Paola Divieti Pajevic, PH.D., M.D.
|Title||Associate Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Endocrine Unit THR 1101
50 Blossom St
Boston MA 02114
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My laboratory is interested in investigating the effects of hormones (parathyroid hormone; PTH), intracellular signaling (Gsa subunit) and mechanical forces (gravity) on osteocytes both “in vivo”, using genetically modified animal models, and “in vitro”. Osteocytes are the cells that reside in the lacunae deep within the mineralized matrix of bone and communicate with one another and with osteoblasts and osteoclasts via gap junctions located at the ends of long cytoplasmic processes that course through tunnels (cannalicula) in the bone. They are the most abundant cells in bone, but their relative inaccessibility and (until recently) the lack of good in vitro cell models have impeded progress in understanding their functional roles. Although it is well established that bone responds to its mechanical environment, the mechanisms underlying mechano-transduction are poorly understood.
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