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Crowley, William
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William Francis Crowley Jr., M.D.
Title
Daniel K. Podolsky Distinguished Professor of Medicine
Institution
Massachusetts General Hospital
Department
Medicine
Address
Massachusetts General Hospital
Repro Endocrine Science Ctr, BHX 5
55 Fruit St
Boston MA 02114
Phone
617/726-5390
Fax
617/726-5357
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
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U01HD044417
(CROWLEY, WILLIAM FRANCIS)
Sep 26, 2002 - Mar 31, 2008
NIH
NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
Role: Principal Investigator
P50HD028138
(SEMINARA, STEPHANIE BETH)
Apr 1, 1997 - Mar 31, 2021
NIH
Harvard Reproductive Endocrine Sciences Center
Role: Principal Investigator
U54HD028138
(CROWLEY, WILLIAM FRANCIS)
Apr 1, 1997 - Mar 31, 2016
NIH
Harvard Reproductive Endocrine Sciences Center
Role: Principal Investigator
U54HD029164
(CROWLEY, WILLIAM F)
Sep 30, 1991 - Jun 30, 2003
NIH
NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
Role: Principal Investigator
T32HD007396
(CROWLEY, WILLIAM FRANCIS)
Jul 15, 1991 - May 31, 2019
NIH
Training Program in Reproductive & Developmental Biology
Role: Principal Investigator
P30HD028138
(CROWLEY, WILLIAM F)
May 1, 1991 - Mar 31, 2000
NIH
REPRODUCTIVE ENDOCRINE SCIENCES CENTER
Role: Principal Investigator
N01HD032837
(CROWLEY, WILLIAM F)
Sep 30, 1983 - Sep 29, 1986
NIH/NICHD
CLINICAL PHARMACOLOGY OF LHRH ANTAGONISTS
Role: Principal Investigator
R01HD018169
(BOEPPLE, PAUL A)
Jul 1, 1983 - Jun 30, 1999
NIH
NEUROENDOCRINE-GONADAL FUNCTION IN PUBERTY
Role: Co-Principal Investigator
R01HD015788
(CROWLEY, WILLIAM FRANCIS)
Jul 1, 1981 - Jul 31, 2013
NIH
The Neuroendocrine Control of Reproduction in the Human
Role: Principal Investigator
R01HD015080
(CROWLEY, WILLIAM F)
Jul 1, 1981 - Dec 31, 1994
NIH
NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE FEMALE
Role: Principal Investigator
M01RR001066
(SLAVIN, PETER L)
Feb 1, 1978 - May 31, 2008
NIH
General Clinical Research Center
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Cassin J,
Stamou MI
, Keefe KW, Sung K, Bojo C, Tonsfeldt KJ, Rojas RA, Ferreira Lopes V, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE,
Crowley WF
,
Seminara SB
, Mellon PL,
Balasubramanian R
. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight. 2023 Jan 05.
PMID:
36602867
.
Citations:
Fields:
Med
Medicine (General)
Lippincott MF
, Xu W, Smith AA, Miao X, Lafont A, Shennib O, Farley GJ,
Sabbagh R
, Delaney A,
Stamou M
, Plummer L, Salnikov K, Georgopoulos NA, Mericq V, Quinton R, Mau-Them FT, Nambot S, Hamad A, Brittain H, Tooze RS, Calpena E, Wilkie AOM, Willems M,
Crowley WF
,
Balasubramanian R
, Lamarche-Vane N, Davis EE,
Seminara SB
. The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. Genet Med. 2022 12; 24(12):2501-2515.
PMID:
36178483
; PMCID:
PMC9730938
.
Citations:
Fields:
Gen
Genetics
Translation:
Humans
Animals
Stamou MI
, Brand H, Wang M, Wong I,
Lippincott MF
, Plummer L,
Crowley WF
,
Talkowski M
,
Seminara S
,
Balasubramanian R
. Prevalence and Phenotypic Effects of Copy Number Variants in Isolated Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. 2022 07 14; 107(8):2228-2242.
PMID:
35574646
; PMCID:
PMC9282252
.
Citations:
1
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Rojas RA, Kutateladze AA, Plummer L,
Stamou M
, Keefe DL, Salnikov KB, Delaney A, Hall JE,
Sadreyev R
, Ji F, Fliers E, Gambosova K, Quinton R, Merino PM, Mericq V,
Seminara SB
,
Crowley WF
,
Balasubramanian R
. Phenotypic continuum between Waardenburg syndrome and idiopathic hypogonadotropic hypogonadism in humans with SOX10 variants. Genet Med. 2021 04; 23(4):629-636.
PMID:
33442024
; PMCID:
PMC8335791
.
Citations:
3
Fields:
Gen
Genetics
Translation:
Humans
Davis EE,
Balasubramanian R
, Kupchinsky ZA, Keefe DL, Plummer L, Khan K, Meczekalski B, Heath KE, Lopez-Gonzalez V, Ballesta-Martinez MJ, Margabanthu G, Price S, Greening J, Brauner R, Valenzuela I, Cusco I, Fernandez-Alvarez P, Wierman ME, Li T, Lage K, Barroso PS,
Chan YM
,
Crowley WF
, Katsanis N. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Hum Mol Genet. 2020 08 11; 29(14):2435-2450.
PMID:
32620954
.
Citations:
1
Fields:
Gen
Genetics
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Xu W, Plummer L, Quinton R, Swords F,
Crowley WF
,
Seminara SB
,
Balasubramanian R
. Hypogonadotropic hypogonadism due to variants in RAB3GAP2: expanding the phenotypic and genotypic spectrum of Martsolf syndrome. Cold Spring Harb Mol Case Stud. 2020 06; 6(3).
PMID:
32376645
.
Citations:
1
Fields:
Gen
Genetics
Translation:
Humans
Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM,
Balasubramanian R
, Delaney A,
Crowley W
, Breedlove SM, Puts DA. Pubertal timing predicts adult psychosexuality: Evidence from typically developing adults and adults with isolated GnRH deficiency. Psychoneuroendocrinology. 2020 09; 119:104733.
PMID:
32563936
; PMCID:
PMC8938930
.
Citations:
3
Fields:
End
Endocrinology
Neu
Neurology
Psy
Psychiatry
Translation:
Humans
Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA,
Jacobsen CM
, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, Kim S, Inoue K, Arora G, Salnikov KB, DiOrio NP, Prada R, Capri Y, Morioka K, Mizota M, Zechi-Ceide RM, Kokitsu-Nakata NM, Tonello C, Vendramini-Pittoli S, da Silva Dalben G,
Balasubramanian R
, Dwyer AA,
Seminara SB
,
Crowley WF
, Plummer L, Hall JE, Graham JM,
Lin AE
, Shaw ND. Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. J Clin Endocrinol Metab. 2020 05 01; 105(5).
PMID:
32034419
; PMCID:
PMC7108682
.
Citations:
4
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Cells
Jee YH, Won S, Lui JC, Jennings M, Whalen P, Yue S, Temnycky AG, Barnes KM, Cheetham T, Boden MG, Radovick S, Quinton R, Leschek EW, Aguilera G, Yanovski JA,
Seminara SB
,
Crowley WF
, Delaney A, Roche KW, Baron J. DLG2 variants in patients with pubertal disorders. Genet Med. 2020 08; 22(8):1329-1337.
PMID:
32341572
; PMCID:
PMC7510947
.
Citations:
1
Fields:
Gen
Genetics
Translation:
Humans
Cells
Stamou M
, Ng SY, Brand H, Wang H, Plummer L, Best L, Havlicek S, Hibberd M, Khor CC,
Gusella J
,
Balasubramanian R
,
Talkowski M
, Stanton LW,
Crowley WF
. A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator. J Clin Endocrinol Metab. 2020 03 01; 105(3).
PMID:
31628846
; PMCID:
PMC7112981
.
Citations:
9
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Cells
Shirazi TN, Self H, Cantor J, Dawood K, Cárdenas R, Rosenfield K, Ortiz T, Carré J, McDaniel MA, Blanchard R,
Balasubramanian R
, Delaney A,
Crowley W
, Breedlove SM, Puts D. Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples. Horm Behav. 2020 05; 121:104712.
PMID:
32059854
; PMCID:
PMC8817672
.
Citations:
3
Fields:
Beh
Behavioral Sciences
End
Endocrinology
Translation:
Humans
Animals
Dwyer AA, Chavan NR, Lewkowitz-Shpuntoff H, Plummer L,
Hayes FJ
,
Seminara SB
,
Crowley WF
, Pitteloud N,
Balasubramanian R
. Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History. J Clin Endocrinol Metab. 2019 08 01; 104(8):3403-3414.
PMID:
31220265
; PMCID:
PMC6594303
.
Citations:
5
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Cox KH, Oliveira LMB, Plummer L, Corbin B,
Gardella T
,
Balasubramanian R
,
Crowley WF
. Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet. 2018 01 15; 27(2):338-350.
PMID:
29161432
; PMCID:
PMC5886255
.
Citations:
8
Fields:
Gen
Genetics
Mol
Molecular Biology
Translation:
Humans
Cells
Balasubramanian R
,
Crowley WF
. Reproductive endocrine phenotypes relating to CHD7 mutations in humans. Am J Med Genet C Semin Med Genet. 2017 12; 175(4):507-515.
PMID:
29152903
.
Citations:
12
Fields:
Gen
Genetics
Translation:
Humans
Animals
Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J, Niederländer NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JM, Plummer L, Albrecht U,
Crowley WF
, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N. KLB, encoding ß-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. EMBO Mol Med. 2017 10; 9(10):1379-1397.
PMID:
28754744
; PMCID:
PMC5623842
.
Citations:
25
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC,
Lippincott MF
, Singh SS, Patel N, Jing JW, Law JR,
Ferraro N
, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH,
Morton CC
, Meehan RR, van Heyningen V, Liao EC,
Balasubramanian R
, Hall JE,
Seminara SB
, Macarthur D, Moore SA, Yoshiura KI,
Gusella JF
, Marsh JA, Graham JM,
Lin AE
, Katsanis N, Jones PL,
Crowley WF
, Davis EE, FitzPatrick DR,
Talkowski ME
. Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 05 26; 49(6):969.
PMID:
28546579
.
Citations:
Fields:
Gen
Genetics
Crowley WF
, Balasubramanian R. MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. J Clin Invest. 2017 Mar 01; 127(3):796-797.
PMID:
28218621
; PMCID:
PMC5330749
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Animals
Cells
Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS,
Collins RL
, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM,
Chiang C
, An Y, Ansari M, Rainger JK, Joss S, Smith JC,
Lippincott MF
, Singh SS, Patel N, Jing JW, Law JR,
Ferraro N
, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N,
Jacobsen C
, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH,
Morton CC
, Meehan RR, van Heyningen V, Liao EC,
Balasubramanian R
, Hall JE,
Seminara SB
, Macarthur D, Moore SA, Yoshiura KI,
Gusella JF
, Marsh JA, Graham JM,
Lin AE
, Katsanis N, Jones PL,
Crowley WF
, Davis EE, FitzPatrick DR,
Talkowski ME
. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248.
PMID:
28067909
.
Citations:
58
Fields:
Gen
Genetics
Translation:
Humans
Kimball AB
, Javorsky E, Ron ES,
Crowley W
,
Langer R
. A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system. J Control Release. 2016 07 10; 233:19-28.
PMID:
27130696
.
Citations:
6
Fields:
Pha
Pharmacology
Translation:
Humans
CT
Clinical Trials
Stamou MI
, Cox KH,
Crowley WF
. Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2016 02; 2016(1):4-22.
PMID:
27454361
.
Citations:
19
Fields:
End
Endocrinology
Translation:
Humans
Stamou MI
, Cox KH,
Crowley WF
. Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2015 Dec; 36(6):603-21.
PMID:
26394276
.
Citations:
18
Fields:
End
Endocrinology
Translation:
Humans
Cells
Choi JH,
Balasubramanian R
, Lee PH, Shaw ND, Hall JE, Plummer L, Buck CL, Kottler ML, Jarzabek K, Wolczynski S, Quinton R, Latronico AC, Dode C, Ogata T, Kim HG, Layman LC,
Gusella JF
,
Crowley WF
. Expanding the Spectrum of Founder Mutations Causing Isolated Gonadotropin-Releasing Hormone Deficiency. J Clin Endocrinol Metab. 2015 Oct; 100(10):E1378-85.
PMID:
26207952
; PMCID:
PMC4596034
.
Citations:
8
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Balasubramanian R
, Choi JH, Francescatto L, Willer J, Horton ER, Asimacopoulos EP, Stankovic KM, Plummer L, Buck CL, Quinton R, Nebesio TD, Mericq V, Merino PM, Meyer BF, Monies D,
Gusella JF
, Al Tassan N, Katsanis N,
Crowley WF
. Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17953-8.
PMID:
25472840
; PMCID:
PMC4273325
.
Citations:
29
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L,
Crowley WF
, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55.
PMID:
25091407
.
Citations:
1
Fields:
End
Endocrinology
Neo
Neoplasms
Translation:
Humans
Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS,
Crowley WF
, Wierman ME. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Apr; 99(4):1452-60.
PMID:
24476074
; PMCID:
PMC3973777
.
Citations:
12
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Animals
Cells
Balasubramanian R
, Cohen DA,
Klerman EB
, Pignatelli D, Hall JE, Dwyer AA,
Czeisler CA
, Pitteloud N,
Crowley WF
. Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab. 2014 Mar; 99(3):E561-6.
PMID:
24423319
; PMCID:
PMC3942237
.
Citations:
2
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Dwyer AA, Sykiotis GP,
Hayes FJ
,
Boepple PA
, Lee H,
Loughlin KR
, Dym M, Sluss PM,
Crowley WF
, Pitteloud N. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1790-5.
PMID:
24037890
; PMCID:
PMC3816270
.
Citations:
28
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans