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Barbara Wegiel, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK125846 (WEGIEL, BARBARA) Mar 29, 2021 - Feb 28, 2025
    NIH
    Characterizing the role of the heme catabolism in tissue damage and inflammation.
    Role: Principal Investigator
  2. R21CA256720 (WEGIEL, BARBARA) Dec 9, 2020 - Nov 30, 2022
    NIH
    Determining the role of gas metabolite in response to immunotherapy
    Role: Principal Investigator
  3. R01DK104714 (WEGIEL, BARBARA) Jan 1, 2016 - Dec 31, 2020
    NIH
    Role of biliverdin reductase during sterile inflammation in the liver.
    Role: Principal Investigator
  4. R21CA169904 (WEGIEL, BARBARA) Aug 6, 2013 - Jul 31, 2015
    NIH
    Heme degradation pathway and immunomodulation in prostate cancer.
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eguchi T, Csizmadia E, Kawai H, Sheta M, Yoshida K, Prince TL, Wegiel B, Calderwood SK. SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration. Cells. 2022 12 10; 11(24). PMID: 36552758; PMCID: PMC9777339.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Canesin G, Feldbrügge L, Wei G, Janovicova L, Janikova M, Csizmadia E, Ariffin J, Hedblom A, Herbert ZT, Robson SC, Celec P, Swanson KD, Nasser I, Popov YV, Wegiel B. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. iScience. 2022 Sep 16; 25(9):104983. PMID: 36093061; PMCID: PMC9450142.
    Citations:    
  3. Hecht JL, Janikova M, Choudhury R, Liu F, Canesin G, Janovicova L, Csizmadia E, Jorgensen EM, Esselen KM, Celec P, Swanson KD, Wegiel B. Labile Heme and Heme Oxygenase-1 Maintain Tumor-Permissive Niche for Endometriosis-Associated Ovarian Cancer. Cancers (Basel). 2022 Apr 29; 14(9). PMID: 35565370; PMCID: PMC9105072.
    Citations:    
  4. Stec DE, Wegiel B, Hinds TD. Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders. Front Pharmacol. 2021; 12:759468. PMID: 34557106; PMCID: PMC8452909.
    Citations:    
  5. Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021 09 02; 184(18):4753-4771.e27. PMID: 34388391; PMCID: PMC8557351.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Hecht J, Suliman S, Wegiel B. Bacillus Calmette-Guerin (BCG) vaccination to treat endometriosis. Vaccine. 2021 12 08; 39(50):7353-7356. PMID: 34301432.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  7. Canesin G, Muralidharan AM, Swanson KD, Wegiel B. HO-1 and Heme: G-Quadruplex Interaction Choreograph DNA Damage Responses and Cancer Growth. Cells. 2021 07 16; 10(7). PMID: 34359970.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Canesin G, Janovicova L, Wegiel B. Measurement of labile and protein-bound heme in fixed prostate cancer cells and in cellular fractions. STAR Protoc. 2021 06 18; 2(2):100491. PMID: 33997811; PMCID: PMC8091920.
    Citations: 1     Fields:    Translation:HumansCells
  9. Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B. Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Rep. 2020 09 22; 32(12):108181. PMID: 32966797.
    Citations: 10     Fields:    Translation:HumansCells
  10. Lilljebjörn LV, Csizmadia E, Hedblom A, Canesin G, Kalbasi A, Li M, Kramer F, Bornfeldt KE, Wegiel B. A Role of the Heme Degradation Pathway in Shaping Prostate Inflammatory Responses and Lipid Metabolism. Am J Pathol. 2020 04; 190(4):830-843. PMID: 32035059; PMCID: PMC7217330.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Canesin G, Hejazi SM, Swanson KD, Wegiel B. Heme-Derived Metabolic Signals Dictate Immune Responses. Front Immunol. 2020; 11:66. PMID: 32082323.
    Citations: 27     Fields:    Translation:HumansAnimals
  12. Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B. Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway. J Immunol. 2019 05 15; 202(10):2982-2990. PMID: 30952817; PMCID: PMC6504595.
    Citations: 10     Fields:    Translation:AnimalsCells
  13. Daneshmandi S, Wegiel B, Seth P. Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma. Cancers (Basel). 2019 Mar 29; 11(4). PMID: 30934955; PMCID: PMC6521327.
    Citations: 32     
  14. Hedblom A, Hejazi SM, Canesin G, Choudhury R, Hanafy KA, Csizmadia E, Persson JL, Wegiel B. Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury. Cell Death Dis. 2019 01 25; 10(2):72. PMID: 30683864; PMCID: PMC6347604.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  15. Wegiel B, Vuerich M, Daneshmandi S, Seth P. Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy. Front Oncol. 2018; 8:284. PMID: 30151352; PMCID: PMC6099109.
    Citations: 39     
  16. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 04; 2(9). PMID: 28469075.
    Citations: 30     Fields:    
  17. Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B. Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity. Cancer Res. 2017 07 01; 77(13):3632-3643. PMID: 28446465; PMCID: PMC5505499.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  18. Wang Y, Hedblom A, Koerner SK, Li M, Jernigan FE, Wegiel B, Sun L. Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation. Bioorg Med Chem Lett. 2016 12 01; 26(23):5703-5706. PMID: 27810244; PMCID: PMC5142821.
    Citations: 4     Fields:    Translation:HumansCells
  19. Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B. Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth. Oncotarget. 2016 Apr 26; 7(17):23919-32. PMID: 26993595.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  20. Wegiel B, Wang Y, Li M, Jernigan F, Sun L. Novel indolyl-chalcones target stathmin to induce cancer cell death. Cell Cycle. 2016 05 02; 15(9):1288-94. PMID: 26986925; PMCID: PMC4889226.
    Citations: 4     Fields:    Translation:HumansCells
  21. Wegiel B, Ahmed A. "Nucleosome debris" provokes coagulation and inflammation. Thromb Res. 2016 Jan; 137:1-2. PMID: 26603319.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Nemeth Z, Li M, Csizmadia E, Döme B, Johansson M, Persson JL, Seth P, Otterbein L, Wegiel B. Heme oxygenase-1 in macrophages controls prostate cancer progression. Oncotarget. 2015 Oct 20; 6(32):33675-88. PMID: 26418896.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  23. Wegiel B, Hauser CJ, Otterbein LE. Heme as a danger molecule in pathogen recognition. Free Radic Biol Med. 2015 Dec; 89:651-61. PMID: 26456060.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  24. Eguchi T, Prince T, Wegiel B, Calderwood SK. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. J Cell Biochem. 2015 Oct; 116(10):2146-54. PMID: 25903835; PMCID: PMC7380561.
    Citations: 25     Fields:    Translation:HumansCells
  25. Ahmad S, Hewett PW, Fujisawa T, Sissaoui S, Cai M, Gueron G, Al-Ani B, Cudmore M, Ahmed SF, Wong MK, Wegiel B, Otterbein LE, Vítek L, Ramma W, Wang K, Ahmed A. Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost. 2015 Feb; 113(2):329-37. PMID: 25354586.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  26. Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. J Clin Invest. 2014 Nov; 124(11):4926-40. PMID: 25295542; PMCID: PMC4347244.
    Citations: 83     Fields:    Translation:AnimalsCells
  27. Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun. 2014 Jun 20; 449(1):94-9. PMID: 24814708; PMCID: PMC4051991.
    Citations: 21     Fields:    Translation:AnimalsCells
  28. Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE. Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells. Cell Death Dis. 2014 Mar 20; 5:e1139. PMID: 24651442.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  29. Wegiel B, Nemeth Z, Correa-Costa M, Bulmer AC, Otterbein LE. Heme oxygenase-1: a metabolic nike. Antioxid Redox Signal. 2014 Apr 10; 20(11):1709-22. PMID: 24180257.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  30. Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B. Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration. Thromb Haemost. 2014 May 05; 111(5):951-9. PMID: 24477332.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res. 2013 Dec 01; 73(23):7009-21. PMID: 24121491; PMCID: PMC3851591.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  32. Wegiel B, Hanto DW, Otterbein LE. The social network of carbon monoxide in medicine. Trends Mol Med. 2013 Jan; 19(1):3-11. PMID: 23140858.
    Citations: 42     Fields:    Translation:Humans
  33. Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S. Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem. 2012 Sep 14; 287(38):32113-23. PMID: 22843690.
    Citations: 34     Fields:    Translation:HumansCells
  34. Wegiel B, Otterbein LE. Go green: the anti-inflammatory effects of biliverdin reductase. Front Pharmacol. 2012; 3:47. PMID: 22438844.
    Citations: 52     
  35. Wegiel B, Gallo D, Csizmadia E, Roger T, Kaczmarek E, Harris C, Zuckerbraun BS, Otterbein LE. Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18849-54. PMID: 22042868.
    Citations: 52     Fields:    Translation:AnimalsCells
  36. Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B. Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14491-6. PMID: 21849621; PMCID: PMC3167547.
    Citations: 27     Fields:    Translation:AnimalsCells
  37. Hanto DW, Maki T, Yoon MH, Csizmadia E, Chin BY, Gallo D, Konduru B, Kuramitsu K, Smith NR, Berssenbrugge A, Attanasio C, Thomas M, Wegiel B, Otterbein LE. Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine. Am J Transplant. 2010 Nov; 10(11):2421-30. PMID: 20977633.
    Citations: 24     Fields:    Translation:Animals
  38. Wegiel B, Persson JL. Effect of a novel botanical agent Drynol Cibotin on human osteoblast cells and implications for osteoporosis: promotion of cell growth, calcium uptake and collagen production. Phytother Res. 2010 Jun; 24 Suppl 2:S139-47. PMID: 19953582.
    Citations:    Fields:    Translation:HumansCells
  39. Wegiel B, Evans S, Hellsten R, Otterbein LE, Bjartell A, Persson JL. Molecular pathways in the progression of hormone-independent and metastatic prostate cancer. Curr Cancer Drug Targets. 2010 Jun; 10(4):392-401. PMID: 20384583.
    Citations: 14     Fields:    Translation:HumansCells
  40. Wegiel B, Gallo DJ, Raman KG, Karlsson JM, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed A, Baty CJ, Otterbein LE. Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation. 2010 Feb 02; 121(4):537-48. PMID: 20083679; PMCID: PMC2841354.
    Citations: 37     Fields:    Translation:AnimalsCells
  41. Wegiel B, Jiborn T, Abrahamson M, Helczynski L, Otterbein L, Persson JL, Bjartell A. Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. PLoS One. 2009 Nov 23; 4(11):e7953. PMID: 19956729.
    Citations: 34     Fields:    Translation:HumansCells
  42. Bil J, Wlodarski P, Winiarska M, Kurzaj Z, Issat T, Jozkowicz A, Wegiel B, Dulak J, Golab J. Photodynamic therapy-driven induction of suicide cytosine deaminase gene. Cancer Lett. 2010 Apr 28; 290(2):216-22. PMID: 19822393.
    Citations:    Fields:    Translation:AnimalsCells
  43. Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE. Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt. J Biol Chem. 2009 Aug 07; 284(32):21369-78. PMID: 19509285.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  44. da Silva CG, Specht A, Wegiel B, Ferran C, Kaczmarek E. Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation. 2009 Feb 17; 119(6):871-9. PMID: 19188511; PMCID: PMC2702845.
    Citations: 41     Fields:    Translation:HumansCells
  45. Wegiel B, Ekberg J, Talasila KM, Jalili S, Persson JL. The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia. Leukemia. 2009 Feb; 23(2):251-61. PMID: 18987662.
    Citations: 8     Fields:    Translation:HumansCells
  46. Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst. 2008 Jul 16; 100(14):1022-36. PMID: 18612129.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  47. Wegiel B, Bjartell A, Culig Z, Persson JL. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. Int J Cancer. 2008 Apr 01; 122(7):1521-9. PMID: 18027847.
    Citations: 73     Fields:    Translation:HumansCells
  48. Wegiel B, Chin BY, Otterbein LE. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle. 2008 May 15; 7(10):1379-84. PMID: 18418071.
    Citations: 7     Fields:    Translation:HumansCells
  49. Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH. Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal. 2007 Dec; 9(12):2175-85. PMID: 17919067.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  50. Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE. Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med (Berl). 2008 Mar; 86(3):267-79. PMID: 18034222.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  51. Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE. Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 01; 178(9):5921-9. PMID: 17442976.
    Citations: 22     Fields:    Translation:AnimalsCells
  52. Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5109-14. PMID: 17360382; PMCID: PMC1820823.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  53. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE. Carbon monoxide reverses established pulmonary hypertension. J Exp Med. 2006 Sep 04; 203(9):2109-19. PMID: 16908624; PMCID: PMC2118401.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  54. Dulak J, Zagorska A, Wegiel B, Loboda A, Jozkowicz A. New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes. Cell Biochem Biophys. 2006; 44(1):31-42. PMID: 16456232; PMCID: PMC1391923.
    Citations: 5     Fields:    Translation:HumansAnimals
  55. Loboda A, Jazwa A, Wegiel B, Jozkowicz A, Dulak J. Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells. Cell Mol Biol (Noisy-le-grand). 2005 Sep 30; 51(4):347-55. PMID: 16309584; PMCID: PMC1403815.
    Citations: 30     Fields:    Translation:HumansCells
  56. Wegiel B, Bjartell A, Ekberg J, Gadaleanu V, Brunhoff C, Persson JL. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. Oncogene. 2005 Sep 22; 24(42):6385-93. PMID: 16007189.
    Citations: 23     Fields:    Translation:HumansCells
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