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Eyal Yaacov Kimchi, M.D.,Ph.D.

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Mentoring
Available: 10/01/21, Expires: 10/20/22

We currently have an exciting, ongoing clinical trial entitled the Study to Assess and Monitor Brain Activity (SAMBA). Delirium is a neuropsychiatric disturbance of attention and awareness with no FDA approved therapies. Affecting more than 20% of hospitalized older adults, delirium is associated with subsequent dementia and hastened death. Because delirium is dynamic and fluctuating, understanding its causes and course remains challenging. In our SAMBA trial we are using new wearable and wireless EEG devices with AI deep learning analysis to track and understand how hospitalized patients can think. We are looking for medical students interesting in participating in various phases of the project, including learning to evaluate delirium in the hospital, learning to develop and apply wireless EEG and other low-touch devices, and speaking to people in follow-up to understand the long-term effects of delirium. Start Date: Ongoing with flexible mix of remote and in person part-time work


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08MH116135 (KIMCHI, EYAL YAACOV) Mar 1, 2018 - Feb 28, 2022
    NIH
    Determining optimal parameters for dynamic cholinergic modulation of associative learning
    Role: Principal Investigator
  2. R03AG050878 (KIMCHI, EYAL YAACOV) Aug 15, 2015 - May 31, 2017
    NIH
    Determining the pathophysiology of delirium in the elderly through translational models
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weinhouse GL, Kimchi E, Watson P, Devlin JW. Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies. Crit Care Explor. 2022 Feb; 4(2):e0628. PMID: 35156048.
    Citations:    
  2. Tesh RA, Sun H, Jing J, Westmeijer M, Neelagiri A, Rajan S, Krishnamurthy PV, Sikka P, Quadri SA, Leone MJ, Paixao L, Panneerselvam E, Eckhardt C, Struck AF, Kaplan PW, Akeju O, Jones D, Kimchi EY, Westover MB. VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations With Clinical Outcomes. Crit Care Explor. 2022 Jan; 4(1):e0611. PMID: 35072078.
    Citations:    
  3. van Sleuwen M, Sun H, Eckhardt C, Neelagiri A, Tesh RA, Westmeijer M, Paixao L, Rajan S, Velpula Krishnamurthy P, Sikka P, Leone MJ, Panneerselvam E, Quadri SA, Akeju O, Kimchi EY, Westover MB. Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S). Crit Care Med. 2022 01 01; 50(1):e11-e19. PMID: 34582420.
    Citations: 1     Fields:    Translation:Humans
  4. Rhee JY, Colman MA, Mendu M, Shah SJ, Fox MD, Rost NS, Kimchi EY. Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis. J Stroke Cerebrovasc Dis. 2022 Mar; 31(3):106270. PMID: 34954599.
    Citations:    Fields:    Translation:Humans
  5. Paixao L, Sun H, Hogan J, Hartnack K, Westmeijer M, Neelagiri A, Zhou DW, McClain LM, Kimchi EY, Purdon PL, Akeju O, Westover MB. ICU delirium burden predicts functional neurologic outcomes. PLoS One. 2021; 16(12):e0259840. PMID: 34855749.
    Citations:    Fields:    Translation:Humans
  6. Robert B, Kimchi EY, Watanabe Y, Chakoma T, Jing M, Li Y, Polley DB. A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes. Elife. 2021 11 25; 10. PMID: 34821218.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Ryan SL, Kimchi EY. Evaluation and Management of Delirium. Semin Neurol. 2021 10; 41(5):572-587. PMID: 34619782.
    Citations:    Fields:    Translation:Humans
  8. Moura Junior V, Westover MB, Li F, Kimchi E, Kennedy M, Benson NM, Moura LM, Hsu J. Hospital complications among older adults: Better processes could reduce the risk of delirium. Health Serv Manage Res. 2021 Jul 11; 9514848211028707. PMID: 34247525.
    Citations:    Fields:    
  9. Lin L, Al-Faraj A, Ayub N, Bravo P, Das S, Ferlini L, Karakis I, Lee JW, Mukerji SS, Newey CR, Pathmanathan J, Abdennadher M, Casassa C, Gaspard N, Goldenholz DM, Gilmore EJ, Jing J, Kim JA, Kimchi EY, Ladha HS, Tobochnik S, Zafar S, Hirsch LJ, Westover MB, Shafi MM. Electroencephalographic Abnormalities are Common in COVID-19 and are Associated with Outcomes. Ann Neurol. 2021 05; 89(5):872-883. PMID: 33704826.
    Citations: 5     Fields:    Translation:Humans
  10. Manzano GS, Danish HH, Chu CJ, Kimchi EY. Child Neurology: Intractable Epilepsy and Transient Deficits in a Patient With a History of Herpes Simplex Virus Encephalitis. Neurology. 2021 04 06; 96(14):679-681. PMID: 33495374.
    Citations:    Fields:    Translation:HumansCells
  11. Ayub N, Cohen J, Jing J, Jain A, Tesh R, Mukerji SS, Zafar SF, Westover MB, Kimchi EY. Clinical Electroencephalography Findings and Considerations in Hospitalized Patients With Coronavirus SARS-CoV-2. Neurohospitalist. 2021 Jul; 11(3):204-213. PMID: 34163546.
    Citations: 2     
  12. Kimchi EY, Coughlin BF, Shanahan BE, Piantoni G, Pezaris J, Cash SS. OpBox: Open Source Tools for Simultaneous EEG and EMG Acquisition from Multiple Subjects. eNeuro. 2020 Sep/Oct; 7(5). PMID: 33060183.
    Citations: 1     Fields:    
  13. Fumeaux NF, Ebrahim S, Coughlin BF, Kadambi A, Azmi A, Xu JX, Abou Jaoude M, Nagaraj SB, Thomson KE, Newell TG, Metcalf CS, Wilcox KS, Kimchi EY, Moraes MFD, Cash SS. Accurate detection of spontaneous seizures using a generalized linear model with external validation. Epilepsia. 2020 09; 61(9):1906-1918. PMID: 32761902.
    Citations: 1     Fields:    Translation:Animals
  14. Vaswani PA, Kimchi EY, Hung AY. CRMP-5-IgG Associated Paraneoplastic Chorea. Mov Disord Clin Pract. 2020 Aug; 7(6):713-715. PMID: 32775525.
    Citations: 1     
  15. Ayub N, Cohen J, Jing J, Jain A, Tesh R, Mukerji SS, Zafar SF, Westover MB, Kimchi EY. Clinical Electroencephalography Findings and Considerations in Hospitalized Patients with Coronavirus SARS-CoV-2. medRxiv. 2020 Jul 15. PMID: 32699855.
    Citations:    
  16. Siciliano CA, Noamany H, Chang CJ, Brown AR, Chen X, Leible D, Lee JJ, Wang J, Vernon AN, Vander Weele CM, Kimchi EY, Heiman M, Tye KM. A cortical-brainstem circuit predicts and governs compulsive alcohol drinking. Science. 2019 11 22; 366(6468):1008-1012. PMID: 31754002.
    Citations: 49     Fields:    Translation:AnimalsCells
  17. Sun H, Kimchi E, Akeju O, Nagaraj SB, McClain LM, Zhou DW, Boyle E, Zheng WL, Ge W, Westover MB. Automated tracking of level of consciousness and delirium in critical illness using deep learning. NPJ Digit Med. 2019; 2:89. PMID: 31508499.
    Citations: 7     
  18. Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 09; 131(3):477-491. PMID: 31166241.
    Citations: 42     Fields:    Translation:Humans
  19. Kimchi EY, Neelagiri A, Whitt W, Sagi AR, Ryan SL, Gadbois G, Groothuysen D, Westover MB. Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes. Neurology. 2019 09 24; 93(13):e1260-e1271. PMID: 31467255.
    Citations: 18     Fields:    Translation:Humans
  20. Vander Weele CM, Siciliano CA, Matthews GA, Namburi P, Izadmehr EM, Espinel IC, Nieh EH, Schut EHS, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi EY, Beyeler A, Wichmann R, Wildes CP, Tye KM. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature. 2018 11; 563(7731):397-401. PMID: 30405240.
    Citations: 51     Fields:    Translation:AnimalsCells
  21. Kimchi EY, Hshieh TT, Guo R, Wong B, O'Connor M, Marcantonio ER, Metzger ED, Strauss J, Arnold SE, Inouye SK, Fong TG. Consensus Approaches to Identify Incident Dementia in Cohort Studies: Systematic Review and Approach in the Successful Aging after Elective Surgery Study. J Am Med Dir Assoc. 2017 Dec 01; 18(12):1010-1018.e1. PMID: 28927945.
    Citations: 8     Fields:    Translation:Humans
  22. Burgos-Robles A, Kimchi EY, Izadmehr EM, Porzenheim MJ, Ramos-Guasp WA, Nieh EH, Felix-Ortiz AC, Namburi P, Leppla CA, Presbrey KN, Anandalingam KK, Pagan-Rivera PA, Anahtar M, Beyeler A, Tye KM. Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. Nat Neurosci. 2017 Jun; 20(6):824-835. PMID: 28436980.
    Citations: 104     Fields:    Translation:Animals
  23. Kimchi EY, Cash SS. Seizures at the scale of individual neurons. Brain. 2015 Oct; 138(Pt 10):2807-8. PMID: 26408654.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Naftulin JS, Kimchi EY, Cash SS. Streamlined, Inexpensive 3D Printing of the Brain and Skull. PLoS One. 2015; 10(8):e0136198. PMID: 26295459.
    Citations: 27     Fields:    Translation:Humans
  25. Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. Br J Anaesth. 2015 Jul; 115 Suppl 1:i58-i65. PMID: 26174302.
    Citations: 13     Fields:    Translation:Animals
  26. Inouye SK, Westendorp RG, Saczynski JS, Kimchi EY, Cleinman AA. Delirium in elderly people--authors'reply. Lancet. 2014 Jun 14; 383(9934):2045. PMID: 24931690.
    Citations: 9     Fields:    Translation:Humans
  27. Berkowitz AL, Kimchi EY, Hwang DY, Vaitkevicius H, Henderson GV, Feske SK, Chou SH. Clinical Reasoning: a 44-year-old woman with headache followed by sudden neurologic decline. Neurology. 2013 Mar 26; 80(13):e136-41. PMID: 23530156.
    Citations:    Fields:    Translation:Humans
  28. Diamond EL, Kimchi EY, Shankar GM, Silverman SB. Transient aqueductal occlusion in intracerebral haemorrhage. Pract Neurol. 2012 Dec; 12(6):388-9. PMID: 23144305.
    Citations: 1     Fields:    Translation:Humans
  29. Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR. Impaired auditory discrimination learning following perinatal nicotine exposure or ß2 nicotinic acetylcholine receptor subunit deletion. Behav Brain Res. 2012 May 16; 231(1):170-80. PMID: 22433585.
    Citations: 10     Fields:    Translation:Animals
  30. Kimchi EY, Laubach M. The dorsomedial striatum reflects response bias during learning. J Neurosci. 2009 Nov 25; 29(47):14891-902. PMID: 19940185.
    Citations: 28     Fields:    Translation:AnimalsCells
  31. Kimchi EY, Torregrossa MM, Taylor JR, Laubach M. Neuronal correlates of instrumental learning in the dorsal striatum. J Neurophysiol. 2009 Jul; 102(1):475-89. PMID: 19439679.
    Citations: 52     Fields:    Translation:AnimalsCells
  32. Kimchi EY, Laubach M. Dynamic encoding of action selection by the medial striatum. J Neurosci. 2009 Mar 11; 29(10):3148-59. PMID: 19279252.
    Citations: 67     Fields:    Translation:Animals
  33. Narayanan NS, Kimchi EY, Laubach M. Redundancy and synergy of neuronal ensembles in motor cortex. J Neurosci. 2005 Apr 27; 25(17):4207-16. PMID: 15858046.
    Citations: 58     Fields:    Translation:AnimalsCells
  34. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res. 2004 Mar 12; 1000(1-2):102-9. PMID: 15053958.
    Citations: 36     Fields:    Translation:AnimalsCells
  35. Christie R, Kimchi E, Kajdasz S, Bacskai B, Hyman BT. Multiphoton microscopy and amyloid angiopathy. Amyloid. 2001 Jul; 8 Suppl 1:48-50. PMID: 11676290.
    Citations: 6     Fields:    Translation:HumansAnimals
  36. Kimchi EY, Kajdasz S, Bacskai BJ, Hyman BT. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. J Neuropathol Exp Neurol. 2001 Mar; 60(3):274-9. PMID: 11245211.
    Citations: 12     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.