Harvard Catalyst Profiles

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Wolfgang G Junger, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35GM136429 (JUNGER, WOLFGANG G) Apr 1, 2020 - Feb 28, 2025
    NIH
    Metabolic and purinergic immune regulation
    Role: Principal Investigator
  2. R01HD098363 (JUNGER, WOLFGANG G) Mar 20, 2019 - Feb 29, 2024
    NIH
    Role of purinergic signaling in pediatric multi-organ failure
    Role: Principal Investigator
  3. T32GM103702 (JUNGER, WOLFGANG G) Jul 1, 2013 - Jun 30, 2019
    NIH
    Harvard Trauma Inflammation Training Program
    Role: Principal Investigator
  4. R01GM116162 (JUNGER, WOLFGANG G) Jun 15, 2009 - Apr 30, 2020
    NIH
    Autocrine regulation of neutrophil chemotaxis
    Role: Principal Investigator
  5. R01AI080582 (JUNGER, WOLFGANG G) Jun 15, 2009 - May 31, 2014
    NIH
    Purinergic receptors in inflammation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C15-C29. PMID: 33052071.
    Citations:    Fields:    Translation:HumansCells
  2. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. PMID: 32999463.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  3. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Aytan D, Shen Y, Junger WG. The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes. Sci Signal. 2020 09 29; 13(651). PMID: 32994212.
    Citations: 1     Fields:    
  4. Ledderose C, Junger WG. Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function. Front Immunol. 2020; 11:549889. PMID: 33133068.
    Citations:    Fields:    
  5. Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Fakhari M, Slubowski CJ, Bahrami S, Ledderose C, Junger WG. Adenosine 5'-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand. Shock. 2020 08; 54(2):237-244. PMID: 31460871.
    Citations: 1     Fields:    
  6. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Junger WG. Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. J Leukoc Biol. 2021 03; 109(3):497-508. PMID: 32531829.
    Citations: 3     Fields:    Translation:HumansCells
  7. Bai A, Moss A, Rothweiler S, Longhi MS, Wu Y, Junger WG, Robson SC. Author Correction: NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2020 06 10; 11(1):3036. PMID: 32522986.
    Citations:    Fields:    
  8. Curioni CC, Boclin KLS, Silveira IH, Canella DS, Castro IRR, Bezerra FF, Junger W, Faerstein E. Neighborhood food environment and consumption of fruit and leafy vegetables: Pro-Saude Study, Brazil. Public Health. 2020 May; 182:7-12. PMID: 32112980.
    Citations:    Fields:    Translation:HumansAnimals
  9. Novak T, Hall MW, McDonald DR, Newhams MM, Mistry AJ, Panoskaltsis-Mortari A, Mourani PM, Loftis LL, Weiss SL, Tarquinio KM, Markovitz B, Hartman ME, Schwarz A, Junger WG, Randolph AG. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11. PMID: 32035159.
    Citations:    Fields:    Translation:HumansCells
  10. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). PMID: 31953256.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Kondo Y, Ledderose C, Slubowski CJ, Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, Aytan D, Arbab M, Junger WG. Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense. J Leukoc Biol. 2019 12; 106(6):1211-1219. PMID: 31392789.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Mühleder S, Fuchs C, Basílio J, Szwarc D, Pill K, Labuda K, Slezak P, Siehs C, Pröll J, Priglinger E, Hoffmann C, Junger WG, Redl H, Holnthoner W. Purinergic P2Y2 receptors modulate endothelial sprouting. Cell Mol Life Sci. 2020 Mar; 77(5):885-901. PMID: 31278420.
    Citations: 3     Fields:    Translation:HumansCells
  13. Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H. Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock. 2019 06; 51(6):698-705. PMID: 30052576.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  14. Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG. Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation. Purinergic Signal. 2019 06; 15(2):127-137. PMID: 30919205.
    Citations: 1     Fields:    Translation:HumansCells
  15. Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG. Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors. J Biol Chem. 2019 04 19; 294(16):6283-6293. PMID: 30787105.
    Citations: 6     Fields:    Translation:HumansCells
  16. Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG. Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1ß Production, and the Host Immune Response to Infection. Crit Care Med. 2018 12; 46(12):e1183-e1189. PMID: 30247270.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  17. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. PMID: 29894310.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  18. Mello PA, Bian S, Baggio Savio LE, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Jun 21. PMID: 28658673.
    Citations:    
  19. de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Sep 15; 8(40):67254-67268. PMID: 28978031.
    Citations: 13     Fields:    
  20. Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med. 2017 Jan; 45(1):e97-e104. PMID: 27548819.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Qi B, Yu T, Wang C, Wang T, Yao J, Zhang X, Deng P, Xia Y, Junger WG, Sun D. Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate. J Exp Clin Cancer Res. 2016 10 03; 35(1):161. PMID: 27716441.
    Citations: 3     Fields:    Translation:HumansCells
  22. Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016 12; 12(4):673-685. PMID: 27577957.
    Citations: 4     Fields:    Translation:HumansCells
  23. Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG. Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther. 2016 05; 38(5):1054-65. PMID: 27156007.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  24. Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG. Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling? Purinergic Signal. 2016 09; 12(3):439-51. PMID: 27020575.
    Citations: 8     Fields:    Translation:HumansCells
  25. Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger WG, Robson SC. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015 Nov 09; 6:8819. PMID: 26549640.
    Citations: 28     Fields:    Translation:HumansCells
  26. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  27. Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015 Sep 28; 210(7):1153-64. PMID: 26416965.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  28. Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG. Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock. 2015 Sep; 44(3):221-7. PMID: 26009814.
    Citations: 7     Fields:    Translation:HumansCells
  29. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546.
    Citations: 14     Fields:    Translation:HumansCells
  30. Delano MJ, Rizoli SB, Rhind SG, Cuschieri J, Junger W, Baker AJ, Dubick MA, Hoyt DB, Bulger EM. Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis. Shock. 2015 Jul; 44(1):25-31. PMID: 25784523.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  31. Ledderose C, Bao Y, Zhang J, Junger WG. Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation. Acta Physiol (Oxf). 2015 Feb; 213(2):334-45. PMID: 25482154.
    Citations: 6     Fields:    Translation:HumansCells
  32. Weihs AM, Fuchs C, Teuschl AH, Hartinger J, Slezak P, Mittermayr R, Redl H, Junger WG, Sitte HH, Rünzler D. Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation. J Biol Chem. 2014 Sep 26; 289(39):27090-27104. PMID: 25118288.
    Citations: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  33. Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J Biol Chem. 2014 Sep 26; 289(39):26794-26803. PMID: 25104353.
    Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
  34. Sumi Y, Woehrle T, Chen Y, Bao Y, Li X, Yao Y, Inoue Y, Tanaka H, Junger WG. Plasma ATP is required for neutrophil activation in a mouse sepsis model. Shock. 2014 Aug; 42(2):142-7. PMID: 24675414.
    Citations: 23     Fields:    Translation:Animals
  35. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. PMID: 25070895.
    Citations: 32     Fields:    Translation:HumansCells
  36. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock. 2014 Jun; 41(6):463-75. PMID: 24569509.
    Citations: 76     Fields:    Translation:HumansAnimals
  37. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM. Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury. Shock. 2013 Nov; 40(5):366-74. PMID: 24088993.
    Citations: 11     Fields:    Translation:HumansCells
  38. Tillinger W, Jilch R, Waldhoer T, Reinisch W, Junger W. Monocyte human leukocyte antigen-DR expression-a tool to distinguish intestinal bacterial infections from inflammatory bowel disease? Shock. 2013 Aug; 40(2):89-94. PMID: 23860582.
    Citations:    Fields:    Translation:HumansCells
  39. Bao Y, Chen Y, Ledderose C, Li L, Junger WG. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013 Aug 02; 288(31):22650-7. PMID: 23798685.
    Citations: 45     Fields:    Translation:HumansCells
  40. Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, Wang C, Tan L, Qi B, Zhu D, Zhang X, Yu T. Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Stem Cells. 2013 Jun; 31(6):1170-80. PMID: 23404811.
    Citations: 28     Fields:    Translation:HumansCells
  41. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9. PMID: 23349052.
    Citations: 16     Fields:    Translation:AnimalsCells
  42. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One. 2013; 8(4):e60184. PMID: 23565201.
    Citations: 49     Fields:    Translation:AnimalsCells
  43. Schmelzle M, Duhme C, Junger W, Salhanick SD, Chen Y, Wu Y, Toxavidis V, Csizmadia E, Han L, Bian S, Fürst G, Nowak M, Karp SJ, Knoefel WT, Esch JSA, Robson SC. CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy. Ann Surg. 2013 Apr; 257(4):693-701. PMID: 23474584.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. PMID: 22859060.
    Citations: 35     Fields:    Translation:AnimalsCells
  45. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock. 2012 Oct; 38(4):341-50. PMID: 22777113.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  46. Manohar M, Hirsh MI, Chen Y, Woehrle T, Karande AA, Junger WG. ATP release and autocrine signaling through P2X4 receptors regulate ?d T cell activation. J Leukoc Biol. 2012 Oct; 92(4):787-94. PMID: 22753954.
    Citations: 19     Fields:    Translation:HumansCells
  47. Chen Y, Junger WG. Measurement of oxidative burst in neutrophils. Methods Mol Biol. 2012; 844:115-24. PMID: 22262438.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  48. Itagaki K, Adibnia Y, Sun S, Zhao C, Sursal T, Chen Y, Junger W, Hauser CJ. Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils. Shock. 2011 Dec; 36(6):548-52. PMID: 21937948.
    Citations: 15     Fields:    Translation:HumansCells
  49. Bulger EM, Tower CM, Warner KJ, Garland T, Cuschieri J, Rizoli S, Rhind S, Junger WG. Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients. Shock. 2011 Nov; 36(5):435-9. PMID: 21841534.
    Citations: 7     Fields:    Translation:HumansCells
  50. Junger WG. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol. 2011 Mar; 11(3):201-12. PMID: 21331080.
    Citations: 277     Fields:    Translation:HumansAnimalsCells
  51. Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh MI, Junger WG. A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation. Shock. 2011 Feb; 35(2):178-83. PMID: 20661181.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  52. Woehrle T, Yip L, Manohar M, Sumi Y, Yao Y, Chen Y, Junger WG. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol. 2010 Dec; 88(6):1181-9. PMID: 20884646.
    Citations: 44     Fields:    Translation:HumansCells
  53. Sumi Y, Woehrle T, Chen Y, Yao Y, Li A, Junger WG. Adrenergic receptor activation involves ATP release and feedback through purinergic receptors. . 2010 Nov; 299(5):C1118-26. PMID: 20668211.
    Citations: 15     Translation:HumansAnimalsCells
  54. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood. 2010 Nov 04; 116(18):3475-84. PMID: 20660288.
    Citations: 124     Fields:    Translation:HumansCells
  55. Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG. Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal. 2010 Jun 08; 3(125):ra45. PMID: 20530802.
    Citations: 80     Fields:    Translation:HumansCells
  56. Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010 May; 51(5):1702-11. PMID: 20146261.
    Citations: 34     Fields:    Translation:AnimalsCells
  57. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010 Mar 04; 464(7285):104-7. PMID: 20203610.
    Citations: 1115     Fields:    Translation:HumansAnimalsCells
  58. Yu T, Junger WG, Yuan C, Jin A, Zhao Y, Zheng X, Zeng Y, Liu J. Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. . 2010 Mar; 298(3):C457-64. PMID: 19889958.
    Citations: 13     Translation:HumansCells
  59. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009 Jun; 23(6):1685-93. PMID: 19211924.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  60. Hirsh MI, Hashiguchi N, Junger WG. Hypertonic saline increases gammadeltaT cell-mediated killing of activated neutrophils. Crit Care Med. 2008 Dec; 36(12):3220-5. PMID: 18936699.
    Citations: 4     Fields:    Translation:HumansCells
  61. Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE. Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. . 2008 Dec; 295(6):R1839-45. PMID: 18832091.
    Citations: 3     Translation:HumansAnimalsCells
  62. Inoue Y, Chen Y, Pauzenberger R, Hirsh MI, Junger WG. Hypertonic saline up-regulates A3 adenosine receptor expression of activated neutrophils and increases acute lung injury after sepsis. Crit Care Med. 2008 Sep; 36(9):2569-75. PMID: 18679117.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  63. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. PMID: 18713747.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  64. Inoue Y, Chen Y, Hirsh MI, Yip L, Junger WG. A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis. Shock. 2008 Aug; 30(2):173-7. PMID: 18091570.
    Citations: 32     Fields:    Translation:AnimalsCells
  65. Junger WG. Purinergic regulation of neutrophil chemotaxis. Cell Mol Life Sci. 2008 Aug; 65(16):2528-40. PMID: 18463789.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  66. Hirsh MI, Junger WG. Roles of heat shock proteins and gamma delta T cells in inflammation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):509-13. PMID: 18566334.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  67. Corriden R, Insel PA, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. . 2007 Oct; 293(4):C1420-5. PMID: 17699635.
    Citations: 31     Translation:HumansCells
  68. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. PMID: 17575258.
    Citations: 101     Fields:    Translation:Animals
  69. Hoda MR, Keely SJ, Bertelsen LS, Junger WG, Dharmasena D, Barrett KE. Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells. Br J Surg. 2007 Mar; 94(3):346-54. PMID: 17212381.
    Citations: 47     Fields:    Translation:HumansCells
  70. Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock. 2007 Mar; 27(3):242-50. PMID: 17304104.
    Citations: 21     Fields:    Translation:HumansCells
  71. Hashiguchi N, Lum L, Romeril E, Chen Y, Yip L, Hoyt DB, Junger WG. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients. J Trauma. 2007 Feb; 62(2):299-306. PMID: 17297316.
    Citations: 9     Fields:    Translation:Humans
  72. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. PMID: 17170310.
    Citations: 345     Fields:    Translation:HumansAnimalsCells
  73. Bahrami S, Zimmermann K, Szelényi Z, Hamar J, Scheiflinger F, Redl H, Junger WG. Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock. Shock. 2006 Mar; 25(3):283-9. PMID: 16552361.
    Citations: 22     Fields:    Translation:Animals
  74. Hirsh MI, Hashiguchi N, Chen Y, Yip L, Junger WG. Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing. Eur J Immunol. 2006 Mar; 36(3):712-21. PMID: 16482515.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  75. Chen Y, Hashiguchi N, Yip L, Junger WG. Hypertonic saline enhances neutrophil elastase release through activation of P2 and A3 receptors. . 2006 Apr; 290(4):C1051-9. PMID: 16282197.
    Citations: 22     Translation:HumansCells
  76. Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, Junger WG. Osmotic regulation of cell function and possible clinical applications. Shock. 2004 May; 21(5):391-400. PMID: 15087814.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  77. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol. 2004 Jul; 76(1):245-53. PMID: 15107462.
    Citations: 41     Fields:    Translation:HumansCells
  78. Doucet JJ, Hoyt DB, Coimbra R, Schmid-Schönbein GW, Junger WG, Paul L W, Loomis WH, Hugli TE. Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. J Trauma. 2004 Mar; 56(3):501-10; discussion 510-1. PMID: 15128119.
    Citations: 12     Fields:    Translation:Animals
  79. Michetti C, Coimbra R, Hoyt DB, Loomis W, Junger W, Wolf P. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res. 2003 Nov; 115(1):92-9. PMID: 14572778.
    Citations: 5     Fields:    Translation:AnimalsCells
  80. Fitzal F, Delano FA, Young C, Rosario HS, Junger WG, Schmid-Schönbein GW. Pancreatic enzymes sustain systemic inflammation after an initial endotoxin challenge. Surgery. 2003 Sep; 134(3):446-56. PMID: 14555932.
    Citations: 13     Fields:    Translation:Animals
  81. Murao Y, Hata M, Ohnishi K, Okuchi K, Nakajima Y, Hiasa Y, Junger WG, Hoyt DB, Ohnishi T. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):23-8. PMID: 12813364.
    Citations: 17     Fields:    Translation:Animals
  82. Murao Y, Loomis W, Wolf P, Hoyt DB, Junger WG. Effect of dose of hypertonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):29-34. PMID: 12813365.
    Citations: 24     Fields:    Translation:AnimalsCells
  83. Junger H, Edelman DB, Junger WG. Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling. J Mol Neurosci. 2003; 21(2):111-20. PMID: 14593211.
    Citations: 3     Fields:    Translation:AnimalsCells
  84. Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003 Feb 14; 278(7):4590-6. PMID: 12464620.
    Citations: 41     Fields:    Translation:HumansCells
  85. Orlic T, Loomis WH, Shreve A, Namiki S, Junger WG. Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. . 2002 Jun; 282(6):C1261-9. PMID: 11997240.
    Citations: 14     Translation:HumansCells
  86. Loomis WH, Namiki S, Hoyt DB, Junger WG. Hypertonicity rescues T cells from suppression by trauma-induced anti-inflammatory mediators. . 2001 Sep; 281(3):C840-8. PMID: 11502561.
    Citations: 19     Translation:HumansCells
  87. Angle N, Cabello-Passini R, Hoyt DB, Loomis WH, Shreve A, Namiki S, Junger WG. Hypertonic saline infusion: can it regulate human neutrophil function? Shock. 2000 Nov; 14(5):503-8. PMID: 11092681.
    Citations: 17     Fields:    Translation:HumansCells
  88. Murao Y, Hoyt DB, Loomis W, Namiki S, Patel N, Wolf P, Junger WG. Does the timing of hypertonic saline resuscitation affect its potential to prevent lung damage? Shock. 2000 Jul; 14(1):18-23. PMID: 10909888.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  89. Junger H, Junger WG. CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms. Neuroreport. 1998 Nov 16; 9(16):3749-54. PMID: 9858391.
    Citations: 6     Fields:    Translation:AnimalsCells
  90. Hutter J, Junger W, Miller K, Moritz E. Subxiphoidal videomediastinoscopy for diagnostic access to the anterior mediastinum. Ann Thorac Surg. 1998 Oct; 66(4):1427-8. PMID: 9800856.
    Citations: 1     Fields:    Translation:Humans
  91. Angle N, Hoyt DB, Cabello-Passini R, Herdon-Remelius C, Loomis W, Junger WG. Hypertonic saline resuscitation reduces neutrophil margination by suppressing neutrophil L selectin expression. J Trauma. 1998 Jul; 45(1):7-12; discussion 12-3. PMID: 9680004.
    Citations: 19     Fields:    Translation:AnimalsCells
  92. Junger WG, Hoyt DB, Davis RE, Herdon-Remelius C, Namiki S, Junger H, Loomis W, Altman A. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest. 1998 Jun 15; 101(12):2768-79. PMID: 9637711.
    Citations: 36     Fields:    Translation:HumansCells
  93. Angle N, Hoyt DB, Coimbra R, Liu F, Herdon-Remelius C, Loomis W, Junger WG. Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock. 1998 Mar; 9(3):164-70. PMID: 9525322.
    Citations: 36     Fields:    Translation:AnimalsCells
  94. Junger W, Junger WG, Hutter J, Miller K, Moritz E. Delayed diagnosis of malignant tumors missed at laparoscopic cholecystectomy. Surg Endosc. 1997 Oct; 11(10):1010-2. PMID: 9381338.
    Citations: 2     Fields:    Translation:Humans
  95. Junger WG, Coimbra R, Liu FC, Herdon-Remelius C, Junger W, Junger H, Loomis W, Hoyt DB, Altman A. Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock. 1997 Oct; 8(4):235-41. PMID: 9329123.
    Citations: 31     Fields:    Translation:HumansAnimals
  96. Miller K, Junger W. Ileocutaneous fistula formation following laparoscopic polypropylene mesh hernia repair. Surg Endosc. 1997 Jul; 11(7):772-3. PMID: 9214331.
    Citations: 27     Fields:    Translation:Humans
  97. Coimbra R, Hoyt DB, Junger WG, Angle N, Wolf P, Loomis W, Evers MF. Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock. J Trauma. 1997 Apr; 42(4):602-6; discussion 606-7. PMID: 9137245.
    Citations: 30     Fields:    Translation:Animals
  98. Junger WG, Hoyt DB, Hamreus M, Liu FC, Herdon-Remelius C, Junger W, Altman A. Hypertonic saline activates protein tyrosine kinases and mitogen-activated protein kinase p38 in T-cells. J Trauma. 1997 Mar; 42(3):437-43; discussion 443-5. PMID: 9095111.
    Citations: 11     Fields:    Translation:HumansCells
  99. Junger W, Junger WG, Miller K, Bahrami S, Redl H, Schlag G, Moritz E. Early detection of anastomotic leaks after colorectal surgery by measuring endotoxin in the drainage fluid. Hepatogastroenterology. 1996 Nov-Dec; 43(12):1523-9. PMID: 8975959.
    Citations: 3     Fields:    Translation:Humans
  100. Liu FC, Hoyt DB, Coimbra R, Junger WG. Proliferation assays with human, rabbit, rat, and mouse lymphocytes. In Vitro Cell Dev Biol Anim. 1996 Oct; 32(9):520-3. PMID: 8946221.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  101. Coimbra R, Junger WG, Hoyt DB, Liu FC, Loomis WH, Evers MF. Hypertonic saline resuscitation restores hemorrhage-induced immunosuppression by decreasing prostaglandin E2 and interleukin-4 production. J Surg Res. 1996 Aug; 64(2):203-9. PMID: 8812634.
    Citations: 12     Fields:    Translation:Animals
  102. Simons RK, Junger WG, Loomis WH, Hoyt DB. Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary CINC activity and neutrophil recruitment--role of circulating TNF-alpha and IL-beta? Shock. 1996 Jul; 6(1):39-45. PMID: 8828083.
    Citations: 9     Fields:    Translation:AnimalsCells
  103. Junger WG, Hoyt DB, Liu FC, Loomis WH, Coimbra R. Immunosuppression after endotoxin shock: the result of multiple anti-inflammatory factors. J Trauma. 1996 May; 40(5):702-9. PMID: 8614067.
    Citations: 7     Fields:    Translation:Animals
  104. Coimbra R, Junger WG, Liu FC, Loomis WH, Hoyt DB. Hypertonic/hyperoncotic fluids reverse prostaglandin E2 (PGE2)-induced T-cell suppression. Shock. 1995 Jul; 4(1):45-9. PMID: 7552777.
    Citations: 10     Fields:    Translation:HumansCells
  105. Junger WG, Hoyt DB, Redl H, Liu FC, Loomis WH, Davies J, Schlag G. Tumor necrosis factor antibody treatment of septic baboons reduces the production of sustained T-cell suppressive factors. Shock. 1995 Mar; 3(3):173-8. PMID: 7773795.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  106. Junger W, Hutter J, Miller K, Moritz E. Significance of preoperative colonoscopy in laparoscopic cholecystectomy. Endoscopy. 1995 Jan; 27(1):138-9. PMID: 7601028.
    Citations:    Fields:    Translation:Humans
  107. Hoyt DB, Junger WG, Loomis WH, Liu FC. Effects of trauma on immune cell function: impairment of intracellular calcium signaling. Shock. 1994 Jul; 2(1):23-8. PMID: 7735980.
    Citations: 7     Fields:    Translation:HumansCells
  108. Junger WG, Liu FC, Loomis WH, Hoyt DB. Hypertonic saline enhances cellular immune function. Circ Shock. 1994 Apr; 42(4):190-6. PMID: 8055665.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  109. Junger WG, Liu FC, Loomis WB, Hoyt DB. Hypertonic saline solution as disinfectant. East Afr Med J. 1994 Feb; 71(2):83. PMID: 7925049.
    Citations: 1     Fields:    Translation:Humans
  110. Miller K, Hölbling N, Hutter J, Junger W, Moritz E, Speil T. Laparoscopic cholecystectomy for patients who have had previous abdominal surgery. Surg Endosc. 1993 Sep-Oct; 7(5):400-3. PMID: 8211616.
    Citations: 11     Fields:    Translation:Humans
  111. Junger WG, Cardoza TA, Liu FC, Hoyt DB, Goodwin R. Improved rapid photometric assay for quantitative measurement of PMN migration. J Immunol Methods. 1993 Mar 15; 160(1):73-9. PMID: 8383721.
    Citations: 6     Fields:    Translation:HumansCells
  112. Junger WG, Hallström S, Liu FC, Redl H, Schlag G. The enzymatic and release characteristics of sheep neutrophil elastase: a comparison with human neutrophil elastase. Biol Chem Hoppe Seyler. 1992 Aug; 373(8):691-8. PMID: 1418684.
    Citations:    Fields:    Translation:HumansAnimalsCells
  113. Junger WG, Hallström S, Redl H, Schlag G. Inhibition of human, ovine, and baboon neutrophil elastase with Eglin c and secretory leukocyte proteinase inhibitor. Biol Chem Hoppe Seyler. 1992 Mar; 373(3):119-22. PMID: 1350199.
    Citations: 3     Fields:    Translation:HumansAnimals
  114. Hoyt DB, Ozkan AN, Frevert J, Junger WG, Loomis WH. Alteration in Ca2+ homeostasis by a trauma peptide. J Surg Res. 1991 Dec; 51(6):477-83. PMID: 1943084.
    Citations: 2     Fields:    Translation:HumansCells
  115. Junger WG, Lieners C, Redl H, Schlag G. Reasons for the ineffectiveness of eglin C to ameliorate endotoxin shock in sheep. Prog Clin Biol Res. 1989; 308:953-7. PMID: 2780742.
    Citations:    Fields:    Translation:HumansAnimalsCells
  116. Junger WG, Hallström S, Redl H, Schlag G. Characterization of sheep alpha-1-proteinase inhibitor: important differences from the human protein. Am Rev Respir Dis. 1988 Nov; 138(5):1358. PMID: 3264484.
    Citations:    Fields:    Translation:HumansAnimals
  117. Junger W, Hallström S, Redl H, Schlag G. Preliminary data on isolation of an elastase-like proteinase and its inhibitor from ovine neutrophil granulocytes. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:63-8. PMID: 3060145.
    Citations: 2     Fields:    Translation:AnimalsCells
  118. Redl H, Schlag G, Vogl C, Schiesser A, Paul E, Thurnher M, Junger W, Traber LD, Traber DL. The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:153-6. PMID: 3060136.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.