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Last Name

profileNancy Louise Chamberlin, PH.D.

TitleAssociate Professor of Neurology
InstitutionBeth Israel Deaconess Medical Center
AddressBeth Israel Deaconess Medical Center
Neurology-E/CLS 711
330 Brookline Ave
Boston MA 02215
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Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01HL095491     (SAPER, CLIFFORD B)Apr 1, 2009 - May 31, 2020
Mechanisms of Arousal in Sleep Apnea
Role: Co-Principal Investigator

P50HL060292     (SAPER, CLIFFORD)Sep 1, 1998 - Aug 31, 2008
Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
Role: Co-Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Geerling JC, Yokota S, Rukhadze I, Roe D, Chamberlin NL. K├Âlliker-Fuse GABAergic and glutamatergic neurons project to distinct targets. J Comp Neurol. 2017 Jun 01; 525(8):1844-1860. PMID: 28032634.
    View in: PubMed
  2. Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 08; 125(2):333-45. PMID: 27341276; PMCID: PMC4955735 [Available on 08/01/17].
  3. Sherman D, Fuller PM, Marcus J, Yu J, Zhang P, Chamberlin NL, Saper CB, Lu J. Anatomical Location of the Mesencephalic Locomotor Region and Its Possible Role in Locomotion, Posture, Cataplexy, and Parkinsonism. Front Neurol. 2015; 6:140. PMID: 26157418; PMCID: PMC4478394.
  4. Yokota S, Kaur S, VanderHorst VG, Saper CB, Chamberlin NL. Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice. J Comp Neurol. 2015 Apr 15; 523(6):907-20. PMID: 25424719; PMCID: PMC4329052.
  5. McSharry DG, Saboisky JP, Deyoung P, Jordan AS, Trinder J, Smales E, Hess L, Chamberlin NL, Malhotra A. Physiological mechanisms of upper airway hypotonia during REM sleep. Sleep. 2014 Mar 01; 37(3):561-9. PMID: 24587579; PMCID: PMC3920322.
  6. Chamberlin NL. Brain circuitry mediating arousal from obstructive sleep apnea. Curr Opin Neurobiol. 2013 Oct; 23(5):774-9. PMID: 23810448; PMCID: PMC4259289.
  7. Kaur S, Pedersen NP, Yokota S, Hur EE, Fuller PM, Lazarus M, Chamberlin NL, Saper CB. Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal. J Neurosci. 2013 May 01; 33(18):7627-40. PMID: 23637157; PMCID: PMC3674488.
  8. Zhu B, Dong Y, Xu Z, Gompf HS, Ward SA, Xue Z, Miao C, Zhang Y, Chamberlin NL, Xie Z. Sleep disturbance induces neuroinflammation and impairment of learning and memory. Neurobiol Dis. 2012 Dec; 48(3):348-55. PMID: 22776332; PMCID: PMC3461115.
  9. Eikermann M, Grosse-Sundrup M, Zaremba S, Henry ME, Bittner EA, Hoffmann U, Chamberlin NL. Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. Anesthesiology. 2012 Jan; 116(1):35-46. PMID: 22108392; PMCID: PMC3246073.
  10. Eikermann M, Vetrivelan R, Grosse-Sundrup M, Henry ME, Hoffmann U, Yokota S, Saper CB, Chamberlin NL. The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia. Brain Res. 2011 Dec 02; 1426:30-7. PMID: 22041226; PMCID: PMC3215917.
  11. Chamberlin NL, Eikermann M. This is no humbug: anesthetic agent-induced unconsciousness and sleep are visibly different. Anesthesiology. 2010 Nov; 113(5):1007-9. PMID: 20881591.
    View in: PubMed
  12. Chamberlin NL, Ling L. The effect of intermittent hypoxia on obstructive sleep apnea: beneficial or detrimental? J Appl Physiol (1985). 2011 Jan; 110(1):9-10. PMID: 20966197.
    View in: PubMed
  13. Eikermann M, Chamberlin NL. Anesthetics and circadian regulation: "hands" or "gears" of the clock? Anesthesiology. 2010 Sep; 113(3):755-6; author reply 756-7. PMID: 20733397.
    View in: PubMed
  14. Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS, Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J. 2010 Sep; 36(3):569-76. PMID: 20032012; PMCID: PMC3496928.
  15. Chamberlin NL, Saper CB. The agony of the ecstasy: serotonin and obstructive sleep apnea. Neurology. 2009 Dec 08; 73(23):1947-8. PMID: 19955498.
    View in: PubMed
  16. Alfille PH, Merritt C, Chamberlin NL, Eikermann M. Control of perioperative muscle strength during ambulatory surgery. Curr Opin Anaesthesiol. 2009 Dec; 22(6):730-7. PMID: 19752726.
    View in: PubMed
  17. Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea. Expert Opin Ther Targets. 2009 Jul; 13(7):795-809. PMID: 19530985; PMCID: PMC2729816.
  18. Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats. Anesthesiology. 2009 Jun; 110(6):1327-34. PMID: 19417601; PMCID: PMC2727066.
  19. Branco LG, Moreira TS, Guyenet PG, Lalley PM, Kawai A, Putnam RW, Chamberlin NL, Saper CB, Gourine AV, Kanamaru M, Homma I. Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites. J Appl Physiol (1985). 2009 Apr; 106(4):1467-70. PMID: 19336680.
    View in: PubMed
  20. Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth. 2008 Sep; 101(3):344-9. PMID: 18559352; PMCID: PMC4994812.
  21. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 01; 508(4):648-62. PMID: 18383504; PMCID: PMC4924624.
  22. Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing. Anesthesiology. 2008 May; 108(5):897-906. PMID: 18431126; PMCID: PMC4939071.
  23. Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL. Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology. 2007 Oct; 107(4):621-9. PMID: 17893459; PMCID: PMC3473079.
  24. Eikermann M, Chamberlin NL, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily. Crit Care Med. 2007 Jun; 35(6):1634-5; author reply 1635. PMID: 17522551; PMCID: PMC3835763.
  25. Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep. Chest. 2007 Jun; 131(6):1702-9. PMID: 17413053; PMCID: PMC2278166.
  26. Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol. 2007 Mar 01; 579(Pt 2):515-26. PMID: 17185342; PMCID: PMC2075396.
  27. Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro. Neuroscience. 2006 Jun 30; 140(2):403-13. PMID: 16542780.
    View in: PubMed
  28. Chamberlin NL. Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing. Respir Physiol Neurobiol. 2004 Nov 15; 143(2-3):115-25. PMID: 15519549.
    View in: PubMed
  29. Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB. Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience. 2003; 119(4):913-8. PMID: 12831851.
    View in: PubMed
  30. Chamberlin NL, Bocchiaro CM, Greene RW, Feldman JL. Nicotinic excitation of rat hypoglossal motoneurons. Neuroscience. 2002; 115(3):861-70. PMID: 12435424.
    View in: PubMed
  31. Chamberlin NL, Mansour A, Watson SJ, Saper CB. Localization of mu-opioid receptors on amygdaloid projection neurons in the parabrachial nucleus of the rat. Brain Res. 1999 May 08; 827(1-2):198-204. PMID: 10320709.
    View in: PubMed
  32. Yamamura H, Malick A, Chamberlin NL, Burstein R. Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. J Neurophysiol. 1999 Feb; 81(2):479-93. PMID: 10036252.
    View in: PubMed
  33. Chamberlin NL, Saper CB. A brainstem network mediating apneic reflexes in the rat. J Neurosci. 1998 Aug 01; 18(15):6048-56. PMID: 9671689.
    View in: PubMed
  34. Chamberlin NL, Du B, de Lacalle S, Saper CB. Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS. Brain Res. 1998 May 18; 793(1-2):169-75. PMID: 9630611; PMCID: PMC4961038.
  35. Muresan V, Abramson T, Lyass A, Winter D, Porro E, Hong F, Chamberlin NL, Schnapp BJ. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Mol Biol Cell. 1998 Mar; 9(3):637-52. PMID: 9487132; PMCID: PMC25292.
  36. Chamberlin NL, Saper CB. Differential distribution of AMPA-selective glutamate receptor subunits in the parabrachial nucleus of the rat. Neuroscience. 1995 Sep; 68(2):435-43. PMID: 7477954.
    View in: PubMed
  37. Chamberlin NL, Saper CB. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J Neurosci. 1994 Nov; 14(11 Pt 1):6500-10. PMID: 7965054.
    View in: PubMed
  38. Chamberlin NL, Saper CB. Topographic organization of cardiovascular responses to electrical and glutamate microstimulation of the parabrachial nucleus in the rat. J Comp Neurol. 1992 Dec 08; 326(2):245-62. PMID: 1362207.
    View in: PubMed
  39. Chamberlin NL, Traub RD, Dingledine R. Role of EPSPs in initiation of spontaneous synchronized burst firing in rat hippocampal neurons bathed in high potassium. J Neurophysiol. 1990 Sep; 64(3):1000-8. PMID: 1977893.
    View in: PubMed
  40. Chamberlin NL, Dingledine R. Control of epileptiform burst rate by CA3 hippocampal cell afterhyperpolarizations in vitro. Brain Res. 1989 Jul 17; 492(1-2):337-46. PMID: 2752304.
    View in: PubMed
  41. Chamberlin NL, Dingledine R. GABAergic inhibition and the induction of spontaneous epileptiform activity by low chloride and high potassium in the hippocampal slice. Brain Res. 1988 Mar 29; 445(1):12-8. PMID: 3365550.
    View in: PubMed
  42. Dingledine R, Boland LM, Chamberlin NL, Kawasaki K, Kleckner NW, Traynelis SF, Verdoorn TA. Amino acid receptors and uptake systems in the mammalian central nervous system. Crit Rev Neurobiol. 1988; 4(1):1-96. PMID: 2461808.
    View in: PubMed
  43. Korn SJ, Giacchino JL, Chamberlin NL, Dingledine R. Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition. J Neurophysiol. 1987 Jan; 57(1):325-40. PMID: 3559679.
    View in: PubMed
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