Harvard Catalyst Profiles

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Lisa D Nickerson, Ph.D.

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2003 - 2005
NIDA NRSA Fellowship
2003 - 2008
NIH Student Loan Repayment Award
2005 - 2010
NIDA K25 Career Development Award
2009 - 2010
Visiting Scientist, FMRIB, Oxford University
Tutor FSL Course
O'Keefe Family Junior Investigator Award for Excellence in Imaging
Chair, Morning Workshop, OHBM
Organizer, Education Course, OHBM
2014 - pres
Director, Applied Neuroimaging Statistics Lab, McLean Hospital
2016 - 2019
Member & Team Leader, Communications Committee, OHBM
NIH Grant Review, Neurotoxicology and Alcohol Study Section, Ad Hoc
2019 - 2021
Communications Committee Blog Team
NIH Grant Review, Adult Psychopathology and Disorders of Aging Study Section, Ad Hoc
2020 - pres
Best Practices Committee on Large-Scale Network Nomenclature
2021 - pres
Associate Editor Human Brain Mapping
Cataldo Award for Excellence in Mentoring

I am the Director of the Applied Neuroimaging Statistics Research Lab at McLean Hospital, which focuses on developing and applying novel machine learning and statistical methods for multimodal neuroimaging data analysis for research on Alzheimer's Disease, drug use and psychiatric disorders. Current research involves combining large-scale open access neuroimaging datasets including HCP, CRHD, ADNI and others with computational approaches such as tensor and matrix decomposition methods, including ICA and linked ICA for data fusion, normative modeling and other techniques to investigate brain structure and function. Current funding includes a five-year R01 to utilize the Human Connectome Project (HCP) Lifespan and Connectomes Related to Human Disease datasets to investigate neuropsychiatric symptoms in Alzheimer's Disease. I provide statistical support, training, and mentoring for students and junior scientists, and I teach seminars and courses on imaging statistics, resting state and task fMRI data processing, multivariate data-driven methods and other imaging analysis topics at Harvard and MIT. I am also a biostatistics consultant for the Harvard Catalyst, a faculty member of the Harvard Mind Brain Behavior and the Harvard Data Science Initiatives and act as mentor to students and post-docs through the HDSI MIND project. My lab is currently accepting new student trainees and I am currently seeking a post-doctoral fellow for a NIDA T32 position for training in neuroimaging of substance use and a post-doctoral fellow to work on an NIA-funded R01 on Multimodal Computational Neuroimaging: Big Data, Neuropsychiatric Symptoms and Alzheimer’s Disease.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50MH106435 (Nickerson, Lisa) Feb 1, 2023 - Jan 31, 2027
    Precision Functional Neuroimaging Core
    Role Description: Functional neuroimaging experiments utilizing both resting state fMRI and task-based fMRI are proposed by individual projects across the Center, to accurately characterize the OCD brain network. The central goal of the present core is to support these projects in acquiring and analyzing functional neuroimaging data using the cutting-edge techniques to achieve subject-level precision.
    Role: Principal Investigator
  2. 1RF1AG078304-01 (NICKERSON, LISA) Sep 30, 2022 - Aug 31, 2027
    Combining Computational Methods, RDoC, and Big Neuroimaging Data to Understand Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
    Role Description: Our goal in this project is: to identify brain-behavior mappings that underpin how neurodeneration of Alzheimer's Disease (AD) and neurocircuitry of neuropsychiatric symptoms (NPS) interact with each other, to establish normative models of these brain-behavior mappings in normal aging, to apply these models to patients to understand the mechanisms of NPS in AD and to identify new treatment targets, and to develop tools that can be used by others to apply our models to new patients for reproducible and generalizable research.
    Role: Principal Investigator
  3. (Nickerson, Lisa) May 1, 2018 - Apr 30, 2021
    President and Fellows of Harvard College
    Sub-Contract for The Harvard Clinical and Translational Science Center (CTR Core E-Research Methods)
    Role Description: The Harvard Catalyst aims to advance human health by supporting and innovating clinical and translational science and training the next generation of researchers.
    Role: Biostatistics Consultant
  4. R21AA024565 (NICKERSON, LISA D) Aug 1, 2016 - Jul 31, 2019
    Sex Differences in the Effects of Alcohol Use Disorder on Brain Circuitry using Existing Data
    Role: Principal Investigator
  5. R01DA037265 (NICKERSON, LISA D) Jul 15, 2014 - Dec 31, 2018
    Multi-modal MRI data fusion to assess neurobiological effects of marijuana use
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.