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Clemens Scherzer, M.D.

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Mentoring
Available: 05/16/14, Expires: 06/01/19

While the number of human genes has shrunk to an estimated ~22,000, a hidden universe of an ever-increasing number of tens of thousands of non-coding RNAs and splice variants is revolutionizing our thinking about the complexity of the human brain. We hypothesize that in complex genetic neurodegenerative diseases such as Parkinson’s (PD) combinatorial effects of genetic and environmental risks disrupt the ordered flow of genetic information into vulnerable brain cells through cell-type-specific modulation of transcript abundance, transcription start site use, and sequence. The PD Brain Map Project’s goal is to chart the flow of information from the entire human genome into a prototype brain cell-type - the dopamine neuron. Genetic variation between more than 100 individuals is examined for correlation with differences in transcribed elements --- both protein-coding and non-coding --- to identify regions of the genome that influence whether, how, and how much a transcript is expressed in this specific cell type in situ in human brains. Transcriptomes of control and diseased brains are probed using laser-capture microdissection, massively parallel sequencing of near ultra-low amounts of RNA, and expression Quantitative Trait Locus analysis. The PD Brain Map will provide a high-resolution encyclopedia of transcribed elements in a prototype cell-type in human brains, help to understand inherited susceptibility to PD, and highlight targets for precision therapies. Pilot phase results indicate that tens of thousands of isoforms of protein-coding genes and of non-coding RNAs are abundantly expressed in dopamine neurons and suggest a more diverse and complex transcriptional architecture than previously imagined.

Support: U01 NS082157; W81XWH-BAA-12-1; Michael J. Fox Foundation; U24 NS072026; P30 AG19610

Available: 10/11/18, Expires: 09/30/20

While the number of human genes has shrunk to an estimated ~22,000, a hidden universe of an ever-increasing number of tens of thousands of non-coding RNAs and splice variants is revolutionizing our thinking about the complexity of the human brain. We hypothesize that in complex genetic neurodegenerative diseases such as Parkinson’s (PD) combinatorial effects of genetic and environmental risks disrupt the ordered flow of genetic information into vulnerable brain cells through cell-type-specific modulation of transcript abundance, transcription start site use, and sequence.

The PD Brain Map Project’s goal is to chart the flow of information from the entire human genome into a prototype brain cell-type - the dopamine neuron. Genetic variation between more than 100 individuals is examined for correlation with differences in transcribed elements --- both protein-coding and non-coding --- to identify regions of the genome that influence whether, how, and how much a transcript is expressed in this specific cell type in situ in human brains. Transcriptomes of control and diseased brains are probed using laser-capture microdissection, massively parallel sequencing of near ultra-low amounts of RNA, and expression Quantitative Trait Locus analysis.

The PD Brain Map will provide a high-resolution encyclopedia of transcribed elements in a prototype cell-type in human brains, help to understand inherited susceptibility to PD, and highlight targets for precision therapies. Pilot phase results indicate that tens of thousands of isoforms of protein-coding genes and of non-coding RNAs are abundantly expressed in dopamine neurons and suggest a more diverse and complex transcriptional architecture than previously imagined.

Support: U01 NS082157; W81XWH-BAA-12-1; Michael J. Fox Foundation; U24 NS072026; P30 AG19610


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG057331 (FEANY, MEL B) Sep 15, 2017 - Jun 30, 2022
    NIH/NIA
    Integrative Multi-Omic Discovery of Proximal Mechanisms Driving Age-Dependent Neurodegeneration
    Role: Co-Principal Investigator
  2. U01NS100603 (SCHERZER, CLEMENS R) Sep 30, 2016 - Aug 31, 2021
    NIH/NINDS
    GBA pathway markers for Lewy body dementias
    Role: Principal Investigator
  3. U01NS095736 (SCHERZER, CLEMENS R) Sep 30, 2016 - Aug 31, 2019
    NIH/NINDS
    Parkinson Disease: Predicting the Future
    Role: Principal Investigator
  4. U01NS082080 (SCHERZER, CLEMENS R) Sep 1, 2013 - Aug 31, 2016
    NIH/NINDS
    A Next Generation of Biomarkers for Incipient Huntington Disease
    Role: Principal Investigator
  5. U01NS082157 (SCHERZER, CLEMENS R) Sep 30, 2012 - Aug 31, 2017
    NIH/NINDS
    Biomarkers for early intervention in Parkinson disease
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Henderson-Smith A, Fisch KM, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland SD, Scherzer CR, Dunckley T, Desplats P. DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics. 2019 Mar 14; 1-18. PMID: 30871403.
    Citations:    
  2. Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR. Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nat Neurosci. 2019 Jan; 22(1):144-147. PMID: 30482917.
    Citations:    Fields:    
  3. Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR. Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nat Neurosci. 2018 Oct; 21(10):1482-1492. PMID: 30224808.
    Citations:    Fields:    
  4. Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, Gwinn K, Huang X, Kopil C, Kremer T, Lasch S, Marek K, Marto JA, Merchant K, Mollenhauer B, Naito A, Potashkin J, Reimer A, Rosenthal LS, Saunders-Pullman R, Scherzer CR, Sherer T, Singleton A, Sutherland M, Thiele I, van der Brug M, Van Keuren-Jensen K, Vaillancourt D, Walt D, West A, Zhang J. Finding useful biomarkers for Parkinson's disease. Sci Transl Med. 2018 Aug 15; 10(454). PMID: 30111645.
    Citations:    Fields:    
  5. Olsen AL, Riise T, Scherzer CR. Discovering New Benefits From Old Drugs With Big Data-Promise for Parkinson Disease. JAMA Neurol. 2018 Aug 01; 75(8):917-920. PMID: 29710184.
    Citations:    Fields:    
  6. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. ß2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. PMID: 28860381.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB, Foroud T, German D, Huang X, Petyuk V, Potashkin JA, Saunders-Pullman R, Sutherland M, Walt DR, West AB, Zhang J, Chen-Plotkin A, Scherzer CR, Vaillancourt DE, Rosenthal LS. Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomark Med. 2017 May; 11(6):451-473. PMID: 28644039.
    Citations: 6     Fields:    Translation:Humans
  8. Liu G, Locascio JJ, Corvol JC, Boot B, Liao Z, Page K, Franco D, Burke K, Jansen IE, Trisini-Lipsanopoulos A, Winder-Rhodes S, Tanner CM, Lang AE, Eberly S, Elbaz A, Brice A, Mangone G, Ravina B, Shoulson I, Cormier-Dequaire F, Heutink P, van Hilten JJ, Barker RA, Williams-Gray CH, Marinus J, Scherzer CR. Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts. Lancet Neurol. 2017 08; 16(8):620-629. PMID: 28629879.
    Citations: 7     Fields:    Translation:Humans
  9. Manocha GD, Floden AM, Puig KL, Nagamoto-Combs K, Scherzer CR, Combs CK. Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. Mol Neurodegener. 2017 02 14; 12(1):17. PMID: 28196514.
    Citations: 7     Fields:    Translation:HumansAnimals
  10. Liu G, Boot B, Locascio JJ, Jansen IE, Winder-Rhodes S, Eberly S, Elbaz A, Brice A, Ravina B, van Hilten JJ, Cormier-Dequaire F, Corvol JC, Barker RA, Heutink P, Marinus J, Williams-Gray CH, Scherzer CR. Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's. Ann Neurol. 2016 Nov; 80(5):674-685. PMID: 27717005.
    Citations: 14     Fields:    Translation:Humans
  11. Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 09; 80(3):355-67. PMID: 27351289.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  12. Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 Aug 30; 87(9):920-6. PMID: 27473132.
    Citations: 17     Fields:    Translation:HumansCells
  13. Hill-Burns EM, Ross OA, Wissemann WT, Soto-Ortolaza AI, Zareparsi S, Siuda J, Lynch T, Wszolek ZK, Silburn PA, Mellick GD, Ritz B, Scherzer CR, Zabetian CP, Factor SA, Breheny PJ, Payami H. Identification of genetic modifiers of age-at-onset for familial Parkinson's disease. Hum Mol Genet. 2016 09 01; 25(17):3849-3862. PMID: 27402877.
    Citations: 6     Fields:    Translation:Humans
  14. Lööv C, Scherzer CR, Hyman BT, Breakefield XO, Ingelsson M. a-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cell Mol Neurobiol. 2016 Apr; 36(3):437-48. PMID: 26993503.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Bakshi R, Mittal S, Liao Z, Scherzer CR. A Feed-Forward Circuit of Endogenous PGC-1a and Estrogen Related Receptor a Regulates the Neuronal Electron Transport Chain. Parkinsons Dis. 2016; 2016:2405176. PMID: 27088034; PMCID: PMC4818948.
    Citations:    
  16. Rosenthal LS, Drake D, Alcalay RN, Babcock D, Bowman FD, Chen-Plotkin A, Dawson TM, Dewey RB, German DC, Huang X, Landin B, McAuliffe M, Petyuk VA, Scherzer CR, Hillaire-Clarke CS, Sieber BA, Sutherland M, Tarn C, West A, Vaillancourt D, Zhang J, Gwinn K. The NINDS Parkinson's disease biomarkers program. Mov Disord. 2016 06; 31(6):915-23. PMID: 26442452.
    Citations: 10     Fields:    Translation:Humans
  17. Sorond FA, Cruz-Almeida Y, Clark DJ, Viswanathan A, Scherzer CR, De Jager P, Csiszar A, Laurienti PJ, Hausdorff JM, Chen WG, Ferrucci L, Rosano C, Studenski SA, Black SE, Lipsitz LA. Aging, the Central Nervous System, and Mobility in Older Adults: Neural Mechanisms of Mobility Impairment. J Gerontol A Biol Sci Med Sci. 2015 Dec; 70(12):1526-32. PMID: 26386013; PMCID: PMC4643615.
    Citations: 10     Fields:    Translation:Humans
  18. Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR. Association between a-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain. 2015 Sep; 138(Pt 9):2659-71. PMID: 26220939; PMCID: PMC4643625.
    Citations: 16     Fields:    Translation:Humans
  19. Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, Mollenhauer B, Scherzer CR, Ivinson AJ, Finke C, Schöls L, Müller Vom Hagen J, Trenkwalder C, Jahn H, Höltje M, Biswal BB, Harms L, Ruprecht K, Buchert R, Höglinger GU, Oertel WH, Unger MM, Körtvélyessy P, Bittner D, Priller J, Spruth EJ, Paul F, Meisel A, Lynch DR, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stöcker W, Dalmau J, Prüss H. High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types. Ann Clin Transl Neurol. 2014 Oct; 1(10):822-32. PMID: 25493273; PMCID: PMC4241809.
    Citations: 18     
  20. Santiago JA, Scherzer CR, Potashkin JA. Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease. PLoS One. 2014; 9(10):e109042. PMID: 25279756; PMCID: PMC4184821.
    Citations: 12     Fields:    Translation:HumansCells
  21. Mehanna R, Scherzer CR, Ding H, Locascio JJ. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker study. Neurology. 2014 May 06; 82(18):1666; discussion 1666. PMID: 24799519.
    Citations: 4     Fields:    Translation:Humans
  22. Ziegler DA, Ashourian P, Wonderlick JS, Sarokhan AK, Prelec D, Scherzer CR, Corkin S. Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms. Scand J Psychol. 2014 Jun; 55(3):278-86. PMID: 24749760.
    Citations: 2     Fields:    Translation:Humans
  23. Cebrián C, Zucca FA, Mauri P, Steinbeck JA, Studer L, Scherzer CR, Kanter E, Budhu S, Mandelbaum J, Vonsattel JP, Zecca L, Loike JD, Sulzer D. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nat Commun. 2014 Apr 16; 5:3633. PMID: 24736453; PMCID: PMC4024461.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  24. Cesani M, Cavalca E, Macco R, Leoncini G, Terreni MR, Lorioli L, Furlan R, Comi G, Doglioni C, Zacchetti D, Sessa M, Scherzer CR, Biffi A. Metallothioneins as dynamic markers for brain disease in lysosomal disorders. Ann Neurol. 2014 Jan; 75(1):127-37. PMID: 24242821; PMCID: PMC4237725.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  25. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787; PMCID: PMC3888173.
    Citations: 22     Fields:    Translation:Humans
  26. Santiago JA, Scherzer CR, Potashkin JA. Specific splice variants are associated with Parkinson's disease. Mov Disord. 2013 Oct; 28(12):1724-7. PMID: 24108702; PMCID: PMC3812386.
    Citations: 10     Fields:    Translation:Humans
  27. Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R, Matson W. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Anal Biochem. 2013 May 15; 436(2):112-20. PMID: 23416183; PMCID: PMC4090024.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84. PMID: 22451204.
    Citations: 80     Fields:    Translation:Humans
  29. van Blitterswijk M, Gulati S, Smoot E, Jaffa M, Maher N, Hyman BT, Ivinson AJ, Scherzer CR, Schoenfeld DA, Cudkowicz ME, Brown RH, Bosco DA. Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Nov; 12(6):430-8. PMID: 22023190; PMCID: PMC3446817.
    Citations: 5     Fields:    Translation:HumansAnimals
  30. Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, Hersch SM, Scherzer CR. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17141-6. PMID: 21969577; PMCID: PMC3193232.
    Citations: 28     Fields:    Translation:HumansAnimalsCTClinical Trials
  31. Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, Unni VK, Hung AY, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Sudarsky LR, Growdon JH, Ivinson AJ, Hyman BT, Scherzer CR. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord. 2011 Oct; 26(12):2283-6. PMID: 21953863; PMCID: PMC3337217.
    Citations: 9     Fields:    Translation:Humans
  32. Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG. Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna). 2011 May; 118(5):795-808. PMID: 21552986; PMCID: PMC3376651.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  33. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR. PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 06; 2(52):52ra73. PMID: 20926834; PMCID: PMC3129986.
    Citations: 212     Fields:    Translation:HumansCells
  34. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14164-9. PMID: 20660724; PMCID: PMC2922576.
    Citations: 137     Fields:    Translation:HumansCells
  35. Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010 Jul 15; 6(7):e1001026. PMID: 20664788; PMCID: PMC2904797.
    Citations: 33     Fields:    Translation:AnimalsCells
  36. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 08; 285(41):31217-32. PMID: 20558735; PMCID: PMC2951196.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  37. Kim J, Amante DJ, Moody JP, Edgerly CK, Bordiuk OL, Smith K, Matson SA, Matson WR, Scherzer CR, Rosas HD, Hersch SM, Ferrante RJ. Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):673-81. PMID: 20460152; PMCID: PMC2893277.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  38. Scherzer C. Interview with Clemens Scherzer--searching for biomarkers in Parkinson's disease. Biomark Med. 2009 Apr; 3(2):113-4. PMID: 20477503.
    Citations: 2     Fields:    
  39. Scherzer CR. Chipping away at diagnostics for neurodegenerative diseases. Neurobiol Dis. 2009 Aug; 35(2):148-56. PMID: 19285134; PMCID: PMC2753504.
    Citations: 10     Fields:    Translation:HumansAnimals
  40. Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG. GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10907-12. PMID: 18669654; PMCID: PMC2504800.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  41. Hennecke G, Scherzer CR. RNA biomarkers of Parkinson's disease: developing tools for novel therapies. Biomark Med. 2008 Feb; 2(1):41-53. PMID: 20477362.
    Citations: 8     Fields:    
  42. Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR. Molecular markers of early Parkinson's disease based on gene expression in blood. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):955-60. PMID: 17215369; PMCID: PMC1766335.
    Citations: 138     Fields:    Translation:Humans
  43. Xu PT, Li YJ, Qin XJ, Scherzer CR, Xu H, Schmechel DE, Hulette CM, Ervin J, Gullans SR, Haines J, Pericak-Vance MA, Gilbert JR. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiol Dis. 2006 Feb; 21(2):256-75. PMID: 16198584.
    Citations: 24     Fields:    Translation:HumansCells
  44. Hauser MA, Li YJ, Xu H, Noureddine MA, Shao YS, Gullans SR, Scherzer CR, Jensen RV, McLaurin AC, Gibson JR, Scott BL, Jewett RM, Stenger JE, Schmechel DE, Hulette CM, Vance JM. Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Arch Neurol. 2005 Jun; 62(6):917-21. PMID: 15956162.
    Citations: 54     Fields:    Translation:Humans
  45. Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol. 2004 Aug; 61(8):1200-5. PMID: 15313836.
    Citations: 109     Fields:    Translation:HumansCells
  46. Scherzer CR, Feany MB. Yeast genetics targets lipids in Parkinson's disease. Trends Genet. 2004 Jul; 20(7):273-7. PMID: 15219388.
    Citations: 11     Fields:    Translation:HumansAnimals
  47. Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, Hauser MA, Scott WK, Small GW, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Mastaglia F, Middleton LT, Roses AD, Saunders AM, Schmechel DE, Gullans SR, Haines JL, Gilbert JR, Vance JM, Pericak-Vance MA, Hulette C, Welsh-Bohmer KA. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet. 2003 Dec 15; 12(24):3259-67. PMID: 14570706.
    Citations: 62     Fields:    Translation:HumansCells
  48. Scherzer CR, Jensen RV, Gullans SR, Feany MB. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2003 Oct 01; 12(19):2457-66. PMID: 12915459.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  49. Thambisetty MR, Scherzer CR, Yu Z, Lennon VA, Newman NJ. Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung. J Neuroophthalmol. 2001 Sep; 21(3):164-7. PMID: 11725180.
    Citations: 6     Fields:    Translation:Humans
  50. Scherzer CR, Landwehrmeyer GB, Kerner JA, Counihan TJ, Kosinski CM, Standaert DG, Daggett LP, Veliçelebi G, Penney JB, Young AB. Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: hippocampus and cortex. J Comp Neurol. 1998 Jan 05; 390(1):75-90. PMID: 9456177.
    Citations: 28     Fields:    Translation:Humans
  51. Kosinski CM, Standaert DG, Counihan TJ, Scherzer CR, Kerner JA, Daggett LP, Veliçelebi G, Penney JB, Young AB, Landwehrmeyer GB. Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: striatum and globus pallidus. J Comp Neurol. 1998 Jan 05; 390(1):63-74. PMID: 9456176.
    Citations: 11     Fields:    Translation:Humans
  52. Counihan TJ, Landwehrmeyer GB, Standaert DG, Kosinski CM, Scherzer CR, Daggett LP, Veliçelebi G, Young AB, Penney JB. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: mesencephalic dopaminergic neurons. J Comp Neurol. 1998 Jan 05; 390(1):91-101. PMID: 9456178.
    Citations: 9     Fields:    Translation:HumansCells
  53. Priller J, Scherzer CR, Faber PW, MacDonald ME, Young AB. Frataxin gene of Friedreich's ataxia is targeted to mitochondria. Ann Neurol. 1997 Aug; 42(2):265-9. PMID: 9266741.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  54. Scherzer CR, Landwehrmeyer GB, Kerner JA, Standaert DG, Hollingsworth ZR, Daggett LP, Veliçelebi G, Penney JB, Young AB. Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum. Neurobiol Dis. 1997; 4(1):35-46. PMID: 9258910.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.