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Can Zhang, PH.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shen XN, Niu LD, Wang YJ, Cao XP, Liu Q, Tan L, Zhang C, Yu JT. Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies. J Neurol Neurosurg Psychiatry. 2019 May; 90(5):590-598. PMID: 30630955.
    Citations:    
  2. Zheng X, Wang X, Wang T, Zhang H, Wu H, Zhang C, Yu L, Guan Y. Gestational Exposure to Particulate Matter 2.5 (PM2.5) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring. Front Neurosci. 2018; 12:1000. PMID: 30666183.
    Citations:    
  3. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). PMID: 30190379.
    Citations: 3     Fields:    Translation:HumansAnimals
  4. Zhao W, Hu JX, Hao RM, Zhang Q, Guo JQ, Li YJ, Xie N, Liu LY, Wang PY, Zhang C, Xie SY. Induction of microRNA-let-7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1. Oncol Rep. 2018 Oct; 40(4):1843-1854. PMID: 30066899.
    Citations:    Fields:    Translation:HumansCells
  5. Hou XH, Feng L, Zhang C, Cao XP, Tan L, Yu JT. Models for predicting risk of dementia: a systematic review. J Neurol Neurosurg Psychiatry. 2019 Apr; 90(4):373-379. PMID: 29954871.
    Citations:    Fields:    
  6. Zhang C, Ward J, Dauch JR, Tanzi RE, Cheng HT. Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome. PLoS One. 2018; 13(2):e0192333. PMID: 29408929.
    Citations:    Fields:    Translation:Animals
  7. Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid ß-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 01 18; 8(1):1144. PMID: 29348604.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Feng L, Li J, Yu JT, Zhang C, Yang B, Vellas B, Li C. Editorial: Prevention of Alzheimer's Disease in Chinese Populations: Status, Challenges and Directions. J Prev Alzheimers Dis. 2018; 5(2):90-94. PMID: 29616700.
    Citations:    
  9. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. PMID: 28874832.
    Citations: 4     Fields:    
  10. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. PMID: 28919280.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Liang F, Wan Y, Schaak D, Ward J, Shen X, Tanzi RE, Zhang C, Quan Q. Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin. Sci Rep. 2017 07 18; 7(1):5722. PMID: 28720893.
    Citations:    Fields:    Translation:AnimalsCells
  12. Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017 Sep 01; 8(9):6155-6164. PMID: 28989646.
    Citations:    
  13. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. PMID: 28416568.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate ?-secretase processing of APP and A?-a protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discov Med. 2017 02; 23(125):121-128. PMID: 28371615.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Zhang C. Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine. Discov Med. 2017 02; 23(125):105-111. PMID: 28371613.
    Citations: 2     Fields:    Translation:HumansAnimals
  16. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. PMID: 27443609.
    Citations: 30     Fields:    Translation:Animals
  17. Yu JT, Zhang C. Pathogenesis and Therapeutic Strategies in Alzheimer's Disease: From Brain to Periphery. Neurotox Res. 2016 Feb; 29(2):197-200. PMID: 26597964.
    Citations:    Fields:    Translation:HumansAnimals
  18. Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9734-9. PMID: 26199414.
    Citations: 15     Fields:    Translation:HumansAnimals
  19. Wang PY, Fang JC, Gao ZH, Zhang C, Xie SY. Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta-analysis. J Diabetes Investig. 2016 Jan; 7(1):56-69. PMID: 26816602.
    Citations: 20     Fields:    Translation:HumansAnimals
  20. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015 May 12; 54(18):2806-16. PMID: 25910068.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057.
    Citations: 149     Fields:    Translation:HumansCells
  22. Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons. J Neurosci. 2014 Mar 05; 34(10):3668-73. PMID: 24599465.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146.
    Citations: 13     Fields:    Translation:HumansCells
  24. Wang PY, Sun YX, Zhang S, Pang M, Zhang HH, Gao SY, Zhang C, Lv CJ, Xie SY. Let-7c inhibits A549 cell proliferation through oncogenic TRIB2 related factors. FEBS Lett. 2013 Aug 19; 587(16):2675-81. PMID: 23850892.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  25. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
    Citations: 19     Fields:    Translation:Humans
  26. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24; 340(6135):924-f. PMID: 23704555.
    Citations: 54     Fields:    Translation:Animals
  27. Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY. Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One. 2013; 8(5):e63648. PMID: 23704927.
    Citations: 27     Fields:    Translation:Humans
  28. Zhang C, Tanzi RE. Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res. 2012 Sep 13. PMID: 22998566.
    Citations: 1     Fields:    
  29. Zhang C. Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease. Discov Med. 2012 Sep; 14(76):189-97. PMID: 23021373.
    Citations: 6     Fields:    Translation:HumansAnimals
  30. Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17; 30(46):15677-85. PMID: 21084623.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  31. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010 Sep 10; 285(37):28472-80. PMID: 20622013.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  32. Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Curr Alzheimer Res. 2010 Feb; 7(1):21-6. PMID: 20205669.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  33. Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem. 2010 Mar 19; 285(12):8515-26. PMID: 20097758.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  34. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Zhang C, Saunders AJ. An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis. Discov Med. 2009 Jun; 8(40):18-22. PMID: 19772837.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  36. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916.
    Citations: 20     Fields:    
  37. Zhang C, Saunders AJ. Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease. Discov Med. 2007 Aug; 7(39):113-7. PMID: 18093473.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  38. Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM. Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. J Mol Recognit. 2006 Jul-Aug; 19(4):354-62. PMID: 16775845.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.