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profileRudolph Emile Tanzi, PH.D.

TitleJoseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Genetics and Aging Research Unit
114 16th Street
Charlestown MA 02129
Phone617/726-6845
Fax617/724-1949
vCardDownload vCard (login for email)

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
RF1AG048080     (TANZI, RUDOLPH EMILE)Sep 1, 2014 - Jun 30, 2019
NIH/NIA
A novel human 3D neural cell culture system for the characterization of AD genes
Role: Co-Principal Investigator

R01AG041856     (TANZI, RUDOLPH EMILE)Sep 30, 2012 - Aug 31, 2017
NIH/NIA
Characterization of Alzheimer's Mutations in ADAM10.
Role: Principal Investigator

R13AG026970     (TANZI, RUDOLPH EMILE)Jul 1, 2005 - Jun 30, 2006
NIH/NIA
Alzheimer's Disease Genes, Cellular Pathways and Therapies
Role: Principal Investigator

R01NS045860     (TANZI, RUDOLPH EMILE)Sep 23, 2002 - Mar 31, 2017
NIH/NINDS
ACAT inhibitors regulate palmitoylated APP and Abeta production
Role: Principal Investigator

R01MH060009     (TANZI, RUDOLPH EMILE)Apr 1, 1999 - Apr 30, 2018
NIH/NIMH
Identification of Functional Genomic Variants in Alzheimer's Disease
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul; 362(1):31-44. PMID: 28416568.
    View in: PubMed
  2. Li A, Hooli B, Mullin K, Tate RE, Bubnys A, Kirchner R, Chapman B, Hofmann O, Hide W, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment. Hum Mol Genet. 2017 Apr 15; 26(8):1472-1482. PMID: 28186563.
    View in: PubMed
  3. Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 May; 41(4):332-340. PMID: 28318110.
    View in: PubMed
  4. Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate ?-secretase processing of APP and A?-a protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discov Med. 2017 Feb; 23(125):121-128. PMID: 28371615.
    View in: PubMed
  5. Men J, Jerwick J, Wu P, Chen M, Alex A, Ma Y, Tanzi RE, Li A, Zhou C. Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy (OCM). J Vis Exp. 2016 Dec 12; (118). PMID: 28060288.
    View in: PubMed
  6. Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish". Mol Neurodegener. 2016 Dec 09; 11(1):75. PMID: 27938410.
    View in: PubMed
  7. Bhattacharyya R, Fenn RH, Barren C, Tanzi RE, Kovacs DM. Palmitoylated APP Forms Dimers, Cleaved by BACE1. PLoS One. 2016; 11(11):e0166400. PMID: 27875558.
    View in: PubMed
  8. Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D. Corrigendum: Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Sci Rep. 2016 Oct 10; 6:34678. PMID: 27721380.
    View in: PubMed
  9. Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D. Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Sci Rep. 2016 Sep 09; 6:32609. PMID: 27611967; PMCID: PMC5017211.
  10. Kumar DK, Eimer WA, Tanzi RE, Moir RD. Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-ß peptide. Neurodegener Dis Manag. 2016 Oct; 6(5):345-8. PMID: 27599536.
    View in: PubMed
  11. Epel ES, Puterman E, Lin J, Blackburn EH, Lum PY, Beckmann ND, Zhu J, Lee E, Gilbert A, Rissman RA, Tanzi RE, Schadt EE. Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry. 2016 Aug 30; 6(8):e880. PMID: 27576169.
    View in: PubMed
  12. Song W, Hooli B, Mullin K, Jin SC, Cella M, Ulland TK, Wang Y, Tanzi RE, Colonna M. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement. 2017 Apr; 13(4):381-387. PMID: 27520774.
    View in: PubMed
  13. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 Jul 21; 6:30028. PMID: 27443609; PMCID: PMC4956742.
  14. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 Aug 15; 26(16):3928-37. PMID: 27426299.
    View in: PubMed
  15. Mills PJ, Wilson KL, Pung MA, Weiss L, Patel S, Doraiswamy PM, Peterson C, Porter V, Schadt E, Chopra D, Tanzi RE. The Self-Directed Biological Transformation Initiative and Well-Being. J Altern Complement Med. 2016 Aug; 22(8):627-34. PMID: 27351443.
    View in: PubMed
  16. Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Amyloid-ß peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016 May 25; 8(340):340ra72. PMID: 27225182.
    View in: PubMed
  17. Newton AC, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCa in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):pc11. PMID: 27165779.
    View in: PubMed
  18. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Ca (PKCa) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):ra47. PMID: 27165780.
    View in: PubMed
  19. Bettayeb K, Hooli BV, Parrado AR, Randolph L, Varotsis D, Aryal S, Gresack J, Tanzi RE, Greengard P, Flajolet M. Relevance of the COPI complex for Alzheimer's disease progression in vivo. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5418-23. PMID: 27114526; PMCID: PMC4868486 [Available on 11/10/16].
  20. Kim BM, You MH, Chen CH, Suh J, Tanzi RE, Ho Lee T. Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein. Hum Mol Genet. 2016 Jun 15; 25(12):2498-2513. PMID: 27094130.
    View in: PubMed
  21. Herold C, Hooli BV, Mullin K, Liu T, Roehr JT, Mattheisen M, Parrado AR, Bertram L, Lange C, Tanzi RE. Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. Mol Psychiatry. 2016 Nov; 21(11):1608-1612. PMID: 26830138.
    View in: PubMed
  22. Men J, Huang Y, Solanki J, Zeng X, Alex A, Jerwick J, Zhang Z, Tanzi RE, Li A, Zhou C. Optical Coherence Tomography for Brain Imaging and Developmental Biology. IEEE J Sel Top Quantum Electron. 2016 Jul-Aug; 22(4). PMID: 27721647.
    View in: PubMed
  23. Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KM, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. Neurobiol Dis. 2016 Jan; 85:187-205. PMID: 26563932.
    View in: PubMed
  24. Alex A, Li A, Tanzi RE, Zhou C. Optogenetic pacing in Drosophila melanogaster. Sci Adv. 2015 Oct; 1(9):e1500639. PMID: 26601299; PMCID: PMC4646813.
  25. Alex A, Li A, Zeng X, Tate RE, McKee ML, Capen DE, Zhang Z, Tanzi RE, Zhou C. A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy. PLoS One. 2015; 10(9):e0137236. PMID: 26348211; PMCID: PMC4565115.
  26. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015 Sep 22; 54(37):5781. PMID: 26348101.
    View in: PubMed
  27. Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG. Massachusetts Alzheimer's Disease Research Center: progress and challenges. Alzheimers Dement. 2015 Oct; 11(10):1241-5. PMID: 26297855; PMCID: PMC4654956 [Available on 10/01/16].
  28. Park S, Lee S, Lee Y, Herold C, Hooli B, Mullin K, Park T, Park C, Bertram L, Lange C, Tanzi R, Won S. Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. BMC Med Genet. 2015 Aug 19; 16:62. PMID: 26286599; PMCID: PMC4593209.
  29. D'Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY. Alzheimer's in 3D culture: challenges and perspectives. Bioessays. 2015 Oct; 37(10):1139-48. PMID: 26252541; PMCID: PMC4674791.
  30. Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aß generation. Mol Neurodegener. 2015 Jul 23; 10:31. PMID: 26202512; PMCID: PMC4511450.
  31. Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9734-9. PMID: 26199414; PMCID: PMC4534214.
  32. Tanzi RE. TREM2 and Risk of Alzheimer's Disease--Friend or Foe? N Engl J Med. 2015 Jun 25; 372(26):2564-5. PMID: 26107057.
    View in: PubMed
  33. Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. A 3D human neural cell culture system for modeling Alzheimer's disease. Nat Protoc. 2015 Jul; 10(7):985-1006. PMID: 26068894; PMCID: PMC4499058.
  34. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015 May 12; 54(18):2806-16. PMID: 25910068; PMCID: PMC4521409.
  35. D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. ?-Secretase modulators reduce endogenous amyloid ß42 levels in human neural progenitor cells without altering neuronal differentiation. FASEB J. 2015 Aug; 29(8):3335-41. PMID: 25903103; PMCID: PMC4511200.
  36. Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature. 2015 Apr 02; 520(7545):E7-8. PMID: 25832413.
    View in: PubMed
  37. Suh J, Moncaster JA, Wang L, Hafeez I, Herz J, Tanzi RE, Goldstein LE, Guénette SY. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J. 2015 Jun; 29(6):2628-39. PMID: 25757569; PMCID: PMC4447227.
  38. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492; PMCID: PMC4339551.
  39. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. PMID: 25531812; PMCID: PMC4324097.
  40. Choi SH, Kim YH, D'Avanzo C, Aronson J, Tanzi RE, Kim DY. Recapitulating amyloid ß and tau pathology in human neural cell culture models: clinical implications. US Neurol. 2015; 11(2):102-105. PMID: 27019672.
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  41. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. PMID: 25285942; PMCID: PMC4374637.
  42. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. PMID: 25199842; PMCID: PMC4314944.
  43. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057; PMCID: PMC4366007.
  44. Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 2014 Oct 07; 83(15):1353-8. PMID: 25186855; PMCID: PMC4189101.
  45. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS One. 2014; 9(5):e96752. PMID: 24796537; PMCID: PMC4010504.
  46. Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons. J Neurosci. 2014 Mar 05; 34(10):3668-73. PMID: 24599465; PMCID: PMC3942582.
  47. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146; PMCID: PMC3929337.
  48. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014 Jan 20; 4:3766. PMID: 24441878; PMCID: PMC3895908.
  49. Bertram L, Parrado AR, Tanzi RE. TREM2 and neurodegenerative disease. N Engl J Med. 2013 Oct 17; 369(16):1565. PMID: 24131185.
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  50. Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate ß-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013 Oct 16; 80(2):385-401. PMID: 24055016; PMCID: PMC4105199.
  51. Xie Z, McAuliffe S, Swain CA, Ward SA, Crosby CA, Zheng H, Sherman J, Dong Y, Zhang Y, Sunder N, Burke D, Washicosky KJ, Tanzi RE, Marcantonio ER. Cerebrospinal fluid aß to tau ratio and postoperative cognitive change. Ann Surg. 2013 Aug; 258(2):364-9. PMID: 23732272; PMCID: PMC3880113.
  52. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
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  53. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24; 340(6135):924-f. PMID: 23704555.
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  54. Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Ubiquilin-1 modulates ?-secretase-mediated e-site cleavage in neuronal cells. Biochemistry. 2013 Jun 04; 52(22):3899-912. PMID: 23663107.
    View in: PubMed
  55. Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Hum Mol Genet. 2013 Sep 15; 22(18):3798-806. PMID: 23696452; PMCID: PMC3749865.
  56. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013 May 22; 78(4):631-43. PMID: 23623698; PMCID: PMC3706457.
  57. Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KM, Tanzi RE, Soininen H, Hiltunen M. Targeting ubiquilin-1 in Alzheimer's disease. Expert Opin Ther Targets. 2013 Jul; 17(7):795-810. PMID: 23600477.
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  58. Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis. 2013; 37(1):217-32. PMID: 23970038.
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  59. Tanzi RE. A brief history of Alzheimer's disease gene discovery. J Alzheimers Dis. 2013; 33 Suppl 1:S5-13. PMID: 22986781.
    View in: PubMed
  60. Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec; 44(12):1349-54. PMID: 23143602; PMCID: PMC3510344.
  61. Wagner SL, Tanzi RE, Mobley WC, Galasko D. Potential use of ?-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. PMID: 22801784; PMCID: PMC3747667.
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  78. Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aß oligomerization. PLoS One. 2011; 6(11):e27019. PMID: 22069482; PMCID: PMC3206055.
  79. Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S. Functional links between Aß toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science. 2011 Dec 02; 334(6060):1241-5. PMID: 22033521; PMCID: PMC3281757.
  80. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63. PMID: 21666433; PMCID: PMC3432861.
  81. Haapasalo A, Viswanathan J, Kurkinen KM, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Commun Integr Biol. 2011 Jul; 4(4):428-32. PMID: 21966562; PMCID: PMC3181512.
  82. Li A, Zhou C, Moore J, Zhang P, Tsai TH, Lee HC, Romano DM, McKee ML, Schoenfeld DA, Serra MJ, Raygor K, Cantiello HF, Fujimoto JG, Tanzi RE. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res. 2011 May; 8(3):313-22. PMID: 21524270.
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  83. Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol. 2011 Jun; 31(11):2326-40. PMID: 21464208; PMCID: PMC3133236.
  84. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841; PMCID: PMC3090745.
  85. Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim CA, Bertram L. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry. 2011 Feb; 68(2):207-13. PMID: 21300948.
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  87. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78. PMID: 21190757; PMCID: PMC3117127.
  88. Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17; 30(46):15677-85. PMID: 21084623; PMCID: PMC3104400.
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  90. Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010 Sep 29; 30(39):13110-5. PMID: 20881129; PMCID: PMC3274732.
  91. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI. Iron-export ferroxidase activity of ß-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010 Sep 17; 142(6):857-67. PMID: 20817278; PMCID: PMC2943017.
  92. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. PMID: 20826309; PMCID: PMC2947312.
  93. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010 Sep 10; 285(37):28472-80. PMID: 20622013; PMCID: PMC2937872.
  94. Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ. Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2011 Jan; 31(1):351-61. PMID: 20588316; PMCID: PMC3049498.
  95. Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. PLoS One. 2010 May 20; 5(5):e10659. PMID: 20502642; PMCID: PMC2873949.
  96. Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. J Neurochem. 2010 Jul; 114(1):160-70. PMID: 20374429.
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  99. Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010 Mar 16; 121(10):1216-26. PMID: 20194882; PMCID: PMC2844798.
  100. Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. Biochem Soc Trans. 2010 Feb; 38(Pt 1):150-5. PMID: 20074050.
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  102. Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem. 2010 Mar 19; 285(12):8515-26. PMID: 20097758; PMCID: PMC2838273.
  103. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415; PMCID: PMC3272776.
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  105. Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis. 2010; 22(1):247-55. PMID: 20847397; PMCID: PMC2964875.
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  109. Won S, Bertram L, Becker D, Tanzi RE, Lange C. Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Stat Biosci. 2009 Nov; 1(2):125-143. PMID: 22582089.
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  111. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. PMID: 19608551; PMCID: PMC2748890.
  112. Hooli BV, Tanzi RE. A current view of Alzheimer's disease. F1000 Biol Rep. 2009 Jul 08; 1:54. PMID: 20948630; PMCID: PMC2948255.
  113. Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C. Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Dec; 17(12):1676-82. PMID: 19491930; PMCID: PMC2796342.
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  115. Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch Neurol. 2009 Feb; 66(2):250-4. PMID: 19204163; PMCID: PMC2841135.
  116. Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cell Signal. 2009 Apr; 21(4):567-76. PMID: 19154786; PMCID: PMC3701301.
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  118. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075; PMCID: PMC2612087.
  119. Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M. GENETICS. The Human Variome Project. Science. 2008 Nov 07; 322(5903):861-2. PMID: 18988827; PMCID: PMC2810956.
  120. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. PMID: 18976728; PMCID: PMC2668052.
  121. Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. J Mol Neurosci. 2009 May; 38(1):19-30. PMID: 18953672.
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  122. Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 2009 Feb; 10(1):19-25. PMID: 18830724; PMCID: PMC2841132.
  123. Bertram L, Tanzi RE. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci. 2008 Oct; 9(10):768-78. PMID: 18802446.
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  124. Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch Neurol. 2008 Oct; 65(10):1368-74. PMID: 18852354; PMCID: PMC2841136.
  125. Lee IH, Culley DJ, Baxter MG, Xie Z, Tanzi RE, Crosby G. Spatial memory is intact in aged rats after propofol anesthesia. Anesth Analg. 2008 Oct; 107(4):1211-5. PMID: 18806029.
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  126. Kavvoura FK, McQueen MB, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JP. Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Am J Epidemiol. 2008 Oct 15; 168(8):855-65. PMID: 18779388; PMCID: PMC3695656.
  127. Tanzi RE, Bertram L. Alzheimer's disease: The latest suspect. Nature. 2008 Aug 07; 454(7205):706-8. PMID: 18685694.
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  128. Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, Deleva K, Lynch T, Kok G, Ritchie CW, Tanzi RE, Cappai R, Masters CL, Barnham KJ, Bush AI. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 2008 Jul 10; 59(1):43-55. PMID: 18614028.
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  129. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008 Jul; 40(7):827-34. PMID: 18583979.
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  130. Tanzi RE. Novel therapeutics for Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):377-80. PMID: 18625448; PMCID: PMC2699250.
  131. Bush AI, Tanzi RE. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics. 2008 Jul; 5(3):421-32. PMID: 18625454; PMCID: PMC2518205.
  132. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534; PMCID: PMC3844798.
  133. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 02; 283(18):11866-75. PMID: 18326038; PMCID: PMC2335348.
  134. Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, Tanzi RE, Stefansson K, Santangelo SL, Gusella JF, Sklar P, Wu BL, Daly MJ. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med. 2008 Feb 14; 358(7):667-75. PMID: 18184952.
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  135. Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol. 2008 Jan; 65(1):94-100. PMID: 18195145.
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  136. McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. Exploring candidate gene associations with neuropsychological performance. Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 05; 144B(8):987-91. PMID: 17579348.
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  137. Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Hum Mol Genet. 2007 Nov 15; 16(22):2703-12. PMID: 17725986.
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  138. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916; PMCID: PMC2071909.
  139. Li A, Xie Z, Dong Y, McKay KM, McKee ML, Tanzi RE. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet. 2007 Nov 01; 16(21):2626-39. PMID: 17704509.
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  140. Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Sep 21; 282(38):28285-95. PMID: 17684015.
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  141. Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 2007 Jun 07; 54(5):721-37. PMID: 17553422; PMCID: PMC1973166.
  142. Blacker D, Lee H, Muzikansky A, Martin EC, Tanzi R, McArdle JJ, Moss M, Albert M. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol. 2007 Jun; 64(6):862-71. PMID: 17562935.
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  143. Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M. Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. J Med Genet. 2007 Sep; 44(9):606-8. PMID: 17496198; PMCID: PMC2597950.
  144. Perry RT, Wiener H, Harrell LE, Blacker D, Tanzi RE, Bertram L, Bassett SS, Go RC. Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 05; 144B(2):220-7. PMID: 17034007.
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  145. Friedlich AL, Tanzi RE, Rogers JT. The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol Psychiatry. 2007 Mar; 12(3):222-3. PMID: 17325711.
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  146. Albert M, Blacker D, Moss MB, Tanzi R, McArdle JJ. Longitudinal change in cognitive performance among individuals with mild cognitive impairment. Neuropsychology. 2007 Mar; 21(2):158-69. PMID: 17402816.
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  147. Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu CE, Rogé B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bölte S, Feineis-Matthews S, Herbrecht E, Schmötzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Koop F, Langemeijer M, Langemeijer M, Hijmans C, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson JA, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A, Meyer KJ. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar; 39(3):319-28. PMID: 17322880; PMCID: PMC4867008.
  148. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 07; 27(6):1247-54. PMID: 17287498.
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  149. Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J Biol Chem. 2007 Mar 16; 282(11):7825-32. PMID: 17244626.
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  150. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007 Jan; 39(1):17-23. PMID: 17192785.
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  151. Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE. Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? J Med Genet. 2007 Jan; 44(1):e63. PMID: 17209133; PMCID: PMC2597918.
  152. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007 Feb 16; 282(7):4318-25. PMID: 17170108.
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  153. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6. PMID: 17234824.
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  154. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
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  155. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):71-8. PMID: 16979155.
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  156. Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE. Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet. 2006 Jul; 79(1):180-3; author reply 183-4. PMID: 16773580; PMCID: PMC1474135.
  157. Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem. 2006 Sep 08; 281(36):26400-7. PMID: 16815845.
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  158. Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid. 2006 Jun; 13(2):86-92. PMID: 16911962.
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  159. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94. PMID: 16645451.
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  160. Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. 2006 Apr; 41(4):346-59. PMID: 16564662.
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  161. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51. PMID: 16503166.
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  162. Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiol Aging. 2007 Jan; 28(1):18.e1-4. PMID: 16378661.
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  163. Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. J Med Genet. 2005 Nov; 42(11):857-62. PMID: 16272261; PMCID: PMC1735943.
  164. Tanzi RE. Tangles and neurodegenerative disease--a surprising twist. N Engl J Med. 2005 Oct 27; 353(17):1853-5. PMID: 16251544.
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  165. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005 Aug 09; 65(3):404-11. PMID: 16087905; PMCID: PMC4335677.
  166. Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem. 2005 Oct; 95(2):446-56. PMID: 16086682.
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  167. Tanzi RE. The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci. 2005 Aug; 8(8):977-9. PMID: 16047022.
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  168. Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. J Biol Chem. 2005 Sep 16; 280(37):32499-504. PMID: 16033761.
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  169. Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Mol Psychiatry. 2005 Jun; 10(6):522-4. PMID: 15768051.
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  170. Bertram L, Tanzi RE. The genetic epidemiology of neurodegenerative disease. J Clin Invest. 2005 Jun; 115(6):1449-57. PMID: 15931380; PMCID: PMC1137006.
  171. Moir RD, Tanzi RE. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Curr Alzheimer Res. 2005 Apr; 2(2):269-73. PMID: 15974929.
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  172. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94. PMID: 15745979.
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  173. Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell. 2005 Feb 25; 120(4):545-55. PMID: 15734686.
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  174. Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. J Biol Chem. 2005 Apr 29; 280(17):17458-63. PMID: 15728175.
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  175. Xie Z, Romano DM, Tanzi RE. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem. 2005 Apr 15; 280(15):15413-21. PMID: 15699037.
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  176. Xie Z, Romano DM, Tanzi RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. J Mol Neurosci. 2005; 25(1):67-77. PMID: 15781968.
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  177. Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem. 2004 Dec; 9(8):954-60. PMID: 15578276.
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  178. Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1641-9. PMID: 15582280.
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  179. Bertram L, Tanzi RE. The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacol Res. 2004 Oct; 50(4):385-96. PMID: 15304236.
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  180. Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 2004 Sep 02; 43(5):605-8. PMID: 15339642.
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  181. Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem. 2004 Aug 13; 279(33):34130-7. PMID: 15184387.
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  182. Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. J Med Genet. 2004 Apr; 41(4):286-8. PMID: 15060104; PMCID: PMC1735718.
  183. Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol. 2004 Apr; 164(4):1425-34. PMID: 15039230; PMCID: PMC1615329.
  184. Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci. 2004 Mar; 1012:153-63. PMID: 15105262.
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  185. Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too many genes? Hum Mol Genet. 2004 Apr 01; 13 Spec No 1:R135-41. PMID: 14764623.
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  186. Bertram L, Menon R, Mullin K, Parkinson M, Bradley ML, Blacker D, Tanzi RE. PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology. 2004 Jan 27; 62(2):304-6. PMID: 14745076.
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  187. Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. J Biol Chem. 2004 Apr 09; 279(15):14673-8. PMID: 14724276.
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  188. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis. 2004; 1(1):29-37. PMID: 16908971.
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  189. Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, Davis S, Beyreuther K, Tanzi RE, Masters CL. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol. 2003 Dec; 60(12):1685-91. PMID: 14676042.
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  190. Saunders AJ, Tanzi RE. Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease. Exp Neurol. 2003 Nov; 184(1):50-3. PMID: 14637079.
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  191. Chang Y, Tesco G, Jeong WJ, Lindsley L, Eckman EA, Eckman CB, Tanzi RE, Guénette SY. Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. J Biol Chem. 2003 Dec 19; 278(51):51100-7. PMID: 14527950.
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  192. Bush AI, Masters CL, Tanzi RE. Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11193-4. PMID: 14506299; PMCID: PMC208731.
  193. Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet. 2003 Nov 01; 12(21):2765-76. PMID: 12966032.
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  194. Tesco G, Koh YH, Tanzi RE. Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). J Biol Chem. 2003 Nov 14; 278(46):46074-80. PMID: 12960154.
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  195. Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RC, Blacker D, Tanzi RE. No association between marker D10S1423 and Alzheimer's disease. Mol Psychiatry. 2003 Jun; 8(6):571-3. PMID: 12851634.
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  196. Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet. 2003 Apr 12; 361(9365):1258-65. PMID: 12699953.
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  197. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci. 2003 Apr; 6(4):345-51. PMID: 12658281.
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  198. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4162-7. PMID: 12634421; PMCID: PMC153065.
  199. Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, Folstein MF, McInnis MG, Bassett SS, Doheny KJ, Pugh EW, Tanzi RE. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet. 2003 Jan 01; 12(1):23-32. PMID: 12490529.
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  200. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002 Nov 22; 277(47):45518-28. PMID: 12198135.
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  201. Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem. 2002 Oct 25; 277(43):40302-8. PMID: 12192006.
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  202. Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, Gullans SR. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):77-82. PMID: 12212798.
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  203. Goto JJ, Tanzi RE. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):37-41. PMID: 12212791.
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  204. Guénette SY, Chang Y, Hyman BT, Tanzi RE, Rebeck GW. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem. 2002 Aug; 82(4):755-62. PMID: 12358780.
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  205. Bush AI, Tanzi RE. The galvanization of beta-amyloid in Alzheimer's disease. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7317-9. PMID: 12032279; PMCID: PMC124227.
  206. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002 Apr 23; 58(8):1188-96. PMID: 11971085.
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  207. Tanzi RE, Bertram L. New frontiers in Alzheimer's disease genetics. Neuron. 2001 Oct 25; 32(2):181-4. PMID: 11683989.
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  208. Bertram L, Tanzi RE. Dancing in the dark? The status of late-onset Alzheimer's disease genetics. J Mol Neurosci. 2001 Oct; 17(2):127-36. PMID: 11816786.
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  209. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12. PMID: 11584272.
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  210. Bertram L, Tanzi RE. Of replications and refutations: the status of Alzheimer's disease genetic research. Curr Neurol Neurosci Rep. 2001 Sep; 1(5):442-50. PMID: 11898555.
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  211. Albert MS, Moss MB, Tanzi R, Jones K. Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc. 2001 Jul; 7(5):631-9. PMID: 11459114.
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  212. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 2001 Jun; 30(3):665-76. PMID: 11430801.
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  213. Kim JW, Chang TS, Lee JE, Huh SH, Yeon SW, Yang WS, Joe CO, Mook-Jung I, Tanzi RE, Kim TW, Choi EJ. Negative regulation of the SAPK/JNK signaling pathway by presenilin 1. J Cell Biol. 2001 Apr 30; 153(3):457-63. PMID: 11331298; PMCID: PMC2190568.
  214. Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet. 2001 Apr 15; 10(9):919-26. PMID: 11309365.
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  215. Rebeck GW, Moir RD, Mui S, Strickland DK, Tanzi RE, Hyman BT. Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Res Mol Brain Res. 2001 Mar 05; 87(2):238-45. PMID: 11245926.
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  216. Bertram L, Guénette S, Jones J, Keeney D, Mullin K, Crystal A, Basu S, Yhu S, Deng A, Rebeck GW, Hyman BT, Go R, McInnis M, Blacker D, Tanzi R. No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease. Ann Neurol. 2001 Jan; 49(1):114-6. PMID: 11198280.
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  217. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 2000 Dec 22; 290(5500):2302-3. PMID: 11125142.
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  218. Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci Lett. 2000 Dec 15; 296(1):17-20. PMID: 11099823.
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  219. Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC. Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet. 2000 Dec 04; 96(6):823-30. PMID: 11121190.
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  220. Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med. 2000 Dec; 6(12):1380-7. PMID: 11100124.
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  221. Bertram L, Blacker D, Crystal A, Mullin K, Keeney D, Jones J, Basu S, Yhu S, Guénette S, McInnis M, Go R, Tanzi R. Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies. Exp Gerontol. 2000 Dec; 35(9-10):1353-61. PMID: 11113613.
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  222. Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Neurosci Lett. 2000 Nov 24; 294(3):135-8. PMID: 11072133.
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  223. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem. 2000 Sep 08; 275(36):27901-8. PMID: 10846187.
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  224. Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 2000 Sep; 27(3):561-72. PMID: 11055438.
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  225. Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J Neurochem. 2000 Sep; 75(3):1219-33. PMID: 10936205.
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  226. Tanzi RE. Alzheimer's disease and related dementias: the road to intervention. Exp Gerontol. 2000 Jul; 35(4):433-7. PMID: 10959030.
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  227. Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 2000 Jun 20; 39(24):7266-75. PMID: 10852726.
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  228. Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. Copper catalyzed oxidation of Alzheimer Abeta. Cell Mol Biol (Noisy-le-grand). 2000 Jun; 46(4):777-83. PMID: 10875439.
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  229. Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun; 130(2-3):209-16. PMID: 10940226.
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  230. Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem. 2000 May 12; 275(19):14440-5. PMID: 10748169.
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  231. Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI. Alzheimer's disease, beta-amyloid protein and zinc. J Nutr. 2000 May; 130(5S Suppl):1488S-92S. PMID: 10801964.
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  232. Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol. 2000 Apr; 47(4):430-9. PMID: 10762153.
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  233. Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000 Mar 10; 275(10):7410-5. PMID: 10702315.
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  234. Tanzi RE. Alzheimer's disease risk and the interleukin-1 genes. Ann Neurol. 2000 Mar; 47(3):283-5. PMID: 10716246.
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  235. Abbenante G, Kovacs DM, Leung DL, Craik DJ, Tanzi RE, Fairlie DP. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochem Biophys Res Commun. 2000 Feb 05; 268(1):133-5. PMID: 10652226.
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  236. Ingano LA, Lentini KM, Kovacs I, Tanzi RE, Kovacs DM. Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Ann N Y Acad Sci. 2000; 920:259-60. PMID: 11193161.
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  237. Cuajungco MP, Fagét KY, Huang X, Tanzi RE, Bush AI. Metal chelation as a potential therapy for Alzheimer's disease. Ann N Y Acad Sci. 2000; 920:292-304. PMID: 11193167.
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  238. Tesco G, Tanzi RE. GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations. Ann N Y Acad Sci. 2000; 920:227-32. PMID: 11193155.
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  239. Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, Bowden EF, Masters CL, Fairlie DP, Tanzi RE, Bush AI. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999 Dec 24; 274(52):37111-6. PMID: 10601271.
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  240. Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J Neurochem. 1999 Dec; 73(6):2278-85. PMID: 10582585.
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  241. Tanzi RE. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. J Clin Invest. 1999 Nov; 104(9):1175-9. PMID: 10545516; PMCID: PMC409831.
  242. Guénette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE. hFE65L influences amyloid precursor protein maturation and secretion. J Neurochem. 1999 Sep; 73(3):985-93. PMID: 10461887.
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  243. Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem. 1999 Aug 13; 274(33):23223-8. PMID: 10438495.
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  244. Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. Eur J Clin Invest. 1999 Jul; 29(7):569-70. PMID: 10411660.
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  245. Tanzi RE. Caspases land on APP: one small step for apoptosis, one giant leap for amyloidosis? Nat Neurosci. 1999 Jul; 2(7):585-6. PMID: 10404170.
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  246. Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 1999 Jun 15; 38(24):7609-16. PMID: 10386999.
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  247. Moir RD, Atwood CS, Romano DM, Laurans MH, Huang X, Bush AI, Smith JD, Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry. 1999 Apr 06; 38(14):4595-603. PMID: 10194381.
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  248. Guénette SY, Tanzi RE. Progress toward valid transgenic mouse models for Alzheimer's disease. Neurobiol Aging. 1999 Mar-Apr; 20(2):201-11. PMID: 10537029.
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  249. Pesce C, Pate G, Valente S, Tanzi R. Focal malakoplakia in chronic periapical periodontitis. Histopathology. 1999 Feb; 34(2):140-3. PMID: 10064393.
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  250. Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Met Ions Biol Syst. 1999; 36:309-64. PMID: 10093929.
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  251. Cuajungco MP, Lees GJ, Kydd RR, Tanzi RE, Bush AI. Zinc and Alzheimer's Disease: An Update. Nutr Neurosci. 1999; 2(4):191-208. PMID: 27415572.
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  252. Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem. 1998 Dec 18; 273(51):33909-14. PMID: 9852041.
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  253. Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, Staehelin H, Growdon JH, Tanzi RE, Hyman BT. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum Mol Genet. 1998 Nov; 7(12):1953-6. PMID: 9811940.
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  254. Tanzi RE. Of calcium, caspases, and cognitive decline. Nat Med. 1998 Oct; 4(10):1127-8. PMID: 9771743.
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  255. Kim TW, Tanzi RE. Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout? Neuron. 1998 Oct; 21(4):657-9. PMID: 9808451.
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  256. Bush AI, Tanzi RE. Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? Arch Neurol. 1998 Sep; 55(9):1179-80. PMID: 9740110.
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  257. Kovacs DM, Tanzi RE. Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cell Mol Life Sci. 1998 Sep; 54(9):902-9. PMID: 9791532.
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  258. McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res. 1998 Aug 31; 804(1):45-51. PMID: 9729270.
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  259. Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RC, Perry R, Watson B, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet. 1998 Aug; 19(4):357-60. PMID: 9697696.
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  260. Etcheberrigaray R, Hirashima N, Nee L, Prince J, Govoni S, Racchi M, Tanzi RE, Alkon DL. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiol Dis. 1998 Jul; 5(1):37-45. PMID: 9702786.
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  261. Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23. PMID: 9667772.
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  262. Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 1998 May 22; 273(21):12817-26. PMID: 9582309.
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  263. Blacker D, Tanzi RE. The genetics of Alzheimer disease: current status and future prospects. Arch Neurol. 1998 Mar; 55(3):294-6. PMID: 9520001.
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  264. Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. J Biol Chem. 1998 Feb 27; 273(9):5013-9. PMID: 9478949.
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  265. Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annu Rev Genet. 1998; 32:461-93. PMID: 9928488.
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  266. Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. Eur Neurol. 1998; 39(2):111-8. PMID: 9520072.
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  267. Finch CE, Tanzi RE. Genetics of aging. Science. 1997 Oct 17; 278(5337):407-11. PMID: 9334291.
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  268. Huang X, Atwood CS, Moir RD, Hartshorn MA, Vonsattel JP, Tanzi RE, Bush AI. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. J Biol Chem. 1997 Oct 17; 272(42):26464-70. PMID: 9334223.
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  269. Kim TW, Tanzi RE. Presenilins and Alzheimer's disease. Curr Opin Neurobiol. 1997 Oct; 7(5):683-8. PMID: 9384549.
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  270. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 1997 Jul 18; 277(5324):373-6. PMID: 9219695.
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  271. Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE. A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol. 1997 Jun; 41(6):809-13. PMID: 9189043.
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  272. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5090-4. PMID: 9144195; PMCID: PMC24636.
  273. Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J Biol Chem. 1997 Apr 25; 272(17):11006-10. PMID: 9110991.
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  274. Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 1997 Apr 15; 36(15):4643-9. PMID: 9109675.
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  275. Pesce C, Rossi R, Lenti E, Tanzi R. G-cell density in the antral mucosa: a feasibility study. Histopathology. 1997 Apr; 30(4):315-8. PMID: 9147077.
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  276. Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4. PMID: 8990127.
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  277. Blacker D, Haines JL, Rodes L, Terwedow H, Go RC, Harrell LE, Perry RT, Bassett SS, Chase G, Meyers D, Albert MS, Tanzi R. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology. 1997 Jan; 48(1):139-47. PMID: 9008509.
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  278. Page K, Hollister R, Tanzi RE, Hyman BT. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14020-4. PMID: 8943053; PMCID: PMC19487.
  279. Guénette SY, Chen J, Jondro PD, Tanzi RE. Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10832-7. PMID: 8855266; PMCID: PMC38241.
  280. Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM, Doms RW. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9223-8. PMID: 8799182; PMCID: PMC38623.
  281. Irizarry MC, Kim TW, McNamara M, Tanzi RE, George JM, Clayton DF, Hyman BT. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol. 1996 Aug; 55(8):889-95. PMID: 8759778.
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  282. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996 Aug; 2(8):864-70. PMID: 8705854.
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  283. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996 Feb; 2(2):224-9. PMID: 8574969.
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  284. Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 1996; 3(3):159-68. PMID: 8980016.
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  285. Tanzi RE. Neuropathology in the Down's syndrome brain. Nat Med. 1996 Jan; 2(1):31-2. PMID: 8564833.
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  286. Hyman BT, Tanzi R. Molecular epidemiology of Alzheimer's disease. N Engl J Med. 1995 Nov 09; 333(19):1283-4. PMID: 7566008.
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  287. Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet. 1995 Sep; 4(9):1527-33. PMID: 8541835.
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  288. Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J. 1995 Aug 15; 310 ( Pt 1):95-9. PMID: 7646477; PMCID: PMC1135859.
  289. Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res. 1995 Aug; 32(1):36-44. PMID: 7494461.
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  290. Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 1995 Jul 28; 82(2):331-40. PMID: 7543026.
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  291. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE, Tanzi RE, et al. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology. 1995 Jul; 45(7):1323-8. PMID: 7617191.
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  292. Bush AI, Moir RD, Rosenkranz KM, Tanzi RE. Response. Science. 1995 Jun 30; 268(5219):1921-3. PMID: 17797535.
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  293. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995 Jun 29; 375(6534):754-60. PMID: 7596406.
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  294. Tanzi RE. A promising animal model of Alzheimer's disease. N Engl J Med. 1995 Jun 01; 332(22):1512-3. PMID: 7739692.
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  295. Locke PA, Conneally PM, Tanzi RE, Gusella JF, Haines JL. Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genet Epidemiol. 1995; 12(1):83-92. PMID: 7713402.
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  296. Gregor P, Gaston SM, Yang X, O'Regan JP, Rosen DR, Tanzi RE, Patterson D, Haines JL, Horvitz HR, Uhl GR, et al. Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Hum Genet. 1994 Nov; 94(5):565-70. PMID: 7959697.
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  297. Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem. 1994 Oct 28; 269(43):26618-21. PMID: 7929392.
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  298. Muramatsu Y, Yamada T, Miura M, Sakai T, Suzuki Y, Serikawa T, Tanzi RE, Matsumoto K. Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats. Gastroenterology. 1994 Oct; 107(4):1189-92. PMID: 7926469.
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  299. Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science. 1994 Sep 02; 265(5177):1464-7. PMID: 8073293.
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  300. Cai X, Szabo P, Ali G, Tanzi RE, Blass JP. Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs. Somat Cell Mol Genet. 1994 Jul; 20(4):339-43. PMID: 7974008.
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  301. Bush AI, Pettingell WH, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. J Biol Chem. 1994 Apr 22; 269(16):12152-8. PMID: 8163520.
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  302. Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. Somat Cell Mol Genet. 1994 Mar; 20(2):99-105. PMID: 8009371.
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  303. Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS. Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem. 1994 Jan 28; 269(4):2637-44. PMID: 8300594.
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  304. Tanzi RE, Bush AI, Wasco W. Genetic studies of Alzheimer's disease: lessons learned and future imperatives. Neurobiol Aging. 1994; 15 Suppl 2:S145-8. PMID: 7700440.
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  305. Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E, Vitale E, Russo JJ, et al. Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet. 1993 Dec; 5(4):338-43. PMID: 8298640.
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  306. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM, et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet. 1993 Dec; 5(4):344-50. PMID: 8298641.
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  307. Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N, Liang Y, Mortilla M, Amaducci L, Bergamini L, Bruni AC, Foncin JF, Macciardi F, Montesi M, Sorbi S, Rainero I, Pinessi L, Polinsky RJ, Frommelt P, Duara R, Lopez R, Pollen D, Gusella JF, Tanzi R, MacLachlan D, Crapper D, St George-Hyslop PH, et al. Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology. 1993 Nov; 43(11):2275-9. PMID: 8232942.
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  308. Wasco W, Peppercorn J, Tanzi RE. Search for the genes responsible for familial Alzheimer's disease. Ann N Y Acad Sci. 1993 Sep 24; 695:203-8. PMID: 8239284.
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  309. Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet. 1993 Sep; 5(1):95-100. PMID: 8220435.
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  310. Hyman BT, Wenniger JJ, Tanzi RE. Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Res Mol Brain Res. 1993 May; 18(3):253-8. PMID: 7684484.
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  311. Tanzi RE, Wenniger JJ, Hyman BT. Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res Mol Brain Res. 1993 May; 18(3):246-52. PMID: 8497186.
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  312. Locke PA, MacDonald ME, Srinidhi J, Gilliam TC, Tanzi RE, Conneally PM, Wexler NS, Haines JL, Gusella JF. A genetic linkage map of the chromosome 4 short arm. Somat Cell Mol Genet. 1993 Jan; 19(1):95-101. PMID: 8096345.
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  313. Wasco W, Brook JD, Tanzi RE. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics. 1993 Jan; 15(1):237-9. PMID: 8432545.
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  314. Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica. 1993; 91(1-3):255-63. PMID: 8125274.
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  315. Pericak-Vance MA, St George-Hyslop PH, Gaskell PC, Growdon J, Crain BJ, Hulette C, Gusella JF, Yamaoka L, Tanzi RE, Roses AD, et al. Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets. Genet Epidemiol. 1993; 10(6):361-4. PMID: 8314027.
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  316. St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin JF, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K, Tanzi R, Tsuda T, Farrer L, Cantu JM, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet. 1992 Dec; 2(4):330-4. PMID: 1303289.
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  317. Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10758-62. PMID: 1279693; PMCID: PMC50421.
  318. Tanzi RE, Romano DM, Berger R, Buraczynska MJ, Gaston SM, Kurnit DM, Patterson D, Gusella JF, Stewart GD. Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21. Genomics. 1992 Oct; 14(2):498-502. PMID: 1427866.
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  319. Vaula G, Mortilla M, Tupler R, Lukiw W, Tanzi R, Nee L, Polinsky R, Foncin JF, Bruni AC, Montesi MP, et al. A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene. Neurosci Lett. 1992 Sep 14; 144(1-2):46-8. PMID: 1436713.
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  320. Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ, et al. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet. 1992 Aug; 51(2):273-82. PMID: 1642228; PMCID: PMC1682666.
  321. Fidani L, Rooke K, Chartier-Harlin MC, Hughes D, Tanzi R, Mullan M, Roques P, Rossor M, Hardy J, Goate A. Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile. Hum Mol Genet. 1992 Jun; 1(3):165-8. PMID: 1303172.
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  322. Tanzi RE, Watkins PC, Stewart GD, Wexler NS, Gusella JF, Haines JL. A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age. Am J Hum Genet. 1992 Mar; 50(3):551-8. PMID: 1347193; PMCID: PMC1684268.
  323. Hyman BT, Tanzi RE. Amyloid, dementia and Alzheimer's disease. Curr Opin Neurol Neurosurg. 1992 Feb; 5(1):88-93. PMID: 1623244.
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  324. Hyman BT, Tanzi RE, Marzloff K, Barbour R, Schenk D. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol. 1992 Jan; 51(1):76-83. PMID: 1740675.
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  325. Haines JL, Trofatter JA, Tanzi RE, Watkins P, Wexler NS, Conneally PM, Gusella JF. Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree. Cytogenet Cell Genet. 1992; 59(2-3):88-9. PMID: 1346592.
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  326. Tanzi RE, George-Hyslop PS, Gusella JF. Molecular genetics of Alzheimer disease amyloid. J Biol Chem. 1991 Nov 05; 266(31):20579-82. PMID: 1939107.
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  327. Tanzi RE. Genetic linkage studies of human neurodegenerative disorders. Curr Opin Neurobiol. 1991 Oct; 1(3):455-61. PMID: 1840379.
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  328. Tanzi RE. Gene mutations in inherited amyloidopathies of the nervous system. Am J Hum Genet. 1991 Sep; 49(3):507-10. PMID: 1831958; PMCID: PMC1683154.
  329. Abe K, Tanzi RE, Kogure K. Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett. 1991 Apr 29; 125(2):172-4. PMID: 1908958.
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  330. Abe K, Tanzi RE, Kogure K. Induction of HSP70 mRNA after transient ischemia in gerbil brain. Neurosci Lett. 1991 Apr 29; 125(2):166-8. PMID: 1908957.
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  331. Abe K, St George-Hyslop PH, Tanzi RE, Kogure K. Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neurosci Lett. 1991 Apr 29; 125(2):169-71. PMID: 1652710.
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  332. Tanzi RE, Hyman BT. Alzheimer's mutation. Nature. 1991 Apr 18; 350(6319):564. PMID: 1901961.
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  333. Tanzi RE, Hyman BT. Studies of amyloid beta-protein precursor expression in Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:149-54. PMID: 1776733.
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  334. Lerner TJ, Arn E, Anderson MA, Klinger KW, Callen DF, Tanzi RE. Two RFLPs detected by a cosmid at locus D16S144. Nucleic Acids Res. 1990 Aug 25; 18(16):4962. PMID: 1975678; PMCID: PMC332031.
  335. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Adv Neurol. 1990; 51:181-4. PMID: 2104687.
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  336. Tanzi RE. The Alzheimer disease-associated amyloid beta protein precursor gene and familial Alzheimer disease. Prog Clin Biol Res. 1990; 360:187-99. PMID: 2123351.
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  337. Tanzi RE, Haines JL, Gusella JF. Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex. Prog Clin Biol Res. 1990; 360:15-26. PMID: 2247506.
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  338. St George-Hyslop PH, Haines JL, Polinsky RJ, Tanzi RE, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. Can J Neurol Sci. 1989 Nov; 16(4 Suppl):465-7. PMID: 2680005.
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  339. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. Prognostic value of the immunocytochemical detection of extramural venous invasion in Dukes' C colorectal adenocarcinomas. A preliminary study. Am J Pathol. 1989 Nov; 135(5):939-45. PMID: 2817085; PMCID: PMC1880106.
  340. St George-Hyslop PH, Myers RH, Haines JL, Farrer LA, Tanzi RE, Abe K, James MF, Conneally PM, Polinsky RJ, Gusella JF. Familial Alzheimer's disease: progress and problems. Neurobiol Aging. 1989 Sep-Oct; 10(5):417-25. PMID: 2682321.
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  341. Conneally PM, Haines JL, Tanzi RE, Wexler NS, Penchaszadeh GK, Harper PS, Folstein SE, Cassiman JJ, Myers RH, Young AB, et al. Huntington disease: no evidence for locus heterogeneity. Genomics. 1989 Aug; 5(2):304-8. PMID: 2571579.
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  342. Van Keuren ML, Stewart GD, Bradley CM, Kurnit DM, Neve RL, Watkins PC, Tanzi RE, Gusella JF, Patterson D. Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes. Am J Med Genet. 1989 Jul; 33(3):369-75. PMID: 2529766.
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  343. Tanzi RE, St George-Hyslop PH, Gusella JF. Molecular genetic approaches to Alzheimer's disease. Trends Neurosci. 1989 Apr; 12(4):152-8. PMID: 2470173.
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  344. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Prog Clin Biol Res. 1989; 317:971-84. PMID: 2513588.
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  345. St George-Hyslop PH, Tanzi RE, Haines JL, Polinsky RJ, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. Eur Neurol. 1989; 29 Suppl 3:25-7. PMID: 2693103.
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  346. Tanzi RE. Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene. Ann Med. 1989; 21(2):91-4. PMID: 2504259.
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  347. Patterson D, Gardiner K, Kao FT, Tanzi R, Watkins P, Gusella JF. Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8266-70. PMID: 2973063; PMCID: PMC282410.
  348. Phelan MC, Morton CC, Stevenson RE, Tanzi RE, Stewart GD, Watkins PC, Gusella JF, Amos JA. Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. Am J Hum Genet. 1988 Oct; 43(4):511-9. PMID: 2902789; PMCID: PMC1715513.
  349. Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science. 1988 Aug 26; 241(4869):1080-4. PMID: 2457949.
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  350. Sacchi N, Cheng SV, Tanzi RE, Gusella JF, Drabkin HA, Patterson D, Haines JH, Papas TS. The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21). Genomics. 1988 Aug; 3(2):110-6. PMID: 3267212.
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  351. Cheng SV, Nadeau JH, Tanzi RE, Watkins PC, Jagadesh J, Taylor BA, Haines JL, Sacchi N, Gusella JF. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):6032-6. PMID: 2901095; PMCID: PMC281899.
  352. Tanzi RE, Haines JL, Watkins PC, Stewart GD, Wallace MR, Hallewell R, Wong C, Wexler NS, Conneally PM, Gusella JF. Genetic linkage map of human chromosome 21. Genomics. 1988 Aug; 3(2):129-36. PMID: 2906323.
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  353. Graw S, Davidson J, Gusella J, Watkins P, Tanzi R, Neve R, Patterson D. Irradiation-reduced human chromosome 21 hybrids. Somat Cell Mol Genet. 1988 May; 14(3):233-42. PMID: 3163426.
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  354. Lapertosa G, Baracchini P, Abbas S, Fulcheri E, Tanzi R, Filipe MI. Tissue evaluation of epithelial and functional markers of cell differentiation and mucins in colonic malignancy: assessment of diagnostic and prognostic value. Pathologica. 1988 Mar-Apr; 80(1066):145-57. PMID: 3226782.
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  355. Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 1988 Feb 11; 331(6156):528-30. PMID: 2893290.
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  356. Stewart GD, Hassold TJ, Berg A, Watkins P, Tanzi R, Kurnit DM. Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21. Am J Hum Genet. 1988 Feb; 42(2):227-36. PMID: 2893544; PMCID: PMC1715248.
  357. St George-Hyslop PH, Tanzi RE, Polinsky RJ, Neve RL, Pollen D, Drachman D, Growdon J, Cupples LA, Nee L, Myers RH, et al. Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science. 1987 Oct 30; 238(4827):664-6. PMID: 2890206.
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  358. Tanzi RE, Bird ED, Latt SA, Neve RL. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Science. 1987 Oct 30; 238(4827):666-9. PMID: 2890207.
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  359. Cheng SV, Gross Lugo T, Tanzi RE, Whitney JB, Fournier RE, Gusella JF. Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. DNA. 1987 Oct; 6(5):401-7. PMID: 2890502.
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  360. Lapertosa G, Baracchini P, Cordone G, Fulcheri E, Laviosa C, Provaggi MA, Rocchetti O, Sanguineti G, Tanzi R. [Use of anti-keratin antibodies in the definition of the grading of laryngeal carcinoma and the study of micro-metastases of the lymph nodes]. Acta Otorhinolaryngol Ital. 1987 Sep-Oct; 7(5):475-83. PMID: 2450444.
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  361. Tanzi RE, St George-Hyslop PH, Haines JL, Polinsky RJ, Nee L, Foncin JF, Neve RL, McClatchey AI, Conneally PM, Gusella JF. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature. 1987 Sep 10-16; 329(6135):156-7. PMID: 2888020.
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  362. Gilliam TC, Tanzi RE, Haines JL, Bonner TI, Faryniarz AG, Hobbs WJ, MacDonald ME, Cheng SV, Folstein SE, Conneally PM, et al. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell. 1987 Aug 14; 50(4):565-71. PMID: 2886227.
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  363. Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. 1987 Jun; 6(3):205-12. PMID: 2885163.
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  364. Watkins PC, Tanzi RE, Cheng SV, Gusella JF. Molecular genetics of human chromosome 21. J Med Genet. 1987 May; 24(5):257-70. PMID: 2884319; PMCID: PMC1050048.
  365. Wexler NS, Young AB, Tanzi RE, Travers H, Starosta-Rubinstein S, Penney JB, Snodgrass SR, Shoulson I, Gomez F, Ramos Arroyo MA, et al. Homozygotes for Huntington's disease. Nature. 1987 Mar 12-18; 326(6109):194-7. PMID: 2881213.
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  366. Gilliam TC, Healey ST, MacDonald ME, Stewart GD, Wasmuth JJ, Tanzi RE, Roy JC, Gusella JF. Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Res. 1987 Feb 25; 15(4):1445-58. PMID: 2881276; PMCID: PMC340560.
  367. Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science. 1987 Feb 20; 235(4791):880-4. PMID: 2949367.
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  368. St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science. 1987 Feb 20; 235(4791):885-90. PMID: 2880399.
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  369. Pesce C, Ciconi M, Tanzi R. A morphometric study of cystadenolymphoma (Warthin's tumor). Acta Otolaryngol. 1987 Jan-Feb; 103(1-2):127-30. PMID: 3564924.
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  370. St George-Hyslop P, Polinsky R, Haines J, Nee L, Tanzi R, Conneally P, Growdon J, Myers R, Pollen D, Drachman D, et al. Search for the familial Alzheimer's disease gene. J Neural Transm Suppl. 1987; 24:13-21. PMID: 2890708.
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  371. Youngman S, Sarfarazi M, Quarrell OW, Conneally PM, Gibbons K, Harper PS, Shaw DJ, Tanzi RE, Wallace MR, Gusella JF. Studies of a DNA marker (G8) genetically linked to Huntington disease in British families. Hum Genet. 1986 Aug; 73(4):333-9. PMID: 3017842.
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  372. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. O-acetylated sialic acid variants in intestinal glandular metaplasia of the urinary tract. Histopathology. 1986 Jul; 10(7):707-12. PMID: 2427432.
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  373. Gusella JA, Gilliam TC, MacDonald ME, Cheng SV, Tanzi RE. Molecular genetics of human chromosome 4. J Med Genet. 1986 Jun; 23(3):193-9. PMID: 2941587; PMCID: PMC1049626.
  374. Breakefield XO, Bressman SB, Kramer PL, Ozelius L, Moskowitz C, Tanzi R, Brin MF, Hobbs W, Kaufman D, Tobin A, et al. Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms. J Neurogenet. 1986 May; 3(3):159-75. PMID: 3016220.
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  375. Gusella JF, Gilliam TC, Tanzi RE, MacDonald ME, Cheng SV, Wallace M, Haines J, Conneally PM, Wexler NS. Molecular genetics of Huntington's disease. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:359-64. PMID: 2884064.
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  376. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. Small blood vessels or lymphatic channels with neoplastic microemboli: a comparative immunohistochemical study. Verh Dtsch Ges Pathol. 1986; 70:358-64. PMID: 3548138.
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  377. Seizinger BR, Tanzi RE, Gilliam TC, Bader JL, Parry DM, Spence MA, Marazita ML, Gibbons K, Hobbs W, Gusella JF. Genetic linkage analysis of neurofibromatosis with DNA markers. Ann N Y Acad Sci. 1986; 486:304-10. PMID: 3105395.
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  378. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. Patterns of mucous secretion in normal and pathological conditions of the endocervix. Eur J Gynaecol Oncol. 1986; 7(2):113-9. PMID: 3720781.
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  379. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. O-acylated sialic acid variants in mucinous tumours of the ovary. Virchows Arch A Pathol Anat Histopathol. 1986; 408(4):395-402. PMID: 2418579.
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  380. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. Immunohistochemical study of carcinoembryonic antigen, epithelial membrane antigen, and secretory immunoglobulin system in the large bowel adenoma-carcinoma sequence. Cancer Detect Prev. 1986; 9(5-6):469-76. PMID: 3536092.
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  381. Harper PS, Youngman S, Anderson MA, Sarfarazi M, Quarrell O, Tanzi R, Shaw D, Wallace P, Conneally PM, Gusella JF. Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families. J Med Genet. 1985 Dec; 22(6):447-50. PMID: 3001311; PMCID: PMC1049504.
  382. Giacchero A, Aste H, Baracchini P, Conio M, Fulcheri E, Lapertosa G, Tanzi R. Primary signet-ring carcinoma of the large bowel. Report of nine cases. Cancer. 1985 Dec 01; 56(11):2723-6. PMID: 2996745.
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  383. Gusella JF, Tanzi RE, Bader PI, Phelan MC, Stevenson R, Hayden MR, Hofman KJ, Faryniarz AG, Gibbons K. Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature. 1985 Nov 7-13; 318(6041):75-8. PMID: 2997623.
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  384. Stewart GD, Tanzi RE, Gusella JF. RFLPS at the D21S19 locus of human chromosome 21. Nucleic Acids Res. 1985 Oct 11; 13(19):7168. PMID: 2997741; PMCID: PMC322032.
  385. Watkins PC, Tanzi RE, Gibbons KT, Tricoli JV, Landes G, Eddy R, Shows TB, Gusella JF. Isolation of polymorphic DNA segments from human chromosome 21. Nucleic Acids Res. 1985 Sep 11; 13(17):6075-88. PMID: 4047940; PMCID: PMC321939.
  386. Kittur SD, Antonarakis SE, Tanzi RE, Meyers DA, Chakravarti A, Groner Y, Phillips JA, Watkins PC, Gusella JF, Kazazian HH. A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21. EMBO J. 1985 Sep; 4(9):2257-60. PMID: 3000767; PMCID: PMC554494.
  387. Lapertosa G, Baracchini P, Fulcheri E, Tanzi R. [The concept of the adenoma-carcinoma sequence in the colon and rectum: histochemical and immunohistochemical study]. Pathologica. 1985 Mar-Apr; 77(1048):133-44. PMID: 3909087.
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  388. Gusella JF, Tanzi RE, Watkins PC, Gibbons KT, Hobbs WJ, Faryniarz AG, Healey ST, Anderson MA. Genetic linkage map for chromosome 21. Ann N Y Acad Sci. 1985; 450:25-31. PMID: 2990310.
    View in: PubMed
  389. Gusella JF, Tanzi RE, Anderson MA, Hobbs W, Gibbons K, Raschtchian R, Gilliam TC, Wallace MR, Wexler NS, Conneally PM. DNA markers for nervous system diseases. Science. 1984 Sep 21; 225(4668):1320-6. PMID: 6089346.
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  390. Lapertosa G, Baracchini P, Chiaramondia M, Fulcheri E, Picciotto A, Tanzi R. Use of Victoria blue in the detection of intrahepatocyte HBs Ag: comparison with other methods. Basic Appl Histochem. 1984; 28(1):59-65. PMID: 6203512.
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  391. Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983 Nov 17-23; 306(5940):234-8. PMID: 6316146.
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  392. Tanzi R, Lapertosa G, Baracchini P. [Adenolymphoma cystadenolymphoma) of the salivary glands. Review of 58 cases]. Pathologica. 1982 Mar-Apr; 74(1030):207-14. PMID: 6752847.
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  393. Badini A, Tanzi R. [Lamellar osmiophilic bodies of type II alveolar cells in human and animal lung. Considerations on their origin, structure and function (author's transl)]. Pathologica. 1979 Mar-Apr; 71(1012):259-63. PMID: 224367.
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  394. Cultrera G, Tanzi R, Creatini F. Studies on parathyroid scintiphotography. Ric Clin Lab. 1976 Oct-Dec; 6(4):368-75. PMID: 1025651.
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  395. Badini A, Tanzi R. Preliminary considerations on the identity of first and second-type alveolar cells in the human lung. Pathologica. 1976 Mar-Apr; 68(977-978):123-36. PMID: 1018975.
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  396. Figari G, Tanzi R. [Pulmonary carcinoma (microcytoma) with metastases in liver angiomas (cavernomas)]. Pathologica. 1976 Mar-Apr; 68(977-978):159-62. PMID: 1018977.
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  397. Badini A, Buffa D, Micheletti V, Tanzi R. [Morphological studies using the optical and electron microscope and short histogenetic considerations on 8 cases of Wilms' tumor]. Pathologica. 1976 Mar-Apr; 68(977-978):137-51. PMID: 190577.
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  398. Cultrera G, Creatini F, Tanzi R. Studies on pancreatic scintiphotography. Ric Clin Lab. 1975 Apr-Jun; 5(2):159-68. PMID: 1228865.
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  399. Toccalino H, Sánchez de la Puente J, O'Donnell JC, Tanzi R. [Fermentative diarrhea in childhood]. Arch Argent Pediatr. 1964 Oct-Dec; 62(4):74-89. PMID: 5834692.
    View in: PubMed
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