Harvard Catalyst Profiles

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Zhen-Yu Jim Sun, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32GM018338 (SUN, ZHEN-YU J) Jan 1, 1997
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, Wagner G, Lang MJ, Reinherz EL. TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76. PMID: 22566957.
    Citations: 39     Fields:    
  2. Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol. 2011 Oct 16; 18(11):1235-43. PMID: 22002224.
    Citations: 56     Fields:    Translation:HumansCells
  3. Milbradt AG, Kulkarni M, Yi T, Takeuchi K, Sun ZY, Luna RE, Selenko P, Näär AM, Wagner G. Structure of the VP16 transactivator target in the Mediator. Nat Struct Mol Biol. 2011 Apr; 18(4):410-5. PMID: 21378963.
    Citations: 47     Fields:    Translation:HumansCells
  4. Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol. 2010 Sep 01; 185(5):2951-9. PMID: 20660709; PMCID: PMC2936104.
    Citations: 23     Fields:    Translation:AnimalsCells
  5. Takeuchi K, Sun ZY, Park S, Wagner G. Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity. Biochemistry. 2010 Jul 13; 49(27):5634-41. PMID: 20527928.
    Citations: 5     Fields:    Translation:Cells
  6. Takeuchi K, Heffron G, Sun ZY, Frueh DP, Wagner G. Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments. J Biomol NMR. 2010 Aug; 47(4):271-82. PMID: 20556482.
    Citations: 15     Fields:    
  7. Takeuchi K, Frueh DP, Sun ZY, Hiller S, Wagner G. CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification. J Biomol NMR. 2010 May; 47(1):55-63. PMID: 20383561.
    Citations: 11     Fields:    Translation:Cells
  8. Takeuchi K, Frueh DP, Hyberts SG, Sun ZY, Wagner G. High-resolution 3D CANCA NMR experiments for complete mainchain assignments using C(alpha) direct detection. J Am Chem Soc. 2010 Mar 10; 132(9):2945-51. PMID: 20155902.
    Citations: 14     Fields:    
  9. Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL. The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem. 2009 Nov 06; 284(45):31028-37. PMID: 19755427.
    Citations: 207     Fields:    Translation:AnimalsCells
  10. Song L, Sun ZY, Coleman KE, Zwick MB, Gach JS, Wang JH, Reinherz EL, Wagner G, Kim M. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):9057-62. PMID: 19458040.
    Citations: 76     Fields:    Translation:HumansCells
  11. Takeuchi K, Sun ZY, Wagner G. Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems. J Am Chem Soc. 2008 Dec 24; 130(51):17210-1. PMID: 19049287.
    Citations: 20     Fields:    Translation:Cells
  12. Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G. Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol. 2008 Jul 18; 380(4):704-16. PMID: 18555270.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  13. Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity. 2008 Jan; 28(1):52-63. PMID: 18191596.
    Citations: 173     Fields:    Translation:HumansCells
  14. Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul 25; 26(14):3474-83. PMID: 17599068; PMCID: PMC1933403.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  15. Takeuchi K, Roehrl MH, Sun ZY, Wagner G. Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure. 2007 May; 15(5):587-97. PMID: 17502104.
    Citations: 21     Fields:    Translation:HumansCells
  16. Touma M, Sun ZY, Clayton LK, Marissen WE, Kruisbeek AM, Wagner G, Reinherz EL. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol. 2007 Mar 15; 178(6):3668-79. PMID: 17339464.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Frueh DP, Sun ZY, Vosburg DA, Walsh CT, Hoch JC, Wagner G. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc. 2006 May 03; 128(17):5757-63. PMID: 16637644.
    Citations: 34     Fields:    
  18. Monnier N, Higo-Moriguchi K, Sun ZY, Prasad BV, Taniguchi K, Dormitzer PR. High-resolution molecular and antigen structure of the VP8* core of a sialic acid-independent human rotavirus strain. J Virol. 2006 Feb; 80(3):1513-23. PMID: 16415027; PMCID: PMC1346936.
    Citations: 38     Fields:    Translation:HumansCells
  19. Sun ZY, Frueh DP, Selenko P, Hoch JC, Wagner G. Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. J Biomol NMR. 2005 Sep; 33(1):43-50. PMID: 16222556.
    Citations: 33     Fields:    Translation:Cells
  20. Robinson MA, Park S, Sun ZY, Silver PA, Wagner G, Hogle JM. Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116p. J Biol Chem. 2005 Oct 21; 280(42):35723-32. PMID: 16105837.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 05; 280(31):28701-10. PMID: 15964836.
    Citations: 30     Fields:    Translation:AnimalsCells
  22. Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol. 2005 Jun; 12(6):526-32. PMID: 15895093.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  23. Sun ZY, Hyberts SG, Rovnyak D, Park S, Stern AS, Hoch JC, Wagner G. High-resolution aliphatic side-chain assignments in 3D HCcoNH experiments with joint H-C evolution and non-uniform sampling. J Biomol NMR. 2005 May; 32(1):55-60. PMID: 16041483.
    Citations: 12     Fields:    
  24. Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G. Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16867-72. PMID: 15557001; PMCID: PMC534738.
    Citations: 49     Fields:    Translation:AnimalsCells
  25. Rovnyak D, Frueh DP, Sastry M, Sun ZY, Stern AS, Hoch JC, Wagner G. Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. J Magn Reson. 2004 Sep; 170(1):15-21. PMID: 15324754.
    Citations: 85     Fields:    Translation:Cells
  26. Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. J Virol. 2004 Jan; 78(1):413-23. PMID: 14671122; PMCID: PMC303419.
    Citations: 14     Fields:    Translation:HumansCells
  27. Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8. PMID: 14500983.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  28. Dial R, Sun ZY, Freedman SJ. Three conformational states of the p300 CH1 domain define its functional properties. Biochemistry. 2003 Aug 26; 42(33):9937-45. PMID: 12924942.
    Citations: 14     Fields:    Translation:HumansCells
  29. Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol. 2003 Jul; 10(7):504-12. PMID: 12778114.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  30. Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. J Biol Chem. 2003 Apr 11; 278(15):13462-7. PMID: 12556468.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  31. Dormitzer PR, Sun ZY, Blixt O, Paulson JC, Wagner G, Harrison SC. Specificity and affinity of sialic acid binding by the rhesus rotavirus VP8* core. J Virol. 2002 Oct; 76(20):10512-7. PMID: 12239329; PMCID: PMC136543.
    Citations: 32     Fields:    Translation:AnimalsCells
  32. Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5367-72. PMID: 11959990; PMCID: PMC122775.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  33. Dormitzer PR, Sun ZY, Wagner G, Harrison SC. The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J. 2002 Mar 01; 21(5):885-97. PMID: 11867517; PMCID: PMC125907.
    Citations: 133     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.