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Can Zhang, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Serge G, Aisen PS, Vellas B. Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020 Jul 20. PMID: 32690803.
  2. Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-ß Protein Precursor in Astrocytes Both in vitro and in vivo. J Alzheimers Dis. 2020 Jun 24. PMID: 32597805.
  3. Wang ZT, Zhang C, Wang YJ, Dong Q, Tan L, Yu JT. Selective neuronal vulnerability in Alzheimer's disease. Ageing Res Rev. 2020 Jun 20; 62:101114. PMID: 32569730.
  4. Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. Hum Mol Genet. 2020 Apr 15; 29(6):955-966. PMID: 31995180.
  5. Ma C, Su J, Sun Y, Feng Y, Shen N, Li B, Liang Y, Yang X, Wu H, Zhang H, Herrmann A, Tanzi RE, Liu K, Zhang C. Significant Upregulation of Alzheimer's ß-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides. Angew Chem Int Ed Engl. 2019 12 16; 58(51):18703-18709. PMID: 31609093.
  6. Wang T, Zhang T, Sun L, Li W, Zhang C, Yu L, Guan Y. Gestational B-vitamin supplementation alleviates PM2.5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring. Ecotoxicol Environ Saf. 2019 Dec 15; 185:109686. PMID: 31546205.
  7. Dou KX, Zhang C, Tan CC, Xu W, Li JQ, Cao XP, Tan L, Yu JT. Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aß42 decline in non-demented elders. Aging (Albany NY). 2019 08 01; 11(15):5433-5444. PMID: 31370031.
  8. Xu W, Zhang C, Li JQ, Tan CC, Cao XP, Tan L, Yu JT. Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study. Aging (Albany NY). 2019 05 22; 11(10):3156-3169. PMID: 31118310.
  9. Liang YX, Wang NN, Zhang ZY, Juan ZD, Zhang C. Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway. Front Cell Neurosci. 2019; 13:211. PMID: 31156396.
  10. Shen XN, Niu LD, Wang YJ, Cao XP, Liu Q, Tan L, Zhang C, Yu JT. Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies. J Neurol Neurosurg Psychiatry. 2019 05; 90(5):590-598. PMID: 30630955.
  11. Zheng X, Wang X, Wang T, Zhang H, Wu H, Zhang C, Yu L, Guan Y. Gestational Exposure to Particulate Matter 2.5 (PM2.5) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring. Front Neurosci. 2018; 12:1000. PMID: 30666183.
  12. Wan Y, Liang Y, Liang F, Shen N, Shinozuka K, Yu JT, Ran C, Quan Q, Tanzi RE, Zhang C. A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-ß Protein by Modulating AßPP Processing and Autophagy. J Alzheimers Dis. 2019; 72(3):761-771. PMID: 31640096.
  13. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). PMID: 30190379.
    Citations: 3     Fields:    Translation:HumansAnimals
  14. Zhao W, Hu JX, Hao RM, Zhang Q, Guo JQ, Li YJ, Xie N, Liu LY, Wang PY, Zhang C, Xie SY. Induction of microRNA-let-7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1. Oncol Rep. 2018 Oct; 40(4):1843-1854. PMID: 30066899.
    Citations:    Fields:    Translation:HumansCells
  15. Hou XH, Feng L, Zhang C, Cao XP, Tan L, Yu JT. Models for predicting risk of dementia: a systematic review. J Neurol Neurosurg Psychiatry. 2019 04; 90(4):373-379. PMID: 29954871.
    Citations:    Fields:    
  16. Zhang C, Ward J, Dauch JR, Tanzi RE, Cheng HT. Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome. PLoS One. 2018; 13(2):e0192333. PMID: 29408929.
    Citations:    Fields:    Translation:Animals
  17. Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid ß-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 01 18; 8(1):1144. PMID: 29348604.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Feng L, Li J, Yu JT, Zhang C, Yang B, Vellas B, Li C. Editorial: Prevention of Alzheimer's Disease in Chinese Populations: Status, Challenges and Directions. J Prev Alzheimers Dis. 2018; 5(2):90-94. PMID: 29616700.
  19. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. PMID: 28874832.
    Citations: 4     Fields:    
  20. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. PMID: 28919280.
    Citations:    Fields:    Translation:HumansAnimalsCells
  21. Liang F, Wan Y, Schaak D, Ward J, Shen X, Tanzi RE, Zhang C, Quan Q. Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin. Sci Rep. 2017 07 18; 7(1):5722. PMID: 28720893.
    Citations:    Fields:    Translation:AnimalsCells
  22. Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017 Sep 01; 8(9):6155-6164. PMID: 28989646.
  23. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. PMID: 28416568.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate ?-secretase processing of APP and A?-a protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discov Med. 2017 02; 23(125):121-128. PMID: 28371615.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Zhang C. Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine. Discov Med. 2017 02; 23(125):105-111. PMID: 28371613.
    Citations: 2     Fields:    Translation:HumansAnimals
  26. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. PMID: 27443609.
    Citations: 30     Fields:    Translation:Animals
  27. Yu JT, Zhang C. Pathogenesis and Therapeutic Strategies in Alzheimer's Disease: From Brain to Periphery. Neurotox Res. 2016 Feb; 29(2):197-200. PMID: 26597964.
    Citations:    Fields:    Translation:HumansAnimals
  28. Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9734-9. PMID: 26199414.
    Citations: 15     Fields:    Translation:HumansAnimals
  29. Wang PY, Fang JC, Gao ZH, Zhang C, Xie SY. Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta-analysis. J Diabetes Investig. 2016 Jan; 7(1):56-69. PMID: 26816602.
    Citations: 20     Fields:    Translation:HumansAnimals
  30. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015 May 12; 54(18):2806-16. PMID: 25910068.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  31. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057.
    Citations: 149     Fields:    Translation:HumansCells
  32. Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons. J Neurosci. 2014 Mar 05; 34(10):3668-73. PMID: 24599465.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146.
    Citations: 13     Fields:    Translation:HumansCells
  34. Wang PY, Sun YX, Zhang S, Pang M, Zhang HH, Gao SY, Zhang C, Lv CJ, Xie SY. Let-7c inhibits A549 cell proliferation through oncogenic TRIB2 related factors. FEBS Lett. 2013 Aug 19; 587(16):2675-81. PMID: 23850892.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  35. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
    Citations: 19     Fields:    Translation:Humans
  36. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24; 340(6135):924-f. PMID: 23704555.
    Citations: 54     Fields:    Translation:Animals
  37. Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY. Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One. 2013; 8(5):e63648. PMID: 23704927.
    Citations: 27     Fields:    Translation:Humans
  38. Zhang C, Tanzi RE. Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res. 2012 Sep 13. PMID: 22998566.
    Citations: 1     Fields:    
  39. Zhang C. Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease. Discov Med. 2012 Sep; 14(76):189-97. PMID: 23021373.
    Citations: 6     Fields:    Translation:HumansAnimals
  40. Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17; 30(46):15677-85. PMID: 21084623.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  41. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010 Sep 10; 285(37):28472-80. PMID: 20622013.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  42. Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Curr Alzheimer Res. 2010 Feb; 7(1):21-6. PMID: 20205669.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  43. Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem. 2010 Mar 19; 285(12):8515-26. PMID: 20097758.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  44. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  45. Zhang C, Saunders AJ. An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis. Discov Med. 2009 Jun; 8(40):18-22. PMID: 19772837.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  46. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916.
    Citations: 20     Fields:    
  47. Zhang C, Saunders AJ. Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease. Discov Med. 2007 Aug; 7(39):113-7. PMID: 18093473.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  48. Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM. Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. J Mol Recognit. 2006 Jul-Aug; 19(4):354-62. PMID: 16775845.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.