Harvard Catalyst Profiles

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Lisa D Nickerson, Ph.D.

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2003 - 2005
NIDA NRSA Fellowship
2003 - 2008
NIH Student Loan Repayment Award
2005 - 2010
NIDA K25 Career Development Award
2009 - 2010
Visiting Scientist, FMRIB, Oxford University
Tutor FSL Course
O'Keefe Family Junior Investigator Award for Excellence in Imaging
Chair, Morning Workshop, OHBM
Organizer, Education Course, OHBM
2014 - pres
Director, Applied Neuroimaging Statistics Lab, McLean Hospital
2016 - 2019
Member & Team Leader, Communications Committee, OHBM
NIH Grant Review, Neurotoxicology and Alcohol Study Section, Ad Hoc
2019 - pres
Communications Committee Blog Team
NIH Grant Review, Adult Psychopathology and Disorders of Aging Study Section, Ad Hoc
2020 - pres
Best Practices Committee on Large-Scale Network Nomenclature
2021 - pres
Associate Editor Human Brain Mapping

I am the Director of the Applied Neuroimaging Statistics Lab at McLean Hospital, which focuses on developing new statistical methods for functional magnetic resonance imaging (fMRI) data analysis, and on applying state-of-the-art analysis methods such as multi-modal data fusion and machine learning methods for basic neuroscience research on drug use and psychiatric disorders. Current research involves using large-scale open access neuroimaging datasets including HCP and UK Biobank to develop and apply new statistical methods and machine learning techniques, including tensor and matrix decomposition methods such as ICA and linked ICA for data fusion tor investigate brain structure and function in drug use and psychiatric disorders. Specific projects utilize the Human Connectome Project (HCP) data to investigate alcohol and cannabis use on brain circuitry implicated in social cognition and for methods development. I also provide statistical support and training for numerous junior scientists and collaborators, mentoring, and I teach seminars and courses on imaging statistics, resting state and task fMRI data processing, multivariate data-driven methods and other imaging analysis topics. I am alsoa biostatistics consultant for the Harvard Catalyst. I am a faculty member of the Harvard Mind Brain Behavior and the Harvard Data Science Initiatives and act as mentor to students and post-docs through the HDSI MIND project. My lab is currently accepting new trainees.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Nickerson, Lisa) May 1, 2018 - Apr 30, 2021
    President and Fellows of Harvard College
    Sub-Contract for The Harvard Clinical and Translational Science Center (CTR Core E-Research Methods)
    Role Description: The Harvard Catalyst aims to advance human health by supporting and innovating clinical and translational science and training the next generation of researchers.
    Role: Biostatistics Consultant
  2. R21AA024565 (NICKERSON, LISA D) Aug 1, 2016 - Jul 31, 2019
    Sex Differences in the Effects of Alcohol Use Disorder on Brain Circuitry using Existing Data
    Role: Principal Investigator
  3. R01DA037265 (NICKERSON, LISA D) Jul 15, 2014 - Dec 31, 2018
    Multi-modal MRI data fusion to assess neurobiological effects of marijuana use
    Role: Principal Investigator
  4. R21DA032257 (NICKERSON, LISA D) Feb 15, 2012 - Oct 31, 2014
    Neural Mechanisms Underlying Nicotine and Alcohol Combinations: Quantitative fMRI
    Role: Principal Investigator
  5. K25DA017712 (NICKERSON, LISA D) Apr 1, 2005 - Sep 30, 2010
    Novel Use of fMRI to Study Substance Abuse Problems
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ironside M, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Duda JM, Chen X, Nickerson LD, Null KE, Nascimento N, Crowley DJ, Misra M, Goldstein JM, Pizzagalli DA. Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation. Neuropsychopharmacology. 2021 11; 46(12):2188-2196. PMID: 34363015.
    Citations:    Fields:    
  2. Hu G, Wang D, Luo S, Hao Y, Nickerson LD, Cong F. Frequency specific co-activation pattern analysis via sparse nonnegative tensor decomposition. J Neurosci Methods. 2021 10 01; 362:109299. PMID: 34339754.
    Citations:    Fields:    Translation:Humans
  3. Jain FA, Chernyak S, Nickerson L, Abrams M, Iacoboni M, Christov-Moore L, Connolly CG, Fisher LB, Sakurai H, Bentley K, Tan E, Pittman M, Lavretsky H, Leuchter AF. Mentalizing imagery therapy for depressed family dementia caregivers: Feasibility, clinical outcomes and brain connectivity changes. J Affect Disord Rep. 2021 Jul; 5. PMID: 34498016.
  4. Yuksel C, Chen X, Chouinard VA, Nickerson LD, Gardner M, Cohen T, Öngür D, Du F. Abnormal Brain Bioenergetics in First-Episode Psychosis. Schizophr Bull Open. 2021 Jan; 2(1):sgaa073. PMID: 33554120.
  5. Sneider JT, Cohen-Gilbert JE, Hamilton DA, Seraikas AM, Oot EN, Schuttenberg EM, Nickerson LD, Silveri MM. Brain Activation during Memory Retrieval is Associated with Depression Severity in Women. Psychiatry Res Neuroimaging. 2021 01 30; 307:111204. PMID: 33393466.
    Citations:    Fields:    Translation:Humans
  6. Hu G, Waters AB, Aslan S, Frederick B, Cong F, Nickerson LD. Snowball ICA: A Model Order Free Independent Component Analysis Strategy for Functional Magnetic Resonance Imaging Data. Front Neurosci. 2020; 14:569657. PMID: 33071741.
    Citations: 1     
  7. Harnett NG, Stevens JS, Fani N, van Rooij SJH, Ely TD, Michopoulos V, Hudak L, Rothbaum AO, Hinrichs R, Winters SJ, Jovanovic T, Rothbaum BO, Nickerson LD, Ressler KJ. Acute Posttraumatic Symptoms Are Associated With Multimodal Neuroimaging Structural Covariance Patterns: A Possible Role for the Neural Substrates of Visual Processing in Posttraumatic Stress Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Aug 07. PMID: 33012681.
    Citations:    Fields:    
  8. Li H, Smith SM, Gruber S, Lukas SE, Silveri MM, Hill KP, Killgore WDS, Nickerson LD. Denoising scanner effects from multimodal MRI data using linked independent component analysis. Neuroimage. 2020 03; 208:116388. PMID: 31765802.
    Citations: 4     Fields:    Translation:Humans
  9. Maksimovskiy AL, Oot EN, Seraikas AM, Rieselbach M, Caine C, Sneider JT, Cohen-Gilbert JE, Harris SK, Nickerson LD, Rohan ML, Silveri MM. Morphometric Biomarkers of Adolescents With Familial Risk for Alcohol Use Disorder. Alcohol Clin Exp Res. 2019 11; 43(11):2354-2366. PMID: 31529792.
    Citations:    Fields:    Translation:Humans
  10. Janes AC, Krantz NL, Nickerson LD, Frederick BB, Lukas SE. Craving and Cue Reactivity in Nicotine-Dependent Tobacco Smokers Is Associated With Different Insula Networks. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 01; 5(1):76-83. PMID: 31706906.
    Citations: 4     Fields:    Translation:Humans
  11. Hu G, Zhang Q, Waters AB, Li H, Zhang C, Wu J, Cong F, Nickerson LD. Tensor clustering on outer-product of coefficient and component matrices of independent component analysis for reliable functional magnetic resonance imaging data decomposition. J Neurosci Methods. 2019 09 01; 325:108359. PMID: 31306718.
    Citations: 2     Fields:    Translation:Humans
  12. Maher S, Ekstrom T, Ongur D, Levy DL, Norton DJ, Nickerson LD, Chen Y. Functional disconnection between the visual cortex and right fusiform face area in schizophrenia. Schizophr Res. 2019 07; 209:72-79. PMID: 31126803.
    Citations: 2     Fields:    Translation:Humans
  13. Nickerson LD. Replication of Resting State-Task Network Correspondence and Novel Findings on Brain Network Activation During Task fMRI in the Human Connectome Project Study. Sci Rep. 2018 12 03; 8(1):17543. PMID: 30510165.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  14. Sneider JT, Cohen-Gilbert JE, Hamilton DA, Stein ER, Golan N, Oot EN, Seraikas AM, Rohan ML, Harris SK, Nickerson LD, Silveri MM. Adolescent Hippocampal and Prefrontal Brain Activation During Performance of the Virtual Morris Water Task. Front Hum Neurosci. 2018; 12:238. PMID: 29997486.
    Citations: 3     
  15. Dumais KM, Chernyak S, Nickerson LD, Janes AC. Sex differences in default mode and dorsal attention network engagement. PLoS One. 2018; 13(6):e0199049. PMID: 29902249.
    Citations: 9     Fields:    Translation:Humans
  16. Killgore WDS, Smith R, Olson EA, Weber M, Rauch SL, Nickerson LD. Emotional intelligence is associated with connectivity within and between resting state networks. Soc Cogn Affect Neurosci. 2017 10 01; 12(10):1624-1636. PMID: 28981827.
    Citations: 5     Fields:    Translation:Humans
  17. Cohen-Gilbert JE, Nickerson LD, Sneider JT, Oot EN, Seraikas AM, Rohan ML, Silveri MM. College Binge Drinking Associated with Decreased Frontal Activation to Negative Emotional Distractors during Inhibitory Control. Front Psychol. 2017; 8:1650. PMID: 29018380.
    Citations: 12     
  18. Olson EA, Cui J, Fukunaga R, Nickerson LD, Rauch SL, Rosso IM. Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study. Depress Anxiety. 2017 05; 34(5):437-445. PMID: 28294462.
    Citations: 21     Fields:    Translation:Humans
  19. Nickerson LD, Smith SM, Öngür D, Beckmann CF. Using Dual Regression to Investigate Network Shape and Amplitude in Functional Connectivity Analyses. Front Neurosci. 2017; 11:115. PMID: 28348512.
    Citations: 81     
  20. Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM. Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. Hum Brain Mapp. 2017 04; 38(4):2276-2325. PMID: 28145075.
    Citations: 12     Fields:    Translation:HumansAnimals
  21. Li H, Nickerson LD, Nichols TE, Gao JH. Comparison of a non-stationary voxelation-corrected cluster-size test with TFCE for group-Level MRI inference. Hum Brain Mapp. 2017 03; 38(3):1269-1280. PMID: 27785843.
    Citations: 6     Fields:    Translation:Humans
  22. Maher S, Ekstrom T, Tong Y, Nickerson LD, Frederick B, Chen Y. Greater sensitivity of the cortical face processing system to perceptually-equated face detection. Brain Res. 2016 Jan 15; 1631:13-21. PMID: 26592952.
    Citations: 1     Fields:    Translation:Humans
  23. Fan Y, Nickerson LD, Li H, Ma Y, Lyu B, Miao X, Zhuo Y, Ge J, Zou Q, Gao JH. Functional Connectivity-Based Parcellation of the Thalamus: An Unsupervised Clustering Method and Its Validity Investigation. Brain Connect. 2015 Dec; 5(10):620-30. PMID: 26106821.
    Citations: 11     Fields:    Translation:Humans
  24. Bolo NR, Musen G, Simonson DC, Nickerson LD, Flores VL, Siracusa T, Hager B, Lyoo IK, Renshaw PF, Jacobson AM. Functional Connectivity of Insula, Basal Ganglia, and Prefrontal Executive Control Networks during Hypoglycemia in Type 1 Diabetes. J Neurosci. 2015 Aug 05; 35(31):11012-23. PMID: 26245963.
    Citations: 20     Fields:    Translation:Humans
  25. Mashhoon Y, Sava S, Sneider JT, Nickerson LD, Silveri MM. Cortical thinness and volume differences associated with marijuana abuse in emerging adults. Drug Alcohol Depend. 2015 Oct 01; 155:275-83. PMID: 26249265.
    Citations: 17     Fields:    Translation:HumansAnimals
  26. Li H, Nickerson LD, Zhao X, Nichols TE, Gao JH. A voxelation-corrected non-stationary 3D cluster-size test based on random field theory. Neuroimage. 2015 Sep; 118:676-82. PMID: 26067343.
    Citations: 2     Fields:    Translation:Humans
  27. Li H and Nickerson LD (co-firsts), Xiong J, Zou Q, Fan Y, Ma Y, Shi T, Ge J, Gao JH. A high performance 3D cluster-based test of unsmoothed fMRI data. Neuroimage. 2014; (98):537-46.
  28. Admon R, Nickerson LD, Dillon DG, Holmes AJ, Bogdan R, Kumar P, Dougherty DD, Iosifescu DV, Mischoulon D, Fava M, Pizzagalli DA. Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties. Psychol Med. 2015 Jan; 45(1):121-31. PMID: 25055809.
    Citations: 23     Fields:    Translation:Humans
  29. Kumar P, Berghorst LH, Nickerson LD, Dutra SJ, Goer FK, Greve DN, Pizzagalli DA. Differential effects of acute stress on anticipatory and consummatory phases of reward processing. Neuroscience. 2014 Apr 25; 266:1-12. PMID: 24508744.
    Citations: 37     Fields:    Translation:Humans
  30. Janes AC, Farmer S, Frederick Bd, Nickerson LD, Lukas SE. An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling. PLoS One. 2014; 9(2):e88228. PMID: 24505440.
    Citations: 19     Fields:    Translation:HumansAnimals
  31. Janes AC, Ross RS, Farmer S, Frederick BB, Nickerson LD, Lukas SE, Stern CE. Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task. Addict Biol. 2015 Mar; 20(2):349-56. PMID: 24261848.
    Citations: 18     Fields:    Translation:Humans
  32. Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick Bd. Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage. 2013 Aug 01; 76:202-15. PMID: 23523805.
    Citations: 31     Fields:    Translation:Humans
  33. Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage. 2013 Apr 15; 70:211-22. PMID: 23296183.
    Citations: 27     Fields:    Translation:Humans
  34. Frederick Bd, Nickerson LD, Tong Y. Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS). Neuroimage. 2012 Apr 15; 60(3):1913-23. PMID: 22342801.
    Citations: 23     Fields:    Translation:Humans
  35. Janes AC and Nickerson LD (co-firsts), Frederick Bde B, Kaufman MJ. Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. Drug Alcohol Depend. 2012; 3(125):252-9.
  36. Filippini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CE. Age-related adaptations of brain function during a memory task are also present at rest. Neuroimage. 2012 Feb 15; 59(4):3821-8. PMID: 22155375.
    Citations: 16     Fields:    Translation:Humans
  37. Nickerson LD, Ravichandran C, Lundahl LH, Rodolico J, Dunlap S, Trksak GH, Lukas SE. Cue reactivity in cannabis-dependent adolescents. Psychol Addict Behav. 2011 Mar; 25(1):168-73. PMID: 21142334.
    Citations: 10     Fields:    Translation:Humans
  38. Lowen SB, Nickerson LD, Levin JM. Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI. Pharmacol Biochem Behav. 2009 Apr; 92(2):277-82. PMID: 19138702.
    Citations: 3     Fields:    Translation:Humans
  39. Frederick Bd, Lindsey KP, Nickerson LD, Ryan ET, Lukas SE. An MR-compatible device for delivering smoked marijuana during functional imaging. Pharmacol Biochem Behav. 2007 May; 87(1):81-9. PMID: 17521714.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  40. Nickerson LD, Narayana S, Lancaster JL, Fox PT, Gao JH. Estimation of the local statistical noise in positron emission tomography revisited: practical implementation. Neuroimage. 2003 Jun; 19(2 Pt 1):442-56. PMID: 12814593.
    Citations: 2     Fields:    Translation:Humans
  41. Nunneley SA, Martin CC, Slauson JW, Hearon CM, Nickerson LD, Mason PA. Changes in regional cerebral metabolism during systemic hyperthermia in humans. J Appl Physiol (1985). 2002 Feb; 92(2):846-51. PMID: 11796700.
    Citations: 19     Fields:    Translation:Humans
  42. Nickerson LD, Martin CC, Lancaster JL, Gao JH, Fox PT. A tool for comparison of PET and fMRI methods: calculation of the uncertainty in the location of an activation site in a PET image. Neuroimage. 2001 Jul; 14(1 Pt 1):194-201. PMID: 11525328.
    Citations: 4     Fields:    Translation:Humans
  43. Liu HL, Pu Y, Nickerson LD, Liu Y, Fox PT, Gao JH. Comparison of the temporal response in perfusion and BOLD-based event-related functional MRI. Magn Reson Med. 2000 May; 43(5):768-72. PMID: 10800045.
    Citations: 9     Fields:    Translation:Humans
  44. Liu HL, Pu Y, Liu Y, Nickerson L, Andrews T, Fox PT, Gao JH. Cerebral blood flow measurement by dynamic contrast MRI using singular value decomposition with an adaptive threshold. Magn Reson Med. 1999 Jul; 42(1):167-72. PMID: 10398963.
    Citations: 20     Fields:    Translation:Humans
  45. Martin CC, Jerabek PA, Nickerson LD, Fox PT. Effect of partition coefficient, permeability surface product, and radioisotope on the signal-to-noise ratio in PET functional brain mapping: a computer simulation. Hum Brain Mapp. 1999; 7(3):151-60. PMID: 10194616.
    Citations:    Fields:    
  46. Martin CC, Williams RF, Gao JH, Nickerson LD, Xiong J, Fox PT. The pharmacokinetics of hyperpolarized xenon: implications for cerebral MRI. J Magn Reson Imaging. 1997 Sep-Oct; 7(5):848-54. PMID: 9307910.
    Citations: 9     Fields:    Translation:Humans
  47. Xiong J, Nickerson LD, Downs JH, Fox PT. Basic principles and neurosurgical applications of positron emission tomography. Neurosurg Clin N Am. 1997 Jul; 8(3):293-306. PMID: 9188539.
    Citations: 1     Fields:    Translation:Humans
  48. Martin CC, Christian BT, Satter MR, Nickerson LH, Nickles RJ. Quantitative PET with positron emitters that emit prompt gamma rays. IEEE Trans Med Imaging. 1995; 14(4):681-7. PMID: 18215872.
    Citations: 14     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.