 05 14; 9(1):1884. PMID: 29760382.
    Citations: 14     Fields:    Translation:HumansCells
  8. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 01 05; 359(6371):48-55. PMID: 29302006.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  9. Mahmutovic S, Clark L, Levis SC, Briggiler AM, Enria DA, Harrison SC, Abraham J. Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. . 2015 Dec 09; 18(6):705-13. PMID: 26651946.
    Citations: 21     Translation:HumansCells
  10. Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL. Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol. 2013; 11(5):e1001571. PMID: 23723737.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  11. Helguera G, Jemielity S, Abraham J, Cordo SM, Martinez MG, Rodríguez JA, Bregni C, Wang JJ, Farzan M, Penichet ML, Candurra NA, Choe H. An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses. J Virol. 2012 Apr; 86(7):4024-8. PMID: 22278244.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  12. Choe H, Jemielity S, Abraham J, Radoshitzky SR, Farzan M. Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses. Curr Opin Microbiol. 2011 Aug; 14(4):476-82. PMID: 21807555.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  13. Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. PMID: 20208545.
    Citations: 69     Fields:    Translation:HumansCells
  14. Hood CL, Abraham J, Boyington JC, Leung K, Kwong PD, Nabel GJ. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar; 84(6):2972-82. PMID: 20053739.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  15. Abraham J, Kwong JA, Albariño CG, Lu JG, Radoshitzky SR, Salazar-Bravo J, Farzan M, Spiropoulou CF, Choe H. Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses. PLoS Pathog. 2009 Apr; 5(4):e1000358. PMID: 19343214.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  16. Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature. 2007 Mar 01; 446(7131):92-6. PMID: 17287727.
    Citations: 180     Fields:    Translation:HumansCells
  17. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006 Jun 15; 107(12):4781-9. PMID: 16467198.
    Citations: 902     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.