Harvard Catalyst Profiles

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Bruce R. Ksander, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R24EY028767 (FRANK, NATASHA Y) Apr 1, 2018 - Jan 31, 2023
    Multipotent ABCB5-positive cell therapeutics for corneal disease
    Role: Co-Principal Investigator
  2. R01EY025794 (FRANK, MARKUS H.) Apr 1, 2016 - Mar 31, 2021
    ABCB5-positive stem cells for LSCD therapy
    Role: Co-Principal Investigator
  3. R21EY020987 (BUYS, EMMANUEL S) Jan 1, 2011 - Dec 31, 2012
    sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
    Role: Co-Principal Investigator
  4. R01EY016486 (KSANDER, BRUCE R) May 1, 2005 - Apr 30, 2009
    Role: Principal Investigator
  5. R01EY009294 (KSANDER, BRUCE R) May 1, 1993 - Dec 31, 2002
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sasamoto Y, Lee CAA, Wilson BJ, Buerger F, Martin G, Mishra A, Kiritoshi S, Tran J, Gonzalez G, Hildebrandt F, Jo VY, Lian CG, Murphy GF, Ksander BR, Frank MH, Frank NY. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 08 09; 40(6):111166. PMID: 35947947; PMCID: PMC9480518.
    Citations:    Fields:    Translation:Cells
  2. Karg MM, John L, Refaian N, Buettner C, Rottmar T, Sommer J, Bock B, Resheq YJ, Ksander BR, Heindl LM, Mackensen A, Bosch JJ. Midkine Promotes Metastasis and Therapeutic Resistance via mTOR/RPS6 in Uveal Melanoma. Mol Cancer Res. 2022 08 05; 20(8):1320-1336. PMID: 35503453.
    Citations:    Fields:    
  3. Sasamoto Y, Lee CAA, Yoshihara M, Martin G, Ksander BR, Frank MH, Frank NY. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. PMID: 34653711; PMCID: PMC8511872.
    Citations: 2     Fields:    Translation:HumansCells
  4. Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566.
    Citations: 1     
  5. Norrick A, Esterlechner J, Niebergall-Roth E, Dehio U, Sadeghi S, Schröder HM, Ballikaya S, Stemler N, Ganss C, Dieter K, Dachtler AK, Merz P, Sel S, Chodosh J, Cursiefen C, Frank NY, Auffarth GU, Ksander B, Frank MH, Kluth MA. Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency. Stem Cell Res Ther. 2021 03 19; 12(1):194. PMID: 33741066; PMCID: PMC7980611.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865; PMCID: PMC7752134.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  7. Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. PMID: 31655212.
    Citations: 3     Fields:    Translation:HumansCells
  8. Okunuki Y, Mukai R, Nakao T, Tabor SJ, Butovsky O, Dana R, Ksander BR, Connor KM. Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9989-9998. PMID: 31023885.
    Citations: 37     Fields:    Translation:AnimalsCells
  9. Gregory-Ksander M, Perez VL, Marshak-Rothstein A, Ksander BR. Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis. Exp Eye Res. 2019 02; 179:47-54. PMID: 30365944.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Okunuki Y, Mukai R, Pearsall EA, Klokman G, Husain D, Park DH, Korobkina E, Weiner HL, Butovsky O, Ksander BR, Miller JW, Connor KM. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6264-E6273. PMID: 29915052; PMCID: PMC6142210.
    Citations: 41     Fields:    Translation:AnimalsCells
  11. Sasamoto Y, Ksander BR, Frank MH, Frank NY. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. PMID: 29471701; PMCID: PMC6317528.
    Citations: 16     Fields:    Translation:HumansCells
  12. Cao J, Brouwer NJ, Jordanova ES, Marinkovic M, van Duinen SG, de Waard NE, Ksander BR, Mulder A, Claas FHJ, Heemskerk MHM, Jager MJ. HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status. Invest Ophthalmol Vis Sci. 2018 02 01; 59(2):1005-1015. PMID: 29450544.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Smith JR, Pe'er J, Belfort RN, Cardoso F, Carvajal RD, Carvalho C, Coupland SE, Desjardins L, Francis JH, Gallie BL, Gombos DS, Grossniklaus HE, Heegaard S, Jager MJ, Kaliki S, Ksander BR, Maeurer M, Moreno E, Pulido JS, Ryll B, Singh AD, Zhao J, Parreira A, Wilson DJ, O'Brien JM. Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference. Transl Vis Sci Technol. 2019 Jan; 8(1):9. PMID: 30652059; PMCID: PMC6333107.
    Citations: 4     Fields:    
  14. Gonzalez G, Sasamoto Y, Ksander BR, Frank MH, Frank NY. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2018 03; 7(2). PMID: 29105366.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  15. Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M. Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma. J Immunol. 2016 12 15; 197(12):4626-4638. PMID: 27849168; PMCID: PMC5136323.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  16. Jager MJ, Magner JA, Ksander BR, Dubovy SR. Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2016 Aug; 114:T5. PMID: 28018010.
    Citations: 32     Fields:    Translation:HumansCells
  17. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  18. Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG. Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015 Nov 19; 6:e1986. PMID: 26583327.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  19. Schlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM. A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5965-73. PMID: 26377082.
    Citations: 7     Fields:    Translation:AnimalsCells
  20. de Waard NE, Cao J, McGuire SP, Kolovou PE, Jordanova ES, Ksander BR, Jager MJ. A Murine Model for Metastatic Conjunctival Melanoma. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2325-33. PMID: 25722211.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  21. de Waard NE, Kolovou PE, McGuire SP, Cao J, Frank NY, Frank MH, Jager MJ, Ksander BR. Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma. Ocul Oncol Pathol. 2015 Apr; 1(3):182-189. PMID: 25960995; PMCID: PMC4423550.
    Citations: 5     
  22. Duminuco R, Noble JW, Goody J, Sharma M, Ksander BR, Roskelley CD, Cox ME, Mills J. Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines. Cell Cycle. 2015; 14(18):2924-37. PMID: 26176204; PMCID: PMC4825635.
    Citations: 6     Fields:    Translation:HumansCells
  23. van der Ent W, Burrello C, Teunisse AF, Ksander BR, van der Velden PA, Jager MJ, Jochemsen AG, Snaar-Jagalska BE. Modeling of human uveal melanoma in zebrafish xenograft embryos. Invest Ophthalmol Vis Sci. 2014 Sep 23; 55(10):6612-22. PMID: 25249605.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  24. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17; 511(7509):353-7. PMID: 25030174.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  25. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. PMID: 24882515; PMCID: PMC4074519.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  26. Buys ES, Potter LR, Pasquale LR, Ksander BR. Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma. Front Mol Neurosci. 2014; 7:38. PMID: 24904270.
    Citations: 26     
  27. Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas TD, Marmalidou A, Ksander BR, Miller JW, Gragoudas E, Vavvas DG. Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Apr 29; 55(7):4175-85. PMID: 24781943; PMCID: PMC4089421.
    Citations: 3     Fields:    Translation:HumansCells
  28. Sugi N, Whiston EA, Ksander BR, Gregory MS. Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance. Infect Immun. 2013 Jun; 81(6):2217-25. PMID: 23569113.
    Citations: 12     Fields:    Translation:AnimalsCells
  29. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6. PMID: 25206015.
    Citations: 1     
  30. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308.
    Citations: 31     Fields:    Translation:AnimalsCells
  31. Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):110-20. PMID: 23221073.
    Citations: 136     Fields:    Translation:HumansCells
  32. Bejjani A, Choi MR, Cassidy L, Collins DW, O'Brien JM, Murray T, Ksander BR, Seigel GM. RB116: an RB1+ retinoblastoma cell line expressing primitive markers. Mol Vis. 2012; 18:2805-13. PMID: 23233783.
    Citations: 6     Fields:    Translation:HumansCells
  33. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013 Jan 10; 49(1):94-108. PMID: 23177739; PMCID: PMC3545055.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  34. Haile ST, Bosch JJ, Agu NI, Zeender AM, Somasundaram P, Srivastava MK, Britting S, Wolf JB, Ksander BR, Ostrand-Rosenberg S. Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80. J Immunol. 2011 Jun 15; 186(12):6822-9. PMID: 21555531; PMCID: PMC3377446.
    Citations: 50     Fields:    Translation:HumansCells
  35. Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR. Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011 Mar 29; 6(3):e17659. PMID: 21479271.
    Citations: 44     Fields:    Translation:AnimalsCells
  36. Klocke J, Barcia RN, Heimer S, Cario E, Zieske J, Gilmore MS, Ksander BR, Gregory MS. Spontaneous bacterial keratitis in CD36 knockout mice. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):256-63. PMID: 20847111.
    Citations: 4     Fields:    Translation:AnimalsCells
  37. Theodoropoulou S, Kolovou PE, Morizane Y, Kayama M, Nicolaou F, Miller JW, Gragoudas E, Ksander BR, Vavvas DG. Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30. PMID: 20371623.
    Citations: 20     Fields:    Translation:HumansCells
  38. Hamrah P, Haskova Z, Taylor AW, Zhang Q, Ksander BR, Dana MR. Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection. Transplantation. 2009 Jul 27; 88(2):180-7. PMID: 19623012.
    Citations: 11     Fields:    Translation:Animals
  39. Bosch JJ, Iheagwara UK, Reid S, Srivastava MK, Wolf J, Lotem M, Ksander BR, Ostrand-Rosenberg S. Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells. Cancer Immunol Immunother. 2010 Jan; 59(1):103-12. PMID: 19557412.
    Citations: 6     Fields:    Translation:HumansCells
  40. Srivastava MK, Bosch JJ, Thompson JA, Ksander BR, Edelman MJ, Ostrand-Rosenberg S. Lung cancer patients' CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells. Cancer Immunol Immunother. 2008 Oct; 57(10):1493-504. PMID: 18322683.
    Citations: 44     Fields:    Translation:HumansCells
  41. Whiston EA, Sugi N, Kamradt MC, Sack C, Heimer SR, Engelbert M, Wawrousek EF, Gilmore MS, Ksander BR, Gregory MS. alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis. Infect Immun. 2008 Apr; 76(4):1781-90. PMID: 18227158.
    Citations: 50     Fields:    Translation:AnimalsCells
  42. Gregory MS, Saff RR, Marshak-Rothstein A, Ksander BR. Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand. Cancer Res. 2007 Dec 15; 67(24):11951-8. PMID: 18089826.
    Citations: 6     Fields:    Translation:AnimalsCells
  43. Thompson JA, Srivastava MK, Bosch JJ, Clements VK, Ksander BR, Ostrand-Rosenberg S. The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+ T lymphocytes. Cancer Immunol Immunother. 2008 Mar; 57(3):389-98. PMID: 17724589; PMCID: PMC2810506.
    Citations: 25     Fields:    Translation:HumansCells
  44. Ksander BR, Streilein JW. Recovery of activated cytotoxic T cells from minor H incompatible tumor graft rejection sites. 1989. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):205-13. PMID: 17613835.
    Citations:    Fields:    Translation:AnimalsCells
  45. Bosch JJ, Thompson JA, Srivastava MK, Iheagwara UK, Murray TG, Lotem M, Ksander BR, Ostrand-Rosenberg S. MHC class II-transduced tumor cells originating in the immune-privileged eye prime and boost CD4(+) T lymphocytes that cross-react with primary and metastatic uveal melanoma cells. Cancer Res. 2007 May 01; 67(9):4499-506. PMID: 17483366.
    Citations: 17     Fields:    Translation:HumansCells
  46. Chen PW, Ksander BR. Influence of immune surveillance and immune privilege on formation of intraocular tumors. Chem Immunol Allergy. 2007; 92:276-289. PMID: 17264503.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  47. Chen PW, Uno T, Ksander BR. Tumor escape mutants develop within an immune-privileged environment in the absence of T cell selection. J Immunol. 2006 Jul 01; 177(1):162-8. PMID: 16785511.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Chen PW, Uno T, Ksander BR. Requirement of CD80+ costimulation for rejection of ocular tumors and termination of immune privilege. Exp Eye Res. 2006 Sep; 83(3):574-83. PMID: 16643898.
    Citations:    Fields:    Translation:AnimalsCells
  49. Thompson JA, Dissanayake SK, Ksander BR, Knutson KL, Disis ML, Ostrand-Rosenberg S. Tumor cells transduced with the MHC class II Transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain. Cancer Res. 2006 Jan 15; 66(2):1147-54. PMID: 16424052.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  50. Chen PW, Ksander BR. Termination of systemic immunity in the presence of intraocular tumors: influence of ocular immune privilege on tumor vaccines. Curr Eye Res. 2006 Jan; 31(1):43-55. PMID: 16421019.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  51. Gregory MS, Koh S, Huang E, Saff RR, Marshak-Rothstein A, Mukai S, Ksander BR. A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2495-502. PMID: 15980241.
    Citations: 4     Fields:    Translation:AnimalsCells
  52. Radosevich M, Song Z, Gorga JC, Ksander B, Ono SJ. Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3185-95. PMID: 15326139.
    Citations: 12     Fields:    Translation:HumansCells
  53. Carlson EC, Liu CY, Yang X, Gregory M, Ksander B, Drazba J, Perez VL. In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2194-200. PMID: 15223795.
    Citations: 14     Fields:    Translation:AnimalsCells
  54. Dissanayake SK, Thompson JA, Bosch JJ, Clements VK, Chen PW, Ksander BR, Ostrand-Rosenberg S. Activation of tumor-specific CD4(+) T lymphocytes by major histocompatibility complex class II tumor cell vaccines: a novel cell-based immunotherapy. Cancer Res. 2004 Mar 01; 64(5):1867-74. PMID: 14996751.
    Citations: 24     Fields:    Translation:HumansCells
  55. van der Velden PA, Zuidervaart W, Hurks MHMH, Pavey S, Ksander BR, Krijgsman E, Frants RR, Tensen CP, Willemze R, Jager MJ, Gruis NA. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer. 2003 Sep 10; 106(4):472-479. PMID: 12845640.
    Citations: 25     Fields:    Translation:HumansCells
  56. Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SW. By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med. 2003 May 19; 197(10):1335-44. PMID: 12756269; PMCID: PMC2193785.
    Citations: 48     Fields:    Translation:AnimalsCells
  57. Walker TM, Van Ginkel PR, Gee RL, Ahmadi H, Subramanian L, Ksander BR, Meisner LF, Albert DM, Polans AS. Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma. Arch Ophthalmol. 2002 Dec; 120(12):1719-25. PMID: 12470148.
    Citations: 11     Fields:    Translation:HumansCells
  58. Gregory MS, Repp AC, Holhbaum AM, Saff RR, Marshak-Rothstein A, Ksander BR. Membrane Fas ligand activates innate immunity and terminates ocular immune privilege. J Immunol. 2002 Sep 01; 169(5):2727-35. PMID: 12193747.
    Citations: 21     Fields:    Translation:AnimalsCells
  59. Naus NC, van Drunen E, de Klein A, Luyten GP, Paridaens DA, Alers JC, Ksander BR, Beverloo HB, Slater RM. Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization. Genes Chromosomes Cancer. 2001 Mar; 30(3):267-73. PMID: 11170284.
    Citations: 11     Fields:    Translation:HumansCells
  60. Yamada J, Ksander BR, Streilein JW. Cytotoxic T cells play no essential role in acute rejection of orthotopic corneal allografts in mice. Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):386-92. PMID: 11157871.
    Citations: 8     Fields:    Translation:AnimalsCells
  61. Sano Y, Ksander BR, Streilein JW. Analysis of primed donor-specific T cells in recipient mice bearing orthotopic corneal allografts. Transplantation. 2000 Nov 15; 70(9):1302-10. PMID: 11087144.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  62. Naus NC, Zuidervaart W, Rayman N, Slater R, van Drunen E, Ksander B, Luyten GP, Klein A. Mutation analysis of the PTEN gene in uveal melanoma cell lines. Int J Cancer. 2000 Jul 01; 87(1):151-3. PMID: 10861467.
    Citations: 7     Fields:    Translation:HumansCells
  63. Sano Y, Ksander BR, Streilein JW. Langerhans cells, orthotopic corneal allografts, and direct and indirect pathways of T-cell allorecognition. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1422-31. PMID: 10798658.
    Citations: 8     Fields:    Translation:AnimalsCells
  64. Takeuchi M, Alard P, Verbik D, Ksander B, Streilein JW. Anterior chamber-associated immune deviation-inducing cells activate T cells, and rescue them from antigen-induced apoptosis. Immunology. 1999 Dec; 98(4):576-83. PMID: 10594691.
    Citations: 2     Fields:    Translation:AnimalsCells
  65. Wenkel H, Chen PW, Ksander BR, Streilein JW. Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3202-8. PMID: 10586943.
    Citations: 7     Fields:    Translation:AnimalsPHPublic Health
  66. Zierhut M, Streilein JW, Schreiber H, Jager MJ, Ruiter D, Ksander BR. Immunology of ocular tumours. Immunol Today. 1999 Nov; 20(11):482-5. PMID: 10529773.
    Citations:    Fields:    Translation:Humans
  67. Sano Y, Streilein JW, Ksander BR. Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: evidence that graft antigens are recognized exclusively via the "indirect pathway". Transplantation. 1999 Oct 15; 68(7):963-70. PMID: 10532535.
    Citations: 12     Fields:    Translation:AnimalsCells
  68. Streilein JW, Yamada J, Dana MR, Ksander BR. Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts. Transplant Proc. 1999 May; 31(3):1472-5. PMID: 10330973.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  69. Chen PW, Ksander BR. Immune privilege, tumors, and the eye. Chem Immunol. 1999; 73:137-58. PMID: 10590578.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  70. Ksander BR, Chen PW. Immunotherapy of uveal melanoma. Dev Ophthalmol. 1999; 30:220-30. PMID: 10627926.
    Citations: 2     Fields:    Translation:HumansAnimals
  71. Gordon LB, Nolan SC, Ksander BR, Knopf PM, Harling-Berg CJ. Normal cerebrospinal fluid suppresses the in vitro development of cytotoxic T cells: role of the brain microenvironment in CNS immune regulation. J Neuroimmunol. 1998 Aug 01; 88(1-2):77-84. PMID: 9688327.
    Citations: 12     Fields:    Translation:AnimalsCells
  72. Ksander BR, Geer DC, Chen PW, Salgaller ML, Rubsamen P, Murray TG. Uveal melanomas contain antigenically specific and non-specific infiltrating lymphocytes. Curr Eye Res. 1998 Feb; 17(2):165-73. PMID: 9523095.
    Citations: 15     Fields:    Translation:HumansCells
  73. Verbik DJ, Murray TG, Tran JM, Ksander BR. Melanomas that develop within the eye inhibit lymphocyte proliferation. Int J Cancer. 1997 Nov 14; 73(4):470-8. PMID: 9389558.
    Citations: 42     Fields:    Translation:HumansCells
  74. Uno T, Chen PW, Murray TG, Podack ER, Ksander BR. Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2531-9. PMID: 9375572.
    Citations: 1     Fields:    Translation:HumansCells
  75. Murray TG, Cicciarelli N, McCabe CM, Ksander B, Feuer W, Schiffman J, Mieler WF, O'Brien JM. In vitro efficacy of carboplatin and hyperthermia in a murine retinoblastoma cell line. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2516-22. PMID: 9375570.
    Citations: 7     Fields:    Translation:AnimalsCells
  76. Streilein JW, Okamoto S, Hara Y, Kosiewicz M, Ksander B. Blood-borne signals that induce anterior chamber-associated immune deviation after intracameral injection of antigen. Invest Ophthalmol Vis Sci. 1997 Oct; 38(11):2245-54. PMID: 9344347.
    Citations: 8     Fields:    Translation:AnimalsCells
  77. Streilein JW, Dana MR, Ksander BR. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol Today. 1997 Sep; 18(9):443-9. PMID: 9293161.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  78. Chen PW, Murray TG, Uno T, Salgaller ML, Reddy R, Ksander BR. Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease. Clin Exp Metastasis. 1997 Sep; 15(5):509-18. PMID: 9247253.
    Citations: 32     Fields:    Translation:HumansCells
  79. Chen PW, Murray TG, Salgaller ML, Ksander BR. Expression of MAGE genes in ocular melanoma cell lines. J Immunother. 1997 Jul; 20(4):265-75. PMID: 9220316.
    Citations: 7     Fields:    Translation:HumansCells
  80. Sano Y, Ksander BR, Streilein JW. Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens. Invest Ophthalmol Vis Sci. 1997 May; 38(6):1130-8. PMID: 9152232.
    Citations: 14     Fields:    Translation:Animals
  81. Streilein JW, Ksander BR, Taylor AW. Immune deviation in relation to ocular immune privilege. J Immunol. 1997 Apr 15; 158(8):3557-60. PMID: 9103414.
    Citations: 26     Fields:    Translation:HumansAnimals
  82. Chen PW, Geer DC, Podack ER, Ksander BR. Tumor cells transfected with B7-1 and interleukin-12 cDNA induce protective immunity. Ann N Y Acad Sci. 1996 Oct 31; 795:325-7. PMID: 8958945.
    Citations:    Fields:    Translation:AnimalsCells
  83. Uno T, Streilein JW, Ksander BR. The effect of IL-12 on immune privilege of the eye. Ann N Y Acad Sci. 1996 Oct 31; 795:426-8. PMID: 8958974.
    Citations: 1     Fields:    Translation:Animals
  84. Ksander BR, Sano Y, Streilein JW. Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes. Transpl Immunol. 1996 Mar; 4(1):49-52. PMID: 8762010.
    Citations: 9     Fields:    Translation:AnimalsCells
  85. Sano Y, Ksander BR, Streilein JW. Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice. Transpl Immunol. 1996 Mar; 4(1):53-6. PMID: 8762011.
    Citations: 23     Fields:    Translation:Animals
  86. Sano Y, Ksander BR, Streilein JW. Fate of orthotopic corneal allografts in eyes that cannot support anterior chamber-associated immune deviation induction. Invest Ophthalmol Vis Sci. 1995 Oct; 36(11):2176-85. PMID: 7558710.
    Citations: 24     Fields:    Translation:Animals
  87. Sonoda Y, Sano Y, Ksander B, Streilein JW. Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice. Invest Ophthalmol Vis Sci. 1995 Feb; 36(2):427-34. PMID: 7843911.
    Citations: 16     Fields:    Translation:AnimalsCells
  88. Kosiewicz MM, Okamoto S, Miki S, Ksander BR, Shimizu T, Streilein JW. Imposing deviant immunity on the presensitized state. J Immunol. 1994 Oct 01; 153(7):2962-73. PMID: 8089480.
    Citations: 12     Fields:    Translation:AnimalsCells
  89. Ksander BR, Streilein JW. Regulation of the immune response within privileged sites. Chem Immunol. 1994; 58:117-45. PMID: 8011150.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  90. Miki S, Ksander B, Streilein JW. Complete elimination ('cure') of progressively growing intraocular tumors by local injection of tumor-specific CD8+ T lymphocytes. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3622-34. PMID: 8258521.
    Citations: 1     Fields:    Translation:AnimalsCells
  91. Sonoda Y, Ksander B, Streilein JW. Evidence that active suppression contributes to the success of H-2-incompatible orthotopic corneal allografts in mice. Transplant Proc. 1993 Feb; 25(1 Pt 2):1374-6. PMID: 8442147.
    Citations: 1     Fields:    Translation:AnimalsCells
  92. Bando Y, Ksander BR, Streilein JW. Incomplete activation of lymphokine-producing T cells by alloantigenic intraocular tumours in anterior chamber-associated immune deviation. Immunology. 1993 Feb; 78(2):266-72. PMID: 8097183.
    Citations:    Fields:    Translation:AnimalsCells
  93. Miki S, Ksander B, Streilein JW. Studies on the minimum requirements for in vitro "cure" of tumor cells by cytotoxic T lymphocytes. Reg Immunol. 1992 Nov-Dec; 4(6):352-62. PMID: 1297406.
    Citations:    Fields:    Translation:AnimalsCells
  94. Ksander BR, Acevedo J, Streilein JW. Local T helper cell signals by lymphocytes infiltrating intraocular tumors. J Immunol. 1992 Mar 15; 148(6):1955-63. PMID: 1531848.
    Citations:    Fields:    Translation:AnimalsCells
  95. Ksander BR, Rubsamen PE, Olsen KR, Cousins SW, Streilein JW. Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3198-208. PMID: 1748551.
    Citations: 29     Fields:    Translation:HumansCells
  96. Bando Y, Ksander BR, Streilein JW. Characterization of specific T helper cell activity in mice bearing alloantigenic tumors in the anterior chamber of the eye. Eur J Immunol. 1991 Aug; 21(8):1923-31. PMID: 1831132.
    Citations: 5     Fields:    Translation:AnimalsCells
  97. Ksander BR, Mammolenti MM, Streilein JW. Termination of immune privilege in the anterior chamber of the eye when tumor-infiltrating lymphocytes acquire cytolytic function. Transplantation. 1991 Jul; 52(1):128-33. PMID: 1907041.
    Citations: 1     Fields:    Translation:AnimalsCells
  98. Ksander BR, Bando Y, Acevedo J, Streilein JW. Infiltration and accumulation of precursor cytotoxic T-cells increase with time in progressively growing ocular tumors. Cancer Res. 1991 Jun 15; 51(12):3153-8. PMID: 1904003.
    Citations: 6     Fields:    Translation:AnimalsCells
  99. Ksander BR, Streilein JW. Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites. J Immunol. 1990 Oct 01; 145(7):2057-63. PMID: 1975822.
    Citations: 8     Fields:    Translation:AnimalsCells
  100. Ksander BR, Streilein JW. Recovery of activated cytotoxic T cells from minor H incompatible tumor graft rejection sites. J Immunol. 1989 Jul 15; 143(2):426-31. PMID: 2500481.
    Citations: 1     Fields:    Translation:AnimalsCells
  101. Ksander BR, Streilein JW. Immune privilege to MHC-disparate tumor grafts in the anterior chamber of the eye. I. Quantitative analysis of intraocular tumor growth and the corresponding delayed hypersensitivity response. Transplantation. 1989 Apr; 47(4):661-7. PMID: 2523103.
    Citations: 2     Fields:    Translation:AnimalsCells
  102. Ksander BR, Streilein JW. Analysis of cytotoxic T cell responses to intracameral allogeneic tumors. Invest Ophthalmol Vis Sci. 1989 Feb; 30(2):323-9. PMID: 2492486.
    Citations: 16     Fields:    Translation:AnimalsCells
  103. Kaiser CJ, Ksander BR, Streilein JW. Inhibition of lymphocyte proliferation by aqueous humor. Reg Immunol. 1989 Jan-Feb; 2(1):42-9. PMID: 2534948.
    Citations: 17     Fields:    Translation:AnimalsCells
  104. Ksander BR, Hendricks RL. Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions. Invest Ophthalmol Vis Sci. 1987 Dec; 28(12):1986-93. PMID: 2824400.
    Citations: 15     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.