Harvard Catalyst Profiles

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Richard Ian Gregory, Ph.D.

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Title
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Mentoring
completed student projects
The Use of MicroRNAs in Directed Mouse Embryonic Stem Cell Differentiation
Summer, 06/01/09 - 08/15/09

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu Q, Peng X, Shen M, Qian Q, Xing J, Li C, Gregory RI. Ribo-uORF: a comprehensive data resource of upstream open reading frames (uORFs) based on ribosome profiling. Nucleic Acids Res. 2023 01 06; 51(D1):D248-D261. PMID: 36440758; PMCID: PMC9825487.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Structural basis of regulated m7G tRNA modification by METTL1-WDR4. Nature. 2023 01; 613(7943):391-397. PMID: 36599985.
    Citations: 1     Fields:    Translation:HumansCells
  3. Yang X, Triboulet R, Liu Q, Sendinc E, Gregory RI. Exon junction complex shapes the m6A epitranscriptome. Nat Commun. 2022 12 23; 13(1):7904. PMID: 36550132; PMCID: PMC9780246.
    Citations: 2     Fields:    Translation:Cells
  4. Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022 11; 23(11):651-664. PMID: 35681060.
    Citations: 8     Fields:    Translation:HumansCells
  5. Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. J Clin Invest. 2021 11 15; 131(22). PMID: 34779407; PMCID: PMC8592552.
    Citations: 2     Fields:    Translation:HumansCells
  6. Ramírez-Moya J, Miliotis C, Baker AR, Gregory RI, Slack FJ, Santisteban P. An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Mol Cancer. 2021 09 08; 20(1):115. PMID: 34496885; PMCID: PMC8424981.
    Citations: 7     Fields:    Translation:HumansCells
  7. Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Mol Cell. 2021 08 19; 81(16):3323-3338.e14. PMID: 34352207; PMCID: PMC8380730.
    Citations: 61     Fields:    Translation:HumansCells
  8. Xiong X, Hou L, Park YP, Molinie B, Gregory RI, Kellis M. Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet. 2021 08; 53(8):1156-1165. PMID: 34211177; PMCID: PMC9112289.
    Citations: 22     Fields:    Translation:HumansCells
  9. Li J, Gregory RI. Mining for METTL3 inhibitors to suppress cancer. Nat Struct Mol Biol. 2021 06; 28(6):460-462. PMID: 34040230; PMCID: PMC8197751.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Cui Y, Lyu X, Ding L, Ke L, Yang D, Pirouz M, Qi Y, Ong J, Gao G, Du P, Gregory RI. Global miRNA dosage control of embryonic germ layer specification. Nature. 2021 05; 593(7860):602-606. PMID: 33953397; PMCID: PMC8297444.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Cui J, Liu Q, Sendinc E, Shi Y, Gregory RI. Nucleotide resolution profiling of m3C RNA modification by HAC-seq. Nucleic Acids Res. 2021 03 18; 49(5):e27. PMID: 33313824.
    Citations: 16     Fields:    Translation:HumansCells
  12. Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J, Sarapuu A, Choe J, Ivanova I, Krause DS, von Kriegsheim A, Much C, Morgan M, Gregory RI, Mead AJ, O'Carroll D, Kranc KR. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 03 01; 218(3). PMID: 33156926; PMCID: PMC7653684.
    Citations: 37     Fields:    Translation:AnimalsCells
  13. Liu Q, Lang X, Gregory RI. An Informatics Pipeline for Profiling and Annotating RNA Modifications. Methods Mol Biol. 2021; 2298:15-27. PMID: 34085236.
    Citations:    Fields:    Translation:HumansCells
  14. Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). PMID: 33087503; PMCID: PMC7709865.
    Citations: 10     Fields:    Translation:HumansAnimals
  15. Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 09; 19(18):2314-2326. PMID: 32816599.
    Citations: 3     Fields:    Translation:HumansCells
  16. Liu Q, Shvarts T, Sliz P, Gregory RI. RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. PMID: 32427338.
    Citations: 19     Fields:    Translation:AnimalsCells
  17. Pirouz M, Wang CH, Liu Q, Ebrahimi AG, Shamsi F, Tseng YH, Gregory RI. The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun. 2020 05 26; 11(1):2619. PMID: 32457326.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  18. Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547. PMID: 31913360.
    Citations: 41     Fields:    Translation:HumansCells
  19. Lin S, Liu Q, Jiang YZ, Gregory RI. Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq. Nat Protoc. 2019 11; 14(11):3220-3242. PMID: 31619810; PMCID: PMC8959837.
    Citations: 26     Fields:    Translation:AnimalsCells
  20. Liu Q, Gregory RI. RNAmod: an integrated system for the annotation of mRNA modifications. Nucleic Acids Res. 2019 07 02; 47(W1):W548-W555. PMID: 31147718; PMCID: PMC6602476.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  21. Pirouz M, Munafò M, Ebrahimi AG, Choe J, Gregory RI. Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance. Nat Struct Mol Biol. 2019 06; 26(6):490-500. PMID: 31160785.
    Citations: 11     Fields:    Translation:AnimalsCells
  22. Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6. PMID: 31031138.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  23. Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. PMID: 30991026; PMCID: PMC6541931.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  24. Pirouz M, Ebrahimi AG, Gregory RI. Unraveling 3'-end RNA uridylation at nucleotide resolution. Methods. 2019 02 15; 155:10-19. PMID: 30395968; PMCID: PMC6387850.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. PMID: 30232453.
    Citations: 271     Fields:    Translation:HumansAnimalsCells
  26. Park HH, Triboulet R, Bentler M, Guda S, Du P, Xu H, Gregory RI, Brendel C, Williams DA. DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mol Ther Nucleic Acids. 2018 Sep 07; 12:591-599. PMID: 30195795.
    Citations: 3     
  27. Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5. PMID: 29983320; PMCID: PMC6086580.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  28. Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI. An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. Cell Stem Cell. 2018 Jun 01; 22(6):851-864.e5. PMID: 29804889.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  29. Ogórek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. PMID: 29509898; PMCID: PMC5905583.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  30. Cinkornpumin J, Roos M, Nguyen L, Liu X, Gaeta X, Lin S, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE. A small molecule screen to identify regulators of let-7 targets. Sci Rep. 2017 11 21; 7(1):15973. PMID: 29162914.
    Citations: 7     Fields:    Translation:HumansCells
  31. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. PMID: 27992407; PMCID: PMC5182091.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  32. Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. PMID: 27599293; PMCID: PMC5096824.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  33. Pirouz M, Du P, Munafò M, Gregory RI. Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73. PMID: 27498873.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  34. Lin S, Choe J, Du P, Triboulet R, Gregory RI. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345. PMID: 27117702; PMCID: PMC4860043.
    Citations: 687     Fields:    Translation:HumansCells
  35. Triboulet R, Pirouz M, Gregory RI. A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6. PMID: 26440890.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  36. Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. PMID: 26299972; PMCID: PMC5384103.
    Citations: 38     Fields:    Translation:AnimalsCells
  37. Du P, Wang L, Sliz P, Gregory RI. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. PMID: 26255770.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  38. Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. PMID: 26080908; PMCID: PMC4817887.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  39. Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33. PMID: 25998712; PMCID: PMC4859809.
    Citations: 882     Fields:    Translation:HumansAnimalsCells
  40. Lin S, Gregory RI. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. PMID: 26114892.
    Citations: 27     Fields:    Translation:HumansCells
  41. Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. PMID: 25223788.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  42. Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906. PMID: 24581491; PMCID: PMC3982296.
    Citations: 193     Fields:    Translation:HumansCells
  43. Lin S, Gregory RI. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31. PMID: 24481042.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  44. Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013 Oct 10; 52(1):101-12. PMID: 24055342; PMCID: PMC3843377.
    Citations: 546     Fields:    Translation:HumansAnimalsCells
  45. Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013 Nov; 19(11):1583-93. PMID: 24049110.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  46. Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73. PMID: 23666760; PMCID: PMC3775935.
    Citations: 63     Fields:    Translation:AnimalsCells
  47. Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9. PMID: 23378032; PMCID: PMC3652309.
    Citations: 25     Fields:    Translation:AnimalsCells
  48. Chang HM, Triboulet R, Thornton JE, Gregory RI. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8. PMID: 23594738.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  49. Martinez NJ, Gregory RI. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12. PMID: 23485552.
    Citations: 58     Fields:    Translation:AnimalsCells
  50. Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science. 2012 Dec 14; 338(6113):1465-9. PMID: 23239736.
    Citations: 443     Fields:    Translation:HumansAnimalsCells
  51. Silveira-Neto AP, Leal LF, Emerman AB, Henderson KD, Piskounova E, Henderson BE, Gregory RI, Silveira LF, Hirschhorn JN, Nguyen TT, Beneduzzi D, Tusset C, Reis AC, Brito VN, Mendonca BB, Palmert MR, Antonini SR, Latronico AC. Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr. 2012; 78(3):144-50. PMID: 22964795.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  52. Thornton JE, Chang HM, Piskounova E, Gregory RI. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85. PMID: 22898984.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  53. Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82. PMID: 22784697.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  54. Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923. PMID: 22735451.
    Citations: 79     Fields:    Translation:HumansCells
  55. Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79. PMID: 22118463.
    Citations: 318     Fields:    Translation:HumansCells
  56. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. PMID: 22078496.
    Citations: 198     Fields:    Translation:AnimalsCells
  57. Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94. PMID: 21962509; PMCID: PMC3353524.
    Citations: 440     Fields:    Translation:HumansAnimals
  58. Chang HM, Gregory RI. MicroRNAs and reprogramming. Nat Biotechnol. 2011 Jun 07; 29(6):499-500. PMID: 21654668.
    Citations: 4     Fields:    Translation:HumansCells
  59. Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. PMID: 21255825.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  60. Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, MacKay JL, Gregory RI, Roth FP. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43. PMID: 21252293.
    Citations: 13     Fields:    Translation:HumansAnimals
  61. Triboulet R, Gregory RI. Autoregulatory mechanisms controlling the microprocessor. Adv Exp Med Biol. 2011; 700:56-66. PMID: 21755473.
    Citations:    Fields:    Translation:HumansCells
  62. Triboulet R, Gregory RI. Pumilio turns on microRNA function. Nat Cell Biol. 2010 Oct; 12(10):928-9. PMID: 20885420.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  63. Martinez NJ, Gregory RI. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5. PMID: 20621047.
    Citations: 73     Fields:    Translation:Cells
  64. Triboulet R, Gregory RI. Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66. PMID: 21627030.
    Citations: 8     Fields:    Translation:HumansAnimals
  65. Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5. PMID: 19713958.
    Citations: 300     Fields:    Translation:AnimalsCells
  66. Triboulet R, Chang HM, Lapierre RJ, Gregory RI. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009 Jun; 15(6):1005-11. PMID: 19383765.
    Citations: 75     Fields:    Translation:HumansCells
  67. Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009 Mar; 11(3):228-34. PMID: 19255566.
    Citations: 1190     Fields:    Translation:HumansAnimalsCells
  68. Ho J, Ng KH, Rosen S, Dostal A, Gregory RI, Kreidberg JA. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol. 2008 Nov; 19(11):2069-75. PMID: 18832437; PMCID: PMC2573018.
    Citations: 145     Fields:    Translation:AnimalsCells
  69. Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. PMID: 18550544.
    Citations: 200     Fields:    Translation:HumansCells
  70. Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. PMID: 18538729.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  71. Li Q, Gregory RI. MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6. PMID: 18371442.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  72. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100. PMID: 18292307; PMCID: PMC3368499.
    Citations: 761     Fields:    Translation:HumansAnimalsCells
  73. Chendrimada TP, Finn KJ, Ji X, Baillat D, Gregory RI, Liebhaber SA, Pasquinelli AE, Shiekhattar R. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. PMID: 17507929.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  74. Gregory RI, Chendrimada TP, Shiekhattar R. MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol. 2006; 342:33-47. PMID: 16957365.
    Citations: 74     Fields:    Translation:HumansCells
  75. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005 Nov 18; 123(4):631-40. PMID: 16271387.
    Citations: 647     Fields:    Translation:HumansCells
  76. Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005 Aug 04; 436(7051):740-4. PMID: 15973356; PMCID: PMC2944926.
    Citations: 910     Fields:    Translation:HumansCells
  77. Gregory RI, Shiekhattar R. MicroRNA biogenesis and cancer. Cancer Res. 2005 May 01; 65(9):3509-12. PMID: 15867338.
    Citations: 256     Fields:    Translation:Humans
  78. Gregory RI, Shiekhattar R. Chromatin modifiers and carcinogenesis. Trends Cell Biol. 2004 Dec; 14(12):695-702. PMID: 15564046.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  79. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R. The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004 Nov 11; 432(7014):235-40. PMID: 15531877.
    Citations: 1191     Fields:    Translation:HumansCells
  80. Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G, D'Urso M, Feil R, D'Esposito M. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet. 2002 Dec 01; 11(25):3191-8. PMID: 12444103.
    Citations: 19     Fields:    Translation:HumansCells
  81. Gregory RI, O'Neill LP, Randall TE, Fournier C, Khosla S, Turner BM, Feil R. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem. 2002 Apr 05; 277(14):11728-34. PMID: 11821379.
    Citations: 11     Fields:    Translation:AnimalsCells
  82. Gregory RI, Randall TE, Johnson CA, Khosla S, Hatada I, O'Neill LP, Turner BM, Feil R. DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol. 2001 Aug; 21(16):5426-36. PMID: 11463825; PMCID: PMC87265.
    Citations: 36     Fields:    Translation:AnimalsCells
  83. Thompson SL, Konfortova G, Gregory RI, Reik W, Dean W, Feil R. Environmental effects on genomic imprinting in mammals. Toxicol Lett. 2001 Mar 31; 120(1-3):143-50. PMID: 11323171.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  84. Gregory RI, Khosla S, Feil R. Probing chromatin structure with nuclease sensitivity assays. Methods Mol Biol. 2001; 181:269-84. PMID: 12843457.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  85. Gregory RI, Feil R. Analysis of chromatin in limited numbers of cells: a PCR-SSCP based assay of allele-specific nuclease sensitivity. Nucleic Acids Res. 1999 Nov 15; 27(22):e32. PMID: 10536165; PMCID: PMC148708.
    Citations: 4     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.