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Katia Georgopoulos, Ph.D.

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Mentoring
In Vitro Studies of Ikaros Gene Family Effects on Lymphoid Development
Summer, 06/01/99 - 08/31/99

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR069132 (GEORGOPOULOS, KATIA) Jul 11, 2016 - Jun 30, 2021
    NIH/NIAMS
    Epigenetic regulation of proinflammatory responses in the skin
    Role: Principal Investigator
  2. R21AI124326 (GEORGOPOULOS, KATIA) Mar 15, 2016 - Feb 28, 2018
    NIH/NIAID
    Mechanisms of human pre-B cell differentiation
    Role: Principal Investigator
  3. R01CA190964 (VAN ETTEN, RICHARD A.) Dec 1, 2014 - Nov 30, 2019
    NIH/NCI
    Role of IKAROS in the Biology and Therapy of High-Risk Precursor B-Cell Leukemia
    Role: Principal Investigator
  4. R01AR064390 (GEORGOPOULOS, KATIA) Sep 25, 2013 - Aug 31, 2014
    NIH/NIAMS
    Epigenetic regulation of epidermal homeostasis
    Role: Principal Investigator
  5. R01CA158006 (GEORGOPOULOS, KATIA) Dec 1, 2011 - Nov 30, 2016
    NIH/NCI
    Ikaros-based epigenetic regulation of T cell leukemogenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shibata S, Kashiwagi M, Morgan BA, Georgopoulos K. Functional interactions between Mi-2ß and AP1 complexes control response and recovery from skin barrier disruption. J Exp Med. 2020 Mar 02; 217(3). PMID: 31834931.
    Citations:    
  2. Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K. Chromatin restriction by the nucleosome remodeler Mi-2ß and functional interplay with lineage-specific transcription regulators control B-cell differentiation. Genes Dev. 2019 07 01; 33(13-14):763-781. PMID: 31123064.
    Citations:    
  3. Murthy V, Tebaldi T, Yoshida T, Erdin S, Calzonetti T, Vijayvargia R, Tripathi T, Kerschbamer E, Seong IS, Quattrone A, Talkowski ME, Gusella JF, Georgopoulos K, MacDonald ME, Biagioli M. Hypomorphic mutation of the mouse Huntington's disease gene orthologue. PLoS Genet. 2019 03; 15(3):e1007765. PMID: 30897080.
    Citations:    
  4. McClatchey AI, Georgopoulos K. Actin' Up to Stop SNFin Out TEAD. Dev Cell. 2018 12 17; 47(6):693-695. PMID: 30562513.
    Citations:    Fields:    
  5. Hu Y, Yoshida T, Georgopoulos K. Transcriptional circuits in B cell transformation. Curr Opin Hematol. 2017 Jul; 24(4):345-352. PMID: 28463873.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Georgopoulos K. The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma. Genes Dev. 2017 03 01; 31(5):439-450. PMID: 28385788.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Kashiwagi M, Hosoi J, Lai JF, Brissette J, Ziegler SF, Morgan BA, Georgopoulos K. Direct control of regulatory T cells by keratinocytes. Nat Immunol. 2017 03; 18(3):334-343. PMID: 28092372.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Georgopoulos K. In search of the mechanism that shapes the neutrophil's nucleus. Genes Dev. 2017 01 15; 31(2):85-87. PMID: 28202537.
    Citations:    Fields:    Translation:HumansCells
  9. Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jiménez-Andrade GY, Sano Y, Choo MK, Seavitt J, Venigalla RK, Otsu K, Georgopoulos K, Arthur JS, Park JM. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017 02 03; 292(5):1762-1772. PMID: 28011639.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev. 2016 09 01; 30(17):1971-90. PMID: 27664237.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Georgopoulos K. Induction of Bcl11b during T cell commitment through a tripartite mechanism. Nat Immunol. 2016 07 19; 17(8):903-4. PMID: 27434004.
    Citations:    Fields:    Translation:HumansCells
  12. Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10; 23(5):881-92. PMID: 27166947.
    Citations: 7     Fields:    
  13. Perotti EA, Georgopoulos K, Yoshida T. An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities. PLoS One. 2015; 10(7):e0131568. PMID: 26135129.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Georgopoulos K. Ebf1 in DNA repair and leukemogenesis. Blood. 2015 Jun 25; 125(26):3969-71. PMID: 26113531.
    Citations:    
  15. Yoshida T, Georgopoulos K. Ikaros fingers on lymphocyte differentiation. Int J Hematol. 2014 Sep; 100(3):220-9. PMID: 25085254.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  16. Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP, Fioravante D, Regehr WG, Gygi SP, Georgopoulos K, Bonni A. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron. 2014 Jul 02; 83(1):122-34. PMID: 24991957.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  17. Joshi I, Yoshida T, Jena N, Qi X, Zhang J, Van Etten RA, Georgopoulos K. Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia. Nat Immunol. 2014 Mar; 15(3):294-304. PMID: 24509510.
    Citations: 43     Fields:    Translation:AnimalsCells
  18. Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. ß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6. PMID: 24371308.
    Citations: 22     Fields:    Translation:AnimalsCells
  19. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2013 Dec 18; 15(1):109. PMID: 24352327.
    Citations:    
  20. Yoshida T, Georgopoulos K. GATA-3 controls self-renewal in stressed HSCs. Nat Immunol. 2013 Oct; 14(10):1032-3. PMID: 24048133.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K. Transcriptional regulation of the Ikzf1 locus. Blood. 2013 Oct 31; 122(18):3149-59. PMID: 24002445.
    Citations: 14     Fields:    Translation:AnimalsCells
  22. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012 Jul 01; 13(8):770-7. PMID: 22751139.
    Citations: 84     Fields:    Translation:AnimalsCells
  23. Han R, Beppu H, Lee YK, Georgopoulos K, Larue L, Li E, Weiner L, Brissette JL. A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis. 2012 Nov; 50(11):783-800. PMID: 22611050.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012 Aug 10; 21(12):2239-51. PMID: 22142223.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Zhang J, Jackson AF, Naito T, Dose M, Seavitt J, Liu F, Heller EJ, Kashiwagi M, Yoshida T, Gounari F, Petrie HT, Georgopoulos K. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nat Immunol. 2011 Nov 13; 13(1):86-94. PMID: 22080921.
    Citations: 76     Fields:    Translation:AnimalsCells
  26. Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, Kioussis D. Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development. J Immunol. 2011 Jun 01; 186(11):6368-77. PMID: 21515796.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K. Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity. 2010 Nov 24; 33(5):685-98. PMID: 21093322.
    Citations: 43     Fields:    Translation:AnimalsCells
  28. Yoshida T, Ng SY, Georgopoulos K. Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr Opin Immunol. 2010 Apr; 22(2):154-60. PMID: 20299195.
    Citations: 23     Fields:    Translation:HumansAnimals
  29. Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein JL, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, Canals JM. Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons. J Comp Neurol. 2010 Feb 01; 518(3):329-51. PMID: 19950118.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nat Immunol. 2009 Oct; 10(10):1110-7. PMID: 19734904.
    Citations: 49     Fields:    Translation:AnimalsCells
  31. Ng SY, Yoshida T, Zhang J, Georgopoulos K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity. 2009 Apr 17; 30(4):493-507. PMID: 19345118.
    Citations: 102     Fields:    Translation:AnimalsCells
  32. Georgopoulos K. Acute lymphoblastic leukemia--on the wings of IKAROS. N Engl J Med. 2009 Jan 29; 360(5):524-6. PMID: 19131438.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Georgopoulos K. From immunity to tolerance through HDAC. Nat Immunol. 2009 Jan; 10(1):13-4. PMID: 19088734.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008 May 01; 22(9):1174-89. PMID: 18451107.
    Citations: 74     Fields:    Translation:AnimalsCells
  35. Naito T, Gómez-Del Arco P, Williams CJ, Georgopoulos K. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity. 2007 Nov; 27(5):723-34. PMID: 17980631.
    Citations: 45     Fields:    Translation:AnimalsCells
  36. Kioussis D, Georgopoulos K. Epigenetic flexibility underlying lineage choices in the adaptive immune system. Science. 2007 Aug 03; 317(5838):620-2. PMID: 17673651.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  37. Agoston DV, Szemes M, Dobi A, Palkovits M, Georgopoulos K, Gyorgy A, Ring MA. Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation. J Neurochem. 2007 Sep; 102(6):1805-1816. PMID: 17504264.
    Citations: 12     Fields:    Translation:AnimalsCells
  38. Kashiwagi M, Morgan BA, Georgopoulos K. The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007 Apr; 134(8):1571-82. PMID: 17360773.
    Citations: 32     Fields:    Translation:AnimalsCells
  39. Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007 Mar; 26(3):335-44. PMID: 17363301.
    Citations: 68     Fields:    Translation:AnimalsCells
  40. Ng SY, Yoshida T, Georgopoulos K. Ikaros and chromatin regulation in early hematopoiesis. Curr Opin Immunol. 2007 Apr; 19(2):116-22. PMID: 17307348.
    Citations: 24     Fields:    Translation:AnimalsCells
  41. Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K. Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol. 2006 Apr; 7(4):382-91. PMID: 16518393.
    Citations: 94     Fields:    Translation:AnimalsCells
  42. Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E. Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development. 2006 Mar; 133(6):1183-92. PMID: 16501171.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  43. Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Mol Cell Biol. 2005 Dec; 25(24):11145-55. PMID: 16314534.
    Citations: 15     Fields:    Translation:AnimalsCells
  44. Gómez-del Arco P, Koipally J, Georgopoulos K. Ikaros SUMOylation: switching out of repression. Mol Cell Biol. 2005 Apr; 25(7):2688-97. PMID: 15767674.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  45. Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K. The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity. 2004 Jun; 20(6):719-33. PMID: 15189737.
    Citations: 107     Fields:    Translation:AnimalsCells
  46. Gómez-del Arco P, Maki K, Georgopoulos K. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition. Mol Cell Biol. 2004 Apr; 24(7):2797-807. PMID: 15024069.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  47. Cortés M, Georgopoulos K. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. J Exp Med. 2004 Jan 19; 199(2):209-19. PMID: 14718515.
    Citations: 33     Fields:    Translation:AnimalsCellsPHPublic Health
  48. Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K. A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. EMBO J. 2003 May 01; 22(9):2211-23. PMID: 12727887.
    Citations: 13     Fields:    Translation:AnimalsCells
  49. Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P. Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice. J Immunol. 2003 Feb 15; 170(4):1699-706. PMID: 12574333.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  50. Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol Cell. 2002 Dec; 10(6):1403-15. PMID: 12504015.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  51. Koipally J, Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros. J Biol Chem. 2002 Aug 02; 277(31):27697-705. PMID: 12015313.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  52. Koipally J, Georgopoulos K. Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. J Biol Chem. 2002 Jun 28; 277(26):23143-9. PMID: 11959865.
    Citations: 30     Fields:    Translation:AnimalsCells
  53. Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol. 2002 Mar; 2(3):162-74. PMID: 11913067.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  54. Koipally J, Heller EJ, Seavitt JR, Georgopoulos K. Unconventional potentiation of gene expression by Ikaros. J Biol Chem. 2002 Apr 12; 277(15):13007-15. PMID: 11799125.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  55. DiFronzo NL, Leung CT, Mammel MK, Georgopoulos K, Taylor BJ, Pham QN. Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus. J Virol. 2002 Jan; 76(1):78-87. PMID: 11739673.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  56. Cariappa A, Tang M, Parng C, Nebelitskiy E, Carroll M, Georgopoulos K, Pillai S. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 2001 May; 14(5):603-15. PMID: 11371362.
    Citations: 82     Fields:    Translation:AnimalsCells
  57. Yamada A, Takaki S, Hayashi F, Georgopoulos K, Perlmutter RM, Takatsu K. Identification and characterization of a transcriptional regulator for the lck proximal promoter. J Biol Chem. 2001 May 25; 276(21):18082-9. PMID: 11278409.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  58. Wu L, Vandenabeele S, Georgopoulos K. Derivation of dendritic cells from myeloid and lymphoid precursors. Int Rev Immunol. 2001 Feb; 20(1):117-35. PMID: 11342301.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  59. Koipally J, Georgopoulos K. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem. 2000 Jun 30; 275(26):19594-602. PMID: 10766745.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  60. Galy A, Christopherson I, Ferlazzo G, Liu G, Spits H, Georgopoulos K. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood. 2000 Jan 01; 95(1):128-37. PMID: 10607695.
    Citations: 8     Fields:    Translation:HumansCells
  61. Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J Exp Med. 1999 Nov 01; 190(9):1201-14. PMID: 10544193.
    Citations: 51     Fields:    Translation:AnimalsCells
  62. Winandy S, Wu L, Wang JH, Georgopoulos K. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med. 1999 Oct 18; 190(8):1039-48. PMID: 10523602.
    Citations: 53     Fields:    Translation:AnimalsCells
  63. Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 1999 Jun 01; 18(11):3090-100. PMID: 10357820.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  64. Georgopoulos K. Gene regulation and cancer. AACR meeting review, the Homestead, Hot Springs, VA, USA, 14-18 October 1998. Biochim Biophys Acta. 1999 May 31; 1423(3):R75-9. PMID: 10382542.
    Citations:    Fields:    Translation:HumansAnimalsCells
  65. Cortes M, Wong E, Koipally J, Georgopoulos K. Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol. 1999 Apr; 11(2):167-71. PMID: 10322160.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  66. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999 Mar; 10(3):345-55. PMID: 10204490.
    Citations: 206     Fields:    Translation:AnimalsCells
  67. Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity. 1999 Mar; 10(3):333-43. PMID: 10204489.
    Citations: 56     Fields:    Translation:AnimalsCells
  68. Koipally J, Kim J, Jones B, Jackson A, Avitahl N, Winandy S, Trevisan M, Nichogiannopoulou A, Kelley C, Georgopoulos K. Ikaros chromatin remodeling complexes in the control of differentiation of the hemo-lymphoid system. Cold Spring Harb Symp Quant Biol. 1999; 64:79-86. PMID: 11232340.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  69. Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K. Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct; 9(4):543-53. PMID: 9806640.
    Citations: 68     Fields:    Translation:AnimalsCells
  70. Shortman K, Vremec D, Corcoran LM, Georgopoulos K, Lucas K, Wu L. The linkage between T-cell and dendritic cell development in the mouse thymus. Immunol Rev. 1998 Oct; 165:39-46. PMID: 9850850.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  71. Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol. 1998 Apr 23; 8(9):508-15. PMID: 9560339.
    Citations: 54     Fields:    Translation:AnimalsCells
  72. Nichogiannopoulou A, Trevisan M, Friedrich C, Georgopoulos K. Ikaros in hemopoietic lineage determination and homeostasis. Semin Immunol. 1998 Apr; 10(2):119-25. PMID: 9618757.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  73. Georgopoulos K. Introduction. Semin Immunol. 1998 Apr; 10(2):101-2. PMID: 9653041.
    Citations:    Fields:    
  74. Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity. 1997 Oct; 7(4):483-92. PMID: 9354469.
    Citations: 47     Fields:    Translation:AnimalsCells
  75. Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15; 16(8):2004-13. PMID: 9155026.
    Citations: 83     Fields:    Translation:AnimalsCells
  76. Georgopoulos K. Transcription factors required for lymphoid lineage commitment. Curr Opin Immunol. 1997 Apr; 9(2):222-7. PMID: 9099800.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  77. Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol. 1997; 15:155-76. PMID: 9143685.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  78. Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity. 1996 Dec; 5(6):537-49. PMID: 8986714.
    Citations: 161     Fields:    Translation:AnimalsCells
  79. Sun L, Liu A, Georgopoulos K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 1996 Oct 01; 15(19):5358-69. PMID: 8895580.
    Citations: 97     Fields:    Translation:AnimalsCells
  80. Feretis C, Benakis P, Dimopoulos C, Georgopoulos K, Manouras A, Apostolidis N. Palliation of large-bowel obstruction due to recurrent rectosigmoid tumor using self-expandable endoprostheses. Endoscopy. 1996 Mar; 28(3):319-22. PMID: 8781801.
    Citations: 1     Fields:    Translation:Humans
  81. Feretis C, Benakis P, Dimopoulos C, Georgopoulos K, Milas F, Manouras A, Apostolidis N. Palliation of malignant gastric outlet obstruction with self-expanding metal stents. Endoscopy. 1996 Feb; 28(2):225-8. PMID: 8739737.
    Citations: 11     Fields:    Translation:Humans
  82. Molnár A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol. 1996 Jan 15; 156(2):585-92. PMID: 8543809.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  83. Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell. 1995 Oct 20; 83(2):289-99. PMID: 7585946.
    Citations: 132     Fields:    Translation:AnimalsCells
  84. Molnár A, Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol. 1994 Dec; 14(12):8292-303. PMID: 7969165.
    Citations: 117     Fields:    Translation:AnimalsCells
  85. Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 1994 Oct 07; 79(1):143-56. PMID: 7923373.
    Citations: 217     Fields:    Translation:AnimalsCells
  86. Clevers HC, Oosterwegel MA, Georgopoulos K. Transcription factors in early T-cell development. Immunol Today. 1993 Dec; 14(12):591-6. PMID: 7905739.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  87. Georgopoulos K, Moore DD, Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30; 258(5083):808-12. PMID: 1439790.
    Citations: 93     Fields:    Translation:AnimalsCells
  88. Georgopoulos K, Morgan BA, Moore DD. Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer. Mol Cell Biol. 1992 Feb; 12(2):747-57. PMID: 1531087.
    Citations: 19     Fields:    Translation:AnimalsCells
  89. Oosterwegel M, van de Wetering M, Dooijes D, Klomp L, Winoto A, Georgopoulos K, Meijlink F, Clevers H. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. J Exp Med. 1991 May 01; 173(5):1133-42. PMID: 1827138.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  90. Georgopoulos K, Galson D, Terhorst C. Tissue-specific nuclear factors mediate expression of the CD3 delta gene during T cell development. EMBO J. 1990 Jan; 9(1):109-15. PMID: 2136828.
    Citations: 11     Fields:    Translation:Cells
  91. Wilkinson MF, Georgopoulos K, Terhorst C, MacLeod CL. The CD3 delta gene encodes multiple transcripts regulated by transcriptional and post-transcriptional mechanisms. Eur J Immunol. 1989 Dec; 19(12):2355-60. PMID: 2532602.
    Citations: 4     Fields:    Translation:AnimalsCells
  92. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell. 1988 Dec 02; 55(5):917-24. PMID: 3142692.
    Citations: 242     Fields:    Translation:Cells
  93. Clevers H, Dunlap S, Saito H, Georgopoulos K, Wileman T, Terhorst C. Characterization and expression of the murine CD3-epsilon gene. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8623-7. PMID: 2973066.
    Citations: 5     Fields:    Translation:AnimalsCells
  94. Georgopoulos K, van den Elsen P, Bier E, Maxam A, Terhorst C. A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene. EMBO J. 1988 Aug; 7(8):2401-7. PMID: 2847918.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  95. Saito H, Koyama T, Georgopoulos K, Clevers H, Haser WG, LeBien T, Tonegawa S, Terhorst C. Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9131-4. PMID: 2827170.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  96. van den Elsen P, Georgopoulos K, Shepley BA, Orkin S, Terhorst C. Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. Proc Natl Acad Sci U S A. 1986 May; 83(9):2944-8. PMID: 2939461.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  97. Terhorst C, de Vries J, Georgopoulos K, Gold D, Oettgen H, Pettey C, Spits H, Ucker D, van den Elsen P, Wileman T. The T cell receptor/T3 complex. Year Immunol. 1986; 2:245-53. PMID: 2437726.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  98. Georgopoulos K, Dick WC, Goodacre JA, Pain RH. A reinvestigation of the cross-reactivity between Klebsiella and HLA-B27 in the aetiology of ankylosing spondylitis. Clin Exp Immunol. 1985 Dec; 62(3):662-71. PMID: 3878755.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.