Harvard Catalyst Profiles

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Thomas E. Scammell, M.D.


Univ. of Rochester, Rochester, NYBS1984Neuroscience
Univ. of Mass. Medical School, Worcester, MAMD1988Medicine
Univ. of Mass. Medical Center, Worcester, MA1990Medicine Resident
Univ. of California, San Francisco, CA1993Neurology Residency

Neurobiology of narcolepsy [login at prompt]
Available: 10/01/23, Expires: 10/31/24

Narcolepsy is a common sleep disorder caused by loss of the orexin-producing neurons in the hypothalamus. The student will perform basic science research using mouse models of narcolepsy to identify the brain circuits that give rise to sleepiness and cataplexy. Techniques may include fiber photometry to track neuronal activity and levels of neurotransmitters, optogenetics, chemogenetics, sleep recordings in mice, and anatomic studies. Prior experience in basic animal research is helpful but not necessary. The mentor (Dr. Scammell) has an office next to the lab in the Center for Life Sciences and will meet with the student at least weekly.

Does REM Sleep Influence Cataplexy?
Summer, 05/20/10 - 08/31/10
Circadian Rhythms in Mice with Genetic Ablation of the Orexin Neurons
Summer, 07/01/05 - 09/01/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01HL149630 (SAPER, CLIFFORD B) Jul 1, 2020 - Jun 30, 2025
    Mechanisms of sleep and sleep apnea
    Role: Co-Investigator
  2. U54AG062322 (JOFFE, HADINE) Jun 1, 2020 - May 31, 2025
    Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes
    Role: Co-Investigator
  3. R01NS106032 (SCAMMELL, THOMAS E) Jul 1, 2018 - Apr 30, 2022
    Mechanisms of Cataplexy
    Role: Principal Investigator
  4. P01HL095491 (SAPER, CLIFFORD B) Apr 1, 2009 - May 31, 2021
    Mechanisms of Arousal in Sleep Apnea
    Role: Co-Principal Investigator
  5. R01MH062589 (SCAMMELL, THOMAS EMERY) Aug 15, 2001 - Apr 30, 2007
    Circadian and Aminergic Regulation of Orexin Neurons
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.