Harvard Catalyst Profiles

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Richard Charles Mulligan, Ph.D.

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Mentoring
A Gene therapy Approach Towards Blocking EPHRIN-B2/EPH-B4 Vascular Interactions in Tumor Angiogenesis
Summer, 06/23/99 - 08/31/99

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RC1DK087006 (MULLIGAN, RICHARD C) Sep 30, 2009 - Aug 31, 2012
    NIH/NIDDK
    Engineered in vivo nuclear fusion: application to regenerative medicine
    Role: Principal Investigator
  2. R01GM079187 (MULLIGAN, RICHARD C) Aug 1, 2007 - May 31, 2013
    NIH/NIGMS
    Improving the Safety Profile of Lentiviral Vectors
    Role: Principal Investigator
  3. R01GM075127 (MULLIGAN, RICHARD C) Jul 1, 2005 - Jun 30, 2010
    NIH/NIGMS
    Exogenous Gene Control via Modulation of RNA Self-Cleavage
    Role: Principal Investigator
  4. P01HL059316 (DZAU, VICTOR J) Sep 30, 1997 - Aug 31, 2002
    NIH/NHLBI
    CORE--PILOT AND FEASIBILITY STUDIES
    Role: Co-Principal Investigator
  5. P50HL059316 (DZAU, VICTOR J) Sep 30, 1997 - Aug 31, 2002
    NIH/NHLBI
    GENE TRANSFER PROGRAM IN HEART, LUNG, AND BLOOD DISEASE
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Peng CZ, Grant JD, Heath AC, Reiersen AM, Mulligan RC, Anokhin AP. Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study. Dev Psychopathol. 2016 May; 28(2):517-26. PMID: 26612434.
    Citations: 2     Fields:    Translation:Humans
  2. Mulligan RC. Development of gene transfer technology. Hum Gene Ther. 2014 Dec; 25(12):995-1002. PMID: 25513845.
    Citations: 3     Fields:    Translation:Humans
  3. Anokhin AP, Golosheykin S, Mulligan RC. Long-term test-retest reliability of delayed reward discounting in adolescents. Behav Processes. 2015 Feb; 111:55-9. PMID: 25447508.
    Citations: 11     Fields:    Translation:Humans
  4. Anokhin AP, Grant JD, Mulligan RC, Heath AC. The genetics of impulsivity: evidence for the heritability of delay discounting. Biol Psychiatry. 2015 May 15; 77(10):887-94. PMID: 25555481.
    Citations: 26     Fields:    Translation:Humans
  5. Mulligan RC, Kristjansson SD, Reiersen AM, Parra AS, Anokhin AP. Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene. Neuropsychologia. 2014 Sep; 62:306-18. PMID: 25107677.
    Citations: 6     Fields:    Translation:HumansCells
  6. Xu X, Clark US, David SP, Mulligan RC, Knopik VS, McGeary J, MacKillop J, McCaffery J, Niaura RS, Sweet LH. Effects of nicotine deprivation and replacement on BOLD-fMRI response to smoking cues as a function of DRD4 VNTR genotype. Nicotine Tob Res. 2014 Jul; 16(7):939-47. PMID: 24659022.
    Citations: 6     Fields:    Translation:HumansCells
  7. Mulligan RC, Reiersen AM, Todorov AA. Attention-Deficit/Hyperactivity Disorder, Autistic Traits, and Substance Use Among Missouri Adolescents. Scand J Child Adolesc Psychiatr Psychol. 2014; 2(2):86-92. PMID: 26146608.
    Citations: 2     
  8. Burkhardt UE, Hainz U, Stevenson K, Goldstein NR, Pasek M, Naito M, Wu D, Ho VT, Alonso A, Hammond NN, Wong J, Sievers QL, Brusic A, McDonough SM, Zeng W, Perrin A, Brown JR, Canning CM, Koreth J, Cutler C, Armand P, Neuberg D, Lee JS, Antin JH, Mulligan RC, Sasada T, Ritz J, Soiffer RJ, Dranoff G, Alyea EP, Wu CJ. Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells. J Clin Invest. 2013 Sep; 123(9):3756-65. PMID: 23912587.
    Citations: 28     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  9. Brusic A, Hainz U, Wadleigh M, Neuberg D, Su M, Canning CM, Deangelo DJ, Stone RM, Lee JS, Mulligan RC, Ritz J, Dranoff G, Sasada T, Wu CJ. Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology. 2012 Oct 01; 1(7):1095-1103. PMID: 23170257.
    Citations: 9     
  10. Clark US, Cohen RA, Sweet LH, Gongvatana A, Devlin KN, Hana GN, Westbrook ML, Mulligan RC, Jerskey BA, White TL, Navia B, Tashima KT. Effects of HIV and early life stress on amygdala morphometry and neurocognitive function. J Int Neuropsychol Soc. 2012 Jul; 18(4):657-68. PMID: 22621973.
    Citations: 14     Fields:    Translation:Humans
  11. Herson S, Hentati F, Rigolet A, Behin A, Romero NB, Leturcq F, Laforêt P, Maisonobe T, Amouri R, Haddad H, Audit M, Montus M, Masurier C, Gjata B, Georger C, Cheraï M, Carlier P, Hogrel JY, Herson A, Allenbach Y, Lemoine FM, Klatzmann D, Sweeney HL, Mulligan RC, Eymard B, Caizergues D, Voït T, Benveniste O. A phase I trial of adeno-associated virus serotype 1-?-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C. Brain. 2012 Feb; 135(Pt 2):483-92. PMID: 22240777.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  12. Mulligan RC, Knopik VS, Sweet LH, Fischer M, Seidenberg M, Rao SM. Neural correlates of inhibitory control in adult attention deficit/hyperactivity disorder: evidence from the Milwaukee longitudinal sample. Psychiatry Res. 2011 Nov 30; 194(2):119-29. PMID: 21937201.
    Citations: 22     Fields:    Translation:Humans
  13. Schwenter F, Zarei S, Luy P, Padrun V, Bouche N, Lee JS, Mulligan RC, Morel P, Mach N. Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy. Cancer Gene Ther. 2011 Aug; 18(8):553-62. PMID: 21566667.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  14. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. PMID: 21307849.
    Citations: 415     Fields:    Translation:AnimalsCells
  15. Sanchez CE, Tierney TS, Gale JT, Alavian KN, Sahin A, Lee JS, Mulligan RC, Carter BS. Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg. 2011 Mar; 114(3):672-80. PMID: 20950087.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Danos O, Davies K, Lehn P, Mulligan R. The ARRIVE guidelines, a welcome improvement to standards for reporting animal research. J Gene Med. 2010 Jul; 12(7):559-60. PMID: 20603891.
    Citations: 9     Fields:    Translation:Animals
  17. Sweet LH, Mulligan RC, Finnerty CE, Jerskey BA, David SP, Cohen RA, Niaura RS. Effects of nicotine withdrawal on verbal working memory and associated brain response. Psychiatry Res. 2010 Jul 30; 183(1):69-74. PMID: 20570495.
    Citations: 18     Fields:    Translation:Humans
  18. Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest. 2010 Jan; 120(1):379-89. PMID: 20038801.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  19. Irani F, Sweet LH, Haley AP, Gunstad JJ, Jerskey BA, Mulligan RC, Jefferson AL, Poppas A, Cohen RA. A fMRI Study of Verbal Working Memory, Cardiac Output, and Ejection Fraction in Elderly Patients with Cardiovascular Disease. Brain Imaging Behav. 2009 Dec; 3(4):350-357. PMID: 23227137.
    Citations: 5     Fields:    
  20. Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter BS. Genetically engineered T cells to target EGFRvIII expressing glioblastoma. J Neurooncol. 2009 Sep; 94(3):373-82. PMID: 19387557.
    Citations: 32     Fields:    Translation:HumansCells
  21. Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods Mol Biol. 2009; 540:335-47. PMID: 19381571.
    Citations: 1     Fields:    Translation:HumansCells
  22. Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ. Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10185-90. PMID: 18632559.
    Citations: 39     Fields:    Translation:AnimalsCells
  23. Rodino-Klapac LR, Lee JS, Mulligan RC, Clark KR, Mendell JR. Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D. Neurology. 2008 Jul 22; 71(4):240-7. PMID: 18525034.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  24. Szentirmai O, Baker CH, Bullain SS, Lin N, Takahashi M, Folkman J, Mulligan RC, Carter BS. Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation. J Neurosurg. 2008 May; 108(5):979-88. PMID: 18447716.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008 Apr; 118(4):1511-8. PMID: 18324336.
    Citations: 38     Fields:    Translation:HumansCells
  26. Sweet LH, Paskavitz JF, Haley AP, Gunstad JJ, Mulligan RC, Nyalakanti PK, Cohen RA. Imaging phonological similarity effects on verbal working memory. Neuropsychologia. 2008 Mar 07; 46(4):1114-23. PMID: 18155074.
    Citations: 17     Fields:    Translation:Humans
  27. Paul R, Grieve SM, Chaudary B, Gordon N, Lawrence J, Cooper N, Clark CR, Kukla M, Mulligan R, Gordon E. Relative contributions of the cerebellar vermis and prefrontal lobe volumes on cognitive function across the adult lifespan. Neurobiol Aging. 2009 Mar; 30(3):457-65. PMID: 17869383.
    Citations: 18     Fields:    Translation:Humans
  28. Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR. Engineering high-speed allosteric hammerhead ribozymes. Biol Chem. 2007 Aug; 388(8):779-86. PMID: 17655496.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  29. Chan RK, Garfein E, Gigante PR, Liu P, Agha RA, Mulligan R, Orgill DP. Side population hematopoietic stem cells promote wound healing in diabetic mice. Plast Reconstr Surg. 2007 Aug; 120(2):407-11; discussion 412-3. PMID: 17632341.
    Citations: 6     Fields:    Translation:Animals
  30. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32. PMID: 17568820.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  31. Butler MO, Lee JS, Ansén S, Neuberg D, Hodi FS, Murray AP, Drury L, Berezovskaya A, Mulligan RC, Nadler LM, Hirano N. Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res. 2007 Mar 15; 13(6):1857-67. PMID: 17363542.
    Citations: 49     Fields:    Translation:HumansCells
  32. Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D. PPARalpha deficiency in inflammatory cells suppresses tumor growth. PLoS One. 2007 Feb 28; 2(2):e260. PMID: 17327920.
    Citations: 44     Fields:    Translation:AnimalsCells
  33. Hägerkvist R, Mokhtari D, Lindholm C, Farnebo F, Mostoslavsky G, Mulligan RC, Welsh N, Welsh M. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. Exp Cell Res. 2007 Jan 15; 313(2):284-91. PMID: 17112510.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  34. Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16406-11. PMID: 17062750.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  35. Murphy GJ, Mostoslavsky G, Kotton DN, Mulligan RC. Exogenous control of mammalian gene expression via modulation of translational termination. Nat Med. 2006 Sep; 12(9):1093-9. PMID: 16892063.
    Citations: 25     Fields:    Translation:AnimalsCells
  36. Bullain SS, Szentirmai O, Lin N, Sanchez CE, Mulligan RC, Carter B. Chimeric T-cell Receptor Therapy for Glioblastoma Multiforme 895. Neurosurgery. 2006 Aug 01; 59(2):486. PMID: 28180724.
    Citations:    
  37. Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med. 2006 Jul; 12(7):793-800. PMID: 16799557.
    Citations: 58     Fields:    Translation:Animals
  38. Simons JW, Carducci MA, Mikhak B, Lim M, Biedrzycki B, Borellini F, Clift SM, Hege KM, Ando DG, Piantadosi S, Mulligan R, Nelson WG. Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer. Clin Cancer Res. 2006 Jun 01; 12(11 Pt 1):3394-401. PMID: 16740763.
    Citations: 43     Fields:    Translation:HumansCellsCTClinical Trials
  39. Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7378-83. PMID: 16670198.
    Citations: 45     Fields:    Translation:AnimalsCells
  40. Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006 May; 12(5):797-806. PMID: 16556935.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  41. Szentirmai O, Baker CH, Lin N, Szucs S, Takahashi M, Kiryu S, Kung AL, Mulligan RC, Carter BS. Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect. Neurosurgery. 2006 Feb; 58(2):365-72; discussion 365-72. PMID: 16462491.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  42. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27; 124(2):315-29. PMID: 16439206.
    Citations: 534     Fields:    Translation:HumansAnimalsCells
  43. Balazs AB, Fabian AJ, Esmon CT, Mulligan RC. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood. 2006 Mar 15; 107(6):2317-21. PMID: 16304059.
    Citations: 79     Fields:    Translation:AnimalsCells
  44. Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84. PMID: 15965465.
    Citations: 289     Fields:    Translation:HumansAnimalsCells
  45. Kotton DN, Fabian AJ, Mulligan RC. Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):328-34. PMID: 15961722.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  46. Mostoslavsky G, Kotton DN, Fabian AJ, Gray JT, Lee JS, Mulligan RC. Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation. Mol Ther. 2005 Jun; 11(6):932-40. PMID: 15922964.
    Citations: 73     Fields:    Translation:AnimalsCells
  47. Kotton DN, Fabian AJ, Mulligan RC. A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity. Blood. 2005 Sep 01; 106(5):1574-80. PMID: 15870171.
    Citations: 18     Fields:    Translation:AnimalsCells
  48. Mackinnon A, Mulligan R. [The estimation of premorbid intelligence levels in French speakers]. Encephale. 2005 Jan-Feb; 31(1 Pt 1):31-43. PMID: 15971638.
    Citations: 24     Fields:    Translation:Humans
  49. Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GC. Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol. 2004 Nov; 13(3):191-200. PMID: 15381202.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Tani K, Azuma M, Nakazaki Y, Oyaizu N, Hase H, Ohata J, Takahashi K, OiwaMonna M, Hanazawa K, Wakumoto Y, Kawai K, Noguchi M, Soda Y, Kunisaki R, Watari K, Takahashi S, Machida U, Satoh N, Tojo A, Maekawa T, Eriguchi M, Tomikawa S, Tahara H, Inoue Y, Yoshikawa H, Yamada Y, Iwamoto A, Hamada H, Yamashita N, Okumura K, Kakizoe T, Akaza H, Fujime M, Clift S, Ando D, Mulligan R, Asano S. Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings. Mol Ther. 2004 Oct; 10(4):799-816. PMID: 15451464.
    Citations: 19     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  51. Yen L, Svendsen J, Lee JS, Gray JT, Magnier M, Baba T, D'Amato RJ, Mulligan RC. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature. 2004 Sep 23; 431(7007):471-6. PMID: 15386015.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  52. Chang LK, Garcia-Cardeña G, Farnebo F, Fannon M, Chen EJ, Butterfield C, Moses MA, Mulligan RC, Folkman J, Kaipainen A. Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11658-63. PMID: 15289610.
    Citations: 94     Fields:    Translation:AnimalsCells
  53. Michurina T, Krasnov P, Balazs A, Nakaya N, Vasilieva T, Kuzin B, Khrushchov N, Mulligan RC, Enikolopov G. Nitric oxide is a regulator of hematopoietic stem cell activity. Mol Ther. 2004 Aug; 10(2):241-8. PMID: 15294171.
    Citations: 13     Fields:    Translation:AnimalsCells
  54. Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, Sodroski J. TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11827-32. PMID: 15280539.
    Citations: 161     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  55. Podar K, Mostoslavsky G, Sattler M, Tai YT, Hayashi T, Catley LP, Hideshima T, Mulligan RC, Chauhan D, Anderson KC. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. J Biol Chem. 2004 May 14; 279(20):21658-65. PMID: 15010462.
    Citations: 21     Fields:    Translation:HumansCells
  56. Matsuzaki Y, Kinjo K, Mulligan RC, Okano H. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity. 2004 Jan; 20(1):87-93. PMID: 14738767.
    Citations: 79     Fields:    Translation:AnimalsCells
  57. Griese DP, Ehsan A, Melo LG, Kong D, Zhang L, Mann MJ, Pratt RE, Mulligan RC, Dzau VJ. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation. 2003 Nov 25; 108(21):2710-5. PMID: 14597586.
    Citations: 101     Fields:    Translation:AnimalsCells
  58. Soiffer R, Hodi FS, Haluska F, Jung K, Gillessen S, Singer S, Tanabe K, Duda R, Mentzer S, Jaklitsch M, Bueno R, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Mihm M, Dranoff G. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol. 2003 Sep 01; 21(17):3343-50. PMID: 12947071.
    Citations: 68     Fields:    Translation:HumansCellsCTClinical Trials
  59. Robert C, Klein C, Cheng G, Kogan A, Mulligan RC, von Andrian UH, Kupper TS. Gene therapy to target dendritic cells from blood to lymph nodes. Gene Ther. 2003 Aug; 10(17):1479-86. PMID: 12900763.
    Citations: 9     Fields:    Translation:HumansCells
  60. Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol. 2003 Apr; 23(7):2395-406. PMID: 12640123.
    Citations: 14     Fields:    Translation:AnimalsCells
  61. Salgia R, Lynch T, Skarin A, Lucca J, Lynch C, Jung K, Hodi FS, Jaklitsch M, Mentzer S, Swanson S, Lukanich J, Bueno R, Wain J, Mathisen D, Wright C, Fidias P, Donahue D, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Sugarbaker D, Mihm M, Dranoff G. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol. 2003 Feb 15; 21(4):624-30. PMID: 12586798.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  62. Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB. Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. Blood. 2003 Mar 15; 101(6):2159-66. PMID: 12433691.
    Citations: 31     Fields:    Translation:AnimalsCells
  63. Conte MS, Mann MJ, Simosa HF, Rhynhart KK, Mulligan RC. Genetic interventions for vein bypass graft disease: a review. J Vasc Surg. 2002 Nov; 36(5):1040-52. PMID: 12422116.
    Citations: 7     Fields:    Translation:HumansAnimals
  64. Tseng JF, Farnebo FA, Kisker O, Becker CM, Kuo CJ, Folkman J, Mulligan RC. Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice. Surgery. 2002 Nov; 132(5):857-65. PMID: 12464871.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science. 2002 Oct 18; 298(5593):597-600. PMID: 12228720.
    Citations: 446     Fields:    Translation:AnimalsCells
  66. Becker CM, Farnebo FA, Iordanescu I, Behonick DJ, Shih MC, Dunning P, Christofferson R, Mulligan RC, Taylor GA, Kuo CJ, Zetter BR. Gene therapy of prostate cancer with the soluble vascular endothelial growth factor receptor Flk1. . 2002 Sep-Oct; 1(5):548-53. PMID: 12496487.
    Citations: 13     Translation:HumansAnimalsCells
  67. Kawai K, Tani K, Yamashita N, Tomikawa S, Eriguchi M, Fujime M, Okumura K, Kakizoe T, Clift S, Ando D, Mulligan R, Yamauchi A, Noguchi M, Asano S, Akaza H. Advanced renal cell carcinoma treated with granulocyte-macrophage colony-stimulating factor gene therapy: a clinical course of the first Japanese experience. Int J Urol. 2002 Aug; 9(8):462-6. PMID: 12225344.
    Citations: 4     Fields:    Translation:Humans
  68. Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul; 30(7):809-15. PMID: 12135680.
    Citations: 5     Fields:    Translation:AnimalsCells
  69. Tseng JF, Mulligan RC. Gene therapy for pancreatic cancer. Surg Oncol Clin N Am. 2002 Jul; 11(3):537-69. PMID: 12487056.
    Citations: 3     Fields:    Translation:Humans
  70. Niederman TM, Ghogawala Z, Carter BS, Tompkins HS, Russell MM, Mulligan RC. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7009-14. PMID: 11997459.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  71. Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. PMID: 11584271.
    Citations: 116     Fields:    Translation:AnimalsCells
  72. Hilton JF, Alves M, Anastos K, Canchola AJ, Cohen M, Delapenha R, Greenspan D, Levine A, MacPhail LA, Micci SJ, Mulligan R, Navazesh M, Phelan J, Tsaknis P. Accuracy of diagnoses of HIV-related oral lesions by medical clinicians. Findings from the Women's Interagency HIV Study. Community Dent Oral Epidemiol. 2001 Oct; 29(5):362-72. PMID: 11553109.
    Citations: 3     Fields:    Translation:HumansCells
  73. Mackinnon A, Mulligan R. The Psychogeriatric Assessment Scales (PAS): psychometric properties in French and German speaking populations. Int J Geriatr Psychiatry. 2001 Sep; 16(9):892-9. PMID: 11571770.
    Citations:    Fields:    Translation:Humans
  74. Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702. PMID: 11443115.
    Citations: 3     Fields:    Translation:AnimalsCells
  75. Kuo CJ, Farnebo F, Yu EY, Christofferson R, Swearingen RA, Carter R, von Recum HA, Yuan J, Kamihara J, Flynn E, D'Amato R, Folkman J, Mulligan RC. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4605-10. PMID: 11274374.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  76. Kuo CJ, LaMontagne KR, Garcia-Cardeña G, Ackley BD, Kalman D, Park S, Christofferson R, Kamihara J, Ding YH, Lo KM, Gillies S, Folkman J, Mulligan RC, Javaherian K. Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain. J Cell Biol. 2001 Mar 19; 152(6):1233-46. PMID: 11257123.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  77. Snitkovsky S, Niederman TM, Mulligan RC, Young JA. Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein. J Virol. 2001 Feb; 75(3):1571-5. PMID: 11152532.
    Citations: 9     Fields:    Translation:Cells
  78. Lundberg C, Jungles SJ, Mulligan RC. Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy. Nat Biotechnol. 2001 Feb; 19(2):169-72. PMID: 11175734.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  79. Hirosue S, Müller BG, Mulligan RC, Langer R. Plasmid DNA encapsulation and release from solvent diffusion nanospheres. J Control Release. 2001 Jan 29; 70(1-2):231-42. PMID: 11166423.
    Citations: 11     Fields:    Translation:Cells
  80. Snitkovsky S, Niederman TM, Carter BS, Mulligan RC, Young JA. A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor. J Virol. 2000 Oct; 74(20):9540-5. PMID: 11000224.
    Citations: 11     Fields:    Translation:HumansCells
  81. Storms RW, Goodell MA, Fisher A, Mulligan RC, Smith C. Hoechst dye efflux reveals a novel CD7(+)CD34(-) lymphoid progenitor in human umbilical cord blood. Blood. 2000 Sep 15; 96(6):2125-33. PMID: 10979957.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  82. Greenspan D, Komaroff E, Redford M, Phelan JA, Navazesh M, Alves ME, Kamrath H, Mulligan R, Barr CE, Greenspan JS. Oral mucosal lesions and HIV viral load in the Women's Interagency HIV Study (WIHS). . 2000 Sep 01; 25(1):44-50. PMID: 11064503.
    Citations: 15     Translation:Humans
  83. Navazesh M, Mulligan R, Komaroff E, Redford M, Greenspan D, Phelan J. The prevalence of xerostomia and salivary gland hypofunction in a cohort of HIV-positive and at-risk women. J Dent Res. 2000 Jul; 79(7):1502-7. PMID: 11005735.
    Citations: 13     Fields:    Translation:Humans
  84. Dahl AM, Klein C, Andres PG, London CA, Lodge MP, Mulligan RC, Abbas AK. Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes. J Exp Med. 2000 Jun 19; 191(12):2031-8. PMID: 10859328.
    Citations: 14     Fields:    Translation:AnimalsCells
  85. Klein C, Bueler H, Mulligan RC. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. J Exp Med. 2000 May 15; 191(10):1699-708. PMID: 10811863.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  86. Feng D, Nagy JA, Brekken RA, Pettersson A, Manseau EJ, Pyne K, Mulligan R, Thorpe PE, Dvorak HF, Dvorak AM. Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors. J Histochem Cytochem. 2000 Apr; 48(4):545-56. PMID: 10727296.
    Citations: 26     Fields:    Translation:AnimalsCells
  87. Pettersson A, Nagy JA, Brown LF, Sundberg C, Morgan E, Jungles S, Carter R, Krieger JE, Manseau EJ, Harvey VS, Eckelhoefer IA, Feng D, Dvorak AM, Mulligan RC, Dvorak HF. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest. 2000 Jan; 80(1):99-115. PMID: 10653008.
    Citations: 104     Fields:    Translation:Animals
  88. Nelson WG, Simons JW, Mikhak B, Chang JF, DeMarzo AM, Carducci MA, Kim M, Weber CE, Baccala AA, Goeman MA, Clift SM, Ando DG, Levitsky HI, Cohen LK, Sanda MG, Mulligan RC, Partin AW, Carter HB, Piantadosi S, Marshall FF. Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies. Cancer Chemother Pharmacol. 2000; 46 Suppl:S67-72. PMID: 10950151.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  89. Dzau V, Frank M, Reich M, Austin MJ, Aebersold R, Cowley A, Housman D, Mulligan R, Rosenberg R. Constants and scientific progress. Physiol Genomics. 1999 Nov 11; 1(3):107. PMID: 11015568.
    Citations:    Fields:    
  90. Simons JW, Mikhak B, Chang JF, DeMarzo AM, Carducci MA, Lim M, Weber CE, Baccala AA, Goemann MA, Clift SM, Ando DG, Levitsky HI, Cohen LK, Sanda MG, Mulligan RC, Partin AW, Carter HB, Piantadosi S, Marshall FF, Nelson WG. Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer. Cancer Res. 1999 Oct 15; 59(20):5160-8. PMID: 10537292.
    Citations: 67     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  91. Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF, Kunkel LM, Mulligan RC. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature. 1999 Sep 23; 401(6751):390-4. PMID: 10517639.
    Citations: 359     Fields:    Translation:AnimalsCells
  92. Dzau VJ, Austin MJ, Brown P, Cowley A, Housman D, Mulligan R, Rosenberg R. Revolution and renaissance. Physiol Genomics. 1999 Jul 15; 1(1):1-2. PMID: 11015554.
    Citations: 1     Fields:    Translation:HumansAnimals
  93. Feng S, Quickel RR, Hollister-Lock J, McLeod M, Bonner-Weir S, Mulligan RC, Weir GC. Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig. Transplantation. 1999 Jun 27; 67(12):1607-13. PMID: 10401769.
    Citations: 2     Fields:    Translation:Animals
  94. Zehntner S, Townsend W, Parkes J, Schmidt C, Down M, Bell J, Mulligan R, O'Rourke M, Ellem K, Thomas R. Tumor metastasis biopsy as a surrogate marker of response to melanoma immunotherapy. Pathology. 1999 May; 31(2):116-22. PMID: 10399166.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  95. Rebel VI, Tanaka M, Lee JS, Hartnett S, Pulsipher M, Nathan DG, Mulligan RC, Sieff CA. One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Blood. 1999 Apr 01; 93(7):2217-24. PMID: 10090930.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  96. Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Cohen LK, Mulligan RC, Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13141-6. PMID: 9789055.
    Citations: 95     Fields:    Translation:HumansCellsCTClinical Trials
  97. Pulsipher M, Kupfer GM, Naf D, Suliman A, Lee JS, Jakobs P, Grompe M, Joenje H, Sieff C, Guinan E, Mulligan R, D'Andrea AD. Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. Mol Med. 1998 Jul; 4(7):468-79. PMID: 9713825.
    Citations: 13     Fields:    Translation:HumansCells
  98. Gainsford T, Roberts AW, Kimura S, Metcalf D, Dranoff G, Mulligan RC, Begley CG, Robb L, Alexander WS. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Blood. 1998 Apr 15; 91(8):2745-52. PMID: 9531584.
    Citations: 10     Fields:    Translation:AnimalsCells
  99. Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature. 1998 Mar 05; 392(6671):90-3. PMID: 9510253.
    Citations: 147     Fields:    Translation:AnimalsCells
  100. Mach N, Lantz CS, Galli SJ, Reznikoff G, Mihm M, Small C, Granstein R, Beissert S, Sadelain M, Mulligan RC, Dranoff G. Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 1998 Feb 01; 91(3):778-83. PMID: 9446636.
    Citations: 16     Fields:    Translation:AnimalsCells
  101. McArthur JG, Mulligan RC. Induction of protective anti-tumor immunity by gene-modified dendritic cells. J Immunother. 1998 Jan; 21(1):41-7. PMID: 9456435.
    Citations: 5     Fields:    Translation:AnimalsCells
  102. Sonderbye L, Feng S, Yacoubian S, Buehler H, Ahsan N, Mulligan R, Langhoff E. In vivo and in vitro modulation of immune stimulatory capacity of primary dendritic cells by adenovirus-mediated gene transduction. Exp Clin Immunogenet. 1998; 15(2):100-11. PMID: 9691204.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  103. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med. 1997 Dec; 3(12):1337-45. PMID: 9396603.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  104. Kaptein LC, Van Beusechem VW, Rivière I, Mulligan RC, Valerio D. Long-term in vivo expression of the MFG-ADA retroviral vector in rhesus monkeys transplanted with transduced bone marrow cells. Hum Gene Ther. 1997 Sep 01; 8(13):1605-10. PMID: 9322093.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  105. Lindemann D, Patriquin E, Feng S, Mulligan RC. Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo. Mol Med. 1997 Jul; 3(7):466-76. PMID: 9260158.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  106. Simons JW, Jaffee EM, Weber CE, Levitsky HI, Nelson WG, Carducci MA, Lazenby AJ, Cohen LK, Finn CC, Clift SM, Hauda KM, Beck LA, Leiferman KM, Owens AH, Piantadosi S, Dranoff G, Mulligan RC, Pardoll DM, Marshall FF. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res. 1997 Apr 15; 57(8):1537-46. PMID: 9108457.
    Citations: 61     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  107. Ellem KA, O'Rourke MG, Johnson GR, Parry G, Misko IS, Schmidt CW, Parsons PG, Burrows SR, Cross S, Fell A, Li CL, Bell JR, Dubois PJ, Moss DJ, Good MF, Kelso A, Cohen LK, Dranoff G, Mulligan RC. A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy. Cancer Immunol Immunother. 1997 Mar; 44(1):10-20. PMID: 9111579.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  108. Lieschke GJ, Rao PK, Gately MK, Mulligan RC. Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo. Nat Biotechnol. 1997 Jan; 15(1):35-40. PMID: 9035103.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  109. Dranoff G, Soiffer R, Lynch T, Mihm M, Jung K, Kolesar K, Liebster L, Lam P, Duda R, Mentzer S, Singer S, Tanabe K, Johnson R, Sober A, Bhan A, Clift S, Cohen L, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Mulligan RC. A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. Hum Gene Ther. 1997 Jan 01; 8(1):111-23. PMID: 8990000.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  110. Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11400-6. PMID: 8876147.
    Citations: 292     Fields:    Translation:HumansAnimalsCells
  111. Naito T, Yokoyama H, Moore KJ, Dranoff G, Mulligan RC, Kelley VR. A gene transfer system establishes interleukin-6 neither promotes nor suppresses renal injury. Am J Physiol. 1996 Sep; 271(3 Pt 2):F603-9. PMID: 8853422.
    Citations:    Fields:    Translation:Animals
  112. Büeler H, Mulligan RC. Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1. Mol Med. 1996 Sep; 2(5):545-55. PMID: 8898371.
    Citations: 10     Fields:    Translation:AnimalsCells
  113. Huang YY, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonjans L, Kandel ER, Godfraind JM, Mulligan R, Collen D, Carmeliet P. Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8699-704. PMID: 8710934.
    Citations: 62     Fields:    Translation:Animals
  114. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 1996 Aug 02; 273(5275):663-6. PMID: 8662561.
    Citations: 268     Fields:    Translation:AnimalsCells
  115. Naito T, Yokoyama H, Moore KJ, Dranoff G, Mulligan RC, Kelley VR. Macrophage growth factors introduced into the kidney initiate renal injury. Mol Med. 1996 May; 2(3):297-312. PMID: 8784783.
    Citations: 13     Fields:    Translation:AnimalsCells
  116. Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996 Apr 12; 272(5259):263-7. PMID: 8602510.
    Citations: 1336     Fields:    Translation:HumansAnimalsCells
  117. Chang AE, Sondak VK, Bishop DK, Nickoloff BJ, Mulligan RC, Mulé JJ. Adoptive immunotherapy of cancer with activated lymph node cells primed in vivo with autologous tumor cells transduced with the GM-CSF gene. Hum Gene Ther. 1996 Apr 10; 7(6):773-92. PMID: 9053030.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  118. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996 Apr 01; 183(4):1797-806. PMID: 8666936.
    Citations: 834     Fields:    Translation:AnimalsCells
  119. Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC, Dranoff G, Jobe AH. Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. Am J Physiol. 1996 Apr; 270(4 Pt 1):L650-8. PMID: 8928826.
    Citations: 34     Fields:    Translation:Animals
  120. Dewerchin M, Nuffelen AV, Wallays G, Bouché A, Moons L, Carmeliet P, Mulligan RC, Collen D. Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. 1996 Feb 01; 97(3):870-8. PMID: 8609247.
    Citations: 44     Fields:    Translation:AnimalsCells
  121. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest. 1996 Feb 01; 97(3):649-55. PMID: 8609219.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  122. Hakim LS, Kulaksizoglu H, Mulligan R, Greenfield A, Goldstein I. Evolving concepts in the diagnosis and treatment of arterial high flow priapism. J Urol. 1996 Feb; 155(2):541-8. PMID: 8558656.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  123. Yokoyama H, Naito T, Dranoff G, Mulligan RC, Rubin-Kelley V. Gene transfer of macrophage growth factors into the kidney of lpr mice initiates renal injury. Contrib Nephrol. 1996; 118:94-9. PMID: 8744045.
    Citations: 1     Fields:    Translation:Animals
  124. Krall WJ, Skelton DC, Yu XJ, Riviere I, Lehn P, Mulligan RC, Kohn DB. Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells. Gene Ther. 1996 Jan; 3(1):37-48. PMID: 8929910.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  125. Leonardsson G, Peng XR, Liu K, Nordström L, Carmeliet P, Mulligan R, Collen D, Ny T. Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12446-50. PMID: 8618918.
    Citations: 9     Fields:    Translation:Animals
  126. Tani K, Lin T, Hibino H, Takahashi K, Nakazaki Y, Takahashi S, Nagayama H, Ozawa K, Saitoh I, Mulligan R, et al. Transduction of LacZ gene into leukemia cells using viral vectors of retrovirus and adenovirus. Leukemia. 1995 Oct; 9 Suppl 1:S64-5. PMID: 7475316.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  127. Hurford RK, Dranoff G, Mulligan RC, Tepper RI. Gene therapy of metastatic cancer by in vivo retroviral gene targeting. Nat Genet. 1995 Aug; 10(4):430-5. PMID: 7670493.
    Citations: 17     Fields:    Translation:AnimalsCells
  128. Sadelain M, Wang CH, Antoniou M, Grosveld F, Mulligan RC. Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6728-32. PMID: 7624311.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  129. Rivière I, Brose K, Mulligan RC. Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6733-7. PMID: 7624312.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  130. Willemsen R, Tybulewicz V, Sidransky E, Eliason WK, Martin BM, LaMarca ME, Reuser AJ, Tremblay M, Westphal H, Mulligan RC, et al. A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse. Mol Chem Neuropathol. 1995 Feb-Apr; 24(2-3):179-92. PMID: 7632321.
    Citations: 10     Fields:    Translation:AnimalsCells
  131. Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan RC, Collen D. Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice. Ann N Y Acad Sci. 1995 Jan 17; 748:367-81; discussion 381-2. PMID: 7695179.
    Citations: 8     Fields:    Translation:AnimalsCells
  132. Dranoff G, Mulligan RC. Gene transfer as cancer therapy. Adv Immunol. 1995; 58:417-54. PMID: 7741031.
    Citations: 15     Fields:    Translation:HumansAnimalsPHPublic Health
  133. Shworak NW, Shirakawa M, Colliec-Jouault S, Liu J, Mulligan RC, Birinyi LK, Rosenberg RD. Pathway-specific regulation of the synthesis of anticoagulantly active heparan sulfate. J Biol Chem. 1994 Oct 07; 269(40):24941-52. PMID: 7929177.
    Citations: 16     Fields:    Translation:AnimalsCells
  134. Carmeliet P, Mulligan RC, Collen D. Transgenic animals as tools for the study of fibrinolysis in vivo. J Intern Med. 1994 Oct; 236(4):455-9. PMID: 7931048.
    Citations: 1     Fields:    Translation:AnimalsCells
  135. Vogt PM, Thompson S, Andree C, Liu P, Breuing K, Hatzis D, Brown H, Mulligan RC, Eriksson E. Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9307-11. PMID: 7937761.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  136. Shworak NW, Shirakawa M, Mulligan RC, Rosenberg RD. Characterization of ryudocan glycosaminoglycan acceptor sites. J Biol Chem. 1994 Aug 19; 269(33):21204-14. PMID: 7520439.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  137. Conte MS, Birinyi LK, Miyata T, Fallon JT, Gold HK, Whittemore AD, Mulligan RC. Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells. Circulation. 1994 May; 89(5):2161-9. PMID: 8181141.
    Citations: 6     Fields:    Translation:AnimalsCells
  138. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC. Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31; 368(6470):419-24. PMID: 8133887.
    Citations: 219