Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jonathan Abraham, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI141940 (COEN, DONALD M) Nov 9, 2018 - Oct 31, 2021
    Structural studies of herpesvirus DNA polymerases
    Role: Co-Principal Investigator
  2. DP5OD023084 (ABRAHAM, JONATHAN) Sep 22, 2016 - Aug 31, 2021
    Antibody therapeutics for human viral hemorrhagic fevers and prevention of late neurological syndromes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hale M, Netland J, Chen Y, Thouvenel CD, Smith KN, Rich LM, Vanderwall ER, Miranda MC, Eggenberger J, Hao L, Watson MJ, Mundorff CC, Rodda LB, King NP, Guttman M, Gale M, Abraham J, Debley JS, Pepper M, Rawlings DJ. IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2. J Exp Med. 2022 09 05; 219(9). PMID: 35938988; PMCID: PMC9365875.
    Citations:    Fields:    Translation:HumansCells
  2. Rubin EJ, Baden LR, Abraham J, Morrissey S. Audio Interview: Viral Evolution and the Future of Monoclonal Antibodies. N Engl J Med. 2022 06 16; 386(24):e75. PMID: 35704488.
    Citations:    Fields:    Translation:HumansCells
  3. Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson LA, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J. Fc?R-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 2022 06; 606(7914):576-584. PMID: 35385861.
    Citations: 22     Fields:    Translation:HumansCells
  4. Tolan NV, Sherman AC, Zhou G, Nabel KG, Desjardins M, Melanson S, Kanjilal S, Moheed S, Kupelian J, Kaufman RM, Ryan ET, LaRocque RC, Branda JA, Dighe AS, Abraham J, Baden LR, Charles RC, Turbett SE. The Effect of Vaccine Type and SARS-CoV-2 Lineage on Commercial SARS-CoV-2 Serologic and Pseudotype Neutralization Assays in mRNA Vaccine Recipients. Microbiol Spectr. 2022 04 27; 10(2):e0021122. PMID: 35311584; PMCID: PMC9045317.
    Citations: 1     Fields:    Translation:HumansCells
  5. Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22. PMID: 35259335; PMCID: PMC8978092.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Ferrero S, Flores MD, Short C, Vazquez CA, Clark LE, Ziegenbein J, Zink S, Fuentes D, Payes C, Batto MV, Collazo M, García CC, Abraham J, Cordo SM, Rodriguez JA, Helguera G. Correction for Ferrero et al., "Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain". J Virol. 2022 Feb 23; 96(4):e0216321. PMID: 35195450; PMCID: PMC8865448.
    Citations:    Fields:    
  7. Hickerson BT, Daniels-Wells TR, Payes C, Clark LE, Candelaria PV, Bailey KW, Sefing EJ, Zink S, Ziegenbein J, Abraham J, Helguera G, Penichet ML, Gowen BB. Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections. Nat Commun. 2022 01 28; 13(1):558. PMID: 35091550; PMCID: PMC8799657.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J. Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain. Science. 2022 01 21; 375(6578):eabl6251. PMID: 34855508; PMCID: PMC9127715.
    Citations: 17     Fields:    Translation:HumansCells
  9. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J. VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2022 02; 602(7897):475-480. PMID: 34929721; PMCID: PMC8808280.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  10. Coen DM, Lawler JL, Abraham J. Herpesvirus DNA polymerase: Structures, functions, and mechanisms. Enzymes. 2021; 50:133-178. PMID: 34861935.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Ferrero S, Flores MD, Short C, Vazquez CA, Clark LE, Ziegenbein J, Zink S, Fuentes D, Payes C, Batto MV, Collazo M, García CC, Abraham J, Cordo SM, Rodriguez JA, Helguera G. Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain. J Virol. 2021 08 10; 95(17):e0186820. PMID: 34132574; PMCID: PMC8354235.
    Citations: 3     Fields:    Translation:HumansCells
  12. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 10; 17(10):1057-1064. PMID: 34168368; PMCID: PMC8463502.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Sahtoe DD, Coscia A, Mustafaoglu N, Miller LM, Olal D, Vulovic I, Yu TY, Goreshnik I, Lin YR, Clark L, Busch F, Stewart L, Wysocki VH, Ingber DE, Abraham J, Baker D. Transferrin receptor targeting by de novo sheet extension. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33879614.
    Citations: 5     Fields:    Translation:Humans
  14. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021 05 13; 184(10):2605-2617.e18. PMID: 33831372; PMCID: PMC7962548.
    Citations: 58     Fields:    Translation:HumansCells
  15. Rubin EJ, Baden LR, Abraham J, Morrissey S. Audio Interview: The Implications of Changes in the Structural Biology of SARS-CoV-2. N Engl J Med. 2021 03 11; 384(10):e48. PMID: 33704945.
    Citations:    Fields:    Translation:HumansCells
  16. Koma T, Huang C, Coscia A, Hallam S, Manning JT, Maruyama J, Walker AG, Miller M, Smith JN, Patterson M, Abraham J, Paessler S. Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity. PLoS Pathog. 2021 03; 17(3):e1009356. PMID: 33647064.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Griffiths A, Abraham J. Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. bioRxiv. 2020 Nov 13. PMID: 33200128.
  18. Abraham J. Passive antibody therapy in COVID-19. Nat Rev Immunol. 2020 07; 20(7):401-403. PMID: 32533109.
    Citations: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Clark LE, Mahmutovic S, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA, Wucherpfennig KW, Paessler S, Abraham J. Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun. 2018 05 14; 9(1):1884. PMID: 29760382.
    Citations: 22     Fields:    Translation:HumansCells
  20. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 01 05; 359(6371):48-55. PMID: 29302006; PMCID: PMC5788258.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  21. Mahmutovic S, Clark L, Levis SC, Briggiler AM, Enria DA, Harrison SC, Abraham J. Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Cell Host Microbe. 2015 Dec 09; 18(6):705-13. PMID: 26651946; PMCID: PMC4685251.
    Citations: 28     Fields:    Translation:HumansCells
  22. Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL. Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol. 2013; 11(5):e1001571. PMID: 23723737.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  23. Helguera G, Jemielity S, Abraham J, Cordo SM, Martinez MG, Rodríguez JA, Bregni C, Wang JJ, Farzan M, Penichet ML, Candurra NA, Choe H. An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses. J Virol. 2012 Apr; 86(7):4024-8. PMID: 22278244.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  24. Choe H, Jemielity S, Abraham J, Radoshitzky SR, Farzan M. Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses. Curr Opin Microbiol. 2011 Aug; 14(4):476-82. PMID: 21807555.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  25. Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. PMID: 20208545.
    Citations: 79     Fields:    Translation:HumansCells
  26. Hood CL, Abraham J, Boyington JC, Leung K, Kwong PD, Nabel GJ. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar; 84(6):2972-82. PMID: 20053739.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  27. Abraham J, Kwong JA, Albariño CG, Lu JG, Radoshitzky SR, Salazar-Bravo J, Farzan M, Spiropoulou CF, Choe H. Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses. PLoS Pathog. 2009 Apr; 5(4):e1000358. PMID: 19343214.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  28. Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature. 2007 Mar 01; 446(7131):92-6. PMID: 17287727.
    Citations: 232     Fields:    Translation:HumansCells
  29. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006 Jun 15; 107(12):4781-9. PMID: 16467198; PMCID: PMC1895811.
    Citations: 976     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Abraham's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (144)
Co-Authors (49)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.