Harvard Catalyst Profiles

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Lisa D Nickerson, Ph.D.

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Biography
2003 - 2005
NIDA NRSA Fellowship
2003 - 2008
NIH Student Loan Repayment Award
2005 - 2010
NIDA K25 Career Development Award
2009 - 2010
Visiting Scientist, FMRIB, Oxford University
2010
Tutor FSL Course
2012
O'Keefe Family Junior Investigator Award for Excellence in Imaging
2013
Chair, Morning Workshop, OHBM
2014
Organizer, Education Course, OHBM
2014 - pres
Director, Applied Neuroimaging Statistics Lab, McLean Hospital
2016 - 2019
Member & Team Leader, Communications Committee, OHBM
2019
NIH Grant Review, Neurotoxicology and Alcohol Study Section, Ad Hoc
2019 - 2021
Communications Committee Blog Team
2019
NIH Grant Review, Adult Psychopathology and Disorders of Aging Study Section, Ad Hoc
2020 - pres
Best Practices Committee on Large-Scale Network Nomenclature
2021 - pres
Associate Editor Human Brain Mapping
2022
Cataldo Award for Excellence in Mentoring

Overview
I am the Director of the Applied Neuroimaging Statistics Lab at McLean Hospital, which focuses on developing new statistical methods for functional magnetic resonance imaging (fMRI) data analysis, and on applying state-of-the-art analysis methods such as multi-modal data fusion and machine learning methods for basic neuroscience research on drug use and psychiatric disorders. Current research involves using large-scale open access neuroimaging datasets including HCP and UK Biobank to develop and apply new statistical methods and machine learning techniques, including tensor and matrix decomposition methods such as ICA and linked ICA for data fusion tor investigate brain structure and function in drug use and psychiatric disorders. Current funding includes a five-year R01 to utilize the Human Connectome Project (HCP) Lifespan and Connectomes Related to Human Disease datasets to investigate neuropsychiatric symptoms in Alzheimer's Disease. I also provide statistical support and training for numerous junior scientists and collaborators, mentoring, and I teach seminars and courses on imaging statistics, resting state and task fMRI data processing, multivariate data-driven methods and other imaging analysis topics. I am also a biostatistics consultant for the Harvard Catalyst, a faculty member of the Harvard Mind Brain Behavior and the Harvard Data Science Initiatives and act as mentor to students and post-docs through the HDSI MIND project. My lab is currently accepting new trainees and I am currently seeking post-doctoral fellows.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1RF1AG078304-01 (NICKERSON, LISA) Sep 30, 2022 - Aug 31, 2027
    NIH
    Combining Computational Methods, RDoC, and Big Neuroimaging Data to Understand Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
    Role Description: Our goal in this project is: to identify brain-behavior mappings that underpin how neurodeneration of Alzheimer's Disease (AD) and neurocircuitry of neuropsychiatric symptoms (NPS) interact with each other, to establish normative models of these brain-behavior mappings in normal aging, to apply these models to patients to understand the mechanisms of NPS in AD and to identify new treatment targets, and to develop tools that can be used by others to apply our models to new patients for reproducible and generalizable research.
    Role: Principal Investigator
  2. (Nickerson, Lisa) May 1, 2018 - Apr 30, 2021
    President and Fellows of Harvard College
    Sub-Contract for The Harvard Clinical and Translational Science Center (CTR Core E-Research Methods)
    Role Description: The Harvard Catalyst aims to advance human health by supporting and innovating clinical and translational science and training the next generation of researchers.
    Role: Biostatistics Consultant
  3. R21AA024565 (NICKERSON, LISA D) Aug 1, 2016 - Jul 31, 2019
    NIH
    Sex Differences in the Effects of Alcohol Use Disorder on Brain Circuitry using Existing Data
    Role: Principal Investigator
  4. R01DA037265 (NICKERSON, LISA D) Jul 15, 2014 - Dec 31, 2018
    NIH
    Multi-modal MRI data fusion to assess neurobiological effects of marijuana use
    Role: Principal Investigator
  5. R21DA032257 (NICKERSON, LISA D) Feb 15, 2012 - Oct 31, 2014
    NIH
    Neural Mechanisms Underlying Nicotine and Alcohol Combinations: Quantitative fMRI
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.