Harvard Catalyst Profiles

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Patricia Donahoe, M.D.

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Mentoring
Available: 07/01/11, Expires: 06/30/20

Defining the genetic causes of Congenital Diaphragamatic Hernia using next generation sequencing, array CGH, and classical genetic linkage analysis, coupled with bioinformatic analyses and determining new therapeutics to alleviate the pulmonary hypoplasia and pulmonary hypertension responsible for the lethality of CDH

Available: 09/01/13, Expires: 08/30/20

Isolation of ovarian cancer ascitesto determine mechanisms of action of Mullerian Inhibting Substance against stem cell population. Student projects will vary depending on stage of project, student's interest. Single cell sequencing has been used to uncover the role of MIS in inhibiting primordial follicles and preserving ovary reserve for contraception and protection during chemotherapy.

Mutational Analysis of patients with Huma Ovarian Cancer for p16 and E2F1 Genes
Summer, 06/18/01 - 08/10/01
Developing statistical models for reconstructing patient haplotypes from a maximally informative set of tag SNPs
Summer, 06/01/04 - 09/01/04
Genetic Expression Profiling in Ovarian Cancer Cells Induced by Mullerian Inhibiting Substance
Summer, 06/08/15 - 08/17/15
MIS Mediated signaling in Proliferation and Apoptosisof the Normal Breast
Summer, 06/25/01 - 08/17/01
The Transformation of Human Fimbria Cells to Tumorgenic Serous Carcinoma Cells
Summer, 06/15/08 - 08/15/08
Genetic Mechanisms Underlying Lung Hypoplasia in Congenital Diaphragmatic Hernia
Summer, 05/21/09 - 08/28/09
Sialyl Acetyl Esterase: A Regulator of Humoral Immune Responses and Susceptibility to Lupus
Summer, 05/30/06 - 09/01/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01HD068250 (DONAHOE, PATRICIA K) Jul 1, 2011 - Apr 30, 2022
    NIH/NICHD
    Gene Mutation and Rescue in Human Diaphragmatic Hernia
    Role: Principal Investigator
  2. R01HD055150 (DONAHOE, PATRICIA K) Jul 10, 2006 - May 31, 2012
    NIH/NICHD
    Gene Mutation and Rescue in Human Diaphragmatic Hernia
    Role: Principal Investigator
  3. P01HD039942 (DONAHOE, PATRICIA K) Jul 5, 2001 - Mar 31, 2007
    NIH/NICHD
    COMPARATIVE GENOMICS TO CORRECT HUMAN LUNG HYPOPLASIA
    Role: Principal Investigator
  4. U54HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2016
    NIH/NICHD
    Harvard Reproductive Endocrine Sciences Center
    Role: Co-Principal Investigator
  5. R01HD032112 (DONAHOE, PATRICIA K) Aug 1, 1994 - Dec 31, 2005
    NIH/NICHD
    MIS RECEPTORS-NOVEL SERINE/THREONINE KINASE COMPONENTS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qi H, Yu L, Zhou X, Wynn J, Zhao H, Guo Y, Zhu N, Kitaygorodsky A, Hernan R, Aspelund G, Lim FY, Crombleholme T, Cusick R, Azarow K, Danko ME, Chung D, Warner BW, Mychaliska GB, Potoka D, Wagner AJ, ElFiky M, Wilson JM, Nickerson D, Bamshad M, High FA, Longoni M, Donahoe PK, Chung WK, Shen Y. De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders. PLoS Genet. 2018 12; 14(12):e1007822. PMID: 30532227.
    Citations:    Fields:    
  2. Pépin D, Sabatini ME, Donahoe PK. Müllerian inhibiting substance/anti-Müllerian hormone as a fertility preservation agent. Curr Opin Endocrinol Diabetes Obes. 2018 Dec; 25(6):399-405. PMID: 30320617.
    Citations:    Fields:    
  3. Hsu JY, James KE, Bormann CL, Donahoe PK, Pépin D, Sabatini ME. Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2018 Nov 01; 103(11):4187-4196. PMID: 30239805.
    Citations:    Fields:    
  4. Ferguson JM, Pépin D, Duru C, Matejtschuk P, Donahoe PK, Burns CJ. Towards international standardization of immunoassays for Müllerian inhibiting substance/anti-Müllerian hormone. Reprod Biomed Online. 2018 Nov; 37(5):631-640. PMID: 30241771.
    Citations:    Fields:    
  5. Whiting G, Ferguson J, Fang M, Pepin D, Donahoe P, Matejtschuk P, Burns C, Wheeler JX. Quantification of Müllerian Inhibiting Substance/Anti-Müllerian Hormone polypeptide by isotope dilution mass spectrometry. Anal Biochem. 2018 Nov 01; 560:50-55. PMID: 29742446.
    Citations:    Fields:    
  6. Zhu Q, High FA, Zhang C, Cerveira E, Russell MK, Longoni M, Joy MP, Ryan M, Mil-Homens A, Bellfy L, Coletti CM, Bhayani P, Hila R, Wilson JM, Donahoe PK, Lee C. Systematic analysis of copy number variation associated with congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5247-5252. PMID: 29712845.
    Citations:    Fields:    Translation:Humans
  7. Longoni M, High FA, Qi H, Joy MP, Hila R, Coletti CM, Wynn J, Loscertales M, Shan L, Bult CJ, Wilson JM, Shen Y, Chung WK, Donahoe PK. Genome-wide enrichment of damaging de novo variants in patients with isolated and complex congenital diaphragmatic hernia. Hum Genet. 2017 06; 136(6):679-691. PMID: 28303347.
    Citations: 3     Fields:    Translation:HumansCells
  8. Park SH, Chung YJ, Song JY, Kim SI, Pépin D, MacLaughlin DT, Donahoe PK, Kim JH. Müllerian inhibiting substance inhibits an ovarian cancer cell line via ß-catenin interacting protein deregulation of the Wnt signal pathway. Int J Oncol. 2017 Mar; 50(3):1022-1028. PMID: 28197641.
    Citations: 3     Fields:    Translation:HumansCells
  9. Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1688-E1697. PMID: 28137855.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould DB, Sun Y, Maalouf FI, Nagy N, Donahoe PK. Erratum to: Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016 Sep 01; 14(1):73. PMID: 27587011.
    Citations:    Fields:    
  11. Donahoe PK, Longoni M, High FA. Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies. Am J Pathol. 2016 10; 186(10):2532-43. PMID: 27565037.
    Citations: 4     Fields:    Translation:HumansAnimals
  12. Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould DB, Sun Y, Maalouf FI, Nagy N, Donahoe PK. Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016 07 13; 14:59. PMID: 27412481.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Beck TN, Korobeynikov VA, Kudinov AE, Georgopoulos R, Solanki NR, Andrews-Hoke M, Kistner TM, Pépin D, Donahoe PK, Nicolas E, Einarson MB, Zhou Y, Boumber Y, Proia DA, Serebriiskii IG, Golemis EA. Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer. Cell Rep. 2016 07 19; 16(3):657-71. PMID: 27396341.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. High FA, Bhayani P, Wilson JM, Bult CJ, Donahoe PK, Longoni M. De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia. Am J Med Genet A. 2016 09; 170(9):2457-61. PMID: 27363585.
    Citations: 5     Fields:    Translation:Humans
  15. Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS One. 2016; 11(6):e0156595. PMID: 27253518.
    Citations: 10     Fields:    Translation:HumansCells
  16. Sanford EL, Choy KW, Donahoe PK, Tracy AA, Hila R, Loscertales M, Longoni M. MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development. PLoS One. 2016; 11(2):e0149425. PMID: 26891231.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Basal E, Ayeni T, Zhang Q, Langstraat C, Donahoe PK, Pepin D, Yin X, Leof E, Cliby W. Patterns of Müllerian Inhibiting Substance Type II and Candidate Type I Receptors in Epithelial Ovarian Cancer. Curr Mol Med. 2016; 16(3):222-31.