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Thomas James Gardella, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK102495 (VILARDAGA, JEAN-PIERRE) Jul 1, 2014 - May 31, 2018
    NIH/NIDDK
    Structural and Functional Mechanisms of PTH-Receptor Signaling
    Role: Co-Principal Investigator
  2. F32DK008316 (GARDELLA, THOMAS J) Sep 1, 1989
    NIH/NIDDK
    MUTANT ANALYSIS OF HUMAN PARATHYROID HORMONE
    Role: Principal Investigator
  3. P01DK011794 (POTTS, JOHN T) Jan 1, 1979 - Nov 30, 2018
    NIH/NIDDK
    Hormonal Control of Calcium Metabolism
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu S, Cheloha RW, Watanabe T, Gardella TJ, Gellman SH. Receptor selectivity from minimal backbone modification of a polypeptide agonist. Proc Natl Acad Sci U S A. 2018 Nov 15. PMID: 30442659.
    View in: PubMed
  2. Ricarte FR, Le Henaff C, Kolupaeva VG, Gardella TJ, Partridge NC. Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling. J Biol Chem. 2018 Oct 30. PMID: 30377251.
    View in: PubMed
  3. Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, Gregory JW, Allgrove J, Krude H, Mannstadt M, Gardella TJ, Dattani M, Jüppner H, Grüters A. A new multi-system disorder caused by the Gas mutation p.F376V. J Clin Endocrinol Metab. 2018 Oct 11. PMID: 30312418.
    View in: PubMed
  4. Dedic C, Hung TS, Shipley AM, Maeda A, Gardella T, Miller AL, Divieti Pajevic P, Kunkel JG, Rubinacci A. Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes. Bone. 2018 Nov; 116:135-143. PMID: 30053608.
    View in: PubMed
  5. Saito H, Noda H, Gatault P, Bockenhauer D, Loke KY, Hiort O, Silve C, Sharwood E, Martin RM, Dillon MJ, Gillis D, Harris M, Rao SD, Pauli RM, Gardella TJ, Jüppner H. Progression of Mineral Ion Abnormalities in Patients With Jansen Metaphyseal Chondrodysplasia. J Clin Endocrinol Metab. 2018 Jul 01; 103(7):2660-2669. PMID: 29788189.
    View in: PubMed
  6. Cox KH, Oliveira LMB, Plummer L, Corbin B, Gardella T, Balasubramanian R, Crowley WF. Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet. 2018 01 15; 27(2):338-350. PMID: 29161432.
    View in: PubMed
  7. Cheloha RW, Chen B, Kumar NN, Watanabe T, Thorne RG, Li L, Gardella TJ, Gellman SH. Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad ß Residue Distribution. J Med Chem. 2017 Nov 09; 60(21):8816-8833. PMID: 29064243.
    View in: PubMed
  8. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2017 02 22; 8:14745. PMID: 28224982.
    View in: PubMed
  9. Gardella TJ. G-Protein-coupled receptors: Decoding mixed signals. Nat Chem Biol. 2017 02 15; 13(3):247-248. PMID: 28199296.
    View in: PubMed
  10. Roszko KL, Bi R, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M. Knockin mouse with mutant Ga11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI Insight. 2017 Feb 09; 2(3):e91079. PMID: 28194446.
    View in: PubMed
  11. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016 10 19; 7:13176. PMID: 27759007.
    View in: PubMed
  12. Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ. Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res. 2017 01; 32(1):86-98. PMID: 27428040.
    View in: PubMed
  13. Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ. Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS Chem Biol. 2016 10 21; 11(10):2752-2762. PMID: 27533344.
    View in: PubMed
  14. Xiong XF, Zhang H, Underwood CR, Harpsøe K, Gardella TJ, Wöldike MF, Mannstadt M, Gloriam DE, Bräuner-Osborne H, Strømgaard K. Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors. Nat Chem. 2016 11; 8(11):1035-1041. PMID: 27768111.
    View in: PubMed
  15. Nampoothiri S, Fernández-Rebollo E, Yesodharan D, Gardella TJ, Rush ET, Langman CB, Jüppner H. Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia. J Clin Endocrinol Metab. 2016 11; 101(11):4283-4289. PMID: 27410178.
    View in: PubMed
  16. Shimizu M, Joyashiki E, Noda H, Watanabe T, Okazaki M, Nagayasu M, Adachi K, Tamura T, Potts JT, Gardella TJ, Kawabe Y. Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys. J Bone Miner Res. 2016 07; 31(7):1405-12. PMID: 26865415.
    View in: PubMed
  17. Bi R, Fan Y, Lauter K, Hu J, Watanabe T, Cradock J, Yuan Q, Gardella T, Mannstadt M. Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment With a Long-Acting Parathyroid Hormone Analog. J Bone Miner Res. 2016 05; 31(5):975-84. PMID: 26678919.
    View in: PubMed
  18. Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ. Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling. Endocrinology. 2016 Jan; 157(1):141-9. PMID: 26562265; PMCID: PMC4701881 [Available on 01/01/17].
  19. Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ. PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol. 2015 Dec; 11(12):712-24. PMID: 26303600; PMCID: PMC4651712.
  20. Lee S, Mannstadt M, Guo J, Kim SM, Yi HS, Khatri A, Dean T, Okazaki M, Gardella TJ, Jüppner H. A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism. J Bone Miner Res. 2015 Oct; 30(10):1803-13. PMID: 25891861; PMCID: PMC4580526 [Available on 10/01/16].
  21. Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb; 29(2):307-21. PMID: 25584411; PMCID: PMC4318877.
  22. Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):310-37. PMID: 25713287; PMCID: PMC4394688.
  23. Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol. 2014 Sep; 10(9):700-6. PMID: 25271346; PMCID: PMC4417940.
  24. Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol. 2014 Aug 18; 10(9):700-6. PMID: 25133339.
    View in: PubMed
  25. Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep; 10(9):707-9. PMID: 25064832; PMCID: PMC4138287.
  26. Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH. Backbone modification of a polypeptide drug alters duration of action in vivo. Nat Biotechnol. 2014 Jul; 32(7):653-5. PMID: 24929976; PMCID: PMC4205942.
  27. Maeda A, Okazaki M, Baron DM, Dean T, Khatri A, Mahon M, Segawa H, Abou-Samra AB, Jüppner H, Bloch KD, Potts JT, Gardella TJ. Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):5864-9. PMID: 23533279; PMCID: PMC3625299.
  28. Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D. Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F553-64. PMID: 23235478; PMCID: PMC3602717.
  29. Li J, Dong S, Townsend SD, Dean T, Gardella TJ, Danishefsky SJ. Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141). Angew Chem Int Ed Engl. 2012 Dec 03; 51(49):12263-7. PMID: 23124999; PMCID: PMC3739057.
  30. Dong S, Shang S, Li J, Tan Z, Dean T, Maeda A, Gardella TJ, Danishefsky SJ. Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues. J Am Chem Soc. 2012 Sep 12; 134(36):15122-9. PMID: 22891619; PMCID: PMC3462362.
  31. Vilardaga JP, Gardella TJ, Wehbi VL, Feinstein TN. Non-canonical signaling of the PTH receptor. Trends Pharmacol Sci. 2012 Aug; 33(8):423-31. PMID: 22709554; PMCID: PMC3428041.
  32. Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SW. G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Ann N Y Acad Sci. 2011 May; 1226:34-49. PMID: 21615752.
    View in: PubMed
  33. Feinstein TN, Wehbi VL, Ardura JA, Wheeler DS, Ferrandon S, Gardella TJ, Vilardaga JP. Retromer terminates the generation of cAMP by internalized PTH receptors. Nat Chem Biol. 2011 May; 7(5):278-84. PMID: 21445058; PMCID: PMC3079799.
  34. Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT, Mahon MJ, Gardella TJ, Jüppner H. Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs. J Biol Chem. 2011 Jan 14; 286(2):1618-26. PMID: 21047792; PMCID: PMC3020770.
  35. Vilardaga JP, Romero G, Friedman PA, Gardella TJ. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cell Mol Life Sci. 2011 Jan; 68(1):1-13. PMID: 20703892; PMCID: PMC3568769.
  36. Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol. 2009 Oct; 5(10):734-42. PMID: 19701185; PMCID: PMC3032084.
  37. Pioszak AA, Parker NR, Gardella TJ, Xu HE. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem. 2009 Oct 09; 284(41):28382-91. PMID: 19674967; PMCID: PMC2788887.
  38. Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT, Gardella TJ. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16525-30. PMID: 18946036; PMCID: PMC2571912.
  39. Potts JT, Gardella TJ. Progress, paradox, and potential: parathyroid hormone research over five decades. Ann N Y Acad Sci. 2007 Nov; 1117:196-208. PMID: 18056044.
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  40. Dean T, Vilardaga JP, Potts JT, Gardella TJ. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Mol Endocrinol. 2008 Jan; 22(1):156-66. PMID: 17872377; PMCID: PMC2194631.
  41. Potetinova Z, Barbier JR, Suen T, Dean T, Gardella TJ, Willick GE. C-terminal analogues of parathyroid hormone: effect of C-terminus function on helical structure, stability, and bioactivity. Biochemistry. 2006 Sep 19; 45(37):11113-21. PMID: 16964972.
    View in: PubMed
  42. Dean T, Khatri A, Potetinova Z, Willick GE, Gardella TJ. Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor. J Biol Chem. 2006 Oct 27; 281(43):32485-95. PMID: 16923805.
    View in: PubMed
  43. Dean T, Linglart A, Mahon MJ, Bastepe M, Jüppner H, Potts JT, Gardella TJ. Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations. Mol Endocrinol. 2006 Apr; 20(4):931-43. PMID: 16339275; PMCID: PMC3242416.
  44. Barbier JR, Gardella TJ, Dean T, MacLean S, Potetinova Z, Whitfield JF, Willick GE. Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone. Evidence for binding to both the N-terminal extracellular domain and extracellular loop region. J Biol Chem. 2005 Jun 24; 280(25):23771-7. PMID: 15826940.
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  45. Gensure RC, Gardella TJ, Jüppner H. Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun. 2005 Mar 18; 328(3):666-78. PMID: 15694400.
    View in: PubMed
  46. Shimizu N, Dean T, Tsang JC, Khatri A, Potts JT, Gardella TJ. Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor. J Biol Chem. 2005 Jan 21; 280(3):1797-807. PMID: 15550385.
    View in: PubMed
  47. Shimizu N, Dean T, Khatri A, Gardella TJ. Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3. J Bone Miner Res. 2004 Dec; 19(12):2078-86. PMID: 15537452.
    View in: PubMed
  48. Tsomaia N, Shimizu M, Shimizu N, Gardella TJ, Mierke DF. Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone. Biochemistry. 2004 Mar 30; 43(12):3459-70. PMID: 15035617.
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  49. Tsomaia N, Pellegrini M, Hyde K, Gardella TJ, Mierke DF. Toward parathyroid hormone minimization: conformational studies of cyclic PTH(1-14) analogues. Biochemistry. 2004 Jan 27; 43(3):690-9. PMID: 14730973.
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  50. Gensure RC, Shimizu N, Tsang J, Gardella TJ. Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol. 2003 Dec; 17(12):2647-58. PMID: 12947048.
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  51. Shimizu N, Petroni BD, Khatri A, Gardella TJ. Functional evidence for an intramolecular side chain interaction between residues 6 and 10 of receptor-bound parathyroid hormone analogues. Biochemistry. 2003 Mar 04; 42(8):2282-90. PMID: 12600195.
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  52. Shimizu M, Shimizu N, Tsang JC, Petroni BD, Khatri A, Potts JT, Gardella TJ. Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor. Biochemistry. 2002 Nov 05; 41(44):13224-33. PMID: 12403624.
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  53. Piserchio A, Shimizu N, Gardella TJ, Mierke DF. Residue 19 of the parathyroid hormone: structural consequences. Biochemistry. 2002 Nov 05; 41(44):13217-23. PMID: 12403623.
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  54. Shimizu N, Guo J, Gardella TJ. Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor. J Biol Chem. 2001 Dec 28; 276(52):49003-12. PMID: 11604398.
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  55. Gensure RC, Carter PH, Petroni BD, Jüppner H, Gardella TJ. Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis. J Biol Chem. 2001 Nov 16; 276(46):42692-9. PMID: 11553625.
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  56. Shimizu M, Carter PH, Khatri A, Potts JT, Gardella TJ. Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing ligand-receptor interactions. Endocrinology. 2001 Jul; 142(7):3068-74. PMID: 11416029.
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  57. Gardella TJ, Jüppner H. Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab. 2001 Jul; 12(5):210-7. PMID: 11397646.
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  58. Gensure RC, Gardella TJ, Jüppner H. Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking. J Biol Chem. 2001 Aug 03; 276(31):28650-8. PMID: 11356832.
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  59. Carter PH, Gardella TJ. Zinc(II)-mediated enhancement of the agonist activity of histidine-substituted parathyroid hormone(1-14) analogues. Biochim Biophys Acta. 2001 Apr 23; 1538(2-3):290-304. PMID: 11336800.
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  60. Carter PH, Petroni BD, Gensure RC, Schipani E, Potts JT, Gardella TJ. Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations. Endocrinology. 2001 Apr; 142(4):1534-45. PMID: 11250934.
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  61. Jonsson KB, John MR, Gensure RC, Gardella TJ, Jüppner H. Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist. Endocrinology. 2001 Feb; 142(2):704-9. PMID: 11159842.
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  62. Jonsson KB, John MR, Gensure RC, Gardella TJ, Ju Ppner H. Tuberoinfundibular Peptide 39 Binds to the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor, but Functions as an Antagonist**This work was supported by grants from the NIH, NIDDK (DK-11794), the Swedish Foundation for International Cooperation in Research and Higher Education (to K.B.J.), and the Deutsche Forschungsgemeinschaft (JO 315/1-2; to M.R.J.). Endocrinology. 2001 Feb 01; 142(2):704-709. PMID: 28201316.
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  63. Hoare SR, Gardella TJ, Usdin TB. Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformation. J Biol Chem. 2001 Mar 16; 276(11):7741-53. PMID: 11108715.
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  64. Gardella TJ, Jüppner H. Interaction of PTH and PTHrP with their receptors. Rev Endocr Metab Disord. 2000 Nov; 1(4):317-29. PMID: 11706746.
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  65. Shimizu M, Potts JT, Gardella TJ. Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor. J Biol Chem. 2000 Jul 21; 275(29):21836-43. PMID: 10777513.
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  66. Shimizu M, Carter PH, Gardella TJ. Autoactivation of type-1 parathyroid hormone receptors containing a tethered ligand. J Biol Chem. 2000 Jun 30; 275(26):19456-60. PMID: 10751403.
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  67. Carter PH, Shimizu M, Luck MD, Gardella TJ. The hydrophobic residues phenylalanine 184 and leucine 187 in the type-1 parathyroid hormone (PTH) receptor functionally interact with the amino-terminal portion of PTH-(1-34). J Biol Chem. 1999 Nov 05; 274(45):31955-60. PMID: 10542224.
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  68. Carter PH, Jüppner H, Gardella TJ. Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents. Endocrinology. 1999 Nov; 140(11):4972-81. PMID: 10537121.
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  69. Mannstadt M, Jüppner H, Gardella TJ. Receptors for PTH and PTHrP: their biological importance and functional properties. Am J Physiol. 1999 11; 277(5):F665-75. PMID: 10564229.
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  70. Carter PH, Ju Ppner H, Gardella TJ. Studies of the N-Terminal Region of a Parathyroid Hormone-Related Peptide(1-36) Analog: Receptor Subtype-Selective Agonists, Antagonists, and Photochemical Cross-Linking Agents1. Endocrinology. 1999 Nov 01; 140(11):4972-4981. PMID: 28200661.
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  71. Takasu H, Gardella TJ, Luck MD, Potts JT, Bringhurst FR. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands. Biochemistry. 1999 Oct 12; 38(41):13453-60. PMID: 10521252.
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  72. Luck MD, Carter PH, Gardella TJ. The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors. Mol Endocrinol. 1999 May; 13(5):670-80. PMID: 10319318.
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  73. Mannstadt M, Luck MD, Gardella TJ, Jüppner H. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. J Biol Chem. 1998 Jul 03; 273(27):16890-6. PMID: 9642250.
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  74. Bergwitz C, Jusseaume SA, Luck MD, Jüppner H, Gardella TJ. Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide. J Biol Chem. 1997 Nov 14; 272(46):28861-8. PMID: 9360953.
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  75. Potts JT, Gardella TJ, Jüppner H, Kronenberg HM. Structure based design of parathyroid hormone analogs. J Endocrinol. 1997 Sep; 154 Suppl:S15-21. PMID: 9379133.
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  76. Schipani E, Jensen GS, Pincus J, Nissenson RA, Gardella TJ, Jüppner H. Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. Mol Endocrinol. 1997 Jun; 11(7):851-8. PMID: 9178745.
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  77. Potts JT, Gardella TJ, Jüppner H, Kronenberg H. The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues. Osteoporos Int. 1997; 7 Suppl 3:S169-73. PMID: 9536326.
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  78. Bergwitz C, Gardella TJ, Flannery MR, Potts JT, Kronenberg HM, Goldring SR, Jüppner H. Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction. J Biol Chem. 1996 Oct 25; 271(43):26469-72. PMID: 8900113.
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  79. Gardella TJ, Luck MD, Jensen GS, Schipani E, Potts JT, Jüppner H. Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors. Endocrinology. 1996 Sep; 137(9):3936-41. PMID: 8756569.
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  80. Gardella TJ, Luck MD, Jensen GS, Usdin TB, Jüppner H. Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist. J Biol Chem. 1996 Aug 16; 271(33):19888-93. PMID: 8702701.
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  81. Gardella TJ, Luck MD, Fan MH, Lee C. Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. J Biol Chem. 1996 May 31; 271(22):12820-5. PMID: 8662729.
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  82. Lee C, Luck MD, Jüppner H, Potts JT, Kronenberg HM, Gardella TJ. Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop. Mol Endocrinol. 1995 Oct; 9(10):1269-78. PMID: 8544835.
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  83. Gardella TJ, Luck MD, Wilson AK, Keutmann HT, Nussbaum SR, Potts JT, Kronenberg HM. Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand. J Biol Chem. 1995 Mar 24; 270(12):6584-8. PMID: 7896796.
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  84. Lee C, Gardella TJ, Abou-Samra AB, Nussbaum SR, Segre GV, Potts JT, Kronenberg HM, Jüppner H. Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding. Endocrinology. 1994 Oct; 135(4):1488-95. PMID: 7523099.
    View in: PubMed
  85. Gardella TJ, Jüppner H, Wilson AK, Keutmann HT, Abou-Samra AB, Segre GV, Bringhurst FR, Potts JT, Nussbaum SR, Kronenberg HM. Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor. Endocrinology. 1994 Sep; 135(3):1186-94. PMID: 8070362.
    View in: PubMed
  86. Jüppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT, Kronenberg HM, Abou-Samra AB, Segre GV, Gardella TJ. The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34). Endocrinology. 1994 Feb; 134(2):879-84. PMID: 8299582.
    View in: PubMed
  87. Gardella TJ, Wilson AK, Keutmann HT, Oberstein R, Potts JT, Kronenberg M, Nussbaum SR. Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design. Endocrinology. 1993 May; 132(5):2024-30. PMID: 8386605.
    View in: PubMed
  88. Lim SK, Gardella TJ, Baba H, Nussbaum SR, Kronenberg HM. The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion. Endocrinology. 1992 Nov; 131(5):2325-30. PMID: 1425431.
    View in: PubMed
  89. Gardella TJ, Axelrod D, Rubin D, Keutmann HT, Potts JT, Kronenberg HM, Nussbaum SR. Mutational analysis of the receptor-activating region of human parathyroid hormone. J Biol Chem. 1991 Jul 15; 266(20):13141-6. PMID: 1649179.
    View in: PubMed
  90. Lim SK, Gardella T, Thompson A, Rosenberg J, Keutmann H, Potts J, Kronenberg H, Nussbaum S. Full-length chicken parathyroid hormone. Biosynthesis in Escherichia coli and analysis of biologic activity. J Biol Chem. 1991 Feb 25; 266(6):3709-14. PMID: 1847386.
    View in: PubMed
  91. Arnold A, Horst SA, Gardella TJ, Baba H, Levine MA, Kronenberg HM. Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. J Clin Invest. 1990 Oct; 86(4):1084-7. PMID: 2212001; PMCID: PMC296835.
  92. Waldburger C, Gardella T, Wong R, Susskind MM. Changes in conserved region 2 of Escherichia coli sigma 70 affecting promoter recognition. J Mol Biol. 1990 Sep 20; 215(2):267-76. PMID: 2213883.
    View in: PubMed
  93. Gardella TJ, Rubin D, Abou-Samra AB, Keutmann HT, Potts JT, Kronenberg HM, Nussbaum SR. Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein. J Biol Chem. 1990 Sep 15; 265(26):15854-9. PMID: 2168424.
    View in: PubMed
  94. Gardella T, Moyle H, Susskind MM. A mutant Escherichia coli sigma 70 subunit of RNA polymerase with altered promoter specificity. J Mol Biol. 1989 Apr 20; 206(4):579-90. PMID: 2661827.
    View in: PubMed
  95. Graña D, Gardella T, Susskind MM. The effects of mutations in the ant promoter of phage P22 depend on context. Genetics. 1988 Oct; 120(2):319-27. PMID: 3143618; PMCID: PMC1203512.
  96. Gardella T, Medveczky P, Sairenji T, Mulder C. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J Virol. 1984 Apr; 50(1):248-54. PMID: 6321792; PMCID: PMC255605.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.