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Jia-Ren Liu, PH.D.

TitleInstructor in Anaesthesia
InstitutionChildren's Hospital Boston
DepartmentAnaesthesia
AddressChildren's Hospital
Anesthesia, Enders 317
300 Longwood Ave
Boston MA 02115
Phone617/919-2661
vCardDownload vCard (login for email)

 Overview 
 overview
Research fields: Nutrition, Toxicology (Neurotoxicity, Food and Environmental Toxicology) and Food Science. Currently total publications are 126 including peer review papers (102), reviews (7), abstracts (8) and book chapters (9) and 22 research grants as PI, Co-PI and Co-I.


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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li YR, Yun TT, Liu S, Qi WT, Zhao LQ, Liu JR, Li AK. Analysis of water-soluble bioactive compounds in commonly consumed soymilk in China. Journal of Food Composition and Analysis. 2016; 46:29-35.
  2. Liu Z, Han L, Dong Y, Tan Y, Li Y, Zhao M, Xie H, Ju H, Wang H, Zhao Y, Zheng Q, Wang Q, Su J, Fang C, Fu S, Jiang T, Liu J, Li X, Kang C, Ren H. EGFRvIII/integrin ß3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis. Oncotarget. 2015 Dec 22.
    View in: PubMed
  3. Liu JR, Liu Q, Khoury J, Li YJ, Han XH, Li J, Ibla JC. Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1. Int J Biochem Cell Biol. 2016 Jan; 70:140-8.
    View in: PubMed
  4. Liu JR, Han X, Soriano SG, Yuki K. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806.
    View in: PubMed
  5. Zhang JS, Zhang SJ, Li Q, Liu YH, He N, Zhang J, Zhou PH, Li M, Guan T, Liu JR. Tocotrienol-Rich Fraction (TRF) Suppresses the Growth of Human Colon Cancer Xenografts in Balb/C Nude Mice by the Wnt Pathway. PLoS One. 2015; 10(3):e0122175.
    View in: PubMed
  6. Liu JR, Han X, Soriano SG, Yuki K. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9.
    View in: PubMed
  7. Liang P, Liu J, Xiong J, Liu Q, Zhao J, Liang H, Zhao L, Tang H. Neural stem cell-conditioned medium protects neurons and promotes propriospinal neurons relay neural circuit reconnection after spinal cord injury. Cell Transplant. 2014; 23 Suppl 1:45-56.
    View in: PubMed
  8. Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L. Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma. Mol Cancer. 2014; 13:133.
    View in: PubMed
  9. Wang L, Yu K, Zhou BB, Su ZH, Gao S, Chu LL, Liu JR. The inhibitory effects of a new cobalt-based polyoxometalate on the growth of human cancer cells. Dalton Trans. 2014 Apr 28; 43(16):6070-8.
    View in: PubMed
  10. Zheng T, Hong X, Wang J, Pei T, Liang Y, Yin D, Song R, Song X, Lu Z, Qi S, Liu J, Sun B, Xie C, Pan S, Li Y, Luo X, Li S, Fang X, Bhatta N, Jiang H, Liu L. Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma. Hepatology. 2014 Mar; 59(3):935-46.
    View in: PubMed
  11. Fu XY, Li Z, Zhang N, Yu HT, Wang SR, Liu JR. Effects of gastrointestinal motility on obesity. Nutr Metab (Lond). 2014; 11(1):3.
    View in: PubMed
  12. Wang RF, Zhang LH, Shan LH, Sun WG, Chai CC, Wu HM, Ibla JC, Wang LF, Liu JR. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Dec; 95(3):350-56.
    View in: PubMed
  13. Song X, Wang J, Zheng T, Song R, Liang Y, Bhatta N, Yin D, Pan S, Liu J, Jiang H, Liu L. LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathway. Mol Cancer. 2013; 12(1):114.
    View in: PubMed
  14. Wang L, Zhou BB, Yu K, Su ZH, Gao S, Chu LL, Liu JR, Yang GY. Novel antitumor agent, trilacunary Keggin-type tungstobismuthate, inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells. Inorg Chem. 2013 May 6; 52(9):5119-27.
    View in: PubMed
  15. Dong HW, Zhang S, Sun WG, Liu Q, Ibla JC, Soriano SG, Han XH, Liu LX, Li MS, Liu JR. ß-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway. Arch Toxicol. 2013 Oct; 87(10):1797-808.
    View in: PubMed
  16. Liu JR, Baek C, Han XH, Shoureshi P, Soriano SG. Role of glycogen synthase kinase-3ß in ketamine-induced developmental neuroapoptosis in rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i3-9.
    View in: PubMed
  17. Liang Y, Zheng T, Song R, Wang J, Yin D, Wang L, Liu H, Tian L, Fang X, Meng X, Jiang H, Liu J, Liu L. Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1a inhibition in hepatocellular carcinoma. Hepatology. 2013 May; 57(5):1847-57.
    View in: PubMed
  18. Zhang JS, Li DM, Ma Y, He N, Gu Q, Wang FS, Jiang SQ, Chen BQ, Liu JR. ?-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. PLoS One. 2013; 8(2):e57779.
    View in: PubMed
  19. Yu J, Dong HW, Shi LT, Jiang HL, Yu JW, Zhao QW, Cai SC, Han D, Tang XY, Liu JR. Re-examination of the genotoxic activity of water taken from the Songhua River in P. R. China. Arch Environ Contam Toxicol. 2013 Jul; 65(1):78-88.
    View in: PubMed
  20. Liu Q, Dong HW, Sun WG, Liu M, Ibla JC, Liu LX, Parry JW, Han XH, Li MS, Liu JR. Apoptosis initiation of ß-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway. Arch Toxicol. 2013 Mar; 87(3):481-90.
    View in: PubMed
  21. Shan LH, Sun WG, Han W, Qi L, Yang C, Chai CC, Yao K, Zhou QF, Wu HM, Wang LF, Liu JR. Roles of fibroblasts from the interface zone in invasion, migration, proliferation and apoptosis of gastric adenocarcinoma. J Clin Pathol. 2012 Oct; 65(10):888-95.
    View in: PubMed
  22. Liu JR, Liu Q, Li J, Baek C, Han XH, Athiraman U, Soriano SG. Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain. Anesthesiology. 2012 Jul; 117(1):64-71.
    View in: PubMed
  23. Chu YF, Chang WH, Black RM, Liu JR, Sompol P, Chen Y, Wei H, Zhao Q, Cheng IH. Crude caffeine reduces memory impairment and amyloid ß(1-42) levels in an Alzheimer's mouse model. Food Chem. 2012 Dec 1; 135(3):2095-102.
    View in: PubMed
  24. Zuo LL, Wang ZY, Fan ZL, Tian SQ, Liu JR. Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro. Int J Mol Sci. 2012; 13(5):5506-18.
    View in: PubMed
  25. Yang HY, Liu HL, Tian LT, Song RP, Song X, Yin DL, Liang YJ, Qu LD, Jiang HC, Liu JR, Liu LX. Expression and prognostic value of ING3 in human primary hepatocellular carcinoma. Exp Biol Med (Maywood). 2012 Apr; 237(4):352-61.
    View in: PubMed
  26. Zhang HW, Zhang T, Shen BZ, Liu M, Liu JR. Toxicological insight from AP-1 silencing study on proliferation, migration, and dedifferentiation of rat vascular smooth muscle cell. Cardiovasc Toxicol. 2012 Mar; 12(1):25-38.
    View in: PubMed
  27. Yao L, Wang Z, Zhao H, Cheng C, Fu X, Liu J, Yang X. Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. Int J Mol Sci. 2011; 12(11):8096-104.
    View in: PubMed
  28. Dong YW, Zhang F, Liu L, Liu JR. Effects of epidural capsaicin on nociceptive threshold and neurological functions in rabbits. Pain Med. 2011 Dec; 12(12):1777-83.
    View in: PubMed
  29. Chen HS, Liu M, Shi LJ, Zhao JL, Zhang CP, Lin LQ, Liu Y, Zhang SJ, Jin JC, Wang L, Shen BZ, Liu JR. Effects of raspberry phytochemical extract on cell proliferation, apoptosis, and serum proteomics in a rat model. J Food Sci. 2011 Oct; 76(8):T192-8.
    View in: PubMed
  30. Fan ZL, Wang ZY, Liu JR. . Cold-field fruit extracts exert different antioxidant and antiproliferative activities in vitro. Food Chemistry. 129 (2): 402-407. 2011.
  31. Zhang JS, Li DM, He N, Liu YH, Wang CH, Jiang SQ, Chen BQ, Liu JR. A paraptosis-like cell death induced by d-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway. Toxicology. 2011 Jul 11; 285(1-2):8-17.
    View in: PubMed
  32. Li Y, Sun WG, Liu HK, Qi GY, Wang Q, Sun XR, Chen BQ, Liu JR. ?-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell. J Nutr Biochem. 2011 Dec; 22(12):1127-36.
    View in: PubMed
  33. Dong YM, Li Y, Ning H, Wang C, Liu JR, Sun CH. High dietary intake of medium-chain fatty acids during pregnancy in rats prevents later-life obesity in their offspring. J Nutr Biochem. 2011 Aug; 22(8):791-7.
    View in: PubMed
  34. Liu Y, Liu M, Li B, Zhao JL, Zhang CP, Lin LQ, Chen HS, Zhang SJ, Jin JC, Wang L, Li LJ, Liu JR. Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model. Nutr Metab (Lond). 2010; 7:84.
    View in: PubMed
  35. Liu M, Liu RH, Song BB, Li CF, Lin LQ, Zhang CP, Zhao JL, Liu JR. Antiangiogenetic effects of 4 varieties of grapes in vitro. J Food Sci. 2010 Aug 1; 75(6):T99-104.
    View in: PubMed
  36. Bi S, Liu JR, Li Y, Wang Q, Liu HK, Yan YG, Chen BQ, Sun WG. gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. Toxicology. 2010 Jul-Aug; 274(1-3):27-33.
    View in: PubMed
  37. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63.
    View in: PubMed
  38. Liu M, Li CF, Chen HS, Lin LQ, Zhang CP, Zhao JL, Liu Y, Zhang SJ, Jin JC, Wang L, Liu JR. Differential expression of proteomics models of colorectal cancer, colorectal benign disease and healthy controls. Proteome Sci. 2010; 8:16.
    View in: PubMed
  39. Yang HY, Liu HL, Ke J, Wu H, Zhu H, Liu JR, Liu LX, Jiang HC. Expression and prognostic value of Id protein family in human breast carcinoma. Oncol Rep. 2010 Feb; 23(2):321-8.
    View in: PubMed
  40. Liu JR, Dong HW, Sun XR, Wang Q, Sun WG, Parry JW, Liu Q, Han XH, Sun CH, Chen BQ, Yang BF. Effects of beta-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA. Nutr Cancer. 2010; 62(1):58-65.
    View in: PubMed
  41. Su XY, Wang ZY, Liu JR. . In vitro and in vivo antioxidant activity of Pinus koraiensis seed extract containing phenolic compounds. Food Chemistry. 117 (4): 681-686. 2009.
  42. Wang M, Liu JR, Gao JM, Parry JW, Wei YM. Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats. J Agric Food Chem. 2009 Jun 10; 57(11):5106-12.
    View in: PubMed
  43. Liu HK, Wang Q, Li Y, Sun WG, Liu JR, Yang YM, Xu WL, Sun XR, Chen BQ. Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem. 2010 Mar; 21(3):206-13.
    View in: PubMed
  44. Liu M, Lin LQ, Song BB, Wang LF, Zhang CP, Zhao JL, Liu JR. Cranberry phytochemical extract inhibits SGC-7901 cell growth and human tumor xenografts in Balb/c nu/nu mice. J Agric Food Chem. 2009 Jan 28; 57(2):762-8.
    View in: PubMed
  45. Liu JR, Dong HW, Chen BQ, Zhao P, Liu RH. Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat. J Agric Food Chem. 2009 Jan 14; 57(1):297-304.
    View in: PubMed
  46. Xu WL, Liu JR, Liu HK, Qi GY, Sun XR, Sun WG, Chen BQ. Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. Nutrition. 2009 May; 25(5):555-66.
    View in: PubMed
  47. Liu JR, Dong HW, Tang XL, Sun XR, Han XH, Chen BQ, Sun CH, Yang BF. Genotoxicity of water from the Songhua River, China, in 1994-1995 and 2002-2003: Potential risks for human health. Environ Pollut. 2009 Feb; 157(2):357-64.
    View in: PubMed
  48. Sun W, Xu W, Liu H, Liu J, Wang Q, Zhou J, Dong F, Chen B. gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem. 2009 Apr; 20(4):276-84.
    View in: PubMed
  49. Liu JR, Sun XR, Dong HW, Sun CH, Sun WG, Chen BQ, Song YQ, Yang BF. beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int J Cancer. 2008 Jun 15; 122(12):2689-98.
    View in: PubMed
  50. Zhou XR, Sun CH, Liu JR, Zhao D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm IGF Res. 2008 Oct; 18(5):361-8.
    View in: PubMed
  51. Zhang X, Li B, Zhang Y, Liu J. Ceramide induces release of mitochondrial proapoptotic proteins in caspase-dependent and -independent manner in HT-29 cells. Sci China C Life Sci. 2008 Jan; 51(1):66-71.
    View in: PubMed
  52. Sun W, Wang Q, Chen B, Liu J, Liu H, Xu W. Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. Br J Nutr. 2008 Jun; 99(6):1247-54.
    View in: PubMed
  53. Sun X, Liu J, Sun W, Tang X. [Beta-ionone induced apoptosis in SGC-7901 cells]. Wei Sheng Yan Jiu. 2007 Nov; 36(6):667-70.
    View in: PubMed
  54. Liu JR, Pang YX, Tang XL, Dong HW, Chen BQ, Sun CH. Genotoxic activity of organic contamination of the Songhua River in the north-eastern region of the People's Republic of China. Mutat Res. 2007 Dec 1; 634(1-2):81-92.
    View in: PubMed
  55. Liu JR, Yang YM, Dong HW, Sun XR. [Effect of beta-ionone in human mammary cancer cells (Er-) by MAPK pathway]. Wei Sheng Yan Jiu. 2005 Nov; 34(6):706-9.
    View in: PubMed
  56. Liu RH, Liu J, Chen B. Apples prevent mammary tumors in rats. J Agric Food Chem. 2005 Mar 23; 53(6):2341-3.
    View in: PubMed
  57. Chen BQ, Yang YM, Wang Q, Gao YH, Liu JR, Zhang JS, Wang XL, Liu RH. Effects of c9,t11-conjugated linoleic acid on adhesion of human gastric carcinoma cell line SGC-7901. World J Gastroenterol. 2004 May 15; 10(10):1392-6.
    View in: PubMed
  58. Wang XL, Chen BQ, Yang YM, Zheng YM, Liu JR. [The effects of conjugated linoleic acid on the ability of murine macrophage in killing tumor cells]. Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Mar; 38(2):107-10.
    View in: PubMed
  59. Liu J, Li B, Ma R, Chen B. [Inhibitory effect on mammary carcinoma cells induced by beta-ionone]. Wei Sheng Yan Jiu. 2004 Mar; 33(2):151-3, 157.
    View in: PubMed
  60. Liu JR, Chen BQ, Yang BF, Dong HW, Sun CH, Wang Q, Song G, Song YQ. Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone. World J Gastroenterol. 2004 Feb 1; 10(3):348-51.
    View in: PubMed
  61. Liu JR, Yang BF, Chen BQ, Yang YM, Dong HW, Song YQ. Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression. World J Gastroenterol. 2004 Jan 15; 10(2):167-71.
    View in: PubMed
  62. Liu J, Chen B, Yang Y, Wang X. [Effect of apoptosis in human mammary cancer (MCF-7) cells induced by cis9, t11-conjugated linoleic acid]. Wei Sheng Yan Jiu. 2004 Jan; 33(1):58-62.
    View in: PubMed
  63. Chen BQ, Yang YM, Gao YH, Liu JR, Xue YB, Wang XL, Zheng YM, Zhang JS, Liu RH. Inhibitory effects of c9, t11-conjugated linoleic acid on invasion of human gastric carcinoma cell line SGC-7901. World J Gastroenterol. 2003 Sep; 9(9):1909-14.
    View in: PubMed
  64. Liu J, Chen B, Yang Y. [Research on the gap junctional intercellular communication of CHL cells and human cancer cells induced by c9, t11-conjugated linoleic acid]. Wei Sheng Yan Jiu. 2003 Mar; 32(2):113-6.
    View in: PubMed
  65. Yang YM, Chen BQ, Zheng YM, Wang XL, Liu JR, Xue YB, Liu RH. [The effects of conjugated linoleic acid on the expression of invasiveness and metastasis-associated gene of human gastric carcinoma cell line]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Jan; 37(1):26-8.
    View in: PubMed
  66. Chen BQ, Xue YB, Liu JR, Yang YM, Zheng YM, Wang XL, Liu RH. Inhibition of conjugated linoleic acid on mouse forestomach neoplasia induced by benzo (a) pyrene and chemopreventive mechanisms. World J Gastroenterol. 2003 Jan; 9(1):44-9.
    View in: PubMed
  67. Liu JR, Chen BQ, Yang YM, Wang XL, Xue YB, Zheng YM, Liu RH. Effect of apoptosis on gastric adenocarcinoma cell line SGC-7901 induced by cis-9, trans-11-conjugated linoleic acid. World J Gastroenterol. 2002 Dec; 8(6):999-1004.
    View in: PubMed
  68. Liu JR, Chen BQ, Yang YM, Han XH, Xue YB, Wang XL, Zheng YM, Liu RH. Effects ofcis-9,trans-11-conjugated linoleic acid on cancer cell cycle. Environ Health Prev Med. 2002 Nov; 7(5):205-10.
    View in: PubMed
  69. Liu JR, Li BX, Chen BQ, Han XH, Xue YB, Yang YM, Zheng YM, Liu RH. Effect of cis-9, trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line (SGC-7901). World J Gastroenterol. 2002 Apr; 8(2):224-9.
    View in: PubMed
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