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profileBruce R. Ksander, Ph.D.

TitleAssociate Professor of Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Institute
20 Staniford St
Boston MA 02114
Phone617/912-7443
Fax617/912-0101
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01EY025794     (FRANK, MARKUS H.)Apr 1, 2016 - Mar 31, 2021
NIH/NEI
ABCB5-positive stem cells for LSCD therapy
Role: Co-Principal Investigator

R21EY020987     (BUYS, EMMANUEL S)Jan 1, 2011 - Dec 31, 2012
NIH/NEI
sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
Role: Co-Principal Investigator

R01EY016486     (KSANDER, BRUCE R)May 1, 2005 - Apr 30, 2009
NIH/NEI
IMMUNOBIOLOGY OF CORNEAL TRANSPLANTATION
Role: Principal Investigator

R01EY009294     (KSANDER, BRUCE R)May 1, 1993 - Dec 31, 2002
NIH/NEI
CELL MEDIATED IMMUNITY TO OCULAR TUMORS
Role: Principal Investigator

R01EY008122     (KSANDER, BRUCE R)May 1, 1989 - Apr 30, 2004
NIH/NEI
CELL MEDIATED IMMUNE RESPONSE TO INTRAOCULAR TUMORS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gonzalez G, Sasamoto Y, Ksander BR, Frank MH, Frank NY. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2017 Nov 03. PMID: 29105366.
    View in: PubMed
  2. Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M. Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma. J Immunol. 2016 Dec 15; 197(12):4626-4638. PMID: 27849168.
    View in: PubMed
  3. Jager MJ, Magner JA, Ksander BR, Dubovy SR. Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2016 Aug; 114:T5. PMID: 28018010.
    View in: PubMed
  4. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939; PMCID: PMC4740757.
  5. Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG. Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015 Nov 19; 6:e1986. PMID: 26583327; PMCID: PMC4670938.
  6. Schlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM. A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5965-73. PMID: 26377082.
    View in: PubMed
  7. de Waard NE, Cao J, McGuire SP, Kolovou PE, Jordanova ES, Ksander BR, Jager MJ. A Murine Model for Metastatic Conjunctival Melanoma. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2325-33. PMID: 25722211.
    View in: PubMed
  8. de Waard NE, Kolovou PE, McGuire SP, Cao J, Frank NY, Frank MH, Jager MJ, Ksander BR. Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma. Ocul Oncol Pathol. 2015 Apr; 1(3):182-189. PMID: 25960995.
    View in: PubMed
  9. Duminuco R, Noble JW, Goody J, Sharma M, Ksander BR, Roskelley CD, Cox ME, Mills J. Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines. Cell Cycle. 2015; 14(18):2924-37. PMID: 26176204; PMCID: PMC4825635.
  10. van der Ent W, Burrello C, Teunisse AF, Ksander BR, van der Velden PA, Jager MJ, Jochemsen AG, Snaar-Jagalska BE. Modeling of human uveal melanoma in zebrafish xenograft embryos. Invest Ophthalmol Vis Sci. 2014 Sep 23; 55(10):6612-22. PMID: 25249605.
    View in: PubMed
  11. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17; 511(7509):353-7. PMID: 25030174; PMCID: PMC4246512.
  12. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. PMID: 24882515; PMCID: PMC4074519.
  13. Buys ES, Potter LR, Pasquale LR, Ksander BR. Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma. Front Mol Neurosci. 2014; 7:38. PMID: 24904270; PMCID: PMC4032937.
  14. Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas TD, Marmalidou A, Ksander BR, Miller JW, Gragoudas E, Vavvas DG. Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Apr 29; 55(7):4175-85. PMID: 24781943; PMCID: PMC4089421.
  15. Sugi N, Whiston EA, Ksander BR, Gregory MS. Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance. Infect Immun. 2013 Jun; 81(6):2217-25. PMID: 23569113; PMCID: PMC3676017.
  16. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6. PMID: 25206015; PMCID: PMC4117107.
  17. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308; PMCID: PMC3603933.
  18. Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):110-20. PMID: 23221073; PMCID: PMC3544415.
  19. Bejjani A, Choi MR, Cassidy L, Collins DW, O'Brien JM, Murray T, Ksander BR, Seigel GM. RB116: an RB1+ retinoblastoma cell line expressing primitive markers. Mol Vis. 2012; 18:2805-13. PMID: 23233783; PMCID: PMC3519375.
  20. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013 Jan 10; 49(1):94-108. PMID: 23177739; PMCID: PMC3545055.
  21. Haile ST, Bosch JJ, Agu NI, Zeender AM, Somasundaram P, Srivastava MK, Britting S, Wolf JB, Ksander BR, Ostrand-Rosenberg S. Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80. J Immunol. 2011 Jun 15; 186(12):6822-9. PMID: 21555531; PMCID: PMC3377446.
  22. Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR. Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011 Mar 29; 6(3):e17659. PMID: 21479271; PMCID: PMC3066205.
  23. Klocke J, Barcia RN, Heimer S, Cario E, Zieske J, Gilmore MS, Ksander BR, Gregory MS. Spontaneous bacterial keratitis in CD36 knockout mice. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):256-63. PMID: 20847111; PMCID: PMC3053277.
  24. Theodoropoulou S, Kolovou PE, Morizane Y, Kayama M, Nicolaou F, Miller JW, Gragoudas E, Ksander BR, Vavvas DG. Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30. PMID: 20371623; PMCID: PMC2909289.
  25. Hamrah P, Haskova Z, Taylor AW, Zhang Q, Ksander BR, Dana MR. Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection. Transplantation. 2009 Jul 27; 88(2):180-7. PMID: 19623012; PMCID: PMC2735785.
  26. Bosch JJ, Iheagwara UK, Reid S, Srivastava MK, Wolf J, Lotem M, Ksander BR, Ostrand-Rosenberg S. Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells. Cancer Immunol Immunother. 2010 Jan; 59(1):103-12. PMID: 19557412; PMCID: PMC2800822.
  27. Srivastava MK, Bosch JJ, Thompson JA, Ksander BR, Edelman MJ, Ostrand-Rosenberg S. Lung cancer patients' CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells. Cancer Immunol Immunother. 2008 Oct; 57(10):1493-504. PMID: 18322683; PMCID: PMC2805175.
  28. Whiston EA, Sugi N, Kamradt MC, Sack C, Heimer SR, Engelbert M, Wawrousek EF, Gilmore MS, Ksander BR, Gregory MS. alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis. Infect Immun. 2008 Apr; 76(4):1781-90. PMID: 18227158; PMCID: PMC2292870.
  29. Gregory MS, Saff RR, Marshak-Rothstein A, Ksander BR. Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand. Cancer Res. 2007 Dec 15; 67(24):11951-8. PMID: 18089826.
    View in: PubMed
  30. Thompson JA, Srivastava MK, Bosch JJ, Clements VK, Ksander BR, Ostrand-Rosenberg S. The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+ T lymphocytes. Cancer Immunol Immunother. 2008 Mar; 57(3):389-98. PMID: 17724589; PMCID: PMC2810506.
  31. Ksander BR, Streilein JW. Recovery of activated cytotoxic T cells from minor H incompatible tumor graft rejection sites. 1989. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):205-13. PMID: 17613835.
    View in: PubMed
  32. Bosch JJ, Thompson JA, Srivastava MK, Iheagwara UK, Murray TG, Lotem M, Ksander BR, Ostrand-Rosenberg S. MHC class II-transduced tumor cells originating in the immune-privileged eye prime and boost CD4(+) T lymphocytes that cross-react with primary and metastatic uveal melanoma cells. Cancer Res. 2007 May 01; 67(9):4499-506. PMID: 17483366.
    View in: PubMed
  33. Chen PW, Ksander BR. Influence of immune surveillance and immune privilege on formation of intraocular tumors. Chem Immunol Allergy. 2007; 92:276-89. PMID: 17264503.
    View in: PubMed
  34. Chen PW, Uno T, Ksander BR. Tumor escape mutants develop within an immune-privileged environment in the absence of T cell selection. J Immunol. 2006 Jul 01; 177(1):162-8. PMID: 16785511.
    View in: PubMed
  35. Chen PW, Uno T, Ksander BR. Requirement of CD80+ costimulation for rejection of ocular tumors and termination of immune privilege. Exp Eye Res. 2006 Sep; 83(3):574-83. PMID: 16643898.
    View in: PubMed
  36. Thompson JA, Dissanayake SK, Ksander BR, Knutson KL, Disis ML, Ostrand-Rosenberg S. Tumor cells transduced with the MHC class II Transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain. Cancer Res. 2006 Jan 15; 66(2):1147-54. PMID: 16424052.
    View in: PubMed
  37. Chen PW, Ksander BR. Termination of systemic immunity in the presence of intraocular tumors: influence of ocular immune privilege on tumor vaccines. Curr Eye Res. 2006 Jan; 31(1):43-55. PMID: 16421019.
    View in: PubMed
  38. Gregory MS, Koh S, Huang E, Saff RR, Marshak-Rothstein A, Mukai S, Ksander BR. A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2495-502. PMID: 15980241.
    View in: PubMed
  39. Radosevich M, Song Z, Gorga JC, Ksander B, Ono SJ. Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3185-95. PMID: 15326139.
    View in: PubMed
  40. Carlson EC, Liu CY, Yang X, Gregory M, Ksander B, Drazba J, Perez VL. In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2194-200. PMID: 15223795.
    View in: PubMed
  41. Dissanayake SK, Thompson JA, Bosch JJ, Clements VK, Chen PW, Ksander BR, Ostrand-Rosenberg S. Activation of tumor-specific CD4(+) T lymphocytes by major histocompatibility complex class II tumor cell vaccines: a novel cell-based immunotherapy. Cancer Res. 2004 Mar 01; 64(5):1867-74. PMID: 14996751.
    View in: PubMed
  42. van der Velden PA, Zuidervaart W, Hurks MH, Pavey S, Ksander BR, Krijgsman E, Frants RR, Tensen CP, Willemze R, Jager MJ, Gruis NA. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer. 2003 Sep 10; 106(4):472-9. PMID: 12845640.
    View in: PubMed
  43. Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SW. By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med. 2003 May 19; 197(10):1335-44. PMID: 12756269; PMCID: PMC2193785.
  44. Walker TM, Van Ginkel PR, Gee RL, Ahmadi H, Subramanian L, Ksander BR, Meisner LF, Albert DM, Polans AS. Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma. Arch Ophthalmol. 2002 Dec; 120(12):1719-25. PMID: 12470148.
    View in: PubMed
  45. Gregory MS, Repp AC, Holhbaum AM, Saff RR, Marshak-Rothstein A, Ksander BR. Membrane Fas ligand activates innate immunity and terminates ocular immune privilege. J Immunol. 2002 Sep 01; 169(5):2727-35. PMID: 12193747.
    View in: PubMed
  46. Naus NC, van Drunen E, de Klein A, Luyten GP, Paridaens DA, Alers JC, Ksander BR, Beverloo HB, Slater RM. Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization. Genes Chromosomes Cancer. 2001 Mar; 30(3):267-73. PMID: 11170284.
    View in: PubMed
  47. Yamada J, Ksander BR, Streilein JW. Cytotoxic T cells play no essential role in acute rejection of orthotopic corneal allografts in mice. Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):386-92. PMID: 11157871.
    View in: PubMed
  48. Sano Y, Ksander BR, Streilein JW. Analysis of primed donor-specific T cells in recipient mice bearing orthotopic corneal allografts. Transplantation. 2000 Nov 15; 70(9):1302-10. PMID: 11087144.
    View in: PubMed
  49. Naus NC, Zuidervaart W, Rayman N, Slater R, van Drunen E, Ksander B, Luyten GP, Klein A. Mutation analysis of the PTEN gene in uveal melanoma cell lines. Int J Cancer. 2000 Jul 01; 87(1):151-3. PMID: 10861467.
    View in: PubMed
  50. Sano Y, Ksander BR, Streilein JW. Langerhans cells, orthotopic corneal allografts, and direct and indirect pathways of T-cell allorecognition. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1422-31. PMID: 10798658.
    View in: PubMed
  51. Takeuchi M, Alard P, Verbik D, Ksander B, Streilein JW. Anterior chamber-associated immune deviation-inducing cells activate T cells, and rescue them from antigen-induced apoptosis. Immunology. 1999 Dec; 98(4):576-83. PMID: 10594691; PMCID: PMC2326976.
  52. Wenkel H, Chen PW, Ksander BR, Streilein JW. Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3202-8. PMID: 10586943.
    View in: PubMed
  53. Zierhut M, Streilein JW, Schreiber H, Jager MJ, Ruiter D, Ksander BR. Immunology of ocular tumours. Immunol Today. 1999 Nov; 20(11):482-5. PMID: 10529773.
    View in: PubMed
  54. Sano Y, Streilein JW, Ksander BR. Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: evidence that graft antigens are recognized exclusively via the "indirect pathway". Transplantation. 1999 Oct 15; 68(7):963-70. PMID: 10532535.
    View in: PubMed
  55. Streilein JW, Yamada J, Dana MR, Ksander BR. Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts. Transplant Proc. 1999 May; 31(3):1472-5. PMID: 10330973.
    View in: PubMed
  56. Chen PW, Ksander BR. Immune privilege, tumors, and the eye. Chem Immunol. 1999; 73:137-58. PMID: 10590578.
    View in: PubMed
  57. Ksander BR, Chen PW. Immunotherapy of uveal melanoma. Dev Ophthalmol. 1999; 30:220-30. PMID: 10627926.
    View in: PubMed
  58. Gordon LB, Nolan SC, Ksander BR, Knopf PM, Harling-Berg CJ. Normal cerebrospinal fluid suppresses the in vitro development of cytotoxic T cells: role of the brain microenvironment in CNS immune regulation. J Neuroimmunol. 1998 Aug 01; 88(1-2):77-84. PMID: 9688327.
    View in: PubMed
  59. Ksander BR, Geer DC, Chen PW, Salgaller ML, Rubsamen P, Murray TG. Uveal melanomas contain antigenically specific and non-specific infiltrating lymphocytes. Curr Eye Res. 1998 Feb; 17(2):165-73. PMID: 9523095.
    View in: PubMed
  60. Verbik DJ, Murray TG, Tran JM, Ksander BR. Melanomas that develop within the eye inhibit lymphocyte proliferation. Int J Cancer. 1997 Nov 14; 73(4):470-8. PMID: 9389558.
    View in: PubMed
  61. Murray TG, Cicciarelli N, McCabe CM, Ksander B, Feuer W, Schiffman J, Mieler WF, O'Brien JM. In vitro efficacy of carboplatin and hyperthermia in a murine retinoblastoma cell line. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2516-22. PMID: 9375570.
    View in: PubMed
  62. Uno T, Chen PW, Murray TG, Podack ER, Ksander BR. Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2531-9. PMID: 9375572.
    View in: PubMed
  63. Streilein JW, Okamoto S, Hara Y, Kosiewicz M, Ksander B. Blood-borne signals that induce anterior chamber-associated immune deviation after intracameral injection of antigen. Invest Ophthalmol Vis Sci. 1997 Oct; 38(11):2245-54. PMID: 9344347.
    View in: PubMed
  64. Streilein JW, Dana MR, Ksander BR. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol Today. 1997 Sep; 18(9):443-9. PMID: 9293161.
    View in: PubMed
  65. Chen PW, Murray TG, Uno T, Salgaller ML, Reddy R, Ksander BR. Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease. Clin Exp Metastasis. 1997 Sep; 15(5):509-18. PMID: 9247253.
    View in: PubMed
  66. Chen PW, Murray TG, Salgaller ML, Ksander BR. Expression of MAGE genes in ocular melanoma cell lines. J Immunother. 1997 Jul; 20(4):265-75. PMID: 9220316.
    View in: PubMed
  67. Sano Y, Ksander BR, Streilein JW. Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens. Invest Ophthalmol Vis Sci. 1997 May; 38(6):1130-8. PMID: 9152232.
    View in: PubMed
  68. Streilein JW, Ksander BR, Taylor AW. Immune deviation in relation to ocular immune privilege. J Immunol. 1997 Apr 15; 158(8):3557-60. PMID: 9103414.
    View in: PubMed
  69. Uno T, Streilein JW, Ksander BR. The effect of IL-12 on immune privilege of the eye. Ann N Y Acad Sci. 1996 Oct 31; 795:426-8. PMID: 8958974.
    View in: PubMed
  70. Chen PW, Geer DC, Podack ER, Ksander BR. Tumor cells transfected with B7-1 and interleukin-12 cDNA induce protective immunity. Ann N Y Acad Sci. 1996 Oct 31; 795:325-7. PMID: 8958945.
    View in: PubMed
  71. Ksander BR, Sano Y, Streilein JW. Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes. Transpl Immunol. 1996 Mar; 4(1):49-52. PMID: 8762010.
    View in: PubMed
  72. Sano Y, Ksander BR, Streilein JW. Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice. Transpl Immunol. 1996 Mar; 4(1):53-6. PMID: 8762011.
    View in: PubMed
  73. Sano Y, Ksander BR, Streilein JW. Fate of orthotopic corneal allografts in eyes that cannot support anterior chamber-associated immune deviation induction. Invest Ophthalmol Vis Sci. 1995 Oct; 36(11):2176-85. PMID: 7558710.
    View in: PubMed
  74. Sonoda Y, Sano Y, Ksander B, Streilein JW. Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice. Invest Ophthalmol Vis Sci. 1995 Feb; 36(2):427-34. PMID: 7843911.
    View in: PubMed
  75. Kosiewicz MM, Okamoto S, Miki S, Ksander BR, Shimizu T, Streilein JW. Imposing deviant immunity on the presensitized state. J Immunol. 1994 Oct 01; 153(7):2962-73. PMID: 8089480.
    View in: PubMed
  76. Ksander BR, Streilein JW. Regulation of the immune response within privileged sites. Chem Immunol. 1994; 58:117-45. PMID: 8011150.
    View in: PubMed
  77. Miki S, Ksander B, Streilein JW. Complete elimination ('cure') of progressively growing intraocular tumors by local injection of tumor-specific CD8+ T lymphocytes. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3622-34. PMID: 8258521.
    View in: PubMed
  78. Bando Y, Ksander BR, Streilein JW. Incomplete activation of lymphokine-producing T cells by alloantigenic intraocular tumours in anterior chamber-associated immune deviation. Immunology. 1993 Feb; 78(2):266-72. PMID: 8097183; PMCID: PMC1421795.
  79. Sonoda Y, Ksander B, Streilein JW. Evidence that active suppression contributes to the success of H-2-incompatible orthotopic corneal allografts in mice. Transplant Proc. 1993 Feb; 25(1 Pt 2):1374-6. PMID: 8442147.
    View in: PubMed
  80. Miki S, Ksander B, Streilein JW. Studies on the minimum requirements for in vitro "cure" of tumor cells by cytotoxic T lymphocytes. Reg Immunol. 1992 Nov-Dec; 4(6):352-62. PMID: 1297406.
    View in: PubMed
  81. Ksander BR, Acevedo J, Streilein JW. Local T helper cell signals by lymphocytes infiltrating intraocular tumors. J Immunol. 1992 Mar 15; 148(6):1955-63. PMID: 1531848.
    View in: PubMed
  82. Ksander BR, Rubsamen PE, Olsen KR, Cousins SW, Streilein JW. Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3198-208. PMID: 1748551.
    View in: PubMed
  83. Bando Y, Ksander BR, Streilein JW. Characterization of specific T helper cell activity in mice bearing alloantigenic tumors in the anterior chamber of the eye. Eur J Immunol. 1991 Aug; 21(8):1923-31. PMID: 1831132.
    View in: PubMed
  84. Ksander BR, Mammolenti MM, Streilein JW. Termination of immune privilege in the anterior chamber of the eye when tumor-infiltrating lymphocytes acquire cytolytic function. Transplantation. 1991 Jul; 52(1):128-33. PMID: 1907041.
    View in: PubMed
  85. Ksander BR, Bando Y, Acevedo J, Streilein JW. Infiltration and accumulation of precursor cytotoxic T-cells increase with time in progressively growing ocular tumors. Cancer Res. 1991 Jun 15; 51(12):3153-8. PMID: 1904003.
    View in: PubMed
  86. Ksander BR, Streilein JW. Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites. J Immunol. 1990 Oct 01; 145(7):2057-63. PMID: 1975822.
    View in: PubMed
  87. Ksander BR, Streilein JW. Recovery of activated cytotoxic T cells from minor H incompatible tumor graft rejection sites. J Immunol. 1989 Jul 15; 143(2):426-31. PMID: 2500481.
    View in: PubMed
  88. Ksander BR, Streilein JW. Immune privilege to MHC-disparate tumor grafts in the anterior chamber of the eye. I. Quantitative analysis of intraocular tumor growth and the corresponding delayed hypersensitivity response. Transplantation. 1989 Apr; 47(4):661-7. PMID: 2523103.
    View in: PubMed
  89. Ksander BR, Streilein JW. Analysis of cytotoxic T cell responses to intracameral allogeneic tumors. Invest Ophthalmol Vis Sci. 1989 Feb; 30(2):323-9. PMID: 2492486.
    View in: PubMed
  90. Kaiser CJ, Ksander BR, Streilein JW. Inhibition of lymphocyte proliferation by aqueous humor. Reg Immunol. 1989 Jan-Feb; 2(1):42-9. PMID: 2534948.
    View in: PubMed
  91. Ksander BR, Hendricks RL. Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions. Invest Ophthalmol Vis Sci. 1987 Dec; 28(12):1986-93. PMID: 2824400.
    View in: PubMed
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