Harvard Catalyst Profiles

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Daniel James Smith, Ph.D.


Dental Caries Protective-Potential of a C-Terminal Peptide from Streptococcus mutans Glucan Binding Protein B
Summer, 06/20/05 - 08/26/05
Passive Immunization Against Dental Caries
Summer, 06/01/07 - 08/04/07
Interference of Streptococcus sobrinus Biofilm Formation By Anti-Peptide Antibody To Functional Domains Of Glucosyltransferase
Summer, 06/15/09 - 07/31/09
Protective Immunity to S-Mutans Glucan Binding Protein EPITOPES
Summer, 06/18/01 - 08/18/01
Immunogenicity of Epitopes in Putative Functional Domains of S. mutans GbpB.
Summer, 07/01/04 - 08/25/04
N and C terminal mutations of PsbO, the manganese stabilizing protein of Photosystem II
Summer, 06/12/09 - 08/07/09
Mucosal Responses Induced by Rectal Immunization with Mutans Streptococccal Glucotransferase
Part Time/Continuation, 09/01/00 - 04/01/01
Mucosal Responses Induced by Rectal Immunization with Mutans Streptococcal Glucotransferase
Summer, 07/05/00 - 08/30/00

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P30DE020751 (SMITH, DANIEL JAMES) Sep 17, 2009 - Aug 31, 2012
    The Forsyth Core Center for Discovery at the Host-Biofilm Interface
    Role: Principal Investigator
  2. R03TW006324 (SMITH, DANIEL JAMES) Sep 1, 2004 - Aug 31, 2008
    Muscosal Immunity in Heavily S. Mutans Exposed Children
    Role: Principal Investigator
  3. T32DE007327 (VAN DYKE, THOMAS E) Jul 1, 2001 - Dec 31, 2016
    Forsyth Postdoctoral Training in Oral Health Research
    Role: Co-Principal Investigator
  4. R37DE006153 (SMITH, DANIEL JAMES) Aug 1, 1982 - Apr 30, 2009
    Role: Principal Investigator
  5. R01DE006153 (SMITH, DANIEL J.) Aug 1, 1982 - Apr 30, 2003
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pham A, Ledger EL, Coggon CF, Henderson IR, Reid DW, Bell SC, Smith DJ, Wells TJ. Anti-LPS IgA and IgG Can Inhibit Serum Killing of Pseudomonas aeruginosa in Patients with Cystic Fibrosis. Infect Immun. 2021 11 16; 89(12):e0041221. PMID: 34460286; PMCID: PMC8594595.
    Citations:    Fields:    Translation:HumansCells
  2. Harth-Chu EN, Alves LA, Theobaldo JD, Salomão MF, Höfling JF, King WF, Smith DJ, Mattos-Graner RO. PcsB Expression Diversity Influences on Streptococcus mitis Phenotypes Associated With Host Persistence and Virulence. Front Microbiol. 2019; 10:2567. PMID: 31798545; PMCID: PMC6861525.
    Citations: 3     
  3. Kressirer CA, Smith DJ, King WF, Dobeck JM, Starr JR, Tanner ACR. Scardovia wiggsiae and its potential role as a caries pathogen. J Oral Biosci. 2017 Aug; 59(3):135-141. PMID: 29104444; PMCID: PMC5665406.
    Citations: 22     Fields:    
  4. Colombo NH, Pereira JA, da Silva ME, Ribas LF, Parisotto TM, Mattos-Graner Rde O, Smith DJ, Duque C. Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood. Arch Oral Biol. 2016 Jul; 67:22-7. PMID: 27019137.
    Citations: 3     Fields:    Translation:HumansCells
  5. Stipp RN, Boisvert H, Smith DJ, Höfling JF, Duncan MJ, Mattos-Graner RO. CovR and VicRK regulate cell surface biogenesis genes required for biofilm formation in Streptococcus mutans. PLoS One. 2013; 8(3):e58271. PMID: 23554881.
    Citations: 39     Fields:    Translation:Cells
  6. Smith DJ. Prospects in caries vaccine development. J Dent Res. 2012 Mar; 91(3):225-6. PMID: 22027715.
    Citations: 3     Fields:    Translation:HumansAnimals
  7. Duque C, Stipp RN, Wang B, Smith DJ, Höfling JF, Kuramitsu HK, Duncan MJ, Mattos-Graner RO. Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans. Infect Immun. 2011 Feb; 79(2):786-96. PMID: 21078847.
    Citations: 43     Fields:    Translation:Cells
  8. Smith DJ. Dental caries vaccines: prospects and concerns. Expert Rev Vaccines. 2010 Jan; 9(1):1-3. PMID: 20021297.
    Citations: 2     Fields:    Translation:HumansCells
  9. Smith DJ, Mattos-Graner RO. Secretory immunity following mutans streptococcal infection or immunization. Curr Top Microbiol Immunol. 2008; 319:131-56. PMID: 18080417.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  10. Taubman MA, Han X, Larosa KB, Socransky SS, Smith DJ. Periodontal bacterial DNA suppresses the immune response to mutans streptococcal glucosyltransferase. Infect Immun. 2007 Aug; 75(8):4088-96. PMID: 17517867; PMCID: PMC1952018.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Nogueira RD, Alves AC, King WF, Gonçalves RB, Höfling JF, Smith DJ, Mattos-Graner RO. Age-specific salivary immunoglobulin A response to Streptococcus mutans GbpB. Clin Vaccine Immunol. 2007 Jun; 14(6):804-7. PMID: 17475767; PMCID: PMC1951079.
    Citations: 2     Fields:    Translation:HumansCells
  12. Klein MI, Bang S, Flório FM, Höfling JF, Gonçalves RB, Smith DJ, Mattos-Graner RO. Genetic diversity of competence gene loci in clinical genotypes of Streptococcus mutans. J Clin Microbiol. 2006 Aug; 44(8):3015-20. PMID: 16891531; PMCID: PMC1594605.
    Citations: 10     Fields:    Translation:HumansCells
  13. Mattos-Graner RO, Porter KA, Smith DJ, Hosogi Y, Duncan MJ. Functional analysis of glucan binding protein B from Streptococcus mutans. J Bacteriol. 2006 Jun; 188(11):3813-25. PMID: 16707674; PMCID: PMC1482924.
    Citations: 28     Fields:    Translation:Cells
  14. Nogueira RD, Alves AC, Napimoga MH, Smith DJ, Mattos-Graner RO. Characterization of salivary immunoglobulin A responses in children heavily exposed to the oral bacterium Streptococcus mutans: influence of specific antigen recognition in infection. Infect Immun. 2005 Sep; 73(9):5675-84. PMID: 16113285; PMCID: PMC1231082.
    Citations: 21     Fields:    Translation:HumansCells
  15. Smith DJ, King WF, Rivero J, Taubman MA. Immunological and protective effects of diepitopic subunit dental caries vaccines. Infect Immun. 2005 May; 73(5):2797-804. PMID: 15845483; PMCID: PMC1087357.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  16. Mattos-Graner RO, Napimoga MH, Fukushima K, Duncan MJ, Smith DJ. Comparative analysis of Gtf isozyme production and diversity in isolates of Streptococcus mutans with different biofilm growth phenotypes. J Clin Microbiol. 2004 Oct; 42(10):4586-92. PMID: 15472313; PMCID: PMC522304.
    Citations: 32     Fields:    Translation:HumansCells
  17. Russell MW, Childers NK, Michalek SM, Smith DJ, Taubman MA. A Caries Vaccine? The state of the science of immunization against dental caries. Caries Res. 2004 May-Jun; 38(3):230-5. PMID: 15153693.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  18. Smith DJ. Caries vaccines for the twenty-first century. J Dent Educ. 2003 Oct; 67(10):1130-9. PMID: 14587678.
    Citations: 4     Fields:    Translation:HumansCells
  19. Smith DJ, Lam A, Barnes LA, King WF, Peacock Z, Wise DL, Trantolo DJ, Taubman MA. Remote glucosyltransferase-microparticle vaccine delivery induces protective immunity in the oral cavity. Oral Microbiol Immunol. 2003 Aug; 18(4):240-8. PMID: 12823800.
    Citations:    Fields:    Translation:AnimalsCells
  20. Smith DJ, King WF, Barnes LA, Peacock Z, Taubman MA. Immunogenicity and protective immunity induced by synthetic peptides associated with putative immunodominant regions of Streptococcus mutans glucan-binding protein B. Infect Immun. 2003 Mar; 71(3):1179-84. PMID: 12595430.
    Citations: 16     Fields:    Translation:AnimalsCellsPHPublic Health
  21. Smith DJ. Dental caries vaccines: prospects and concerns. Crit Rev Oral Biol Med. 2002; 13(4):335-49. PMID: 12191960.
    Citations: 23     Fields:    Translation:HumansCellsPHPublic Health
  22. Smith DJ, King WF, Barnes LA, Trantolo D, Wise DL, Taubman MA. Facilitated intranasal induction of mucosal and systemic immunity to mutans streptococcal glucosyltransferase peptide vaccines. Infect Immun. 2001 Aug; 69(8):4767-73. PMID: 11447149.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Smith DJ, Heschel RL, King WF, Taubman MA. Antibody to glucosyltransferase induced by synthetic peptides associated with catalytic regions of alpha-amylases. Infect Immun. 1999 May; 67(5):2638-42. PMID: 10225934; PMCID: PMC116017.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Smith DJ, King WF, Wu CD, Shen BI, Taubman MA. Structural and antigenic characteristics of Streptococcus sobrinus glucan binding proteins. Infect Immun. 1998 Nov; 66(11):5565-9. PMID: 9784575; PMCID: PMC108701.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.