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Last Name

profilePaola Divieti Pajevic, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Endocrine Unit THR 1101
50 Blossom St
Boston MA 02114
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My laboratory is interested in investigating the effects of hormones (parathyroid hormone; PTH), intracellular signaling (Gsa subunit) and mechanical forces (gravity) on osteocytes both “in vivo”, using genetically modified animal models, and “in vitro”. Osteocytes are the cells that reside in the lacunae deep within the mineralized matrix of bone and communicate with one another and with osteoblasts and osteoclasts via gap junctions located at the ends of long cytoplasmic processes that course through tunnels (cannalicula) in the bone. They are the most abundant cells in bone, but their relative inaccessibility and (until recently) the lack of good in vitro cell models have impeded progress in understanding their functional roles. Although it is well established that bone responds to its mechanical environment, the mechanisms underlying mechano-transduction are poorly understood.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Panaroni C, Fulzele K, Saini V, Chubb R, Pajevic PD, Wu JY. PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. J Bone Miner Res. 2015 Dec; 30(12):2273-86. PMID: 26191777.
    View in: PubMed
  2. Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD. The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro. J Biol Chem. 2015 Jul 3; 290(27):16744-58. PMID: 25953900; PMCID: PMC4505423 [Available on 07/03/16].
  3. Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res. 2015 Mar; 30(3):400-11. PMID: 25271055; PMCID: PMC4342334 [Available on 03/01/16].
  4. Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Pajevic PD, Kronenberg HM, Wu JY. Loss of Gsa early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors. J Bone Miner Res. 2014 Nov; 29(11):2414-26. PMID: 24806274; PMCID: PMC4220542.
  5. Saini V, Marengi DA, Barry KJ, Fulzele KS, Heiden E, Liu X, Dedic C, Maeda A, Lotinun S, Baron R, Pajevic PD. Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. J Biol Chem. 2013 Jul 12; 288(28):20122-34. PMID: 23729679; PMCID: PMC3711281.
  6. Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct; 84(4):776-85. PMID: 23657144; PMCID: PMC3766419.
  7. Kim SW, Pajevic PD, Selig M, Barry KJ, Yang JY, Shin CS, Baek WY, Kim JE, Kronenberg HM. Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts. J Bone Miner Res. 2012 Oct; 27(10):2075-84. PMID: 22623172; PMCID: PMC3529414.
  8. Bellido T, Saini V, Pajevic PD. Effects of PTH on osteocyte function. Bone. 2013 Jun; 54(2):250-7. PMID: 23017659; PMCID: PMC3552098.
  9. Spatz JM, Fields EE, Yu EW, Divieti Pajevic P, Bouxsein ML, Sibonga JD, Zwart SR, Smith SM. Serum sclerostin increases in healthy adult men during bed rest. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1736-40. PMID: 22767636; PMCID: PMC3431567.
  10. Qing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res. 2012 May; 27(5):1018-29. PMID: 22308018; PMCID: PMC3770147.
  11. Powell WF, Barry KJ, Tulum I, Kobayashi T, Harris SE, Bringhurst FR, Pajevic PD. Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. J Endocrinol. 2011 Apr; 209(1):21-32. PMID: 21220409; PMCID: PMC3783949.
  12. Selim H, Potts J. Jr, Bringhurst F.R. and Divieti P.P. Carboxyl-Terminal Parathyroid Hormone Receptor Regulates Osteocyte Cytoskeleton Through Mechanisms Dependent Upon Calcium Influx. The Open Endocrinology Journal. 2009; 3.
  13. Yang D, Guo J, Divieti P, Shioda T and Bringhurst FR. CBP/P300-Interacting Protein CITED1 Modulates PTH regulation of Osteoblastic Differentiation. Endocrinology. 2008.
  14. Yang D, Singh R, Divieti P, Guo J, Bouxsein ML, Bringhurst FR. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone. 2007 Jun; 40(6):1453-61. PMID: 17376756; PMCID: PMC1976286.
  15. Banerjee S, Selim H, Suliman G, Geller AI, Jüppner H, Bringhurst FR, Divieti P. Synthesis and characterization of novel biotinylated carboxyl-terminal parathyroid hormone peptides that specifically crosslink to the CPTH-receptor. Peptides. 2006 Dec; 27(12):3352-62. PMID: 17028061; PMCID: PMC1764451.
  16. Selim AA, Mahon M, Juppner H, Bringhurst FR, Divieti P. Role of calcium channels in carboxyl-terminal parathyroid hormone receptor signaling. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C114-21. PMID: 16687470.
    View in: PubMed
  17. Yang D, Guo J, Divieti P, Bringhurst FR. Parathyroid hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway. Bone. 2006 Apr; 38(4):485-96. PMID: 16325485.
    View in: PubMed
  18. Divieti PP. PTH and osteocytes. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):328-30. PMID: 16340124.
    View in: PubMed
  19. Mahon MJ, Bonacci TM, Divieti P, Smrcka AV. A docking site for G protein ß? subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Mol Endocrinol. 2006 Jan; 20(1):136-46. PMID: 16099817.
    View in: PubMed
  20. Murray TM, Rao LG, Divieti P, Bringhurst FR. Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl- terminal ligands. Endocr Rev. 2005 Feb; 26(1):78-113. PMID: 15689574.
    View in: PubMed
  21. Divieti P, Geller AI, Suliman G, Jüppner H, Bringhurst FR. Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology. 2005 Apr; 146(4):1863-70. PMID: 15625242.
    View in: PubMed
  22. Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004 Mar; 145(3):1376-85. PMID: 14617570.
    View in: PubMed
  23. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003 Oct 23; 425(6960):841-6. PMID: 14574413.
    View in: PubMed
  24. Jemtland R, Divieti P, Lee K, Segre GV. Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion. Bone. 2003 Jun; 32(6):611-20. PMID: 12810168.
    View in: PubMed
  25. Divieti P, John MR, Jüppner H, Bringhurst FR. Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor. Endocrinology. 2002 Jan; 143(1):171-6. PMID: 11751606.
    View in: PubMed
  26. Gori F, Divieti P, Demay MB. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J Biol Chem. 2001 Dec 7; 276(49):46515-22. PMID: 11551928.
    View in: PubMed
  27. Whitfield JF, Isaacs RJ, Chakravarthy B, Maclean S, Morley P, Willick G, Divieti P, Bringhurst FR. Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C- and N-terminally truncated fragments of parathyroid hormone 1-34. J Bone Miner Res. 2001 Mar; 16(3):441-7. PMID: 11277261.
    View in: PubMed
  28. Guo J, Lanske B, Liu BY, Divieti P, Kronenberg HM, Bringhurst FR. Signal-selectivity of parathyroid hormone (PTH)/PTH-related peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes. Endocrinology. 2001 Mar; 142(3):1260-8. PMID: 11181543.
    View in: PubMed
  29. Divieti P, Inomata N, Chapin K, Singh R, Jüppner H, Bringhurst FR. Receptors for the carboxyl-terminal region of pth(1-84) are highly expressed in osteocytic cells. Endocrinology. 2001 Feb; 142(2):916-25. PMID: 11159865.
    View in: PubMed
  30. Whitfield JF, Morley P, Willick GE, Isaacs RJ, MacLean S, Ross V, Barbier JR, Divieti P, Bringhurst FR. Lactam formation increases receptor binding, adenylyl cyclase stimulation and bone growth stimulation by human parathyroid hormone (hPTH)(1-28)NH2. J Bone Miner Res. 2000 May; 15(5):964-70. PMID: 10804028.
    View in: PubMed
  31. Lanske B, Divieti P, Kovacs CS, Pirro A, Landis WJ, Krane SM, Bringhurst FR, Kronenberg HM. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 1998 Dec; 139(12):5194-204. PMID: 9832460.
    View in: PubMed
  32. Divieti P, Lanske B, Kronenberg HM, Bringhurst FR. Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor. J Bone Miner Res. 1998 Dec; 13(12):1835-45. PMID: 9844101.
    View in: PubMed
  33. Liu BY, Guo J, Lanske B, Divieti P, Kronenberg HM, Bringhurst FR. Conditionally immortalized murine bone marrow stromal cells mediate parathyroid hormone-dependent osteoclastogenesis in vitro. Endocrinology. 1998 Apr; 139(4):1952-64. PMID: 9528982.
    View in: PubMed
  34. Rubinacci A, Divieti P, Polo RM, Zampino M, Resmini G, Tenni R. Effect of an oral calcium load on urinary markers of collagen breakdown. J Endocrinol Invest. 1996 Dec; 19(11):719-26. PMID: 9061504.
    View in: PubMed
  35. Rubinacci A, Divieti P, Lodigiani S, De Ponti A, Samaja M. Thyroid hormones and active calcium transport of inside-out red cell membrane vesicles. Biochem Med Metab Biol. 1992 Dec; 48(3):235-40. PMID: 1335740.
    View in: PubMed
  36. Rubinacci A, Resmini G, Divieti P, Capponi A, Daverio R, Tessari L. [The blood calcium error induced by oral calcium loading: study of the homeostatic compensation mechanism]. Minerva Endocrinol. 1992 Apr-Jun; 17(2):47-54. PMID: 1296144.
    View in: PubMed
  37. Rubinacci A, Divieti P, Capponi A, Resmini G, Daverio R, Veglia F, Tessari L. [Reduction in parathormone secretion after oral calcium loading in osteoporotic adults]. Minerva Endocrinol. 1992 Apr-Jun; 17(2):55-65. PMID: 1296145.
    View in: PubMed
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