Harvard Catalyst Profiles

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Patrizia Vannini, Ph.D.

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Mentoring
current student opportunities
Available: 01/10/23, Expires: 12/31/23

The outbreak of the coronavirus disease (COVID-19) pandemic, along with the global measures used to control the spread of the disease, have been particularly stressful for older adults. Robust evidence suggests that psychosocial (both acute and chronic) stress plays a significant role in the onset of age-related cognitive decline and dementia, such as Alzheimer's disease (AD). Thus, the sudden and drastic changes due to the COVID-19 pandemic may be particularly detrimental to older people and may enhance neurological aging and neurodegeneration-related processes. However, the potential impact of the current pandemic on the health of older adults is currently unknown. Understanding the mechanism linking stress to AD pathology and brain function will improve our understanding of the evolution of AD and offer new prevention strategies. This project presents a unique opportunity to examine relevant clinical data collected during the pandemic from a diverse population of older adults that are part of three natural history, non-interventional imaging studies. Interested student will be involved in quality checking the data, coming up with relevant questions, running statistical analyses and disseminating data. Statistical knowledge (R-software or equivalent) is preferred.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AG061083 (VANNINI, PATRIZIA) Aug 1, 2019 - May 31, 2024
    NIH
    Decoding neural systems underlying anosognosia for memory loss in aging and Alzheimer's disease
    Role: Principal Investigator
  2. R21AG064348 (VANNINI, PATRIZIA) Aug 1, 2019 - Apr 30, 2021
    NIH
    Novel diffusion-weighted MRI assessment of cortical microstructural changes and their relationship to amyloid, tau and cognition in aging and Alzheimer's disease.
    Role: Principal Investigator
  3. K01AG048287 (VANNINI, PATRIZIA) Sep 1, 2014 - Nov 30, 2019
    NIH
    Functional and pathological correlates of memory self-awareness in aging and AD
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vannini P. The Psychological Impact of the Coronavirus Pandemic and the Importance of Resilience. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 02; 8(2):133-134. PMID: 36754483; PMCID: PMC9900080.
    Citations:    Fields:    Translation:HumansPHPublic Health
  2. Montal V, Diez I, Kim CM, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson KA, Sperling RA, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Sci Transl Med. 2022 07 27; 14(655):eabn7273. PMID: 35895837; PMCID: PMC9942690.
    Citations: 2     Fields:    Translation:HumansCells
  3. Farrell ME, Papp KV, Buckley RF, Jacobs HIL, Schultz AP, Properzi MJ, Vannini P, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Association of Emerging ß-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022 04 12; 98(15):e1512-e1524. PMID: 35338074; PMCID: PMC9012271.
    Citations: 2     Fields:    Translation:Humans
  4. Willey B, Mimmack K, Gagliardi G, Dossett ML, Wang S, Udeogu OJ, Donovan NJ, Gatchel JR, Quiroz YT, Amariglio R, Liu CH, Hyun S, ElTohamy A, Rentz D, Sperling RA, Marshall GA, Vannini P. Racial and socioeconomic status differences in stress, posttraumatic growth, and mental health in an older adult cohort during the COVID-19 pandemic. EClinicalMedicine. 2022 Mar; 45:101343. PMID: 35291556; PMCID: PMC8917957.
    Citations: 6     
  5. Munro CE, Buckley R, Vannini P, DeMuro C, Sperling R, Rentz DM, Johnson K, Gatchel JR, Amariglio R. Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer's Disease Biomarkers and Mood Symptoms. Front Aging Neurosci. 2021; 13:806432. PMID: 35173601; PMCID: PMC8841868.
    Citations:    
  6. Gagliardi G, Vannini P. Episodic Memory Impairment Mediates the Loss of Awareness in Mild Cognitive Impairment. Front Aging Neurosci. 2021; 13:802501. PMID: 35126092; PMCID: PMC8814670.
    Citations: 2     
  7. Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz AP, Properzi MJ, Scott MR, Amariglio R, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Association of cortical microstructure with amyloid-ß and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry. 2021 12; 26(12):7813-7822. PMID: 34588623; PMCID: PMC8873001.
    Citations: 2     Fields:    Translation:Humans
  8. Cacciamani F, Houot M, Gagliardi G, Dubois B, Sikkes S, Sánchez-Benavides G, Denicolò E, Molinuevo JL, Vannini P, Epelbaum S. Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis. Front Aging Neurosci. 2021; 13:697234. PMID: 34413767; PMCID: PMC8370471.
    Citations: 6     
  9. Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. Corrigendum to "Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19" [J. Psychiatr. Res. 138 (2021) 176-185]. J Psychiatr Res. 2021 Oct; 142:167-170. PMID: 34359011.
    Citations: 1     Fields:    
  10. Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Front Hum Neurosci. 2021; 15:694274. PMID: 34381343; PMCID: PMC8350487.
    Citations: 1     
  11. Gagliardi G, Kuppe M, Lois C, Hanseeuw B, Vannini P. Pathological correlates of impaired self-awareness of memory function in Alzheimer's disease. Alzheimers Res Ther. 2021 06 25; 13(1):118. PMID: 34172086; PMCID: PMC8234669.
    Citations: 2     Fields:    Translation:Humans
  12. Mayblyum DV, Becker JA, Jacobs HIL, Buckley RF, Schultz AP, Sepulcre J, Sanchez JS, Rubinstein ZB, Katz SR, Moody KA, Vannini P, Papp KV, Rentz DM, Price JC, Sperling RA, Johnson KA, Hanseeuw BJ. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021 May 05. PMID: 33952655.
    Citations: 4     Fields:    
  13. Babulal GM, Torres VL, Acosta D, Agüero C, Aguilar-Navarro S, Amariglio R, Ussui JA, Baena A, Bocanegra Y, Brucki SMD, Bustin J, Cabrera DM, Custodio N, Diaz MM, Peñailillo LD, Franco I, Gatchel JR, Garza-Naveda AP, González Lara M, Gutiérrez-Gutiérrez L, Guzmán-Vélez E, Hanseeuw BJ, Jimenez-Velazquez IZ, Rodríguez TL, Llibre-Guerra J, Marquine MJ, Martinez J, Medina LD, Miranda-Castillo C, Morlett Paredes A, Munera D, Nuñez-Herrera A, de Oliveira MO, Palmer-Cancel SJ, Pardilla-Delgado E, Perales-Puchalt J, Pluim C, Ramirez-Gomez L, Rentz DM, Rivera-Fernández C, Rosselli M, Serrano CM, Suing-Ortega MJ, Slachevsky A, Soto-Añari M, Sperling RA, Torrente F, Thumala D, Vannini P, Vila-Castelar C, Yañez-Escalante T, Quiroz YT. The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. EClinicalMedicine. 2021 May; 35:100848. PMID: 33997742; PMCID: PMC8100067.
    Citations: 7     
  14. Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19. J Psychiatr Res. 2021 06; 138:176-185. PMID: 33862301; PMCID: PMC8369528.
    Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
  15. Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. J Cogn Neurosci. 2021 03; 33(3):499-509. PMID: 33284079; PMCID: PMC8826533.
    Citations:    Fields:    Translation:Humans
  16. Vannini P, Hanseeuw BJ, Gatchel JR, Sikkes SAM, Alzate D, Zuluaga Y, Moreno S, Mendez L, Baena A, Ospina-Lopera P, Tirado V, Henao E, Acosta-Baena N, Giraldo M, Lopera F, Quiroz YT. Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease. JAMA Netw Open. 2020 12 01; 3(12):e2027472. PMID: 33263761.
    Citations: 6     Fields:    Translation:Humans
  17. Bloniecki V, Zetterberg H, Aarsland D, Vannini P, Kvartsberg H, Winblad B, Blennow K, Freund-Levi Y. Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration? Alzheimers Res Ther. 2020 11 17; 12(1):153. PMID: 33203439.
    Citations: 5     Fields:    Translation:Humans
  18. d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 03 14; 30(3):1974-1983. PMID: 31696223.
    Citations: 4     Fields:    Translation:Humans
  19. Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d'Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, Marshall GA, Quiroz YT. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2020 03; 91(3):330-332. PMID: 31874859; PMCID: PMC7397724.
    Citations: 3     Fields:    Translation:Humans
  20. Hanseeuw BJ, Scott MR, Sikkes SAM, Properzi M, Gatchel JR, Salmon E, Marshall GA, Vannini P. Evolution of anosognosia in alzheimer's disease and its relationship to amyloid. Ann Neurol. 2020 02; 87(2):267-280. PMID: 31750553; PMCID: PMC6980336.
    Citations: 21     Fields:    Translation:Humans
  21. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations: 6     Fields:    Translation:Humans
  22. Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P, Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e198964. PMID: 31397865.
    Citations: 32     Fields:    Translation:Humans
  23. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292. PMID: 29792874.
    Citations: 51     Fields:    Translation:Humans
  24. Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. Am J Geriatr Psychiatry. 2018 08; 26(8):896-904. PMID: 29866588; PMCID: PMC6959130.
    Citations: 16     Fields:    Translation:Humans
  25. Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global ß-Amyloid Burden. JAMA Neurol. 2017 12 01; 74(12):1455-1463. PMID: 28973551; PMCID: PMC5774633.
    Citations: 67     Fields:    Translation:Humans
  26. d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018; 17:388-396. PMID: 29159051.
    Citations: 1     Fields:    Translation:Humans
  27. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. Neuroimage Clin. 2017; 15:408-414. PMID: 28616381.
    Citations: 31     Fields:    Translation:Humans
  28. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. 2017 May 02; 88(18):1759-1767. PMID: 28381517.
    Citations: 31     Fields:    Translation:Humans
  29. Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease. Neuropsychologia. 2017 05; 99:343-349. PMID: 28385579.
    Citations: 33     Fields:    Translation:Humans
  30. Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016 Dec 01; 73(12):1230-1237. PMID: 27806159; PMCID: PMC5257284.
    Citations: 63     Fields:    Translation:Humans
  31. Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JD, Sperling RA, Johnson KA, Amariglio RE. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. Int Psychogeriatr. 2017 04; 29(4):645-652. PMID: 27724996.
    Citations: 6     Fields:    Translation:Humans
  32. Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P, Johnson KA, Sperling RA, Rentz DM. Subjective cognitive concerns, amyloid-ß, and neurodegeneration in clinically normal elderly. Neurology. 2015 Jul 07; 85(1):56-62. PMID: 26048028; PMCID: PMC4501939.
    Citations: 78     Fields:    Translation:Humans
  33. Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. J Neurosci. 2014 Apr 09; 34(15):5200-10. PMID: 24719099.
    Citations: 48     Fields:    Translation:Humans
  34. Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA. The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. J Cogn Neurosci. 2013 Jul; 25(7):1163-79. PMID: 23384193.
    Citations: 27     Fields:    Translation:Humans
  35. Huijbers W, Vannini P, Sperling RA, C M P, Cabeza R, Daselaar SM. Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia. 2012 Dec; 50(14):3764-74. PMID: 22982484.
    Citations: 45     Fields:    Translation:Humans
  36. Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA. The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults. Cereb Cortex. 2013 Jun; 23(6):1317-28. PMID: 22586140.
    Citations: 20     Fields:    Translation:Humans
  37. Vannini P, Hedden T, Sullivan C, Sperling RA. Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding. Hum Brain Mapp. 2013 Jul; 34(7):1568-78. PMID: 22344847.
    Citations: 18     Fields:    Translation:Humans
  38. Vannini P, Hedden T, C.Sullivan, Sperling R.A. Human Brain Mapping. Differential Functional Response in the Posteromedial Cortices and Hippocampus to Stimulus Repetition during Successful Memory Encoding. 2012.
  39. Chaves S, Vannini P, Jann K, Wurtz P, Federspiel A, Nyffeler T, Luethi M, Hubl D, Wiest R, Dierks T, Müri RM. The link between visual exploration and neuronal activity: a multi-modal study combining eye tracking, functional magnetic resonance imaging and transcranial magnetic stimulation. Neuroimage. 2012 Feb 15; 59(4):3652-61. PMID: 22079455.
    Citations: 4     Fields:    Translation:HumansCells
  40. Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA. Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiol Aging. 2012 Jul; 33(7):1237-52. PMID: 21334099.
    Citations: 49     Fields:    Translation:Humans
  41. Vannini P, O'Brien J, O'Keefe K, Pihlajamäki M, Laviolette P, Sperling RA. What goes down must come up: role of the posteromedial cortices in encoding and retrieval. Cereb Cortex. 2011 Jan; 21(1):22-34. PMID: 20363808.
    Citations: 53     Fields:    Translation:Humans
  42. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010 Mar; 12(1):27-43. PMID: 20069392.
    Citations: 264     Fields:    Translation:HumansAnimals
  43. Vannini P, Lehmann C, Dierks T, Jann K, Viitanen M, Wahlund LO, Almkvist O. Failure to modulate neural response to increased task demand in mild Alzheimer's disease: fMRI study of visuospatial processing. Neurobiol Dis. 2008 Sep; 31(3):287-97. PMID: 18619845.
    Citations: 6     Fields:    Translation:Humans
  44. Vannini P, Almkvist O, Dierks T, Lehmann C, Wahlund LO. Reduced neuronal efficacy in progressive mild cognitive impairment: a prospective fMRI study on visuospatial processing. Psychiatry Res. 2007 Oct 15; 156(1):43-57. PMID: 17719211.
    Citations: 29     Fields:    Translation:HumansCells
  45. Vannini, P. Functional neurobiology in Normal Aging, Mild Cognitive Impairment and Alzheimer's Disease. Dissertation. 2007.
  46. Federspiel A, Volpe U, Horn H, Dierks T, Franck A, Vannini P, Wahlund LO, Galderisi S, Maj M. Motion standstill leads to activation of inferior parietal lobe. Hum Brain Mapp. 2006 Apr; 27(4):340-9. PMID: 16108019.
    Citations: 2     Fields:    Translation:Humans
  47. Lehmann C, Vannini P, Wahlund LO, Almkvist O, Dierks T. Increased sensitivity in mapping task demand in visuospatial processing using reaction-time-dependent hemodynamic response predictors in rapid event-related fMRI. Neuroimage. 2006 Jun; 31(2):505-12. PMID: 16564707.
    Citations: 5     Fields:    Translation:Humans
  48. Vannini P, Almkvist O, Franck A, Jonsson T, Volpe U, Kristoffersen Wiberg M, Wahlund LO, Dierks T. Task demand modulations of visuospatial processing measured with functional magnetic resonance imaging. Neuroimage. 2004 Jan; 21(1):58-68. PMID: 14741642.
    Citations: 8     Fields:    Translation:Humans
  49. Nyström H, Vannini P, Wahlund LO. [Functional MRI of the elderly can complete the picture of cerebral functions]. Lakartidningen. 2003 Dec 18; 100(51-52):4278-82. PMID: 14756090.
    Citations:    Fields:    Translation:Humans
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