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Anna-Liisa Brownell, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS100164 (BROWNELL, ANNA-LIISA) Sep 30, 2016 - Jun 30, 2021
    Positive Allosteric Modulators as PET Imaging Ligans for mGluR4
    Role: Principal Investigator
  2. R01EB021708 (BROWNELL, ANNA-LIISA) Jul 1, 2016 - Mar 31, 2021
    Designing group specific PET ligands for mGluR2
    Role: Principal Investigator
  3. R01EB012864 (BROWNELL, ANNA-LIISA) Apr 3, 2011 - Mar 31, 2016
    Positive allosteric modulators as PET imaging ligands for mGluR4
    Role: Principal Investigator
  4. S10RR029495 (BROWNELL, ANNA-LIISA) Jul 8, 2010 - Jan 7, 2012
    Inveon: A Triple Modality Biomedical Imaging System
    Role: Principal Investigator
  5. R01MH091684 (BROWNELL, ANNA-LIISA) Jul 1, 2010 - Jul 31, 2014
    Targeting Glial mGluR5 in Schizophrenia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin MD, Fakhri GE, Brownell AL. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Sci Rep. 2021 08 05; 11(1):15897. PMID: 34354107.
    Citations:    Fields:    
  2. Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Mol Imaging Biol. 2021 08; 23(4):527-536. PMID: 33559035.
    Citations:    Fields:    
  3. Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. J Med Chem. 2020 10 22; 63(20):12060-12072. PMID: 32981322.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Yuan G, Shoup TM, Moon SH, Brownell AL. A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes. RSC Adv. 2020 Jul 02; 10(42):25223-25227. PMID: 33014351.
    Citations: 1     
  5. Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. J Med Chem. 2020 03 26; 63(6):3381-3389. PMID: 32081008.
    Citations:    Fields:    Translation:AnimalsCells
  6. Wang J, Shoup TM, Brownell AL, Zhang Z. Improved Synthesis of the Thiophenol Precursor N-(4-Chloro-3-mercaptophenyl)picolinamide for Making the mGluR4 PET Ligand. Tetrahedron. 2019 Jul 19; 75(29):3917-3922. PMID: 32831413.
    Citations:    Fields:    
  7. Wei Q, Wang J, Akam EA, Yin D, Ge Z, Cheng T, Wang X, Brownell AL, Li R. Transition Metal-Free Intermolecular C(sp2)-H Direct Amination of Furanones via a Redox Pathway. J Org Chem. 2019 02 01; 84(3):1310-1319. PMID: 30607949.
    Citations:    Fields:    Translation:Cells
  8. Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Tanabe KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Ther. 2019 05; 26(5-6):145-156. PMID: 30420717.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Wu Z, Ma J, Brownell AL, Wang H, Li C, Meng X, Yuan L, Liu H, Li S, Xie J. Synthesis and evaluation of an N-[18F]fluorodeoxyglycosyl amino acid for PET imaging of tumor metabolism. Nucl Med Biol. 2018 11; 66:40-48. PMID: 30248568.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Poutiainen P, Jaronen M, Quintana FJ, Brownell AL. Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci. 2016; 9:85. PMID: 27695400.
    Citations: 9     
  11. Brownell AL, Kuruppu D, Kil KE, Jokivarsi K, Poutiainen P, Zhu A, Maxwell M. PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene. J Neuroinflammation. 2015 Nov 24; 12:217. PMID: 26597638.
    Citations: 7     Fields:    Translation:HumansAnimals
  12. Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration. Neuropharmacology. 2016 09; 108:462-73. PMID: 26581500.
    Citations:    Fields:    Translation:AnimalsCells
  13. Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett. 2016 Jan 01; 26(1):133-9. PMID: 26602273.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Arsenault D, Coulombe K, Zhu A, Gong C, Kil KE, Choi JK, Poutiainen P, Brownell AL. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS One. 2015; 10(11):e0142093. PMID: 26536027.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Choi JK, Zhu A, Jenkins BG, Hattori S, Kil KE, Takagi T, Ishii S, Miyakawa T, Brownell AL. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neurosci Lett. 2015 Nov 16; 609:159-64. PMID: 26483320.
    Citations: 2     Fields:    Translation:Animals
  16. Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes M, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015 Aug 13; 5:13116. PMID: 26269357.
    Citations: 18     Fields:    Translation:AnimalsCells
  17. Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. Bioorg Med Chem Lett. 2015 Sep 15; 25(18):3956-60. PMID: 26231155.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA. Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus". Circulation. 2015 Jun 16; 131(24):e531-2. PMID: 26078375.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Poutiainen P, Kil KE, Zhang Z, Kuruppu D, Tannous B, Brownell AL. Co-operative binding assay for the characterization of mGlu4 allosteric modulators. Neuropharmacology. 2015 Oct; 97:142-8. PMID: 26025660.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015 Mar 05; 16(3):269-74. PMID: 25732245.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  21. Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. J Dent Res. 2015 Feb; 94(2):320-9. PMID: 25425581.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Kil KE, Poutiainen P, Zhang Z, Zhu A, Choi JK, Jokivarsi K, Brownell AL. Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4). J Med Chem. 2014 Nov 13; 57(21):9130-8. PMID: 25330258.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Hara T, Truelove J, Tawakol A, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA. 18F-fluorodeoxyglucose positron emission tomography/computed tomography enables the detection of recurrent same-site deep vein thrombosis by illuminating recently formed, neutrophil-rich thrombus. Circulation. 2014 Sep 23; 130(13):1044-52. PMID: 25070665.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Brownell AL. Prognostic imaging of neuroblastoma. Eur J Nucl Med Mol Imaging. 2014 Jun; 41(6):1043-5. PMID: 24668276.
    Citations:    Fields:    Translation:Humans
  25. Kuruppu D, Brownell AL, Shah K, Mahmood U, Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Res. 2014 Aug 01; 74(15):4111-21. PMID: 24876106.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Ay I, Blasi F, Rietz TA, Rotile NJ, Kura S, Brownell AL, Day H, Oliveira BL, Looby RJ, Caravan P. In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe. Circ Cardiovasc Imaging. 2014 Jul; 7(4):697-705. PMID: 24777937.
    Citations: 16     Fields:    Translation:Animals
  27. Kil KE, Zhu A, Zhang Z, Choi JK, Kura S, Gong C, Brownell AL. Development of [(123)I]IPEB and [(123)I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5. ACS Med Chem Lett. 2014 Jun 12; 5(6):652-6. PMID: 24944738.
    Citations: 5     
  28. Arsenault D, Zhu A, Gong C, Kil KE, Kura S, Choi JK, Brownell AL. Hypo-anxious phenotype of adolescent offspring prenatally exposed to LPS is associated with reduced mGluR5 expression in hippocampus. Open J Med Psychol. 2014 Apr; 3(3):202-211. PMID: 25419490.
    Citations: 4     
  29. Kil KE, Zhang Z, Jokivarsi K, Gong C, Choi JK, Kura S, Brownell AL. Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4). Bioorg Med Chem. 2013 Oct 01; 21(19):5955-62. PMID: 23978356.
    Citations: 8     Fields:    Translation:Animals
  30. Chen YI, Cypess AM, Sass CA, Brownell AL, Jokivarsi KT, Kahn CR, Kwong KK. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring). 2012 Jul; 20(7):1519-26. PMID: 22343821.
    Citations: 42     Fields:    Translation:Animals
  31. Wang JQ, Zhang Z, Kuruppu D, Brownell AL. Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1958-62. PMID: 22318160.
    Citations: 5     Fields:    Translation:AnimalsCells
  32. Shoup TM, Elmaleh DR, Brownell AL, Zhu A, Guerrero JL, Fischman AJ. Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET. Mol Imaging Biol. 2011 Jun; 13(3):511-517. PMID: 20563755.
    Citations: 18     Fields:    Translation:Animals
  33. Drouin-Ouellet J, Brownell AL, Saint-Pierre M, Fasano C, Emond V, Trudeau LE, Lévesque D, Cicchetti F. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia. 2011 Feb; 59(2):188-99. PMID: 21125661.
    Citations: 29     Fields:    Translation:AnimalsCells
  34. Black YD, Xiao D, Pellegrino D, Kachroo A, Brownell AL, Schwarzschild MA. Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease. Neurosci Lett. 2010 Dec 17; 486(3):161-5. PMID: 20854878.
    Citations: 8     Fields:    Translation:Animals
  35. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51. PMID: 19501164.
    Citations: 14     Fields:    Translation:Animals
  36. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201. PMID: 19386915.
    Citations: 25     Fields:    Translation:AnimalsCells
  37. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. . 2008 Dec; 295(6):H2495-502. PMID: 18978196.
    Citations: 33     Translation:Animals
  38. Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 01; 42(1):248-51. PMID: 18501638.
    Citations: 18     Fields:    Translation:AnimalsCells
  39. Wang JQ, Tueckmantel W, Zhu A, Pellegrino D, Brownell AL. Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5. Synapse. 2007 Dec; 61(12):951-61. PMID: 17787003.
    Citations: 39     Fields:    Translation:Animals
  40. Pellegrino D, Cicchetti F, Wang X, Zhu A, Yu M, Saint-Pierre M, Brownell AL. Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats. J Nucl Med. 2007 Jul; 48(7):1147-53. PMID: 17574972.
    Citations: 20     Fields:    Translation:AnimalsCells
  41. Cicchetti F, Gross RE, Bulte JW, Owen M, Chen I, Saint-Pierre M, Wang X, Yu M, Brownell AL. Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism. Contrast Media Mol Imaging. 2007 May-Jun; 2(3):130-8. PMID: 17583908.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Kuruppu D, Brownell AL, Zhu A, Yu M, Wang X, Kulu Y, Fuchs BC, Kawasaki H, Tanabe KK. Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Res. 2007 Apr 01; 67(7):3295-300. PMID: 17409438.
    Citations: 17     Fields:    Translation:AnimalsCells
  43. Zhu A, Wang X, Yu M, Wang JQ, Brownell AL. Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1623-31. PMID: 17299451.
    Citations: 5     Fields:    Translation:Animals
  44. Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. Neuromolecular Med. 2007; 9(1):55-82. PMID: 17114825.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  45. Elmaleh DR, Fischman AJ, Tawakol A, Zhu A, Shoup TM, Hoffmann U, Brownell AL, Zamecnik PC. Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15992-6. PMID: 17038498.
    Citations: 10     Fields:    Translation:AnimalsCells
  46. Sánchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O. Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):251-6. PMID: 15979668.
    Citations: 3     Fields:    Translation:HumansAnimals
  47. Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. Nucl Med Biol. 2005 Aug; 32(6):631-40. PMID: 16026710.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Wang X, Sarkar A, Cicchetti F, Yu M, Zhu A, Jokivarsi K, Saint-Pierre M, Brownell AL. Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease. J Neurol Sci. 2005 Apr 15; 231(1-2):57-66. PMID: 15792822.
    Citations: 20     Fields:    Translation:AnimalsCells
  49. Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci. 2004 Oct 27; 24(43):9553-60. PMID: 15509742.
    Citations: 40     Fields:    Translation:Animals
  50. McNaught KS, Perl DP, Brownell AL, Olanow CW. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul; 56(1):149-62. PMID: 15236415.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  51. Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF. 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. J Neurochem. 2004 Jun; 89(5):1206-14. PMID: 15147513.
    Citations: 6     Fields:    Translation:Animals
  52. Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation. 2004 May 17; 1(1):6. PMID: 15285796.
    Citations: 60     Fields:    
  53. Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003 Oct; 20(2):1064-75. PMID: 14568476.
    Citations: 21     Fields:    Translation:Animals
  54. Yu M, Någren K, Chen YI, Livni E, Elmaleh D, Kozikowski A, Wang X, Jokivarsi K, Brownell AL. Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug. Life Sci. 2003 Aug 08; 73(12):1577-85. PMID: 12865097.
    Citations: 1     Fields:    Translation:Animals
  55. Sánchez-Pernaute R, Brownell AL, Isacson O. Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration. Neurotoxicology. 2002 Oct; 23(4-5):469-78. PMID: 12428719.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  56. Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E, Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci. 2002 Mar; 15(6):991-8. PMID: 11918659.
    Citations: 118     Fields:    Translation:AnimalsCells
  57. Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2344-9. PMID: 11782534.
    Citations: 268     Fields:    Translation:AnimalsCells
  58. Isacson O, van Horne C, Schumacher JM, Brownell AL. Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology. Adv Neurol. 2001; 86:447-54. PMID: 11554007.
    Citations: 2     Fields:    Translation:HumansCells
  59. Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, Brownell AG, Jengh SM, Healy KE. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem. 2000 Dec 29; 275(52):41263-72. PMID: 10998415.
    Citations: 52     Fields:    Translation:AnimalsCells
  60. Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addict Biol. 2000 Jul 01; 5(3):351-9. PMID: 20575852.
    Citations:    Fields:    
  61. Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse. 2000 Apr; 36(1):57-65. PMID: 10700026.
    Citations: 24     Fields:    Translation:Animals
  62. Chou SR, Brownell A, Ko MS, Kaplan J. Interferon-gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recognition by self-reactive NK cells. Cell Immunol. 2000 Mar 15; 200(2):88-97. PMID: 10753500.
    Citations: 1     Fields:    Translation:AnimalsCells
  63. Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6. PMID: 10549790.
    Citations: 22     Fields:    Translation:AnimalsCells
  64. Brownell AL, Jenkins BG, Isacson O. Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. Biomed Pharmacother. 1999 Apr; 53(3):131-40. PMID: 10349501.
    Citations: 6     Fields:    Translation:HumansAnimals
  65. Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Ann N Y Acad Sci. 1999; 893:214-42. PMID: 10672240.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  66. Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12. PMID: 9809556.
    Citations: 24     Fields:    Translation:AnimalsCells
  67. Brownell AL, Livni E, Galpern W, Isacson O. In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants. Ann Neurol. 1998 Mar; 43(3):387-90. PMID: 9506557.
    Citations: 17     Fields:    Translation:Animals
  68. Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3):389-98. PMID: 9339439.
    Citations: 70     Fields:    Translation:Animals
  69. Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK. Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med. 1996 Jul; 37(7):1186-92. PMID: 8965196.
    Citations: 6     Fields:    Translation:Animals
  70. Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson O. Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 1995 Feb; 64(4):1007-17. PMID: 7753372.
    Citations: 19     Fields:    Translation:Animals
  71. Tsujino S, Shanske S, Brownell AK, Haller RG, DiMauro S. Molecular genetic studies of muscle lactate dehydrogenase deficiency in white patients. Ann Neurol. 1994 Oct; 36(4):661-5. PMID: 7944300.
    Citations: 7     Fields:    Translation:HumansCells
  72. Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK. A method for labeling cells for positron emission tomography (PET) studies. J Immunol Methods. 1994 Sep 30; 175(1):79-87. PMID: 7930641.
    Citations: 10     Fields:    Translation:AnimalsCells
  73. Wüllner U, Pakzaban P, Brownell AL, Hantraye P, Burns L, Shoup T, Elmaleh D, Petto AJ, Spealman RD, Brownell GL, et al. Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT. Exp Neurol. 1994 Apr; 126(2):305-9. PMID: 7925829.
    Citations: 10     Fields:    
  74. Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL. Positron emission tomography of cocaine binding sites on the dopamine transporter. NIDA Res Monogr. 1994; 138:57-69. PMID: 7603545.
    Citations: 1     Fields:    Translation:AnimalsCells
  75. Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51. PMID: 7905836.
    Citations: 2     Fields:    Translation:Animals
  76. Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK. Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors. Cancer Res. 1993 Dec 15; 53(24):5867-71. PMID: 8261395.
    Citations: 21     Fields:    Translation:AnimalsCells
  77. Meltzer PC, Liang AY, Brownell AL, Elmaleh DR, Madras BK. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J Med Chem. 1993 Apr 02; 36(7):855-62. PMID: 8464040.
    Citations: 15     Fields:    Translation:AnimalsCells
  78. Rubin SC, Kairemo KJ, Brownell AL, Daghighian F, Federici MG, Pentlow KS, Finn RD, Lambrecht RM, Hoskins WJ, Lewis JL, et al. High-resolution positron emission tomography of human ovarian cancer in nude rats using 124I-labeled monoclonal antibodies. Gynecol Oncol. 1993 Jan; 48(1):61-7. PMID: 8423023.
    Citations: 8     Fields:    Translation:HumansAnimals
  79. Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O. Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8. PMID: 1515582.
    Citations: 15     Fields:    Translation:AnimalsCells
  80. Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O. A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplant. 1992; 1(4):313-22. PMID: 1344304.
    Citations: 4     Fields:    Translation:Animals
  81. Brownell AL, Kano M, McKinstry RC, Moskowitz MA, Rosen BR, Brownell GL. PET and MR studies of experimental focal stroke. J Comput Assist Tomogr. 1991 May-Jun; 15(3):376-80. PMID: 2026795.
    Citations:    Fields:    Translation:AnimalsCells
  82. Kallinowski F, Brownell AL, Vaupel P, Brownell GL. Combined tissue oxygen tension measurement and positron emission tomography studies on glucose utilization in oncogene-transformed cell line tumour xenografts in nude mice. Br J Radiol. 1991 Apr; 64(760):350-9. PMID: 2025776.
    Citations: 2     Fields:    Translation:AnimalsCells
  83. Yaoita H, Uehara T, Brownell AL, Rabito CA, Ahmad M, Khaw BA, Fischman AJ, Strauss HW. Localization of technetium-99m-glucarate in zones of acute cerebral injury. J Nucl Med. 1991 Feb; 32(2):272-8. PMID: 1704054.
    Citations: 14     Fields:    Translation:Animals
  84. Brownell AL, Karonen SL, Korpela H, Lindroth L, Aaltonen J, Nikkinen P, Lindgren J. A comparison of 131I-labeled antibodies, 2-deoxy-2-[18F]fluoro-D-glucose and 68Ga-EDTA in the imaging of human tumor xenografts in nude mice. Int J Rad Appl Instrum B. 1990; 17(3):281-6. PMID: 2111298.
    Citations:    Fields:    Translation:HumansAnimals
  85. Launes J, Nikkinen P, Lindroth L, Brownell AL, Liewendahl K, Iivanainen M. Brain perfusion defect size in SPECT predicts outcome in cerebral infarction. Nucl Med Commun. 1989 Dec; 10(12):891-900. PMID: 2639677.
    Citations: 3     Fields:    Translation:Humans
  86. Launes J, Nikkinen P, Lindroth L, Brownell AL, Liewendahl K, Iivanainen M. Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography. Lancet. 1988 May 28; 1(8596):1188-91. PMID: 2897007.
    Citations: 11     Fields:    Translation:HumansCells
  87. Brownell AK, Engel AG. Experimental lipid storage myopathy. A quantitative ultrastructural and biochemical study. J Neurol Sci. 1978 Jan; 35(1):31-41. PMID: 203664.
    Citations: 1     Fields:    Translation:AnimalsCells
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