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William Francis Crowley Jr., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U01HD044417 (CROWLEY, WILLIAM FRANCIS) Sep 26, 2002 - Mar 31, 2008
    NIH
    NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
    Role: Principal Investigator
  2. P50HD028138 (SEMINARA, STEPHANIE BETH) Apr 1, 1997 - Mar 31, 2021
    NIH
    Harvard Reproductive Endocrine Sciences Center
    Role: Principal Investigator
  3. U54HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2016
    NIH
    Harvard Reproductive Endocrine Sciences Center
    Role: Principal Investigator
  4. U54HD029164 (CROWLEY, WILLIAM F) Sep 30, 1991 - Jun 30, 2003
    NIH
    NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
    Role: Principal Investigator
  5. T32HD007396 (CROWLEY, WILLIAM FRANCIS) Jul 15, 1991 - May 31, 2019
    NIH
    Training Program in Reproductive & Developmental Biology
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rojas RA, Kutateladze AA, Plummer L, Stamou M, Keefe DL, Salnikov KB, Delaney A, Hall JE, Sadreyev R, Ji F, Fliers E, Gambosova K, Quinton R, Merino PM, Mericq V, Seminara SB, Crowley WF, Balasubramanian R. Phenotypic continuum between Waardenburg syndrome and idiopathic hypogonadotropic hypogonadism in humans with SOX10 variants. Genet Med. 2021 Apr; 23(4):629-636. PMID: 33442024.
    Citations:    Fields:    
  2. Davis EE, Balasubramanian R, Kupchinsky ZA, Keefe DL, Plummer L, Khan K, Meczekalski B, Heath KE, Lopez-Gonzalez V, Ballesta-Martinez MJ, Margabanthu G, Price S, Greening J, Brauner R, Valenzuela I, Cusco I, Fernandez-Alvarez P, Wierman ME, Li T, Lage K, Barroso PS, Chan YM, Crowley WF, Katsanis N. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Hum Mol Genet. 2020 08 11; 29(14):2435-2450. PMID: 32620954.
    Citations:    Fields:    
  3. Xu W, Plummer L, Quinton R, Swords F, Crowley WF, Seminara SB, Balasubramanian R. Hypogonadotropic hypogonadism due to variants in RAB3GAP2: expanding the phenotypic and genotypic spectrum of Martsolf syndrome. Cold Spring Harb Mol Case Stud. 2020 06; 6(3). PMID: 32376645.
    Citations:    Fields:    
  4. Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA. Pubertal timing predicts adult psychosexuality: Evidence from typically developing adults and adults with isolated GnRH deficiency. Psychoneuroendocrinology. 2020 09; 119:104733. PMID: 32563936.
    Citations:    Fields:    
  5. Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, Kim S, Inoue K, Arora G, Salnikov KB, DiOrio NP, Prada R, Capri Y, Morioka K, Mizota M, Zechi-Ceide RM, Kokitsu-Nakata NM, Tonello C, Vendramini-Pittoli S, da Silva Dalben G, Balasubramanian R, Dwyer AA, Seminara SB, Crowley WF, Plummer L, Hall JE, Graham JM, Lin AE, Shaw ND. Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. J Clin Endocrinol Metab. 2020 05 01; 105(5). PMID: 32034419.
    Citations:    Fields:    Translation:HumansCells
  6. Jee YH, Won S, Lui JC, Jennings M, Whalen P, Yue S, Temnycky AG, Barnes KM, Cheetham T, Boden MG, Radovick S, Quinton R, Leschek EW, Aguilera G, Yanovski JA, Seminara SB, Crowley WF, Delaney A, Roche KW, Baron J. DLG2 variants in patients with pubertal disorders. Genet Med. 2020 08; 22(8):1329-1337. PMID: 32341572.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Stamou M, Ng SY, Brand H, Wang H, Plummer L, Best L, Havlicek S, Hibberd M, Khor CC, Gusella J, Balasubramanian R, Talkowski M, Stanton LW, Crowley WF. A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator. J Clin Endocrinol Metab. 2020 03 01; 105(3). PMID: 31628846.
    Citations: 3     Fields:    Translation:HumansCells
  8. Shirazi TN, Self H, Cantor J, Dawood K, Cárdenas R, Rosenfield K, Ortiz T, Carré J, McDaniel MA, Blanchard R, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts D. Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples. Horm Behav. 2020 05; 121:104712. PMID: 32059854.
    Citations:    Fields:    Translation:HumansAnimals
  9. Dwyer AA, Chavan NR, Lewkowitz-Shpuntoff H, Plummer L, Hayes FJ, Seminara SB, Crowley WF, Pitteloud N, Balasubramanian R. Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History. J Clin Endocrinol Metab. 2019 08 01; 104(8):3403-3414. PMID: 31220265.
    Citations: 4     Fields:    Translation:Humans
  10. Cox KH, Oliveira LMB, Plummer L, Corbin B, Gardella T, Balasubramanian R, Crowley WF. Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet. 2018 01 15; 27(2):338-350. PMID: 29161432.
    Citations: 4     Fields:    Translation:HumansCells
  11. Balasubramanian R, Crowley WF. Reproductive endocrine phenotypes relating to CHD7 mutations in humans. Am J Med Genet C Semin Med Genet. 2017 12; 175(4):507-515. PMID: 29152903.
    Citations: 6     Fields:    Translation:HumansAnimals
  12. Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J, Niederländer NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JM, Plummer L, Albrecht U, Crowley WF, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N. KLB, encoding ß-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. EMBO Mol Med. 2017 10; 9(10):1379-1397. PMID: 28754744.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  13. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 05 26; 49(6):969. PMID: 28546579.
    Citations:    Fields:    
  14. Crowley WF, Balasubramanian R. MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. J Clin Invest. 2017 Mar 01; 127(3):796-797. PMID: 28218621.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248. PMID: 28067909.
    Citations: 36     Fields:    Translation:Humans
  16. Kimball AB, Javorsky E, Ron ES, Crowley W, Langer R. A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system. J Control Release. 2016 07 10; 233:19-28. PMID: 27130696.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  17. Stamou MI, Cox KH, Crowley WF. Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2016 02; 2016(1):4-22. PMID: 27454361.
    Citations: 17     Fields:    Translation:Humans
  18. Stamou MI, Cox KH, Crowley WF. Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2015 Dec; 36(6):603-21. PMID: 26394276.
    Citations: 10     Fields:    Translation:HumansCells
  19. Choi JH, Balasubramanian R, Lee PH, Shaw ND, Hall JE, Plummer L, Buck CL, Kottler ML, Jarzabek K, Wolczynski S, Quinton R, Latronico AC, Dode C, Ogata T, Kim HG, Layman LC, Gusella JF, Crowley WF. Expanding the Spectrum of Founder Mutations Causing Isolated Gonadotropin-Releasing Hormone Deficiency. J Clin Endocrinol Metab. 2015 Oct; 100(10):E1378-85. PMID: 26207952.
    Citations: 6     Fields:    Translation:Humans
  20. Balasubramanian R, Choi JH, Francescatto L, Willer J, Horton ER, Asimacopoulos EP, Stankovic KM, Plummer L, Buck CL, Quinton R, Nebesio TD, Mericq V, Merino PM, Meyer BF, Monies D, Gusella JF, Al Tassan N, Katsanis N, Crowley WF. Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17953-8. PMID: 25472840.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
    Citations:    Fields:    Translation:Humans
  22. Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF, Wierman ME. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Apr; 99(4):1452-60. PMID: 24476074.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  23. Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF. Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab. 2014 Mar; 99(3):E561-6. PMID: 24423319.
    Citations: 2     Fields:    Translation:Humans
  24. Dwyer AA, Sykiotis GP, Hayes FJ, Boepple PA, Lee H, Loughlin KR, Dym M, Sluss PM, Crowley WF, Pitteloud N. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1790-5. PMID: 24037890.
    Citations: 18     Fields:    Translation:Humans
  25. Gallin EK, Bond E, Califf RM, Crowley WF, Davis P, Galbraith R, Reece EA. Forging stronger partnerships between academic health centers and patient-driven organizations. Acad Med. 2013 Sep; 88(9):1220-4. PMID: 23887007.
    Citations: 8     Fields:    Translation:Humans
  26. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43. PMID: 23643382.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  27. Costa-Barbosa FA, Balasubramanian R, Keefe KW, Shaw ND, Al-Tassan N, Plummer L, Dwyer AA, Buck CL, Choi JH, Seminara SB, Quinton R, Monies D, Meyer B, Hall JE, Pitteloud N, Crowley WF. Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. J Clin Endocrinol Metab. 2013 May; 98(5):E943-53. PMID: 23533228.
    Citations: 40     Fields:    Translation:HumansCells
  28. Chew S, Balasubramanian R, Chan WM, Kang PB, Andrews C, Webb BD, MacKinnon SE, Oystreck DT, Rankin J, Crawford TO, Geraghty M, Pomeroy SL, Crowley WF, Jabs EW, Hunter DG, Grant PE, Engle EC. A novel syndrome caused by the E410K amino acid substitution in the neuronal ß-tubulin isotype 3. Brain. 2013 Feb; 136(Pt 2):522-35. PMID: 23378218.
    Citations: 36     Fields:    Translation:HumansCells
  29. Abel BS, Shaw ND, Brown JM, Adams JM, Alati T, Martin KA, Pitteloud N, Seminara SB, Plummer L, Pignatelli D, Crowley WF, Welt CK, Hall JE. Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Feb; 98(2):E206-16. PMID: 23341491.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  30. Avbelj Stefanija M, Jeanpierre M, Sykiotis GP, Young J, Quinton R, Abreu AP, Plummer L, Au MG, Balasubramanian R, Dwyer AA, Florez JC, Cheetham T, Pearce SH, Purushothaman R, Schinzel A, Pugeat M, Jacobson-Dickman EE, Ten S, Latronico AC, Gusella JF, Dode C, Crowley WF, Pitteloud N. An ancient founder mutation in PROKR2 impairs human reproduction. Hum Mol Genet. 2012 Oct 01; 21(19):4314-24. PMID: 22773735.
    Citations: 10     Fields:    Translation:Humans
  31. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807. PMID: 22745237.
    Citations: 15     Fields:    Translation:Humans
  32. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab. 2012 Jul; 97(7):E1342-7. PMID: 22547425.
    Citations: 47     Fields:    Translation:Humans
  33. Crowley WF. Commentary: the year in endocrine genetics for basic scientists. Mol Endocrinol. 2011 Dec; 25(12):1989-2002. PMID: 22108799.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  34. Lewkowitz-Shpuntoff HM, Hughes VA, Plummer L, Au MG, Doty RL, Seminara SB, Chan YM, Pitteloud N, Crowley WF, Balasubramanian R. Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. J Clin Endocrinol Metab. 2012 Jan; 97(1):E136-44. PMID: 22072740.
    Citations: 25     Fields:    Translation:Humans
  35. Balasubramanian R, Crowley WF. Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):4-12. PMID: 21782888.
    Citations: 23     Fields:    Translation:HumansCells