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Bastien Pierre Guerin, Ph.D.

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Biography
2008
Computer and Instrumentation Council Young Investigator Award
2005
Rotary International Ambassadorial Scholarship
2005 - 2006
NBCR Summer Institute Travel Award recipient
2006
Jean Gaillard Memorial Fellowship
2005
Arthur-Sachs Fellowship
2010
Fyssen Foundation Research Fellowship (declined)

Overview
My research focuses on MRI (and to some extent PET) technology development and translation to neuro-imaging to help better understand the human brain. I have several areas of specializations:

(i) Modeling and optimization of radio-frequency (RF) and gradient MR sub-systems. My postdoctoral work focused on modeling of RF coils, especially parallel transmission (pTx) coils whereby nuclear spins are excited using several transmit channels as opposed to a single one (transmit phased array). I also developed methodology for the design of pTx RF pulses at low and large flip-angle with explicit control for the specific absorption rate, which is the main safety limitation in high duty-cycle MRI sequences. This work is relevant at 3 Tesla, 7 Tesla and will be crucial to the progress of MRI at 11.7 Tesla and higher. Recently, I have been working together with Prof. Lawrence Wald and Mathias Davids on a modeling and design methodology of gradient coils with an intrinsically lower propensity to create peripheral nerve stimulation (PNS). PNS is the main limitation of MRI acquisition speed in fast imaging sequences such as echo planar imaging and turbo spin echo, therefore such new gradient technology has the potential to dramatically improve speed and data acquisition rate in many clinical and research (fMRI, diffusion imaging) applications.

(ii) Neuro-imaging of patients with deep brain stimulation (DBS) implants. Generally speaking, I am interested in the combined use of neurostimulation strategies and functional imaging methods such as fMRI. Neurostimulation using DBS allows pin-point excitation of the human brain in a very controlled manner and, when combined with fMRI, offers unique brain mapping possibilities. DBS is in itself a fascinating therapy that is poorly understood and holds promise for the treatment of many psychiatric disorders. I use fMRI to study the mechanisms of action of DBS in patients with Parkinson disease and depression. In addition, I study the safety aspects of using DBS in the MR RF environment using electromagnetic modeling.

(iii) Iterative reconstruction, quantitative corrections and physics of positron emission tomography (PET). My interest in this area stems from my PhD work on fully 3D, list-mode reconstruction of PET data with corrections for scatter coincidences and non-rigid respiratory and cardiac motion. A central innovation of my work was to incorporate the information carried by the energy of the detected PET photons into the scatter correction process using a statistical model of the coincidence energy blurring incorporated in the likelihood function of the list-mode PET data. Another innovation was the use of tagged-MRI to track complex non-rigid motions due to respiration and cardiac beating and the incorporation of these motion vector fields in the 3D list-mode PET reconstruction.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00EB019482 (GUERIN, BASTIEN) Jul 1, 2017 - Jun 30, 2020
    NIH/NIBIB
    Neuroimaging of deep brain stimulation patients using safe MRI excitations
    Role: Principal Investigator
  2. K99EB019482 (GUERIN, BASTIEN) Aug 17, 2015 - Jun 30, 2017
    NIH/NIBIB
    Neuroimaging of deep brain stimulation patients using safe MRI excitations
    Role: Principal Investigator
  3. R01EB006847 (WALD, LAWRENCE L) Dec 1, 2006 - May 31, 2021
    NIH/NIBIB
    Parallel Excitation Methods for High Field MRI
    Role: Co-Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Abaci Turk E, Yetisir F, Adalsteinsson E, Gagoski B, Guerin B, Grant PE, Wald LL. Individual variation in simulated fetal SAR assessed in multiple body models. Magn Reson Med. 2020 Apr; 83(4):1418-1428. PMID: 31626373.
    Citations:    
  2. Guerin B, Angelone LM, Dougherty D, Wald LL. Parallel transmission to reduce absorbed power around deep brain stimulation devices in MRI: Impact of number and arrangement of transmit channels. Magn Reson Med. 2020 Jan; 83(1):299-311. PMID: 31389069.
    Citations:    
  3. Guerin B, Iacono MI, Davids M, Dougherty D, Angelone LM, Wald LL. The 'virtual DBS population': five realistic computational models of deep brain stimulation patients for electromagnetic MR safety studies. Phys Med Biol. 2019 02 04; 64(3):035021. PMID: 30625451.
    Citations:    Fields:    
  4. Guerin B, Serano P, Iacono MI, Herrington TM, Widge AS, Dougherty DD, Bonmassar G, Angelone LM, Wald LL. Realistic modeling of deep brain stimulation implants for electromagnetic MRI safety studies. Phys Med Biol. 2018 05 04; 63(9):095015. PMID: 29637905.
    Citations: 1     Fields:    
  5. Davids M, Guérin B, Malzacher M, Schad LR, Wald LL. Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models. Sci Rep. 2017 07 13; 7(1):5316. PMID: 28706244.
    Citations: 2     Fields:    Translation:Humans
  6. Guérin B, Villena JF, Polimeridis AG, Adalsteinsson E, Daniel L, White JK, Rosen BR, Wald LL. Computation of ultimate SAR amplification factors for radiofrequency hyperthermia in non-uniform body models: impact of frequency and tumour location. Int J Hyperthermia. 2018 02; 34(1):87-100. PMID: 28540815.
    Citations:    Fields:    Translation:Humans
  7. Guérin B, Villena JF, Polimeridis AG, Adalsteinsson E, Daniel L, White JK, Wald LL. The ultimate signal-to-noise ratio in realistic body models. Magn Reson Med. 2017 11; 78(5):1969-1980. PMID: 27917528.
    Citations: 1     Fields:    Translation:Humans
  8. Graedel NN, Polimeni JR, Guerin B, Gagoski B, Bonmassar G, Wald LL. Erratum to an anatomically realistic temperature phantom for radiofrequency heating measurements (Magn Reson Med 2015;73:442-450). Magn Reson Med. 2016 11; 76(5):1642. PMID: 27747939.
    Citations:    Fields:    
  9. Stockmann JP, Cooley CZ, Guerin B, Rosen MS, Wald LL. Transmit Array Spatial Encoding (TRASE) using broadband WURST pulses for RF spatial encoding in inhomogeneous B0 fields. J Magn Reson. 2016 07; 268:36-48. PMID: 27155906.
    Citations: 1     Fields:    
  10. Vinding MS, Guérin B, Vosegaard T, Nielsen NC. Local SAR, global SAR, and power-constrained large-flip-angle pulses with optimal control and virtual observation points. Magn Reson Med. 2017 01; 77(1):374-384. PMID: 26715084.
    Citations: 1     Fields:    Translation:HumansCells
  11. Davids M, Schad LR, Wald LL, Guérin B. Fast three-dimensional inner volume excitations using parallel transmission and optimized k-space trajectories. Magn Reson Med. 2016 10; 76(4):1170-82. PMID: 26527590.
    Citations:    Fields:    
  12. Guérin B, Stockmann JP, Baboli M, Torrado-Carvajal A, Stenger AV, Wald LL. Robust time-shifted spoke pulse design in the presence of large B0 variations with simultaneous reduction of through-plane dephasing, B1+ effects, and the specific absorption rate using parallel transmission. Magn Reson Med. 2016 08; 76(2):540-54. PMID: 26444717.
    Citations: 2     Fields:    Translation:HumansCells
  13. Mahmood Z, McDaniel P, Guérin B, Keil B, Vester M, Adalsteinsson E, Wald LL, Daniel L. General design approach and practical realization of decoupling matrices for parallel transmission coils. Magn Reson Med. 2016 07; 76(1):329-39. PMID: 26228386.
    Citations: 1     Fields:    
  14. Martin A, Schiavi E, Eryaman Y, Herraiz JL, Gagoski B, Adalsteinsson E, Wald LL, Guerin B. Parallel transmission pulse design with explicit control for the specific absorption rate in the presence of radiofrequency errors. Magn Reson Med. 2016 06; 75(6):2493-504. PMID: 26147916.
    Citations: 2     Fields:    Translation:HumansCells
  15. Zhao W, Cohen-Adad J, Polimeni JR, Keil B, Guerin B, Setsompop K, Serano P, Mareyam A, Hoecht P, Wald LL. Nineteen-channel receive array and four-channel transmit array coil for cervical spinal cord imaging at 7T. Magn Reson Med. 2014 Jul; 72(1):spcone. PMID: 24934817.
    Citations:    
  16. Eryaman Y, Guerin B, Akgun C, Herraiz JL, Martin A, Torrado-Carvajal A, Malpica N, Hernandez-Tamames JA, Schiavi E, Adalsteinsson E, Wald LL. Parallel transmit pulse design for patients with deep brain stimulation implants. Magn Reson Med. 2015 May; 73(5):1896-903. PMID: 24947104.
    Citations: 6     Fields:    Translation:Humans
  17. Guérin B, Setsompop K, Ye H, Poser BA, Stenger AV, Wald LL. Design of parallel transmission pulses for simultaneous multislice with explicit control for peak power and local specific absorption rate. Magn Reson Med. 2015 May; 73(5):1946-53. PMID: 24938991.
    Citations: 16     Fields:    Translation:Humans
  18. Guérin B, Gebhardt M, Serano P, Adalsteinsson E, Hamm M, Pfeuffer J, Nistler J, Wald LL. Comparison of simulated parallel transmit body arrays at 3 T using excitation uniformity, global SAR, local SAR, and power efficiency metrics. Magn Reson Med. 2015 Mar; 73(3):1137-50. PMID: 24752979.
    Citations: 17     Fields:    Translation:HumansCells
  19. Eryaman Y, Guerin B, Keil B, Mareyam A, Herraiz JL, Kosior RK, Martin A, Torrado-Carvajal A, Malpica N, Hernandez-Tamames JA, Schiavi E, Adalsteinsson E, Wald LL. SAR reduction in 7T C-spine imaging using a "dark modes" transmit array strategy. Magn Reson Med. 2015 Apr; 73(4):1533-9. PMID: 24753012.
    Citations: 4     Fields:    Translation:Humans
  20. Graedel NN, Polimeni JR, Guerin B, Gagoski B, Bonmassar G, Wald LL. An anatomically realistic temperature phantom for radiofrequency heating measurements. Magn Reson Med. 2015 01; 73(1):442-50. PMID: 24549755.
    Citations: 4     Fields:    Translation:Humans
  21. Rakvongthai Y, Ouyang J, Guerin B, Li Q, Alpert NM, El Fakhri G. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach. Med Phys. 2013 Oct; 40(10):102501. PMID: 24089922.
    Citations: 3     Fields:    
  22. Zhao W, Cohen-Adad J, Polimeni JR, Keil B, Guerin B, Setsompop K, Serano P, Mareyam A, Hoecht P, Wald LL. Nineteen-channel receive array and four-channel transmit array coil for cervical spinal cord imaging at 7T. Magn Reson Med. 2014 Jul; 72(1):291-300. PMID: 23963998.
    Citations: 8     Fields:    Translation:Humans
  23. Guérin B, Gebhardt M, Cauley S, Adalsteinsson E, Wald LL. Local specific absorption rate (SAR), global SAR, transmitter power, and excitation accuracy trade-offs in low flip-angle parallel transmit pulse design. Magn Reson Med. 2014 Apr; 71(4):1446-57. PMID: 23776100.
    Citations: 27     Fields:    Translation:Humans
  24. Poser BA, Anderson RJ, Guérin B, Setsompop K, Deng W, Mareyam A, Serano P, Wald LL, Stenger VA. Simultaneous multislice excitation by parallel transmission. Magn Reson Med. 2014 Apr; 71(4):1416-27. PMID: 23716365.
    Citations: 17     Fields:    Translation:Humans
  25. Chun SY, Reese TG, Ouyang J, Guerin B, Catana C, Zhu X, Alpert NM, El Fakhri G. MRI-based nonrigid motion correction in simultaneous PET/MRI. J Nucl Med. 2012 Aug; 53(8):1284-91. PMID: 22743250.
    Citations: 28     Fields:    Translation:Animals
  26. Guérin B, Cho S, Chun SY, Zhu X, Alpert NM, El Fakhri G, Reese T, Catana C. Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged-MRI and PET imaging. Med Phys. 2011 Jun; 38(6):3025-38. PMID: 21815376.
    Citations: 20     Fields:    
  27. Guérin B, El Fakhri G. Novel scatter compensation of list-mode PET data using spatial and energy dependent corrections. IEEE Trans Med Imaging. 2011 Mar; 30(3):759-73. PMID: 21118770.
    Citations:    Fields:    
  28. Guérin B, Fakhri GE. Realistic PET Monte Carlo Simulation With Pixelated Block Detectors, Light Sharing, Random Coincidences and Dead-Time Modeling. IEEE Trans Nucl Sci. 2008; 55(3):942-952. PMID: 19079776.
    Citations: 7     
  29. El Fakhri G, Sitek A, Guérin B, Kijewski MF, Di Carli MF, Moore SC. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. J Nucl Med. 2005 Aug; 46(8):1264-71. PMID: 16085581.
    Citations: 48     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.