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Tina Kapur, Ph.D.

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Biography
Massachusetts Institute of Technology Artificial Intelligence Laboratory, Cambridge, MAPhD06/1999Computer Science
Massachusetts Institute of Technology Artificial Intelligence Laboratory, Cambridge, MASM01/1995Computer Science
Mount Holyoke College, South Hadley, MABA06/1992Mathematics and Computer Science

Overview
I am the founding Executive Director of the NIH-funded National Center for Image Guided Therapy at Brigham and Women's Hospital. I nurture ties within multidisciplinary teams of exceptionally talented scientists and clinicians within our institution and foster complex collaborations across academic institutions, hospitals, industry, and regulatory agencies. My passion is forging collaborations between efforts in open science that could potentially accelerate discoveries that improve health and save lives. I founded the first international open-science hackathon for medical image computing in 2005 and the National Image-guided Therapy workshop in 2006 and have been leading these continuously since then. My research interests are in applying computer vision and machine learning techniques to enable translation research in medicine.

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zaffino P, Pernelle G, Mastmeyer A, Mehrtash A, Zhang H, Kikinis R, Kapur T, Spadea MF. Fully automatic catheter segmentation in MRI with 3D convolutional neural networks: application to MRI-guided gynecologic brachytherapy. Phys Med Biol. 2019 Jul 04. PMID: 31272095.
    Citations:    
  2. Abdelmoula WM, Regan MS, Lopez BGC, Randall EC, Lawler S, Mladek AC, Nowicki MO, Marin BM, Agar JN, Swanson KR, Kapur T, Sarkaria JN, Wells W, Agar NYR. Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data. Anal Chem. 2019 May 07; 91(9):6206-6216. PMID: 30932478.
    Citations:    
  3. Mehrtash A, Ghafoorian M, Pernelle G, Ziaei A, Heslinga FG, Tuncali K, Fedorov A, Kikinis R, Tempany CM, Wells WM, Abolmaesumi P, Kapur T. Automatic Needle Segmentation and Localization in MRI With 3-D Convolutional Neural Networks: Application to MRI-Targeted Prostate Biopsy. IEEE Trans Med Imaging. 2019 Apr; 38(4):1026-1036. PMID: 30334789.
    Citations:    Fields:    
  4. Zhang F, Savadjiev P, Cai W, Song Y, Rathi Y, Tunç B, Parker D, Kapur T, Schultz RT, Makris N, Verma R, O'Donnell LJ. Whole brain white matter connectivity analysis using machine learning: An application to autism. Neuroimage. 2018 05 15; 172:826-837. PMID: 29079524.
    Citations: 3     Fields:    Translation:Humans
  5. Mastmeyer A, Pernelle G, Ma R, Barber L, Kapur T. Accurate model-based segmentation of gynecologic brachytherapy catheter collections in MRI-images. Med Image Anal. 2017 Dec; 42:173-188. PMID: 28803217.
    Citations: 1     Fields:    Translation:Humans
  6. Mehrtash A, Sedghi A, Ghafoorian M, Taghipour M, Tempany CM, Wells WM, Kapur T, Mousavi P, Abolmaesumi P, Fedorov A. Classification of Clinical Significance of MRI Prostate Findings Using 3D Convolutional Neural Networks. Proc SPIE Int Soc Opt Eng. 2017 Feb 11; 10134. PMID: 28615793.
    Citations: 1     
  7. Mehrtash A, Pesteie M, Hetherington J, Behringer PA, Kapur T, Wells WM, Rohling R, Fedorov A, Abolmaesumi P. DeepInfer: Open-Source Deep Learning Deployment Toolkit for Image-Guided Therapy. Proc SPIE Int Soc Opt Eng. 2017 Feb 11; 10135. PMID: 28615794.
    Citations: 3     
  8. Sastry R, Bi WL, Pieper S, Frisken S, Kapur T, Wells W, Golby AJ. Applications of Ultrasound in the Resection of Brain Tumors. J Neuroimaging. 2017 01; 27(1):5-15. PMID: 27541694.
    Citations: 4     Fields:    Translation:Humans
  9. Kapur T, Pieper S, Fedorov A, Fillion-Robin JC, Halle M, O'Donnell L, Lasso A, Ungi T, Pinter C, Finet J, Pujol S, Jagadeesan J, Tokuda J, Norton I, Estepar RSJ, Gering D, Aerts HJWL, Jakab M, Hata N, Ibanez L, Blezek D, Miller J, Aylward S, Grimson WEL, Fichtinger G, Wells WM, Lorensen WE, Schroeder W, Kikinis R. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience. Med Image Anal. 2016 10; 33:176-180. PMID: 27498015.
    Citations: 3     Fields:    Translation:Humans
  10. Li X, Li C, Fedorov A, Kapur T, Yang X. Segmentation of prostate from ultrasound images using level sets on active band and intensity variation across edges. Med Phys. 2016 Jun; 43(6):3090-3103. PMID: 27277056.
    Citations:    Fields:    
  11. Kapur T. MO-DE-202-03: Image-Guided Surgery and Interventions in the Advanced Multimodality Image-Guided Operating (AMIGO) Suite. Med Phys. 2016 Jun; 43(6):3699-3700. PMID: 28047534.
    Citations:    
  12. Mehrtash A, Gupta SN, Shanbhag D, Miller JV, Kapur T, Fennessy FM, Kikinis R, Fedorov A. Bolus arrival time and its effect on tissue characterization with dynamic contrast-enhanced magnetic resonance imaging. J Med Imaging (Bellingham). 2016 Jan; 3(1):014503. PMID: 26989759.
    Citations:    
  13. Tempany CM, Kapur T. Dedication. Magn Reson Imaging Clin N Am. 2015 Nov; 23(4):xv. PMID: 26499286.
    Citations:    
  14. Tempany CM, Kapur T. Magnetic Resonance-Guided Interventions: The State of the Art. Magn Reson Imaging Clin N Am. 2015 Nov; 23(4):xix. PMID: 26499285.
    Citations:    Fields:    Translation:Humans
  15. Fedorov A, Khallaghi S, Sánchez CA, Lasso A, Fels S, Tuncali K, Sugar EN, Kapur T, Zhang C, Wells W, Nguyen PL, Abolmaesumi P, Tempany C. Open-source image registration for MRI-TRUS fusion-guided prostate interventions. Int J Comput Assist Radiol Surg. 2015 Jun; 10(6):925-34. PMID: 25847666.
    Citations: 3     Fields:    Translation:Humans
  16. Tempany CM, Jayender J, Kapur T, Bueno R, Golby A, Agar N, Jolesz FA. Multimodal imaging for improved diagnosis and treatment of cancers. Cancer. 2015 Mar 15; 121(6):817-27. PMID: 25204551.
    Citations: 9     Fields:    Translation:Humans
  17. Wang W, Dumoulin CL, Viswanathan AN, Tse ZT, Mehrtash A, Loew W, Norton I, Tokuda J, Seethamraju RT, Kapur T, Damato AL, Cormack RA, Schmidt EJ. Real-time active MR-tracking of metallic stylets in MR-guided radiation therapy. Magn Reson Med. 2015 May; 73(5):1803-11. PMID: 24903165.
    Citations: 6     Fields:    Translation:Animals
  18. Damato AL, Bhagwat MS, Buzurovic I, Devlin PM, Friesen S, Hansen JL, Kapur T, Lee LJ, Mehrtash A, Nguyen PL, O' Farrell D, Wang W, Viswanathan AN, Cormack RA. WE-A-17A-03: Catheter Digitization in High-Dose-Rate Brachytherapy with the Assistance of An Electromagnetic (EM) Tracking System. Med Phys. 2014 Jun; 41(6):487-488. PMID: 28037155.
    Citations:    
  19. Mehrtash A, Damato A, Pernelle G, Barber L, Farhat N, Viswanathan A, Cormack R, Kapur T. EM-Navigated Catheter Placement for Gynecologic Brachytherapy: An Accuracy Study. Proc SPIE Int Soc Opt Eng. 2014 Mar 12; 9036:90361F. PMID: 25076828.
    Citations: 1     
  20. Fedorov A, Song SE, Kapur T, Owen R, Sugar EN, Nguyen P, Wells WM, Tempany CM. Prototype Design and Phantom Evaluation of a Device for Co-registered MRI/TRUS Imaging of the Prostate. Clin Image Based Proced. 2014; 8361:125-133. PMID: 25364786.
    Citations:    
  21. Pernelle G, Kapur T, Mehrtash A, Penzkofer T, Damato A, Barber L, Schmidt E, Viswanathan A, Cormack R. SU-C-103-05: Automated Interstitial Brachytherapy Catheter Localization From Volumetric MR Data. Med Phys. 2013 Jun; 40(6Part2):94. PMID: 28518333.
    Citations:    
  22. Wang W, Gao Y, Mehrtash A, Seethmaraju R, Kapur T, Vishwanathan A, Schmidt E, Cormack R. WE-G-WAB-01: Real-Time Catheter Tracking and Visualization in MR-Guided Brachytherapy. Med Phys. 2013 Jun; 40(6Part30):505. PMID: 28519133.
    Citations:    
  23. Damato A, Mehrtash A, Kapur T, Viswanathan A, Cormack R. SU-D-108-02: Applications of Electromagnetic Tracking Technology to High Dose Rate (HDR) Interstitial Brachytherapy. Med Phys. 2013 Jun; 40(6Part3):103-104. PMID: 28519560.
    Citations:    
  24. Penzkofer T, Agrawal N, Kapur T, Fedorov A, Cormack RA, D'Amico AV, Tempany CM, Nguyen PL. Location of local recurrence after MRI-guided partial prostate brachytherapy targeting only the peripheral zone: Implications for focal therapy. J Clin Oncol. 2013 Feb 20; 31(6_suppl):149. PMID: 28136859.
    Citations:    
  25. Pernelle G, Mehrtash A, Barber L, Damato A, Wang W, Seethamraju RT, Schmidt E, Cormack RA, Wells W, Viswanathan A, Kapur T. Validation of catheter segmentation for MR-guided gynecologic cancer brachytherapy. Med Image Comput Comput Assist Interv. 2013; 16(Pt 3):380-7. PMID: 24505784.
    Citations: 3     Fields:    Translation:Humans
  26. Kuhnt D, Bauer MH, Egger J, Richter M, Kapur T, Sommer J, Merhof D, Nimsky C. Fiber tractography based on diffusion tensor imaging compared with high-angular-resolution diffusion imaging with compressed sensing: initial experience. Neurosurgery. 2013 Jan; 72 Suppl 1:165-75. PMID: 23254805.
    Citations: 20     Fields:    Translation:HumansCells
  27. Egger J, Kapur T, Fedorov A, Pieper S, Miller JV, Veeraraghavan H, Freisleben B, Golby AJ, Nimsky C, Kikinis R. GBM volumetry using the 3D Slicer medical image computing platform. Sci Rep. 2013; 3:1364. PMID: 23455483.
    Citations: 34     Fields:    Translation:Humans
  28. Egger J, Kapur T, Nimsky C, Kikinis R. Pituitary adenoma volumetry with 3D Slicer. PLoS One. 2012; 7(12):e51788. PMID: 23240062.
    Citations: 14     Fields:    Translation:Humans
  29. Kapur T, Egger J, Damato A, Schmidt EJ, Viswanathan AN. 3-T MR-guided brachytherapy for gynecologic malignancies. Magn Reson Imaging. 2012 Nov; 30(9):1279-90. PMID: 22898699.
    Citations: 22     Fields:    Translation:Humans
  30. Egger J, Freisleben B, Nimsky C, Kapur T. Template-cut: a pattern-based segmentation paradigm. Sci Rep. 2012; 2:420. PMID: 22639728.
    Citations: 5     Fields:    Translation:Humans
  31. Egger J, Tokuda J, Chauvin L, Freisleben B, Nimsky C, Kapur T, Wells W. Integration of the OpenIGTLink network protocol for image-guided therapy with the medical platform MeVisLab. Int J Med Robot. 2012 Sep; 8(3):282-90. PMID: 22374845.
    Citations: 13     Fields:    Translation:Humans
  32. Egger J, Kapur T, Dukatz T, Kolodziej M, Zukic D, Freisleben B, Nimsky C. Square-cut: a segmentation algorithm on the basis of a rectangle shape. PLoS One. 2012; 7(2):e31064. PMID: 22363547.
    Citations: 13     Fields:    Translation:Humans
  33. Egger J, Grosskopf S, Nimsky C, Kapur T, Freisleben B. Modeling and visualization techniques for virtual stenting of aneurysms and stenoses. Comput Med Imaging Graph. 2012 Apr; 36(3):183-203. PMID: 22227385.
    Citations: 1     Fields:    Translation:Humans
  34. Moradi M, Janoos F, Fedorov A, Risholm P, Kapur T, Wolfsberger LD, Nguyen PL, Tempany CM, Wells WM. Two solutions for registration of ultrasound to MRI for image-guided prostate interventions. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:1129-32. PMID: 23366095.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  35. Kapur T, Pieper S, Whitaker R, Aylward S, Jakab M, Schroeder W, Kikinis R. The National Alliance for Medical Image Computing, a roadmap initiative to build a free and open source software infrastructure for translational research in medical image analysis. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):176-80. PMID: 22081219.
    Citations: 4     Fields:    Translation:Humans
  36. Tokuda J, Fischer GS, Papademetris X, Yaniv Z, Ibanez L, Cheng P, Liu H, Blevins J, Arata J, Golby AJ, Kapur T, Pieper S, Burdette EC, Fichtinger G, Tempany CM, Hata N. OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot. 2009 Dec; 5(4):423-34. PMID: 19621334.
    Citations: 63     Fields:    
  37. Dimaio S, Kapur T, Cleary K, Aylward S, Kazanzides P, Vosburgh K, Ellis R, Duncan J, Farahani K, Lemke H, Peters T, Lorensen WB, Gobbi D, Haller J, Clarke LL, Pizer S, Taylor R, Galloway R, Fichtinger G, Hata N, Lawson K, Tempany C, Kikinis R, Jolesz F. Challenges in image-guided therapy system design. Neuroimage. 2007; 37 Suppl 1:S144-51. PMID: 17644360.
    Citations: 11     Fields:    Translation:Humans
  38. Kikinis, R. Kapur, T. Shenton, M.E. Gethe, J.S. Ellisman, M.H. . “Big Science” and Schizophrenia. Biomedical Imaging: Macro to Nano, 2006. 3rd IEEE International Symposium on Biomedical Imaging. 2006.
  39. Seeley; Teresa (Littleton, MA), Lin; Faith (Lexington, MA), Kapur; Tina (Andover, MA), Gregerson; Gene (Bolton, MA). Fluoroscopic tracking and visualization system. 2005.
  40. Yezzi A, Zöllei L, Kapur T. A variational framework for integrating segmentation and registration through active contours. Med Image Anal. 2003 Jun; 7(2):171-85. PMID: 12868620.
    Citations: 13     Fields:    
  41. Seeley; Teresa (Littleton, MA), Lin; Faith (Lexington, MA), Kapur; Tina (Andover, MA), Gregerson; Gene (Bolton, MA). Fluoroscopic tracking and visualization system. 2002.
  42. A Yezzi, L Zollei, T Kapur. A Variational Framework for Joint Segmentation and Registration. IEEE Mathematical Methods in Biomedical Image Analysis. 2001.
  43. Seeley; Teresa (Littleton, MA), Lin; Faith (Lexington, MA), Kapur; Tina (Andover, MA), Gregerson; Gene (Bolton, MA). Fluoroscopic tracking and visualization system. 2000.
  44. Seeley; Teresa (Littleton, MA), Lin; Faith (Lexington, MA), Kapur; Tina (Andover, MA), Gregerson; Gene (Bolton, MA). Fluoroscopic tracking and visualization system. 2000.
  45. Tina Kapur. Model Based Three Dimensional Segmentation of Medical Imagery. 1999.
  46. T. Kapur, P. Beardsley, S. Gibson, W. Grimson, and W. Wells. Model Based Segmentation of Clinical Knee MRI. IEEE Int'l Workshop on Model-Based 3D Image Analysis. 1998; 97--106.
  47. Tina Kapur, W. Eric L. Grimson, Ron Kikinis, William M. Wells. Enhanced Spatial Priors for Segmentation of Magnetic Resonance Imagery. Lecture Notes in Computer Science. Medical Image Computing and Computer-Assisted Interventation. 1998; 1496.
  48. WEL Grimson, GJ Ettinger, T. Kapur, ME Leventon, WM Wells III, R. Kikinis. Utilizing Segmented MRI Data in Image-Guided Surgery. International Journal of Pattern Recognition and Artificial Intelligence. 1997; 11(8):1367-1397.
  49. Kapur T, Grimson WE, Wells WM, Kikinis R. Segmentation of brain tissue from magnetic resonance images. Med Image Anal. 1996 Jun; 1(2):109-27. PMID: 9873924.
    Citations: 23     Fields:    Translation:Humans
  50. Ingrid Carlbom, Tina Kapur, Gudrun Klinker. General-purpose soft tissue segmentation from medical images. Selected papers from the 9th Scandinavian conference on Image analysis : theory and applications of image analysis II:. 1996; 293 - 304 .
  51. Morocz, I., Gudbjartsson, H., Kapur, T., Zientara, G., Smith, S., Muza, S., Lyones, T., and Jolesz, F. Quantitation of diffuse brain edema in acute mountain sickness using 3d mri. Proceedings of Third Annual Meeting of the Society of Magnetic Resonance. 1995.
  52. Tina Kapur. Segmentation of Brain Tissue from Magnetic Resonance Images. 1995.
  53. Tina Kapur, W. Eric L. Grimson, Ron Kikinis. Segmentation of Brain Tissue from MR Images. Lecture Notes In Computer Science; Proceedings of the First International Conference on Computer Vision, Virtual Reality and Robotics in Medicine. 1995; 429 - 433 .
  54. Huppi, P., Tsuji, M., Kapur, T., Barnes, P., Jakab, M., Zientara, G., Kikinis, R., and Jolesz, F. Quantification of changes in postnatal brain development in preterm infants using adaptive segmentation of MRI data, and Quantification of Diffuse Brain Edema in Acute Mountain Sickness Using 3D MRI. Proceedings of Third Annual Meeting of the Society of Magnetic Resonance. 1995; 1.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.