Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Wolfgang G Junger, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD098363 (JUNGER, WOLFGANG G) Mar 20, 2019 - Feb 29, 2024
    NIH/NICHD
    Role of purinergic signaling in pediatric multi-organ failure
    Role: Principal Investigator
  2. T32GM103702 (JUNGER, WOLFGANG G) Jul 1, 2013 - Jun 30, 2018
    NIH/NIGMS
    Harvard Trauma Inflammation Training Program
    Role: Principal Investigator
  3. R01GM116162 (JUNGER, WOLFGANG G) Jun 15, 2009 - Apr 30, 2019
    NIH/NIGMS
    Autocrine regulation of neutrophil chemotaxis
    Role: Principal Investigator
  4. R01AI080582 (JUNGER, WOLFGANG G) Jun 15, 2009 - May 31, 2014
    NIH/NIAID
    Purinergic receptors in inflammation
    Role: Principal Investigator
  5. R01AI072287 (JUNGER, WOLFGANG G) May 15, 2009 - Apr 30, 2012
    NIH/NIAID
    Autocrine control of neutrophil chemotaxis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H. Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock. 2019 Jun; 51(6):698-705. PMID: 30052576.
    Citations:    Fields:    
  2. Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG. Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation. Purinergic Signal. 2019 Mar 27. PMID: 30919205.
    Citations:    
  3. Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG. Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors. J Biol Chem. 2019 Apr 19; 294(16):6283-6293. PMID: 30787105.
    Citations:    
  4. Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG. Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1ß Production, and the Host Immune Response to Infection. Crit Care Med. 2018 Dec; 46(12):e1183-e1189. PMID: 30247270.
    Citations:    Fields:    
  5. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 Aug 01; 128(8):3583-3594. PMID: 29894310.
    Citations:    Fields:    
  6. Mello PA, Bian S, Baggio Savio LE, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Jun 21. PMID: 28658673.
    Citations:    
  7. de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Sep 15; 8(40):67254-67268. PMID: 28978031.
    Citations: 3     Fields:    
  8. Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med. 2017 Jan; 45(1):e97-e104. PMID: 27548819.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Qi B, Yu T, Wang C, Wang T, Yao J, Zhang X, Deng P, Xia Y, Junger WG, Sun D. Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate. J Exp Clin Cancer Res. 2016 10 03; 35(1):161. PMID: 27716441.
    Citations:    Fields:    Translation:HumansCells
  10. Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016 12; 12(4):673-685. PMID: 27577957.
    Citations:    Fields:    Translation:HumansCells
  11. Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG. Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther. 2016 05; 38(5):1054-65. PMID: 27156007.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG. Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling? Purinergic Signal. 2016 09; 12(3):439-51. PMID: 27020575.
    Citations: 2     Fields:    Translation:HumansCells
  13. Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger WG, Robson SC. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015 Nov 09; 6:8819. PMID: 26549640.
    Citations: 12     Fields:    Translation:HumansCells
  14. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  15. Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015 Sep 28; 210(7):1153-64. PMID: 26416965.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG. Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock. 2015 Sep; 44(3):221-7. PMID: 26009814.
    Citations: 3     Fields:    Translation:HumansCells
  17. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546.
    Citations: 5     Fields:    Translation:HumansCells
  18. Delano MJ, Rizoli SB, Rhind SG, Cuschieri J, Junger W, Baker AJ, Dubick MA, Hoyt DB, Bulger EM. Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis. Shock. 2015 Jul; 44(1):25-31. PMID: 25784523.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  19. Ledderose C, Bao Y, Zhang J, Junger WG. Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation. Acta Physiol (Oxf). 2015 Feb; 213(2):334-45. PMID: 25482154.
    Citations: 3     Fields:    Translation:HumansCells
  20. Weihs AM, Fuchs C, Teuschl AH, Hartinger J, Slezak P, Mittermayr R, Redl H, Junger WG, Sitte HH, Rünzler D. Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation. J Biol Chem. 2014 Sep 26; 289(39):27090-104. PMID: 25118288.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  21. Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J Biol Chem. 2014 Sep 26; 289(39):26794-803. PMID: 25104353.
    Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
  22. Sumi Y, Woehrle T, Chen Y, Bao Y, Li X, Yao Y, Inoue Y, Tanaka H, Junger WG. Plasma ATP is required for neutrophil activation in a mouse sepsis model. Shock. 2014 Aug; 42(2):142-7. PMID: 24675414.
    Citations: 9     Fields:    Translation:Animals
  23. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. PMID: 25070895.
    Citations: 23     Fields:    Translation:HumansCells
  24. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock. 2014 Jun; 41(6):463-75. PMID: 24569509.
    Citations: 47     Fields:    Translation:HumansAnimals
  25. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM. Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury. Shock. 2013 Nov; 40(5):366-74. PMID: 24088993.
    Citations: 8     Fields:    Translation:HumansCells
  26. Tillinger W, Jilch R, Waldhoer T, Reinisch W, Junger W. Monocyte human leukocyte antigen-DR expression-a tool to distinguish intestinal bacterial infections from inflammatory bowel disease? Shock. 2013 Aug; 40(2):89-94. PMID: 23860582.
    Citations:    Fields:    Translation:HumansCells
  27. Bao Y, Chen Y, Ledderose C, Li L, Junger WG. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013 Aug 02; 288(31):22650-7. PMID: 23798685.
    Citations: 30     Fields:    Translation:HumansCells
  28. Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, Wang C, Tan L, Qi B, Zhu D, Zhang X, Yu T. Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Stem Cells. 2013 Jun; 31(6):1170-80. PMID: 23404811.
    Citations: 13     Fields:    Translation:HumansCells
  29. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9. PMID: 23349052.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One. 2013; 8(4):e60184. PMID: 23565201.
    Citations: 33     Fields:    Translation:AnimalsCells
  31. Schmelzle M, Duhme C, Junger W, Salhanick SD, Chen Y, Wu Y, Toxavidis V, Csizmadia E, Han L, Bian S, Fürst G, Nowak M, Karp SJ, Knoefel WT, Esch JSA, Robson SC. CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy. Ann Surg. 2013 Apr; 257(4):693-701. PMID: 23474584.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  32. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. PMID: 22859060.
    Citations: 19     Fields:    Translation:AnimalsCells
  33. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock. 2012 Oct; 38(4):341-50. PMID: 22777113.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  34. Manohar M, Hirsh MI, Chen Y, Woehrle T, Karande AA, Junger WG. ATP release and autocrine signaling through P2X4 receptors regulate ?d T cell activation. J Leukoc Biol. 2012 Oct; 92(4):787-94. PMID: 22753954.
    Citations: 11     Fields:    Translation:HumansCells
  35. Chen Y, Junger WG. Measurement of oxidative burst in neutrophils. Methods Mol Biol. 2012; 844:115-24. PMID: 22262438.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  36. Itagaki K, Adibnia Y, Sun S, Zhao C, Sursal T, Chen Y, Junger W, Hauser CJ. Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils. Shock. 2011 Dec; 36(6):548-52. PMID: 21937948.
    Citations: 13     Fields:    Translation:HumansCells
  37. Bulger EM, Tower CM, Warner KJ, Garland T, Cuschieri J, Rizoli S, Rhind S, Junger WG. Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients. Shock. 2011 Nov; 36(5):435-9. PMID: 21841534.
    Citations: 7     Fields:    Translation:HumansCells
  38. Junger WG. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol. 2011 Mar; 11(3):201-12. PMID: 21331080.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  39. Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh MI, Junger WG. A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation. Shock. 2011 Feb; 35(2):178-83. PMID: 20661181.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  40. Woehrle T, Yip L, Manohar M, Sumi Y, Yao Y, Chen Y, Junger WG. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol. 2010 Dec; 88(6):1181-9. PMID: 20884646.
    Citations: 33     Fields:    Translation:HumansCells
  41. Sumi Y, Woehrle T, Chen Y, Yao Y, Li A, Junger WG. Adrenergic receptor activation involves ATP release and feedback through purinergic receptors. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1118-26. PMID: 20668211.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  42. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood. 2010 Nov 04; 116(18):3475-84. PMID: 20660288.
    Citations: 91     Fields:    Translation:HumansCells
  43. Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG. Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal. 2010 Jun 08; 3(125):ra45. PMID: 20530802.
    Citations: 59     Fields:    Translation:HumansCells
  44. Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010 May; 51(5):1702-11. PMID: 20146261.
    Citations: 27     Fields:    Translation:AnimalsCells
  45. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010 Mar 04; 464(7285):104-7. PMID: 20203610.
    Citations: 781     Fields:    Translation:HumansAnimalsCells
  46. Yu T, Junger WG, Yuan C, Jin A, Zhao Y, Zheng X, Zeng Y, Liu J. Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C457-64. PMID: 19889958.
    Citations: 7     Fields:    Translation:HumansCells
  47. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009 Jun; 23(6):1685-93. PMID: 19211924.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  48. Hirsh MI, Hashiguchi N, Junger WG. Hypertonic saline increases gammadeltaT cell-mediated killing of activated neutrophils. Crit Care Med. 2008 Dec; 36(12):3220-5. PMID: 18936699.
    Citations: 3     Fields:    Translation:HumansCells
  49. Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE. Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1839-45. PMID: 18832091.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  50. Inoue Y, Chen Y, Pauzenberger R, Hirsh MI, Junger WG. Hypertonic saline up-regulates A3 adenosine receptor expression of activated neutrophils and increases acute lung injury after sepsis. Crit Care Med. 2008 Sep; 36(9):2569-75. PMID: 18679117.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  51. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. PMID: 18713747.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  52. Inoue Y, Chen Y, Hirsh MI, Yip L, Junger WG. A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis. Shock. 2008 Aug; 30(2):173-7. PMID: 18091570.
    Citations: 28     Fields:    Translation:AnimalsCells
  53. Junger WG. Purinergic regulation of neutrophil chemotaxis. Cell Mol Life Sci. 2008 Aug; 65(16):2528-40. PMID: 18463789.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  54. Hirsh MI, Junger WG. Roles of heat shock proteins and gamma delta T cells in inflammation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):509-13. PMID: 18566334.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  55. Corriden R, Insel PA, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1420-5. PMID: 17699635.
    Citations: 28     Fields:    Translation:HumansCells
  56. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. PMID: 17575258.
    Citations: 87     Fields:    Translation:Animals
  57. Hoda MR, Keely SJ, Bertelsen LS, Junger WG, Dharmasena D, Barrett KE. Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells. Br J Surg. 2007 Mar; 94(3):346-54. PMID: 17212381.
    Citations: 41     Fields:    Translation:HumansCells
  58. Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock. 2007 Mar; 27(3):242-50. PMID: 17304104.
    Citations: 20     Fields:    Translation:HumansCells
  59. Hashiguchi N, Lum L, Romeril E, Chen Y, Yip L, Hoyt DB, Junger WG. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients. J Trauma. 2007 Feb; 62(2):299-306. PMID: 17297316.
    Citations: 7     Fields:    Translation:Humans
  60. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. PMID: 17170310.
    Citations: 267     Fields:    Translation:HumansAnimalsCells
  61. Bahrami S, Zimmermann K, Szelényi Z, Hamar J, Scheiflinger F, Redl H, Junger WG. Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock. Shock. 2006 Mar; 25(3):283-9. PMID: 16552361.
    Citations: 20     Fields:    Translation:Animals
  62. Hirsh MI, Hashiguchi N, Chen Y, Yip L, Junger WG. Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing. Eur J Immunol. 2006 Mar; 36(3):712-21. PMID: 16482515.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  63. Chen Y, Hashiguchi N, Yip L, Junger WG. Hypertonic saline enhances neutrophil elastase release through activation of P2 and A3 receptors. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1051-9. PMID: 16282197.
    Citations: 18     Fields:    Translation:HumansCells
  64. Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, Junger WG. Osmotic regulation of cell function and possible clinical applications. Shock. 2004 May; 21(5):391-400. PMID: 15087814.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  65. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol. 2004 Jul; 76(1):245-53. PMID: 15107462.
    Citations: 34     Fields:    Translation:HumansCells
  66. Doucet JJ, Hoyt DB, Coimbra R, Schmid-Schönbein GW, Junger WG, Paul L W, Loomis WH, Hugli TE. Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. J Trauma. 2004 Mar; 56(3):501-10; discussion 510-1. PMID: 15128119.
    Citations: 11     Fields:    Translation:Animals
  67. Michetti C, Coimbra R, Hoyt DB, Loomis W, Junger W, Wolf P. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res. 2003 Nov; 115(1):92-9. PMID: 14572778.
    Citations: 4     Fields:    Translation:AnimalsCells
  68. Fitzal F, Delano FA, Young C, Rosario HS, Junger WG, Schmid-Schönbein GW. Pancreatic enzymes sustain systemic inflammation after an initial endotoxin challenge. Surgery. 2003 Sep; 134(3):446-56. PMID: 14555932.
    Citations: 13     Fields:    Translation:Animals
  69. Murao Y, Hata M, Ohnishi K, Okuchi K, Nakajima Y, Hiasa Y, Junger WG, Hoyt DB, Ohnishi T. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):23-8. PMID: 12813364.
    Citations: 15     Fields:    Translation:Animals
  70. Murao Y, Loomis W, Wolf P, Hoyt DB, Junger WG. Effect of dose of hypertonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):29-34. PMID: 12813365.
    Citations: 20     Fields:    Translation:AnimalsCells
  71. Junger H, Edelman DB, Junger WG. Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling. J Mol Neurosci. 2003; 21(2):111-20. PMID: 14593211.
    Citations: 3     Fields:    Translation:AnimalsCells
  72. Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003 Feb 14; 278(7):4590-6. PMID: 12464620.
    Citations: 38     Fields:    Translation:HumansCells
  73. Orlic T, Loomis WH, Shreve A, Namiki S, Junger WG. Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1261-9. PMID: 11997240.
    Citations: 13     Fields:    Translation:HumansCells
  74. Loomis WH, Namiki S, Hoyt DB, Junger WG. Hypertonicity rescues T cells from suppression by trauma-induced anti-inflammatory mediators. Am J Physiol Cell Physiol. 2001 Sep; 281(3):C840-8. PMID: 11502561.
    Citations: 17     Fields:    Translation:HumansCells
  75. Angle N, Cabello-Passini R, Hoyt DB, Loomis WH, Shreve A, Namiki S, Junger WG. Hypertonic saline infusion: can it regulate human neutrophil function? Shock. 2000 Nov; 14(5):503-8. PMID: 11092681.
    Citations: 17     Fields:    Translation:HumansCells
  76. Murao Y, Hoyt DB, Loomis W, Namiki S, Patel N, Wolf P, Junger WG. Does the timing of hypertonic saline resuscitation affect its potential to prevent lung damage? Shock. 2000 Jul; 14(1):18-23. PMID: 10909888.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  77. Junger H, Junger WG. CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms. Neuroreport. 1998 Nov 16; 9(16):3749-54. PMID: 9858391.
    Citations: 6     Fields:    Translation:AnimalsCells
  78. Hutter J, Junger W, Miller K, Moritz E. Subxiphoidal videomediastinoscopy for diagnostic access to the anterior mediastinum. Ann Thorac Surg. 1998 Oct; 66(4):1427-8. PMID: 9800856.
    Citations: 1     Fields:    Translation:Humans
  79. Angle N, Hoyt DB, Cabello-Passini R, Herdon-Remelius C, Loomis W, Junger WG. Hypertonic saline resuscitation reduces neutrophil margination by suppressing neutrophil L selectin expression. J Trauma. 1998 Jul; 45(1):7-12; discussion 12-3. PMID: 9680004.
    Citations: 19     Fields:    Translation:AnimalsCells
  80. Junger WG, Hoyt DB, Davis RE, Herdon-Remelius C, Namiki S, Junger H, Loomis W, Altman A. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest. 1998 Jun 15; 101(12):2768-79. PMID: 9637711.
    Citations: 33     Fields:    Translation:HumansCells
  81. Angle N, Hoyt DB, Coimbra R, Liu F, Herdon-Remelius C, Loomis W, Junger WG. Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock. 1998 Mar; 9(3):164-70. PMID: 9525322.
    Citations: 32     Fields:    Translation:AnimalsCells
  82. Junger W, Junger WG, Hutter J, Miller K, Moritz E. Delayed diagnosis of malignant tumors missed at laparoscopic cholecystectomy. Surg Endosc. 1997 Oct; 11(10):1010-2. PMID: 9381338.
    Citations: 2     Fields:    Translation:Humans
  83. Junger WG, Coimbra R, Liu FC, Herdon-Remelius C, Junger W, Junger H, Loomis W, Hoyt DB, Altman A. Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock. 1997 Oct; 8(4):235-41. PMID: 9329123.
    Citations: 31     Fields:    Translation:HumansAnimals
  84. Miller K, Junger W. Ileocutaneous fistula formation following laparoscopic polypropylene mesh hernia repair. Surg Endosc. 1997 Jul; 11(7):772-3. PMID: 9214331.
    Citations: 26     Fields:    Translation:Humans
  85. Coimbra R, Hoyt DB, Junger WG, Angle N, Wolf P, Loomis W, Evers MF. Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock. J Trauma. 1997 Apr; 42(4):602-6; discussion 606-7. PMID: 9137245.
    Citations: 29     Fields:    Translation:Animals
  86. Junger WG, Hoyt DB, Hamreus M, Liu FC, Herdon-Remelius C, Junger W, Altman A. Hypertonic saline activates protein tyrosine kinases and mitogen-activated protein kinase p38 in T-cells. J Trauma. 1997 Mar; 42(3):437-43; discussion 443-5. PMID: 9095111.
    Citations: 10     Fields:    Translation:HumansCells
  87. Junger W, Junger WG, Miller K, Bahrami S, Redl H, Schlag G, Moritz E. Early detection of anastomotic leaks after colorectal surgery by measuring endotoxin in the drainage fluid. Hepatogastroenterology. 1996 Nov-Dec; 43(12):1523-9. PMID: 8975959.
    Citations: 3     Fields:    Translation:Humans
  88. Liu FC, Hoyt DB, Coimbra R, Junger WG. Proliferation assays with human, rabbit, rat, and mouse lymphocytes. In Vitro Cell Dev Biol Anim. 1996 Oct; 32(9):520-3. PMID: 8946221.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  89. Coimbra R, Junger WG, Hoyt DB, Liu FC, Loomis WH, Evers MF. Hypertonic saline resuscitation restores hemorrhage-induced immunosuppression by decreasing prostaglandin E2 and interleukin-4 production. J Surg Res. 1996 Aug; 64(2):203-9. PMID: 8812634.
    Citations: 10     Fields:    Translation:Animals
  90. Simons RK, Junger WG, Loomis WH, Hoyt DB. Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary CINC activity and neutrophil recruitment--role of circulating TNF-alpha and IL-beta? Shock. 1996 Jul; 6(1):39-45. PMID: 8828083.
    Citations: 8     Fields:    Translation:AnimalsCells
  91. Junger WG, Hoyt DB, Liu FC, Loomis WH, Coimbra R. Immunosuppression after endotoxin shock: the result of multiple anti-inflammatory factors. J Trauma. 1996 May; 40(5):702-9. PMID: 8614067.
    Citations: 7     Fields:    Translation:Animals
  92. Coimbra R, Junger WG, Liu FC, Loomis WH, Hoyt DB. Hypertonic/hyperoncotic fluids reverse prostaglandin E2 (PGE2)-induced T-cell suppression. Shock. 1995 Jul; 4(1):45-9. PMID: 7552777.
    Citations: 10     Fields:    Translation:HumansCells
  93. Junger WG, Hoyt DB, Redl H, Liu FC, Loomis WH, Davies J, Schlag G. Tumor necrosis factor antibody treatment of septic baboons reduces the production of sustained T-cell suppressive factors. Shock. 1995 Mar; 3(3):173-8. PMID: 7773795.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  94. Junger W, Hutter J, Miller K, Moritz E. Significance of preoperative colonoscopy in laparoscopic cholecystectomy. Endoscopy. 1995 Jan; 27(1):138-9. PMID: 7601028.
    Citations:    Fields:    Translation:Humans
  95. Hoyt DB, Junger WG, Loomis WH, Liu FC. Effects of trauma on immune cell function: impairment of intracellular calcium signaling. Shock. 1994 Jul; 2(1):23-8. PMID: 7735980.
    Citations: 7     Fields:    Translation:HumansCells
  96. Junger WG, Liu FC, Loomis WH, Hoyt DB. Hypertonic saline enhances cellular immune function. Circ Shock. 1994 Apr; 42(4):190-6. PMID: 8055665.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  97. Junger WG, Liu FC, Loomis WB, Hoyt DB. Hypertonic saline solution as disinfectant. East Afr Med J. 1994 Feb; 71(2):83. PMID: 7925049.
    Citations: 1     Fields:    Translation:Humans
  98. Miller K, Hölbling N, Hutter J, Junger W, Moritz E, Speil T. Laparoscopic cholecystectomy for patients who have had previous abdominal surgery. Surg Endosc. 1993 Sep-Oct; 7(5):400-3. PMID: 8211616.
    Citations: 11     Fields:    Translation:Humans
  99. Junger WG, Cardoza TA, Liu FC, Hoyt DB, Goodwin R. Improved rapid photometric assay for quantitative measurement of PMN migration. J Immunol Methods. 1993 Mar 15; 160(1):73-9. PMID: 8383721.
    Citations: 6     Fields:    Translation:HumansCells
  100. Junger WG, Hallström S, Liu FC, Redl H, Schlag G. The enzymatic and release characteristics of sheep neutrophil elastase: a comparison with human neutrophil elastase. Biol Chem Hoppe Seyler. 1992 Aug; 373(8):691-8. PMID: 1418684.
    Citations:    Fields:    Translation:HumansAnimalsCells
  101. Junger WG, Hallström S, Redl H, Schlag G. Inhibition of human, ovine, and baboon neutrophil elastase with Eglin c and secretory leukocyte proteinase inhibitor. Biol Chem Hoppe Seyler. 1992 Mar; 373(3):119-22. PMID: 1350199.
    Citations: 2     Fields:    Translation:HumansAnimals
  102. Hoyt DB, Ozkan AN, Frevert J, Junger WG, Loomis WH. Alteration in Ca2+ homeostasis by a trauma peptide. J Surg Res. 1991 Dec; 51(6):477-83. PMID: 1943084.
    Citations: 2     Fields:    Translation:HumansCells
  103. Junger WG, Lieners C, Redl H, Schlag G. Reasons for the ineffectiveness of eglin C to ameliorate endotoxin shock in sheep. Prog Clin Biol Res. 1989; 308:953-7. PMID: 2780742.
    Citations:    Fields:    Translation:HumansAnimalsCells
  104. Junger WG, Hallström S, Redl H, Schlag G. Characterization of sheep alpha-1-proteinase inhibitor: important differences from the human protein. Am Rev Respir Dis. 1988 Nov; 138(5):1358. PMID: 3264484.
    Citations:    Fields:    Translation:HumansAnimals
  105. Junger W, Hallström S, Redl H, Schlag G. Preliminary data on isolation of an elastase-like proteinase and its inhibitor from ovine neutrophil granulocytes. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:63-8. PMID: 3060145.
    Citations: 2     Fields:    Translation:AnimalsCells
  106. Redl H, Schlag G, Vogl C, Schiesser A, Paul E, Thurnher M, Junger W, Traber LD, Traber DL. The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:153-6. PMID: 3060136.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.