Harvard Catalyst Profiles

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Can Zhang, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liang Y, Lee DYW, Zhen S, Sun H, Zhu B, Liu J, Lei D, Lin CJ, Zhang S, Jacques NA, Quinti L, Ran C, Wang C, Griciuc A, Choi SH, Dai RH, Efferth T, Tanzi RE, Zhang C. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease. Phytomedicine. 2022 Sep; 104:154158. PMID: 35728383.
    Citations:    Fields:    
  2. Wang Z, Ye J, Zhang K, Ding L, Granzier-Nakajima T, Ranasinghe JC, Xue Y, Sharma S, Biase I, Terrones M, Choi SH, Ran C, Tanzi RE, Huang SX, Zhang C, Huang S. Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy. ACS Nano. 2022 04 26; 16(4):6426-6436. PMID: 35333038.
    Citations: 1     Fields:    
  3. Zhang S, Bai P, Lei D, Liang Y, Zhen S, Bakiasi G, Pang H, Choi SH, Wang C, Tanzi RE, Zhang C. Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models. J Biol Chem. 2022 04; 298(4):101794. PMID: 35248531; PMCID: PMC8958546.
    Citations: 1     Fields:    Translation:Humans
  4. Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimers Dement. 2022 11; 18(11):2117-2130. PMID: 35084109; PMCID: PMC9787711.
    Citations:    Fields:    
  5. Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, Zhang CM, Liang Y, Srinath A, Zhang X, Xia J, Olszewski M, Zhang X, Schipma MJ, Chang EB, Tanzi RE, Gilbert JA, Sisodia SS. Gut microbiota-driven brain Aß amyloidosis in mice requires microglia. J Exp Med. 2022 01 03; 219(1). PMID: 34854884; PMCID: PMC8647415.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Xu Y, Xu Y, Biby S, Bai P, Liu Y, Zhang C, Wang C, Zhang S. Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I. ACS Chem Neurosci. 2021 12 15; 12(24):4491-4499. PMID: 34812607.
    Citations:    Fields:    
  7. Lan Y, Bai P, Liu Y, Afshar S, Striar R, Rattray AK, Meyer TN, Langan AG, Posner AM, Shen S, Tanzi RE, Zhang C, Wang C. Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography. J Med Chem. 2021 10 28; 64(20):15420-15428. PMID: 34652135; PMCID: PMC8858444.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Ou YN, Yang YX, Deng YT, Zhang C, Hu H, Wu BS, Liu Y, Wang YJ, Zhu Y, Suckling J, Tan L, Yu JT. Identification of novel drug targets for Alzheimer's disease by integrating genetics and proteomes from brain and blood. Mol Psychiatry. 2021 10; 26(10):6065-6073. PMID: 34381170.
    Citations: 6     Fields:    Translation:Humans
  9. Zhang T, Sun L, Wang T, Liu C, Zhang H, Zhang C, Yu L. Gestational exposure to PM2.5 leads to cognitive dysfunction in mice offspring via promoting HMGB1-NLRP3 axis mediated hippocampal inflammation. Ecotoxicol Environ Saf. 2021 Oct 15; 223:112617. PMID: 34385058.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022 04; 18(4):645-653. PMID: 34160128; PMCID: PMC8695625.
    Citations: 7     Fields:    Translation:Humans
  11. Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aß domain promotes Aß production in vitro and deposition in vivo. J Exp Med. 2021 06 07; 218(6). PMID: 33822840; PMCID: PMC8034382.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Xu Y, Chen Z, Wey HY, Liang Y, Tanzi RE, Zhang C, Wang C. Molecular imaging of NAD+ -dependent deacetylase SIRT1 in the brain. Alzheimers Dement. 2021 12; 17(12):1988-1997. PMID: 33860595.
    Citations:    Fields:    Translation:Animals
  13. Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Preclinical validation of a potent ?-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). PMID: 33651103; PMCID: PMC7931646.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  14. Ding W, You Z, Chen Q, Yang L, Doheny J, Zhou X, Li N, Wang S, Hu K, Chen L, Xia S, Wu X, Wang C, Zhang C, Chen L, Ritchie C, Huang P, Mao J, Shen S. Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells. Anesth Analg. 2021 04 01; 132(4):1146-1155. PMID: 32889847.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Xu Y, Xu Y, Blevins H, Lan Y, Liu Y, Yuan G, Striar R, Zagaroli JS, Tocci DR, Langan AG, Zhang C, Zhang S, Wang C. Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome. Bioorg Med Chem Lett. 2021 02 15; 34:127777. PMID: 33418063; PMCID: PMC8785901.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Feng L, Romero-Garcia R, Suckling J, Tan J, Larbi A, Cheah I, Wong G, Tsakok M, Lanskey B, Lim D, Li J, Yang J, Goh B, Teck TGC, Ho A, Wang X, Yu JT, Zhang C, Tan C, Chua M, Li J, Totman JJ, Wong C, Loh M, Foo R, Tan CH, Goh LG, Mahendran R, Kennedy BK, Kua EH. Effects of choral singing versus health education on cognitive decline and aging: a randomized controlled trial. Aging (Albany NY). 2020 12 18; 12(24):24798-24816. PMID: 33346748.
    Citations: 2     Fields:    Translation:Humans
  17. Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 12 07; 217(12). PMID: 32936886.
    Citations: 11     Fields:    Translation:HumansAnimals
  18. Xu W, Han SD, Zhang C, Li JQ, Wang YJ, Tan CC, Li HQ, Dong Q, Mei C, Tan L, Yu JT. The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases. Sci Adv. 2020 10; 6(43). PMID: 33087363; PMCID: PMC7577723.
    Citations: 1     Fields:    Translation:Humans
  19. Yang J, Yin W, Van R, Yin K, Wang P, Zheng C, Zhu B, Ran K, Zhang C, Kumar M, Shao Y, Ran C. Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo. Nat Commun. 2020 08 13; 11(1):4052. PMID: 32792510; PMCID: PMC7426431.
    Citations: 1     Fields:    Translation:Animals
  20. Wang HF, Shen XN, Li JQ, Suckling J, Tan CC, Wang YJ, Feng L, Zhang C, Tan L, Dong Q, Touchon J, Gauthier S, Yu JT. Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study. Alzheimers Dement (Amst). 2020; 12(1):e12095. PMID: 32793801; PMCID: PMC7421532.
    Citations: 6     
  21. Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Gauthier S, Aisen PS, Vellas B. Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020 11; 91(11):1201-1209. PMID: 32690803.
    Citations: 48     Fields:    Translation:Humans
  22. Wang X, Wang T, Sun L, Zhang H, Liu C, Zhang C, Yu L. B-vitamin supplementation ameliorates anxiety- and depression-like behavior induced by gestational urban PM2.5 exposure through suppressing neuroinflammation in mice offspring. Environ Pollut. 2020 Nov; 266(Pt 2):115146. PMID: 32663728.
    Citations:    Fields:    Translation:Animals
  23. Wang ZT, Zhang C, Wang YJ, Dong Q, Tan L, Yu JT. Selective neuronal vulnerability in Alzheimer's disease. Ageing Res Rev. 2020 09; 62:101114. PMID: 32569730.
    Citations: 3     Fields:    Translation:HumansCells
  24. Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. Hum Mol Genet. 2020 04 15; 29(6):955-966. PMID: 31995180.
    Citations: 3     Fields:    Translation:HumansCells
  25. Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-ß Protein Precursor in Astrocytes Both in vitro and in vivo. J Alzheimers Dis. 2020; 76(3):1071-1082. PMID: 32597805.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Ma C, Su J, Sun Y, Feng Y, Shen N, Li B, Liang Y, Yang X, Wu H, Zhang H, Herrmann A, Tanzi RE, Liu K, Zhang C. Significant Upregulation of Alzheimer's ß-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides. Angew Chem Int Ed Engl. 2019 12 16; 58(51):18703-18709. PMID: 31609093; PMCID: PMC7187254.
    Citations: 10     Fields:    Translation:HumansCells
  27. Liang Y, Zhang Z, Juan Z, Zhang R, Zhang C. The high-affinity IgG receptor Fc?RI modulates peripheral nerve injury-induced neuropathic pain in rats. Mol Brain. 2019 10 22; 12(1):83. PMID: 31640731.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Wang T, Zhang T, Sun L, Li W, Zhang C, Yu L, Guan Y. Gestational B-vitamin supplementation alleviates PM2.5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring. Ecotoxicol Environ Saf. 2019 Dec 15; 185:109686. PMID: 31546205.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Dou KX, Zhang C, Tan CC, Xu W, Li JQ, Cao XP, Tan L, Yu JT. Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aß42 decline in non-demented elders. Aging (Albany NY). 2019 08 01; 11(15):5433-5444. PMID: 31370031; PMCID: PMC6710044.
    Citations: 1     Fields:    Translation:Humans
  30. Xu W, Zhang C, Li JQ, Tan CC, Cao XP, Tan L, Yu JT. Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study. Aging (Albany NY). 2019 05 22; 11(10):3156-3169. PMID: 31118310.
    Citations: 11     Fields:    Translation:Humans
  31. Liang YX, Wang NN, Zhang ZY, Juan ZD, Zhang C. Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway. Front Cell Neurosci. 2019; 13:211. PMID: 31156396; PMCID: PMC6529821.
    Citations: 12     
  32. Shen XN, Niu LD, Wang YJ, Cao XP, Liu Q, Tan L, Zhang C, Yu JT. Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies. J Neurol Neurosurg Psychiatry. 2019 05; 90(5):590-598. PMID: 30630955.
    Citations: 67     Fields:    Translation:Humans
  33. Zheng X, Wang X, Wang T, Zhang H, Wu H, Zhang C, Yu L, Guan Y. Gestational Exposure to Particulate Matter 2.5 (PM2.5) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring. Front Neurosci. 2018; 12:1000. PMID: 30666183; PMCID: PMC6330280.
    Citations: 6     
  34. Wan Y, Liang Y, Liang F, Shen N, Shinozuka K, Yu JT, Ran C, Quan Q, Tanzi RE, Zhang C. A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-ß Protein by Modulating AßPP Processing and Autophagy. J Alzheimers Dis. 2019; 72(3):761-771. PMID: 31640096.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). PMID: 30190379.
    Citations: 175     Fields:    Translation:HumansAnimals
  36. Zhao W, Hu JX, Hao RM, Zhang Q, Guo JQ, Li YJ, Xie N, Liu LY, Wang PY, Zhang C, Xie SY. Induction of microRNA-let-7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1. Oncol Rep. 2018 Oct; 40(4):1843-1854. PMID: 30066899; PMCID: PMC6111629.
    Citations: 9     Fields:    Translation:HumansCells
  37. Hou XH, Feng L, Zhang C, Cao XP, Tan L, Yu JT. Models for predicting risk of dementia: a systematic review. J Neurol Neurosurg Psychiatry. 2019 04; 90(4):373-379. PMID: 29954871.
    Citations: 37     Fields:    Translation:Humans
  38. Zhang C, Ward J, Dauch JR, Tanzi RE, Cheng HT. Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome. PLoS One. 2018; 13(2):e0192333. PMID: 29408929.
    Citations: 13     Fields:    Translation:Animals
  39. Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid ß-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 01 18; 8(1):1144. PMID: 29348604.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  40. Feng L, Li J, Yu JT, Zhang C, Yang B, Vellas B, Li C. Editorial: Prevention of Alzheimer's Disease in Chinese Populations: Status, Challenges and Directions. J Prev Alzheimers Dis. 2018; 5(2):90-94. PMID: 29616700.
    Citations: 1     Fields:    Translation:Humans
  41. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. PMID: 28874832.
    Citations: 89     Fields:    Translation:Animals
  42. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. PMID: 28919280.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  43. Liang F, Wan Y, Schaak D, Ward J, Shen X, Tanzi RE, Zhang C, Quan Q. Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin. Sci Rep. 2017 07 18; 7(1):5722. PMID: 28720893.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017 Sep 01; 8(9):6155-6164. PMID: 28989646; PMCID: PMC5627602.
    Citations: 2     
  45. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. PMID: 28416568; PMCID: PMC5454592.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  46. Zhang C. Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine. Discov Med. 2017 02; 23(125):105-111. PMID: 28371613.
    Citations: 5     Fields:    Translation:HumansAnimals
  47. Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate ?-secretase processing of APP and A?-a protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discov Med. 2017 02; 23(125):121-128. PMID: 28371615.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  48. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. PMID: 27443609.
    Citations: 186     Fields:    Translation:Animals
  49. Yu JT, Zhang C. Pathogenesis and Therapeutic Strategies in Alzheimer's Disease: From Brain to Periphery. Neurotox Res. 2016 Feb; 29(2):197-200. PMID: 26597964.
    Citations:    Fields:    Translation:HumansAnimals
  50. Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9734-9. PMID: 26199414; PMCID: PMC4534214.
    Citations: 39     Fields:    Translation:HumansAnimals
  51. Wang PY, Fang JC, Gao ZH, Zhang C, Xie SY. Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta-analysis. J Diabetes Investig. 2016 Jan; 7(1):56-69. PMID: 26816602; PMCID: PMC4718092.
    Citations: 98     Fields:    Translation:HumansAnimals
  52. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015 May 12; 54(18):2806-16. PMID: 25910068.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  53. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057.
    Citations: 410     Fields:    Translation:HumansCells
  54. Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons. J Neurosci. 2014 Mar 05; 34(10):3668-73. PMID: 24599465.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  55. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146.
    Citations: 24     Fields:    Translation:HumansCells
  56. Wang PY, Sun YX, Zhang S, Pang M, Zhang HH, Gao SY, Zhang C, Lv CJ, Xie SY. Let-7c inhibits A549 cell proliferation through oncogenic TRIB2 related factors. FEBS Lett. 2013 Aug 19; 587(16):2675-81. PMID: 23850892.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  57. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
    Citations: 37     Fields:    Translation:Humans
  58. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24; 340(6135):924-f. PMID: 23704555.
    Citations: 79     Fields:    Translation:Animals
  59. Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY. Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One. 2013; 8(5):e63648. PMID: 23704927.
    Citations: 71     Fields:    Translation:Humans
  60. Zhang C, Tanzi RE. Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res. 2012 Sep 13. PMID: 22998566.
    Citations: 2     Fields:    
  61. Zhang C. Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease. Discov Med. 2012 Sep; 14(76):189-97. PMID: 23021373.
    Citations: 13     Fields:    Translation:HumansAnimals
  62. Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17; 30(46):15677-85. PMID: 21084623.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  63. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010 Sep 10; 285(37):28472-80. PMID: 20622013.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  64. Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Curr Alzheimer Res. 2010 Feb; 7(1):21-6. PMID: 20205669.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  65. Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem. 2010 Mar 19; 285(12):8515-26. PMID: 20097758.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  66. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  67. Zhang C, Saunders AJ. An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis. Discov Med. 2009 Jun; 8(40):18-22. PMID: 19772837.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  68. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916.
    Citations: 26     Fields:    
  69. Zhang C, Saunders AJ. Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease. Discov Med. 2007 Aug; 7(39):113-7. PMID: 18093473.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  70. Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM. Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. J Mol Recognit. 2006 Jul-Aug; 19(4):354-62. PMID: 16775845.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.