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Joshua M. Kaplan, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK080215 (KAPLAN, JOSHUA M) Dec 1, 2007 - Nov 30, 2017
    Regulation of insulin secretion C. elegans
    Role: Principal Investigator
  2. R13MH081408 (KAPLAN, JOSHUA M) Sep 1, 2007 - Aug 31, 2012
    2008 Cell Biology of the Neuron
    Role: Principal Investigator
  3. R01GM054728 (KAPLAN, JOSHUA M) Aug 1, 1997 - Apr 30, 2019
    Dissecting G protein pathways
    Role: Principal Investigator
  4. R01NS032196 (KAPLAN, JOSHUA M) Jul 1, 1993 - Jun 30, 2020
    Mechanotransduction C. elegans
    Role: Principal Investigator
  5. R37NS032196 (KAPLAN, JOSHUA M) Jul 1, 1993 - Aug 31, 2015
    Mechanotransduction in C elegans
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Piggott CA, Wu Z, Nurrish S, Xu S, Kaplan JM, Chisholm AD, Jin Y. Caenorhabditis elegans Junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin. Genetics. 2021 Apr 19. PMID: 33871019.
    Citations:    Fields:    
  2. Qian KY, Zeng WX, Hao Y, Zeng XT, Liu H, Li L, Chen L, Tian FM, Chang C, Hall Q, Song CX, Gao S, Hu Z, Kaplan JM, Li Q, Tong XJ. Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. Elife. 2021 03 31; 10. PMID: 33787493.
    Citations:    Fields:    
  3. Li L, Liu H, Hall Q, Wang W, Yu Y, Kaplan JM, Hu Z. A Hyperactive Form of unc-13 Enhances Ca2+ Sensitivity and Synaptic Vesicle Release Probability in C. elegans. Cell Rep. 2019 09 10; 28(11):2979-2995.e4. PMID: 31509756.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Liu H, Li L, Nedelcu D, Hall Q, Zhou L, Wang W, Yu Y, Kaplan JM, Hu Z. Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans. Elife. 2019 02 25; 8. PMID: 30802206.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Zhao T, Hao Y, Kaplan JM. Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans. Genetics. 2018 09; 210(1):275-285. PMID: 30049781.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Hao Y, Yang W, Ren J, Hall Q, Zhang Y, Kaplan JM. Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide. Elife. 2018 07 17; 7. PMID: 30014846.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Tong XJ, López-Soto EJ, Li L, Liu H, Nedelcu D, Lipscombe D, Hu Z, Kaplan JM. Retrograde Synaptic Inhibition Is Mediated by a-Neurexin Binding to the a2d Subunits of N-Type Calcium Channels. Neuron. 2017 Jul 19; 95(2):326-340.e5. PMID: 28669545.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  8. Pym E, Sasidharan N, Thompson-Peer KL, Simon DJ, Anselmo A, Sadreyev R, Hall Q, Nurrish S, Kaplan JM. Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression. Elife. 2017 05 06; 6. PMID: 28477407.
    Citations: 2     Fields:    Translation:Animals
  9. Chen D, Taylor KP, Hall Q, Kaplan JM. The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion. Genetics. 2016 11; 204(3):1151-1159. PMID: 27585848.
    Citations: 10     Fields:    Translation:AnimalsCells
  10. Tong XJ, Hu Z, Liu Y, Anderson D, Kaplan JM. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. Elife. 2015 Nov 17; 4:e09648. PMID: 26575289.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  11. Choi S, Taylor KP, Chatzigeorgiou M, Hu Z, Schafer WR, Kaplan JM. Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. PLoS Genet. 2015 Jul; 11(7):e1005359. PMID: 26154367.
    Citations: 23     Fields:    Translation:AnimalsCells
  12. Hu Z, Vashlishan-Murray AB, Kaplan JM. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. J Neurosci. 2015 Jan 21; 35(3):1038-42. PMID: 25609620.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Hu Z, Tong XJ, Kaplan JM. UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. Elife. 2013 Aug 13; 2:e00967. PMID: 23951547.
    Citations: 36     Fields:    Translation:AnimalsCells
  14. Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, and Kaplan JM (2013). . Analysis of NPR-1 Reveals a Circuit Mechanism for Behavioral Quiescence in C. elegans. . Neuron. 2013; 5(78):869-80. View Publication.
  15. Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM. Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans. Neuron. 2013 Jun 05; 78(5):869-80. PMID: 23764289.
    Citations: 64     Fields:    Translation:AnimalsCells
  16. Hu Z, Hom S, Kudze T, Tong XJ, Choi S, Aramuni G, Zhang W, Kaplan JM. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science. 2012 Aug 24; 337(6097):980-4. PMID: 22859820.
    Citations: 50     Fields:    Translation:AnimalsCells
  17. Thompson-Peer KL, Bai J, Hu Z, Kaplan JM. HBL-1 patterns synaptic remodeling in C. elegans. Neuron. 2012 Feb 09; 73(3):453-65. PMID: 22325199.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Hao Y, Hu Z, Sieburth D, Kaplan JM. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012 Jan; 8(1):e1002464. PMID: 22275875.
    Citations: 14     Fields:    Translation:AnimalsCells
  19. Babu K, Hu Z, Chien SC, Garriga G, Kaplan JM. The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron. 2011 Jul 14; 71(1):103-16. PMID: 21745641.
    Citations: 18     Fields:    Translation:AnimalsCells
  20. Hu Z, Pym EC, Babu K, Vashlishan Murray AB, Kaplan JM. A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Neuron. 2011 Jul 14; 71(1):92-102. PMID: 21745640.
    Citations: 34     Fields:    Translation:AnimalsCells
  21. Bai J, Hu Z, Dittman JS, Pym EC, Kaplan JM. Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis. Cell. 2010 Oct 29; 143(3):430-41. PMID: 21029864.
    Citations: 47     Fields:    Translation:AnimalsCells
  22. Ch'ng Q, Sieburth D, Kaplan JM. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008 Nov; 4(11):e1000283. PMID: 19043554.
    Citations: 48     Fields:    Translation:AnimalsCells
  23. Dittman JS, Kaplan JM. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008 Jul 09; 28(28):7104-12. PMID: 18614679.
    Citations: 38     Fields:    Translation:AnimalsCells
  24. McEwen JM, Kaplan JM. UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin. Mol Biol Cell. 2008 Sep; 19(9):3836-46. PMID: 18596236.
    Citations: 39     Fields:    Translation:AnimalsCells
  25. Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008 May 30; 133(5):903-15. PMID: 18510933.
    Citations: 96     Fields:    Translation:AnimalsCells
  26. Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008 May 08; 58(3):346-61. PMID: 18466746.
    Citations: 69     Fields:    Translation:AnimalsCells
  27. Chun DK, McEwen JM, Burbea M, Kaplan JM. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Mol Biol Cell. 2008 Jul; 19(7):2682-95. PMID: 18434599.
    Citations: 41     Fields:    Translation:AnimalsCells
  28. Juo P, Harbaugh T, Garriga G, Kaplan JM. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Mol Biol Cell. 2007 Oct; 18(10):3883-93. PMID: 17671168.
    Citations: 22     Fields:    Translation:AnimalsCells
  29. Sieburth D, Madison JM, Kaplan JM. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007 Jan; 10(1):49-57. PMID: 17128266.
    Citations: 116     Fields:    Translation:AnimalsCells
  30. McEwen JM, Madison JM, Dybbs M, Kaplan JM. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron. 2006 Aug 03; 51(3):303-15. PMID: 16880125.
    Citations: 62     Fields:    Translation:AnimalsCells
  31. Dittman JS, Kaplan JM. Factors regulating the abundance and localization of synaptobrevin in the plasma membrane. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11399-404. PMID: 16844789.
    Citations: 67     Fields:    Translation:AnimalsCells
  32. Madison JM, Nurrish S, Kaplan JM. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005 Dec 20; 15(24):2236-42. PMID: 16271476.
    Citations: 60     Fields:    Translation:AnimalsCells
  33. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 2005 Jul 28; 436(7050):510-7. PMID: 16049479.
    Citations: 176     Fields:    Translation:AnimalsCells
  34. Dybbs M, Ngai J, Kaplan JM. Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion. PLoS Genet. 2005 Jul; 1(1):6-16. PMID: 16103915.
    Citations: 23     Fields:    
  35. Dreier L, Burbea M, Kaplan JM. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron. 2005 Apr 07; 46(1):51-64. PMID: 15820693.
    Citations: 46     Fields:    Translation:AnimalsCells
  36. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20; 308(5725):1164-7. PMID: 15790806.
    Citations: 138     Fields:    Translation:AnimalsCells
  37. Juo P, Kaplan JM. The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol. 2004 Nov 23; 14(22):2057-62. PMID: 15556870.
    Citations: 88     Fields:    Translation:AnimalsCells
  38. Grunwald ME, Mellem JE, Strutz N, Maricq AV, Kaplan JM. Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3190-5. PMID: 14981253.
    Citations: 18     Fields:    Translation:AnimalsCells
  39. Grunwald ME, Kaplan JM. Mutations in the ligand-binding and pore domains control exit of glutamate receptors from the endoplasmic reticulum in C. elegans. Neuropharmacology. 2003 Nov; 45(6):768-76. PMID: 14529715.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Jacob TC, Kaplan JM. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J Neurosci. 2003 Mar 15; 23(6):2122-30. PMID: 12657671.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  41. Burbea M, Dreier L, Dittman JS, Grunwald ME, Kaplan JM. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron. 2002 Jul 03; 35(1):107-20. PMID: 12123612.
    Citations: 121     Fields:    Translation:AnimalsCells
  42. Kass J, Jacob TC, Kim P, Kaplan JM. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci. 2001 Dec 01; 21(23):9265-72. PMID: 11717360.
    Citations: 66     Fields:    Translation:AnimalsCells
  43. Rongo C, Kaplan JM. CaMKII regulates the density of central glutamatergic synapses in vivo. Nature. 1999 Nov 11; 402(6758):195-9. PMID: 10647013.
    Citations: 50     Fields:    Translation:AnimalsCells
  44. Lackner MR, Nurrish SJ, Kaplan JM. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron. 1999 Oct; 24(2):335-46. PMID: 10571228.
    Citations: 129     Fields:    Translation:AnimalsCells
  45. Nurrish S, Ségalat L, Kaplan JM. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Neuron. 1999 Sep; 24(1):231-42. PMID: 10677040.
    Citations: 117     Fields:    Translation:AnimalsCells
  46. Hart AC, Kass J, Shapiro JE, Kaplan JM. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. J Neurosci. 1999 Mar 15; 19(6):1952-8. PMID: 10066248.
    Citations: 66     Fields:    Translation:AnimalsCells
  47. Rongo C, Whitfield CW, Rodal A, Kim SK, Kaplan JM. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell. 1998 Sep 18; 94(6):751-9. PMID: 9753322.
    Citations: 79     Fields:    Translation:AnimalsCells
  48. Berger AJ, Hart AC, Kaplan JM. G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci. 1998 Apr 15; 18(8):2871-80. PMID: 9526004.
    Citations: 37     Fields:    Translation:AnimalsCells
  49. Elkes DA, Cardozo DL, Madison J, Kaplan JM. EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity. Neuron. 1997 Jul; 19(1):165-74. PMID: 9247272.
    Citations: 8     Fields:    Translation:AnimalsCells
  50. Kaplan JM. Sensory signaling in Caenorhabditis elegans. Curr Opin Neurobiol. 1996 Aug; 6(4):494-9. PMID: 8794103.
    Citations: 2     Fields:    Translation:AnimalsCells
  51. Hart AC, Sims S, Kaplan JM. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature. 1995 Nov 02; 378(6552):82-5. PMID: 7477294.
    Citations: 151     Fields:    Translation:AnimalsCells
  52. Ségalat L, Elkes DA, Kaplan JM. Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science. 1995 Mar 17; 267(5204):1648-51. PMID: 7886454.
    Citations: 109     Fields:    Translation:AnimalsCells
  53. Kaplan JM, Horvitz HR. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2227-31. PMID: 8460126.
    Citations: 145     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.