Harvard Catalyst Profiles

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William Francis Crowley Jr., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U01HD044417 (CROWLEY, WILLIAM FRANCIS) Sep 26, 2002 - Mar 31, 2008
    NIH/NICHD
    NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
    Role: Principal Investigator
  2. M01RR001066 (SLAVIN, PETER L) Dec 1, 1997 - Nov 30, 2007
    NIH/NCRR
    General Clinical Research Center
    Role: Co-Principal Investigator
  3. P50HD028138 (SEMINARA, STEPHANIE BETH) Apr 1, 1997 - Mar 31, 2021
    NIH/NICHD
    Harvard Reproductive Endocrine Sciences Center
    Role: Principal Investigator
  4. U54HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2016
    NIH/NICHD
    Harvard Reproductive Endocrine Sciences Center
    Role: Principal Investigator
  5. P30HD028138 (CROWLEY, WILLIAM F) Apr 1, 1997 - Mar 31, 2000
    NIH/NICHD
    REPRODUCTIVE ENDOCRINE SCIENCES CENTER
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Davis EE, Balasubramanian R, Kupchinsky ZA, Keefe DL, Plummer L, Khan K, Meczekalski B, Heath KE, Lopez-Gonzalez V, Ballesta-Martinez MJ, Margabanthu G, Price S, Greening J, Brauner R, Valenzuela I, Cusco I, Fernandez-Alvarez P, Wierman ME, Li T, Lage K, Barroso PS, Chan YM, Crowley WF, Katsanis N. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Hum Mol Genet. 2020 Aug 11; 29(14):2435-2450. PMID: 32620954.
    Citations:    
  2. Xu W, Plummer L, Quinton R, Swords F, Crowley WF, Seminara SB, Balasubramanian R. Hypogonadotropic hypogonadism due to variants in RAB3GAP2: expanding the phenotypic and genotypic spectrum of Martsolf syndrome. Cold Spring Harb Mol Case Stud. 2020 06; 6(3). PMID: 32376645.
    Citations:    
  3. Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA. Pubertal timing predicts adult psychosexuality: Evidence from typically developing adults and adults with isolated GnRH deficiency. Psychoneuroendocrinology. 2020 Sep; 119:104733. PMID: 32563936.
    Citations:    
  4. Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, Kim S, Inoue K, Arora G, Salnikov KB, DiOrio NP, Prada R, Capri Y, Morioka K, Mizota M, Zechi-Ceide RM, Kokitsu-Nakata NM, Tonello C, Vendramini-Pittoli S, da Silva Dalben G, Balasubramanian R, Dwyer AA, Seminara SB, Crowley WF, Plummer L, Hall JE, Graham JM, Lin AE, Shaw ND. Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. J Clin Endocrinol Metab. 2020 May 01; 105(5). PMID: 32034419.
    Citations:    
  5. Jee YH, Won S, Lui JC, Jennings M, Whalen P, Yue S, Temnycky AG, Barnes KM, Cheetham T, Boden MG, Radovick S, Quinton R, Leschek EW, Aguilera G, Yanovski JA, Seminara SB, Crowley WF, Delaney A, Roche KW, Baron J. DLG2 variants in patients with pubertal disorders. Genet Med. 2020 Aug; 22(8):1329-1337. PMID: 32341572.
    Citations:    
  6. Stamou M, Ng SY, Brand H, Wang H, Plummer L, Best L, Havlicek S, Hibberd M, Khor CC, Gusella J, Balasubramanian R, Talkowski M, Stanton LW, Crowley WF. A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator. J Clin Endocrinol Metab. 2020 Mar 01; 105(3). PMID: 31628846.
    Citations:    
  7. Shirazi TN, Self H, Cantor J, Dawood K, Cárdenas R, Rosenfield K, Ortiz T, Carré J, McDaniel MA, Blanchard R, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts D. Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples. Horm Behav. 2020 May; 121:104712. PMID: 32059854.
    Citations:    
  8. Dwyer AA, Chavan NR, Lewkowitz-Shpuntoff H, Plummer L, Hayes FJ, Seminara SB, Crowley WF, Pitteloud N, Balasubramanian R. Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History. J Clin Endocrinol Metab. 2019 08 01; 104(8):3403-3414. PMID: 31220265.
    Citations:    
  9. Cox KH, Oliveira LMB, Plummer L, Corbin B, Gardella T, Balasubramanian R, Crowley WF. Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet. 2018 01 15; 27(2):338-350. PMID: 29161432.
    Citations:    Fields:    Translation:HumansCells
  10. Balasubramanian R, Crowley WF. Reproductive endocrine phenotypes relating to CHD7 mutations in humans. Am J Med Genet C Semin Med Genet. 2017 12; 175(4):507-515. PMID: 29152903.
    Citations:    Fields:    Translation:HumansAnimals
  11. Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J, Niederländer NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JM, Plummer L, Albrecht U, Crowley WF, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N. KLB, encoding ß-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. EMBO Mol Med. 2017 10; 9(10):1379-1397. PMID: 28754744.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 05 26; 49(6):969. PMID: 28546579.
    Citations:    Fields:    
  13. Crowley WF, Balasubramanian R. MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. J Clin Invest. 2017 Mar 01; 127(3):796-797. PMID: 28218621.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248. PMID: 28067909.
    Citations: 14     Fields:    Translation:Humans
  15. Kimball AB, Javorsky E, Ron ES, Crowley W, Langer R. A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system. J Control Release. 2016 07 10; 233:19-28. PMID: 27130696.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  16. Stamou MI, Cox KH, Crowley WF. Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2016 02; 2016(1):4-22. PMID: 27454361.
    Citations: 4     Fields:    Translation:Humans
  17. Stamou MI, Cox KH, Crowley WF. Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev. 2015 Dec; 36(6):603-21. PMID: 26394276.
    Citations: 6     Fields:    Translation:HumansCells
  18. Choi JH, Balasubramanian R, Lee PH, Shaw ND, Hall JE, Plummer L, Buck CL, Kottler ML, Jarzabek K, Wolczynski S, Quinton R, Latronico AC, Dode C, Ogata T, Kim HG, Layman LC, Gusella JF, Crowley WF. Expanding the Spectrum of Founder Mutations Causing Isolated Gonadotropin-Releasing Hormone Deficiency. J Clin Endocrinol Metab. 2015 Oct; 100(10):E1378-85. PMID: 26207952.
    Citations: 2     Fields:    Translation:Humans
  19. Balasubramanian R, Choi JH, Francescatto L, Willer J, Horton ER, Asimacopoulos EP, Stankovic KM, Plummer L, Buck CL, Quinton R, Nebesio TD, Mericq V, Merino PM, Meyer BF, Monies D, Gusella JF, Al Tassan N, Katsanis N, Crowley WF. Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17953-8. PMID: 25472840.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
    Citations:    Fields:    Translation:Humans
  21. Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF, Wierman ME. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Apr; 99(4):1452-60. PMID: 24476074.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  22. Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF. Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab. 2014 Mar; 99(3):E561-6. PMID: 24423319.
    Citations: 1     Fields:    Translation:Humans
  23. Dwyer AA, Sykiotis GP, Hayes FJ, Boepple PA, Lee H, Loughlin KR, Dym M, Sluss PM, Crowley WF, Pitteloud N. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1790-5. PMID: 24037890.
    Citations: 7     Fields:    Translation:Humans
  24. Gallin EK, Bond E, Califf RM, Crowley WF, Davis P, Galbraith R, Reece EA. Forging stronger partnerships between academic health centers and patient-driven organizations. Acad Med. 2013 Sep; 88(9):1220-4. PMID: 23887007.
    Citations: 4     Fields:    Translation:Humans
  25. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43. PMID: 23643382.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  26. Costa-Barbosa FA, Balasubramanian R, Keefe KW, Shaw ND, Al-Tassan N, Plummer L, Dwyer AA, Buck CL, Choi JH, Seminara SB, Quinton R, Monies D, Meyer B, Hall JE, Pitteloud N, Crowley WF. Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. J Clin Endocrinol Metab. 2013 May; 98(5):E943-53. PMID: 23533228.
    Citations: 22     Fields:    Translation:HumansCells
  27. Chew S, Balasubramanian R, Chan WM, Kang PB, Andrews C, Webb BD, MacKinnon SE, Oystreck DT, Rankin J, Crawford TO, Geraghty M, Pomeroy SL, Crowley WF, Jabs EW, Hunter DG, Grant PE, Engle EC. A novel syndrome caused by the E410K amino acid substitution in the neuronal ß-tubulin isotype 3. Brain. 2013 Feb; 136(Pt 2):522-35. PMID: 23378218.
    Citations: 22     Fields:    Translation:HumansCells
  28. Abel BS, Shaw ND, Brown JM, Adams JM, Alati T, Martin KA, Pitteloud N, Seminara SB, Plummer L, Pignatelli D, Crowley WF, Welt CK, Hall JE. Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Feb; 98(2):E206-16. PMID: 23341491.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  29. Avbelj Stefanija M, Jeanpierre M, Sykiotis GP, Young J, Quinton R, Abreu AP, Plummer L, Au MG, Balasubramanian R, Dwyer AA, Florez JC, Cheetham T, Pearce SH, Purushothaman R, Schinzel A, Pugeat M, Jacobson-Dickman EE, Ten S, Latronico AC, Gusella JF, Dode C, Crowley WF, Pitteloud N. An ancient founder mutation in PROKR2 impairs human reproduction. Hum Mol Genet. 2012 Oct 01; 21(19):4314-24. PMID: 22773735.
    Citations: 6     Fields:    Translation:Humans
  30. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807. PMID: 22745237.
    Citations: 10     Fields:    Translation:Humans
  31. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab. 2012 Jul; 97(7):E1342-7. PMID: 22547425.
    Citations: 34     Fields:    Translation:Humans
  32. Crowley WF. Commentary: the year in endocrine genetics for basic scientists. Mol Endocrinol. 2011 Dec; 25(12):1989-2002. PMID: 22108799.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  33. Lewkowitz-Shpuntoff HM, Hughes VA, Plummer L, Au MG, Doty RL, Seminara SB, Chan YM, Pitteloud N, Crowley WF, Balasubramanian R. Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. J Clin Endocrinol Metab. 2012 Jan; 97(1):E136-44. PMID: 22072740.
    Citations: 16     Fields:    Translation:Humans
  34. Balasubramanian R, Crowley WF. Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):4-12. PMID: 21782888.
    Citations: 17     Fields:    Translation:HumansCells
  35. Crowley WF. The developmental biology of the GnRH neurons. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):1-3. PMID: 21741438.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, Bülow HE. Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11524-9. PMID: 21700882.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  37. Au MG, Crowley WF, Buck CL. Genetic counseling for isolated GnRH deficiency. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):102-9. PMID: 21664415.
    Citations: 7     Fields:    Translation:HumansAnimals
  38. Balasubramanian R, Plummer L, Sidis Y, Pitteloud N, Martin C, Zhou QY, Crowley WF. The puzzles of the prokineticin 2 pathway in human reproduction. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):44-50. PMID: 21664414.
    Citations: 4     Fields:    Translation:HumansAnimals
  39. Chan YM, Butler JP, Pinnell NE, Pralong FP, Crowley WF, Ren C, Chan KK, Seminara SB. Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab. 2011 Jun; 96(6):E908-15. PMID: 21470997.
    Citations: 28     Fields:    Translation:Humans
  40. Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF, Martin KA, Hall JE, Pitteloud N. A genetic basis for functional hypothalamic amenorrhea. N Engl J Med. 2011 Jan 20; 364(3):215-25. PMID: 21247312.
    Citations: 34     Fields:    Translation:Humans
  41. Shaw ND, Seminara SB, Welt CK, Au MG, Plummer L, Hughes VA, Dwyer AA, Martin KA, Quinton R, Mericq V, Merino PM, Gusella JF, Crowley WF, Pitteloud N, Hall JE. Expanding the phenotype and genotype of female GnRH deficiency. J Clin Endocrinol Metab. 2011 Mar; 96(3):E566-76. PMID: 21209029.
    Citations: 27     Fields:    Translation:Humans
  42. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46. PMID: 21037178.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  43. Sykiotis GP, Plummer L, Hughes VA, Au M, Durrani S, Nayak-Young S, Dwyer AA, Quinton R, Hall JE, Gusella JF, Seminara SB, Crowley WF, Pitteloud N. Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15140-4. PMID: 20696889.
    Citations: 86     Fields:    Translation:Humans
  44. Balasubramanian R, Dwyer A, Seminara SB, Pitteloud N, Kaiser UB, Crowley WF. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology. 2010; 92(2):81-99. PMID: 20606386.
    Citations: 23     Fields:    Translation:HumansAnimals
  45. Dwyer AA, Hayes FJ, Plummer L, Pitteloud N, Crowley WF. The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2010 Sep; 95(9):4235-43. PMID: 20591981.
    Citations: 6     Fields:    Translation:Humans
  46. Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF. Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med. 2010 May 19; 2(32):32rv2. PMID: 20484732.
    Citations: 16     Fields:    Translation:HumansAnimals
  47. Kuohung W, Burnett M, Mukhtyar D, Schuman E, Ni J, Crowley WF, Glicksman MA, Kaiser UB. A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. J Biomol Screen. 2010 Jun; 15(5):508-17. PMID: 20460252.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  48. Sykiotis GP, Hoang XH, Avbelj M, Hayes FJ, Thambundit A, Dwyer A, Au M, Plummer L, Crowley WF, Pitteloud N. Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. J Clin Endocrinol Metab. 2010 Jun; 95(6):3019-27. PMID: 20382682.
    Citations: 20     Fields:    Translation:Humans
  49. Ravikumar B, Crowley WF. Kallmann Syndrome and hypogonadotropic Hypogonadism.Concluding remarks. Front Horm Res. 2010; 39:168-169. PMID: 20389094.
    Citations:    Fields:    Translation:Humans
  50. Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010 Jun; 95(6):2857-67. PMID: 20332248.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  51. Pitteloud N, Thambundit A, Dwyer AA, Falardeau JL, Plummer L, Caronia LM, Hayes FJ, Lee H, Boepple PA, Crowley WF. Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation. Neuroendocrinology. 2009; 90(3):260-8. PMID: 19829004.
    Citations: 3     Fields:    Translation:Humans
  52. Crowley WF, Gusella JF. Changing models of biomedical research. Sci Transl Med. 2009 Oct 07; 1(1):1cm1. PMID: 20368150.
    Citations: 2     Fields:    Translation:Humans
  53. Chan YM, de Guillebon A, Lang-Muritano M, Plummer L, Cerrato F, Tsiaras S, Gaspert A, Lavoie HB, Wu CH, Crowley WF, Amory JK, Pitteloud N, Seminara SB. GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11703-8. PMID: 19567835.
    Citations: 51     Fields:    Translation:HumansCells
  54. Andrews N, Burris JE, Cech TR, Coller BS, Crowley WF, Gallin EK, Kelner KL, Kirch DG, Leshner AI, Morris CD, Nguyen FT, Oates J, Sung NS. Translational careers. Science. 2009 May 15; 324(5929):855. PMID: 19443750.
    Citations: 4     Fields:    Translation:Humans
  55. Broder-Fingert S, Crowley WF, Boepple PA. Safety of frequent venous blood sampling in a pediatric research population. J Pediatr. 2009 Apr; 154(4):578-81. PMID: 19026428.
    Citations: 5     Fields:    Translation:Humans
  56. Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, Ogata T, Sato N, Claahsen-van der Grinten HL, van der Donk K, Seminara S, Bergman JE, Brunner HG, Crowley WF, Hoefsloot LH. CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome. Clin Genet. 2009 Jan; 75(1):65-71. PMID: 19021638.
    Citations: 55     Fields:    Translation:Humans
  57. Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF, Zhou QY, Pitteloud N. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab. 2008 Sep; 93(9):3551-9. PMID: 18559922.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  58. Seminara SB, Crowley WF. Kisspeptin and GPR54: discovery of a novel pathway in reproduction. J Neuroendocrinol. 2008 Jun; 20(6):727-31. PMID: 18601695.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  59. DiLaura R, Turisco F, McGrew C, Reel S, Glaser J, Crowley WF. Use of informatics and information technologies in the clinical research enterprise within US academic medical centers: progress and challenges from 2005 to 2007. J Investig Med. 2008 Jun; 56(5):770-9. PMID: 18525452.
    Citations: 8     Fields:    
  60. Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF, Hayes FJ. The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men. J Clin Endocrinol Metab. 2008 Jul; 93(7):2686-92. PMID: 18445673.
    Citations: 15     Fields:    Translation:Humans
  61. Boepple PA, Hayes FJ, Dwyer AA, Raivio T, Lee H, Crowley WF, Pitteloud N. Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab. 2008 May; 93(5):1809-14. PMID: 18270253.
    Citations: 5     Fields:    Translation:Humans
  62. Crowley WF, Pitteloud N, Seminara S. New genes controlling human reproduction and how you find them. Trans Am Clin Climatol Assoc. 2008; 119:29-37; discussion 37-8. PMID: 18596868.
    Citations: 9     Fields:    Translation:HumansAnimals
  63. Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab. 2008 Mar; 93(3):784-91. PMID: 18073301.
    Citations: 23     Fields:    Translation:Humans
  64. Sluss PM, Hayes FJ, Adams JM, Barnes W, Williams G, Frost S, Ramp J, Pacenti D, Lehotay DC, George S, Ramsay C, Doss RC, Crowley WF. Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect. Clin Chim Acta. 2008 Feb; 388(1-2):99-105. PMID: 18023274.
    Citations: 13     Fields:    Translation:Humans
  65. Hughes VA, Boepple PA, Crowley WF, Seminara SB. Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness. Neuroendocrinology. 2008; 87(3):142-50. PMID: 18063854.
    Citations: 4     Fields:    Translation:Humans
  66. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. PMID: 17959774.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  67. Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF, Pitteloud N. Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med. 2007 Aug 30; 357(9):863-73. PMID: 17761590.
    Citations: 86     Fields:    Translation:Humans
  68. Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF, Plant TM. Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology. 2007 Jul; 148(7):3364-70. PMID: 17412800.
    Citations: 41     Fields:    Translation:HumansAnimals
  69. Crowley WF. Drug development and clinical research in the UK. Lancet. 2007 Jan 20; 369(9557):174-5. PMID: 17240271.
    Citations:    Fields:    Translation:Humans
  70. Pitteloud N, Quinton