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Leo E. Otterbein, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R41HL150889 (GOMPERTS, EDWARD) Aug 15, 2020 - Jan 31, 2022
    HBI-002 to Prevent Anthracycline-Related Cardiotoxicity
    Role: Co-Principal Investigator
  2. R41DK123933 (GOMPERTS, EDWARD) May 16, 2020 - Oct 31, 2021
    HBI-002 to Treat Ulcerative Colitis
    Role: Co-Principal Investigator
  3. R01DK119202 (WANG, BINGHE) Jun 10, 2019 - Jun 30, 2024
    Examining Carbon Monoxide to Treat Inflammatory Conditions using Experimental Colitis Models
    Role: Co-Principal Investigator
  4. R43GM125430 (GOMPERTS, EDWARD) Apr 1, 2018 - Sep 30, 2019
    HBI-002 to Treat Traumatic Injury
    Role: Co-Principal Investigator
  5. R44DK111260 (GOMPERTS, EDWARD) Aug 15, 2016 - Jun 30, 2018
    HBI-002 to Treat Delayed Graft Function in Kidney Transplant
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Konecna B, Park J, Kwon WY, Vlkova B, Zhang Q, Huang W, In Kim H, Yaffe MB, Otterbein LE, Itagaki K, Hauser CJ. MONOCYTE EXOCYTOSIS OF MITOCHONDRIAL DAMPS IN SEPSIS SUPPRESSES NEUTROPHIL CHEMOTAXIS. J Trauma Acute Care Surg. 2020 Oct 05. PMID: 33021603.
  2. Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Ann Surg. 2020 Oct; 272(4):604-610. PMID: 32932316.
  3. Tift MS, Alves de Souza RW, Weber J, Heinrich EC, Villafuerte FC, Malhotra A, Otterbein LE, Simonson TS. Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia. Front Physiol. 2020; 11:886. PMID: 32792988.
  4. Hanidziar D, Nakahori Y, Cahill LA, Gallo D, Keegan JW, Nguyen JP, Otterbein LE, Lederer JA, Robson SC. Characterization of pulmonary immune responses to hyperoxia by high-dimensional mass cytometry analyses. Sci Rep. 2020 03 13; 10(1):4677. PMID: 32170168.
  5. Cahill LA, Guo F, Nguyen J, Zhang F, Seshadri A, Keegan J, Hauser CJ, Otterbein LE, Robson S, Shaefi S, Yaffe MB, Lederer JA. Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets. Injury. 2020 Apr; 51(4):819-829. PMID: 32171537.
  6. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Crit Care Med. 2020 02; 48(2):e123-e132. PMID: 31939811.
  7. Yang X, de Caestecker M, Otterbein LE, Wang B. Carbon monoxide: An emerging therapy for acute kidney injury. Med Res Rev. 2020 Jul; 40(4):1147-1177. PMID: 31820474.
  8. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Crit Care Med. 2019 Nov 15. PMID: 31743227.
  9. Cyr A, Chambers L, Waltz PK, Whelan SP, Kohut L, Carchman E, Dyer M, Luciano J, Kautza B, Gomez HD, Otterbein LE, Rosengart MR, Shiva S, Zuckerbraun BS. Endotoxin Engages Mitochondrial Quality Control via an iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes. Oxid Med Cell Longev. 2019; 2019:4745067. PMID: 31772705.
  10. Otterbein LE. Conquering Radicals with a Sense of Humor. Cell Chem Biol. 2019 10 17; 26(10):1335-1337. PMID: 31626781.
  11. Lee GR, Shaefi S, Otterbein LE. HO-1 and CD39: It Takes Two to Protect the Realm. Front Immunol. 2019; 10:1765. PMID: 31402920.
  12. Lee H, Li C, Zhang Y, Zhang D, Otterbein LE, Jin Y. Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli. J Exp Med. 2019 09 02; 216(9):2202-2220. PMID: 31235510.
  13. Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B. Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway. J Immunol. 2019 05 15; 202(10):2982-2990. PMID: 30952817.
  14. Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K. A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils. J Trauma Acute Care Surg. 2018 11; 85(5):936-943. PMID: 29787548.
    Citations: 1     Fields:    
  15. Belcher JD, Gomperts E, Nguyen J, Chen C, Abdulla F, Kiser ZM, Gallo D, Levy H, Otterbein LE, Vercellotti GM. Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia. PLoS One. 2018; 13(10):e0205194. PMID: 30308028.
    Citations:    Fields:    
  16. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1a-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018 11; 94:122-133. PMID: 30098863.
    Citations:    Fields:    
  17. Hauser CJ, Otterbein LE. Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis. Eur J Trauma Emerg Surg. 2018 Jun; 44(3):317-324. PMID: 29797026.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Zheng Y, Ji X, Yu B, Ji K, Gallo D, Csizmadia E, Zhu M, Choudhury MR, De La Cruz LKC, Chittavong V, Pan Z, Yuan Z, Otterbein LE, Wang B. Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide. Nat Chem. 2018 07; 10(7):787-794. PMID: 29760413.
    Citations: 2     Fields:    
  19. Correa-Costa M, Gallo D, Csizmadia E, Gomperts E, Lieberum JL, Hauser CJ, Ji X, Wang B, Câmara NOS, Robson SC, Otterbein LE. Carbon monoxide protects the kidney through the central circadian clock and CD39. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2302-E2310. PMID: 29463714.
    Citations: 1     Fields:    Translation:HumansAnimals
  20. Shankar P, Robson SC, Otterbein LE, Shaefi S. Clinical Implications of Hyperoxia. Int Anesthesiol Clin. 2018; 56(1):68-79. PMID: 29227312.
    Citations:    Fields:    
  21. Hopper CP, Meinel L, Steiger C, Otterbein LE. Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics? Curr Pharm Des. 2018; 24(20):2264-2282. PMID: 30039755.
    Citations:    Fields:    
  22. Shaefi S, Marcantonio ER, Mueller A, Banner-Goodspeed V, Robson SC, Spear K, Otterbein LE, O'Gara BP, Talmor DS, Subramaniam B. Intraoperative oxygen concentration and neurocognition after cardiac surgery: study protocol for a randomized controlled trial. Trials. 2017 Dec 19; 18(1):600. PMID: 29254495.
    Citations:    Fields:    Translation:Humans
  23. Schallner N, Lieberum JL, Gallo D, LeBlanc RH, Fuller PM, Hanafy KA, Otterbein LE. Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice. Stroke. 2017 09; 48(9):2565-2573. PMID: 28747460.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Lee H, Zhang D, Wu J, Otterbein LE, Jin Y. Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin ß1 Recycling. J Immunol. 2017 08 15; 199(4):1453-1464. PMID: 28674181.
    Citations: 3     Fields:    Translation:AnimalsCells
  25. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 04; 2(9). PMID: 28469075.
    Citations: 2     Fields:    
  26. Itagaki K, Riça I, Zhang J, Gallo D, DePrato M, Otterbein LE, Hauser CJ. Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns. J Trauma Acute Care Surg. 2017 05; 82(5):853-860. PMID: 28431414.
    Citations: 1     Fields:    Translation:AnimalsCells
  27. Gomperts E, Belcher JD, Otterbein LE, Coates TD, Wood J, Skolnick BE, Levy H, Vercellotti GM. The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises. Am J Hematol. 2017 Jun; 92(6):569-582. PMID: 28378932.
    Citations:    Fields:    Translation:HumansAnimalsCells
  28. Sandler N, Kaczmarek E, Itagaki K, Zheng Y, Otterbein L, Khabbaz K, Liu D, Senthilnathan V, Gruen RL, Hauser CJ. Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation. Heart Lung Circ. 2018 Jan; 27(1):122-129. PMID: 28487062.
    Citations: 5     Fields:    Translation:HumansCells
  29. Chan MC, Ziegler O, Liu L, Rowe GC, Das S, Otterbein LE, Arany Z. Heme oxygenase and carbon monoxide protect from muscle dystrophy. Skelet Muscle. 2016 11 28; 6(1):41. PMID: 27906108.
    Citations:    Fields:    Translation:HumansAnimalsCells
  30. Otterbein LE, Foresti R, Motterlini R. Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival. Circ Res. 2016 06 10; 118(12):1940-1959. PMID: 27283533.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  31. Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B. Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth. Oncotarget. 2016 Apr 26; 7(17):23919-32. PMID: 26993595.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  32. Attanasio C, Latancia MT, Otterbein LE, Netti PA. Update on Renal Replacement Therapy: Implantable Artificial Devices and Bioengineered Organs. Tissue Eng Part B Rev. 2016 08; 22(4):330-40. PMID: 26905099.
    Citations: 4     Fields:    Translation:Humans
  33. Ji X, Damera K, Zheng Y, Yu B, Otterbein LE, Wang B. Toward Carbon Monoxide-Based Therapeutics: Critical Drug Delivery and Developability Issues. J Pharm Sci. 2016 Feb; 105(2):406-416. PMID: 26869408.
    Citations: 7     Fields:    Translation:HumansAnimals
  34. Nemeth Z, Li M, Csizmadia E, Döme B, Johansson M, Persson JL, Seth P, Otterbein L, Wegiel B. Heme oxygenase-1 in macrophages controls prostate cancer progression. Oncotarget. 2015 Oct 20; 6(32):33675-88. PMID: 26418896.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Wegiel B, Hauser CJ, Otterbein LE. Heme as a danger molecule in pathogen recognition. Free Radic Biol Med. 2015 Dec; 89:651-61. PMID: 26456060.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  36. Maharshak N, Ryu HS, Fan TJ, Onyiah JC, Schulz S, Otterbein SL, Wong R, Hansen JJ, Otterbein LE, Carroll IM, Plevy SE. Escherichia coli heme oxygenase modulates host innate immune responses. Microbiol Immunol. 2015 Aug; 59(8):452-65. PMID: 26146866.
    Citations: 3     Fields:    Translation:AnimalsCells
  37. Schallner N, Pandit R, LeBlanc R, Thomas AJ, Ogilvy CS, Zuckerbraun BS, Gallo D, Otterbein LE, Hanafy KA. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest. 2015 Jul 01; 125(7):2609-25. PMID: 26011640.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  38. Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-a. Nat Med. 2015 Jun; 21(6):638-46. PMID: 26005855.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  39. Itagaki K, Kaczmarek E, Lee YT, Tang IT, Isal B, Adibnia Y, Sandler N, Grimm MJ, Segal BH, Otterbein LE, Hauser CJ. Mitochondrial DNA released by trauma induces neutrophil extracellular traps. PLoS One. 2015; 10(3):e0120549. PMID: 25774524.
    Citations: 24     Fields:    Translation:HumansCells
  40. Schallner N, Otterbein LE. Friend or foe? Carbon monoxide and the mitochondria. Front Physiol. 2015; 6:17. PMID: 25691872.
    Citations: 3     
  41. Li H, Itagaki K, Sandler N, Gallo D, Galenkamp A, Kaczmarek E, Livingston DH, Zeng Y, Lee YT, Tang IT, Isal B, Otterbein L, Hauser CJ. Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2. J Trauma Acute Care Surg. 2015 Feb; 78(2):272-9; discussion 279-81. PMID: 25757111.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Nassour I, Kautza B, Rubin M, Escobar D, Luciano J, Loughran P, Gomez H, Scott J, Gallo D, Brumfield J, Otterbein LE, Zuckerbraun BS. Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury. Shock. 2015 Feb; 43(2):166-71. PMID: 25243427.
    Citations: 10     Fields:    Translation:AnimalsCells
  43. Otterbein LE, Fan Z, Koulmanda M, Thronley T, Strom TB. Innate immunity for better or worse govern the allograft response. Curr Opin Organ Transplant. 2015 Feb; 20(1):8-12. PMID: 25563986.
    Citations: 5     Fields:    Translation:HumansAnimals
  44. Ahmad S, Hewett PW, Fujisawa T, Sissaoui S, Cai M, Gueron G, Al-Ani B, Cudmore M, Ahmed SF, Wong MK, Wegiel B, Otterbein LE, Vítek L, Ramma W, Wang K, Ahmed A. Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost. 2015 Feb; 113(2):329-37. PMID: 25354586.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  45. Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. J Clin Invest. 2014 Nov; 124(11):4926-40. PMID: 25295542.
    Citations: 42     Fields:    Translation:AnimalsCells
  46. Bon J, Kahloon R, Zhang Y, Xue J, Fuhrman CR, Tan J, Burger M, Kass DJ, Csizmadia E, Otterbein L, Chandra D, Bhargava A, Pilewski JM, Roodman GD, Sciurba FC, Duncan SR. Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One. 2014; 9(9):e105066. PMID: 25216103.
    Citations: 3     Fields:    Translation:HumansCells
  47. Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun. 2014 Jun 20; 449(1):94-9. PMID: 24814708.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE. Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells. Cell Death Dis. 2014 Mar 20; 5:e1139. PMID: 24651442.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Wegiel B, Nemeth Z, Correa-Costa M, Bulmer AC, Otterbein LE. Heme oxygenase-1: a metabolic nike. Antioxid Redox Signal. 2014 Apr 10; 20(11):1709-22. PMID: 24180257.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  50. Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B. Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration. Thromb Haemost. 2014 May 05; 111(5):951-9. PMID: 24477332.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  51. Dong H, Huang H, Yun X, Kim DS, Yue Y, Wu H, Sutter A, Chavin KD, Otterbein LE, Adams DB, Kim YB, Wang H. Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology. 2014 Mar; 155(3):818-28. PMID: 24424052.
    Citations: 22     Fields:    Translation:AnimalsCells
  52. Onyiah JC, Sheikh SZ, Maharshak N, Otterbein LE, Plevy SE. Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota. Gut Microbes. 2014 Mar-Apr; 5(2):220-4. PMID: 24637794.
    Citations: 7     Fields:    Translation:HumansAnimals
  53. Jangi S, Otterbein L, Robson S. The molecular basis for the immunomodulatory activities of unconjugated bilirubin. Int J Biochem Cell Biol. 2013 Dec; 45(12):2843-51. PMID: 24144577.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  54. Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res. 2013 Dec 01; 73(23):7009-21. PMID: 24121491.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  55. Andria B, Bracco A, Attanasio C, Castaldo S, Cerrito MG, Cozzolino S, Di Napoli D, Giovannoni R, Mancini A, Musumeci A, Mezza E, Nasti M, Scuderi V, Staibano S, Lavitrano M, Otterbein LE, Calise F. Biliverdin protects against liver ischemia reperfusion injury in swine. PLoS One. 2013; 8(7):e69972. PMID: 23922878.
    Citations: 2     Fields:    Translation:Animals
  56. Xue J, Kass DJ, Bon J, Vuga L, Tan J, Csizmadia E, Otterbein L, Soejima M, Levesque MC, Gibson KF, Kaminski N, Pilewski JM, Donahoe M, Sciurba FC, Duncan SR. Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients. J Immunol. 2013 Sep 01; 191(5):2089-95. PMID: 23872052.
    Citations: 23     Fields:    Translation:HumansCells
  57. Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y. Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol. 2013 Jul; 183(1):182-94. PMID: 23680654.
    Citations: 30     Fields:    Translation:Animals
  58. Seixas JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, Rodrigues SS, Guerreiro BH, Gonçalves AM, Penacho N, Marques AR, Coelho AC, Reis PM, Romão MJ, Romão CC. Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics. Dalton Trans. 2013 May 07; 42(17):5985-98. PMID: 23223860.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  59. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9. PMID: 23349052.
    Citations: 9     Fields:    Translation:AnimalsCells
  60. Schallner N, Romão CC, Biermann J, Lagrèze WA, Otterbein LE, Buerkle H, Loop T, Goebel U. Carbon monoxide abrogates ischemic insult to neuronal cells via the soluble guanylate cyclase-cGMP pathway. PLoS One. 2013; 8(4):e60672. PMID: 23593279.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  61. Kahloon RA, Xue J, Bhargava A, Csizmadia E, Otterbein L, Kass DJ, Bon J, Soejima M, Levesque MC, Lindell KO, Gibson KF, Kaminski N, Banga G, Oddis CV, Pilewski JM, Sciurba FC, Donahoe M, Zhang Y, Duncan SR. Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):768-75. PMID: 23262513.
    Citations: 34     Fields:    Translation:Humans
  62. Sun S, Sursal T, Adibnia Y, Zhao C, Zheng Y, Li H, Otterbein LE, Hauser CJ, Itagaki K. Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One. 2013; 8(3):e59989. PMID: 23527291.
    Citations: 44     Fields:    Translation:HumansCells
  63. Otterbein LE. Quoth the Raven: carbon monoxide and nothing more. Med Gas Res. 2013 Mar 06; 3(1):7. PMID: 23497398.
    Citations: 3     
  64. Hanafy KA, Oh J, Otterbein LE. Carbon Monoxide and the brain: time to rethink the dogma. Curr Pharm Des. 2013; 19(15):2771-5. PMID: 23092321.
    Citations: 10     Fields:    Translation:Humans
  65. Onyiah JC, Sheikh SZ, Maharshak N, Steinbach EC, Russo SM, Kobayashi T, Mackey LC, Hansen JJ, Moeser AJ, Rawls JF, Borst LB, Otterbein LE, Plevy SE. Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology. 2013 Apr; 144(4):789-98. PMID: 23266559.
    Citations: 28     Fields:    Translation:AnimalsCells
  66. Wegiel B, Hanto DW, Otterbein LE. The social network of carbon monoxide in medicine. Trends Mol Med. 2013 Jan; 19(1):3-11. PMID: 23140858.
    Citations: 29     Fields:    Translation:Humans
  67. Mahan VL, Zurakowski D, Otterbein LE, Pigula FA. Inhaled carbon monoxide provides cerebral cytoprotection in pigs. PLoS One. 2012; 7(8):e41982. PMID: 22879904.
    Citations: 10     Fields:    Translation:AnimalsCells
  68. Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S. Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem. 2012 Sep 14; 287(38):32113-23. PMID: 22843690.
    Citations: 23     Fields:    Translation:HumansCells
  69. Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE, Wagner O. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 2012 Jun 06; 15(6):813-26. PMID: 22682222.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  70. Wang H, Wu H, Rocuts F, Gu Z, Bach FH, Otterbein LE. Activation of peroxisome proliferator-activated receptor ? prolongs islet allograft survival. Cell Transplant. 2012; 21(10):2111-8. PMID: 22469179.
    Citations: 1     Fields:    Translation:AnimalsCells
  71. Wegiel B, Otterbein LE. Go green: the anti-inflammatory effects of biliverdin reductase. Front Pharmacol. 2012; 3:47. PMID: 22438844.
    Citations: 23     
  72. Stoeckius M, Erat A, Fujikawa T, Hiromura M, Koulova A, Otterbein L, Bianchi C, Tobiasch E, Dagon Y, Sellke FW, Usheva A. Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin. J Biol Chem. 2012 May 04; 287(19):15418-26. PMID: 22262839.
    Citations: 7     Fields:    Translation:HumansCells
  73. Wang H, Ferran C, Attanasio C, Calise F, Otterbein LE. Induction of protective genes leads to islet survival and function. J Transplant. 2011; 2011:141898. PMID: 22220267.
    Citations: 7     
  74. Wegiel B, Gallo D, Csizmadia E, Roger T, Kaczmarek E, Harris C, Zuckerbraun BS, Otterbein LE. Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18849-54. PMID: 22042868.
    Citations: 24     Fields:    Translation:AnimalsCells
  75. Haschemi A, Chin BY, Jeitler M, Esterbauer H, Wagner O, Bilban M, Otterbein LE. Carbon monoxide induced PPAR? SUMOylation and UCP2 block inflammatory gene expression in macrophages. PLoS One. 2011; 6(10):e26376. PMID: 22046279.
    Citations: 6     Fields:    Translation:AnimalsCells
  76. Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B. Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14491-6. PMID: 21849621.
    Citations: 13     Fields:    Translation:AnimalsCells
  77. Kuramitsu K, Gallo D, Yoon M, Chin BY, Csizmadia E, Hanto DW, Otterbein LE. Carbon monoxide enhances early liver regeneration in mice after hepatectomy. Hepatology. 2011 Jun; 53(6):2016-26. PMID: 21433045.
    Citations: 14     Fields:    Translation:AnimalsCells
  78. Sheikh SZ, Hegazi RA, Kobayashi T, Onyiah JC, Russo SM, Matsuoka K, Sepulveda AR, Li F, Otterbein LE, Plevy SE. An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. J Immunol. 2011 May 01; 186(9):5506-13. PMID: 21444764.
    Citations: 44     Fields:    Translation:AnimalsCells
  79. Cerrito MG, Scagliarini A, Froio A, Liloia A, Busnelli M, Giovannoni R, Otterbein LE, Mainetti L, Villa M, Bach FH, Leone BE, Biasi GM, Lavitrano M. Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells. Biol Pharm Bull. 2011; 34(8):1204-14. PMID: 21804207.
    Citations: 4     Fields:    Translation:AnimalsCells
  80. Hanto DW, Maki T, Yoon MH, Csizmadia E, Chin BY, Gallo D, Konduru B, Kuramitsu K, Smith NR, Berssenbrugge A, Attanasio C, Thomas M, Wegiel B, Otterbein LE. Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine. Am J Transplant. 2010 Nov; 10(11):2421-30. PMID: 20977633.
    Citations: 17     Fields:    Translation:Animals
  81. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010 Sep; 9(9):728-43. PMID: 20811383.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  82. Wegiel B, Evans S, Hellsten R, Otterbein LE, Bjartell A, Persson JL. Molecular pathways in the progression of hormone-independent and metastatic prostate cancer. Curr Cancer Drug Targets. 2010 Jun; 10(4):392-401. PMID: 20384583.
    Citations: 14     Fields:    Translation:HumansCells
  83. Wegiel B, Gallo DJ, Raman KG, Karlsson JM, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed A, Baty CJ, Otterbein LE. Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation. 2010 Feb 02; 121(4):537-48. PMID: 20083679.
    Citations: 26     Fields:    Translation:AnimalsCells
  84. Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732. PMID: 20090940.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  85. Wegiel B, Jiborn T, Abrahamson M, Helczynski L, Otterbein L, Persson JL, Bjartell A. Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. PLoS One. 2009 Nov 23; 4(11):e7953. PMID: 19956729.
    Citations: 25     Fields:    Translation:HumansCells
  86. Chin BY, Otterbein LE. Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule. Curr Opin Pharmacol. 2009 Aug; 9(4):490-500. PMID: 19640789.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  87. Otterbein LE. The evolution of carbon monoxide into medicine. Respir Care. 2009 Jul; 54(7):925-32. PMID: 19558742.
    Citations: 8     Fields:    Translation:HumansAnimals
  88. Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE. Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt. J Biol Chem. 2009 Aug 07; 284(32):21369-78. PMID: 19509285.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  89. Bilban M, Haslinger P, Prast J, Klinglmüller F, Woelfel T, Haider S, Sachs A, Otterbein LE, Desoye G, Hiden U, Wagner O, Knöfler M. Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma. Endocrinology. 2009 Feb; 150(2):1000-13. PMID: 18845641.
    Citations: 36     Fields:    Translation:HumansCells
  90. Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst. 2008 Jul 16; 100(14):1022-36. PMID: 18612129.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  91. Wegiel B, Chin BY, Otterbein LE. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. . 2008 May 15; 7(10):1379-84. PMID: 18418071.
    Citations: 3     Fields:    Translation:HumansCells
  92. Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE. Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med (Berl). 2008 Mar; 86(3):267-79. PMID: 18034222.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  93. Feghali-Bostwick CA, Gadgil AS, Otterbein LE, Pilewski JM, Stoner MW, Csizmadia E, Zhang Y, Sciurba FC, Duncan SR. Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Jan 15; 177(2):156-63. PMID: 17975205.
    Citations: 72     Fields:    Translation:Humans
  94. Lee SS, Gao W, Mazzola S, Thomas MN, Csizmadia E, Otterbein LE, Bach FH, Wang H. Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells. FASEB J. 2007 Nov; 21(13):3450-7. PMID: 17551098.
    Citations: 34     Fields:    Translation:AnimalsCells
  95. Goldberg A, Parolini M, Chin BY, Czismadia E, Otterbein LE, Bach FH, Wang H. Toll-like receptor 4 suppression leads to islet allograft survival. FASEB J. 2007 Sep; 21(11):2840-8. PMID: 17475921.
    Citations: 26     Fields:    Translation:AnimalsCells
  96. Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE. Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 01; 178(9):5921-9. PMID: 17442976.
    Citations: 17     Fields:    Translation:AnimalsCells
  97. Scott JR, Chin BY, Bilban MH, Otterbein LE. Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic? Trends Pharmacol Sci. 2007 May; 28(5):200-5. PMID: 17416426.
    Citations: 13     Fields:    Translation:Humans
  98. Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5109-14. PMID: 17360382.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  99. Zuckerbraun BS, Chin BY, Bilban M, d'Avila JC, Rao J, Billiar TR, Otterbein LE. Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J. 2007 Apr; 21(4):1099-106. PMID: 17264172.
    Citations: 79     Fields:    Translation:AnimalsCells
  100. Ramlawi B, Scott JR, Feng J, Mieno S, Raman KG, Gallo D, Csizmadia E, Yoke Chin B, Bach FH, Otterbein LE, Sellke FW. Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine. J Surg Res. 2007 Mar; 138(1):121-7. PMID: 17196991.
    Citations: 5     Fields:    Translation:AnimalsCells
  101. Zhang X, Shan P, Jiang G, Zhang SS, Otterbein LE, Fu XY, Lee PJ. Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. FASEB J. 2006 Oct; 20(12):2156-8. PMID: 16971418.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  102. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE. Carbon monoxide reverses established pulmonary hypertension. J Exp Med. 2006 Sep 04; 203(9):2109-19. PMID: 16908624.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  103. Raman KG, Barbato JE, Ifedigbo E, Ozanich BA, Zenati MS, Otterbein LE, Tzeng E. Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide. J Vasc Surg. 2006 Jul; 44(1):151-8. PMID: 16828440.
    Citations: 9     Fields:    Translation:AnimalsCells
  104. Bilban M, Bach FH, Otterbein SL, Ifedigbo E, d'Avila JC, Esterbauer H, Chin BY, Usheva A, Robson SC, Wagner O, Otterbein LE. Carbon monoxide orchestrates a protective response through PPARgamma. Immunity. 2006 May; 24(5):601-10. PMID: 16713977.
    Citations: 54     Fields:    Translation:AnimalsCells
  105. Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest. 2006 Mar; 116(3):808-16. PMID: 16485041.
    Citations: 88     Fields:    Translation:AnimalsCells
  106. Hegazi RA, Rao KN, Mayle A, Sepulveda AR, Otterbein LE, Plevy SE. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med. 2005 Dec 19; 202(12):1703-13. PMID: 16365149.
    Citations: 71     Fields:    Translation:AnimalsCells
  107. Mazzola S, Forni M, Albertini M, Bacci ML, Zannoni A, Gentilini F, Lavitrano M, Bach FH, Otterbein LE, Clement MG. Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs. FASEB J. 2005 Dec; 19(14):2045-7. PMID: 16223783.
    Citations: 28     Fields:    Translation:AnimalsCells
  108. Otterbein LE, May A, Chin BY. Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR)4 expression. Cell Mol Biol (Noisy-le-grand). 2005 Oct 03; 51(5):433-40. PMID: 16309564.
    Citations: 21     Fields:    Translation:AnimalsCells
  109. Sarady-Andrews JK, Liu F, Gallo D, Nakao A, Overhaus M, Ollinger R, Choi AM, Otterbein LE. Biliverdin administration protects against endotoxin-induced acute lung injury in rats. . 2005 Dec; 289(6):L1131-7. PMID: 16155084.
    Citations: 58     Fields:    Translation:AnimalsCells
  110. Ollinger R, Bilban M, Erat A, Froio A, McDaid J, Tyagi S, Csizmadia E, Graça-Souza AV, Liloia A, Soares MP, Otterbein LE, Usheva A, Yamashita K, Bach FH. Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation. Circulation. 2005 Aug 16; 112(7):1030-9. PMID: 16087796.
    Citations: 58     Fields:    Translation:Animals
  111. Moore BA, Overhaus M, Whitcomb J, Ifedigbo E, Choi AM, Otterbein LE, Bauer AJ. Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med. 2005 Jun; 33(6):1317-26. PMID: 15942350.
    Citations: 24     Fields:    Translation:Animals
  112. Zuckerbraun BS, McCloskey CA, Gallo D, Liu F, Ifedigbo E, Otterbein LE, Billiar TR. Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. Shock. 2005 Jun; 23(6):527-32. PMID: 15897805.
    Citations: 31     Fields:    Translation:AnimalsCells
  113. Zuckerbraun BS, Otterbein LE, Boyle P, Jaffe R, Upperman J, Zamora R, Ford HR. Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G607-13. PMID: 15890710.
    Citations: 24     Fields:    Translation:AnimalsCells
  114. Nakao A, Neto JS, Kanno S, Stolz DB, Kimizuka K, Liu F, Bach FH, Billiar TR, Choi AM, Otterbein LE, Murase N. Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant. 2005 Feb; 5(2):282-91. PMID: 15643987.
    Citations: 52     Fields:    Translation:AnimalsCells
  115. Ott MC, Scott JR, Bihari A, Badhwar A, Otterbein LE, Gray DK, Harris KA, Potter RF. Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion. FASEB J. 2005 Jan; 19(1):106-8. PMID: 15514102.
    Citations: 11     Fields:    Translation:Animals
  116. Neto JS, Nakao A, Kimizuka K, Romanosky AJ, Stolz DB, Uchiyama T, Nalesnik MA, Otterbein LE, Murase N. Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F979-89. PMID: 15292046.
    Citations: 50     Fields:    Translation:Animals
  117. Nakao A, Otterbein LE, Overhaus M, Sarady JK, Tsung A, Kimizuka K, Nalesnik MA, Kaizu T, Uchiyama T, Liu F, Murase N, Bauer AJ, Bach FH. Biliverdin protects the functional integrity of a transplanted syngeneic small bowel. Gastroenterology. 2004 Aug; 127(2):595-606. PMID: 15300591.
    Citations: 33     Fields:    Translation:Animals
  118. Song R, Zhou Z, Kim PK, Shapiro RA, Liu F, Ferran C, Choi AM, Otterbein LE. Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. J Biol Chem. 2004 Oct 22; 279(43):44327-34. PMID: 15280387.
    Citations: 25     Fields:    Translation:HumansCells
  119. Lavitrano M, Smolenski RT, Musumeci A, Maccherini M, Slominska E, Di Florio E, Bracco A, Mancini A, Stassi G, Patti M, Giovannoni R, Froio A, Simeone F, Forni M, Bacci ML, D'Alise G, Cozzi E, Otterbein LE, Yacoub MH, Bach FH, Calise F. Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. FASEB J. 2004 Jul; 18(10):1093-5. PMID: 15132974.
    Citations: 27     Fields:    Translation:AnimalsCells
  120. Sarady JK, Zuckerbraun BS, Bilban M, Wagner O, Usheva A, Liu F, Ifedigbo E, Zamora R, Choi AM, Otterbein LE. Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J. 2004 May; 18(7):854-6. PMID: 15001560.
    Citations: 45     Fields:    Translation:AnimalsCells
  121. Ryter SW, Otterbein LE. Carbon monoxide in biology and medicine. Bioessays. 2004 Mar; 26(3):270-80. PMID: 14988928.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  122. Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graça-Souza AV, Ollinger R, Czismadia E, May GA, Ifedigbo E, Otterbein LE, Bach FH, Soares MP. Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J. 2004 Apr; 18(6):771-2. PMID: 14977880.
    Citations: 58     Fields:    Translation:Animals
  123. Song R, Mahidhara RS, Zhou Z, Hoffman RA, Seol DW, Flavell RA, Billiar TR, Otterbein LE, Choi AM. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J Immunol. 2004 Jan 15; 172(2):1220-6. PMID: 14707100.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  124. Kim PK, Zuckerbraun BS, Otterbein LE, Vodovotz Y, Billiar TR. 'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity. Biol Chem. 2004 Jan; 385(1):11-5. PMID: 14977041.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  125. Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse DE, Fearns C, Ulevitch RJ, Knickelbein R, Flavell RA, Choi AM. MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. Am J Pathol. 2003 Dec; 163(6):2555-63. PMID: 14633627.
    Citations: 49     Fields:    Translation:AnimalsCells
  126. Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, Otterbein LE. Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med. 2003 Dec 01; 198(11):1707-16. PMID: 14657222.
    Citations: 48     Fields:    Translation:Animals
  127. Nakao A, Kimizuka K, Stolz DB, Neto JS, Kaizu T, Choi AM, Uchiyama T, Zuckerbraun BS, Nalesnik MA, Otterbein LE, Murase N. Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. Am J Pathol. 2003 Oct; 163(4):1587-98. PMID: 14507665.
    Citations: 58     Fields:    Translation:Animals
  128. Nakao A, Moore BA, Murase N, Liu F, Zuckerbraun BS, Bach FH, Choi AM, Nalesnik MA, Otterbein LE, Bauer AJ. Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility. Gut. 2003 Sep; 52(9):1278-85. PMID: 12912858.
    Citations: 33     Fields:    Translation:Animals
  129. Nakao A, Kimizuka K, Stolz DB, Seda Neto J, Kaizu T, Choi AM, Uchiyama T, Zuckerbraun BS, Bauer AJ, Nalesnik MA, Otterbein LE, Geller DA, Murase N. Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts. Surgery. 2003 Aug; 134(2):285-92. PMID: 12947331.
    Citations: 19     Fields:    Translation:Animals
  130. Ameredes BT, Otterbein LE, Kohut LK, Gligonic AL, Calhoun WJ, Choi AM. Low-dose carbon monoxide reduces airway hyperresponsiveness in mice. . 2003 Dec; 285(6):L1270-6. PMID: 12896878.
    Citations: 16     Fields:    Translation:Animals
  131. Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003 Aug; 24(8):449-55. PMID: 12909459.
    Citations: 301     Fields:    Translation:HumansAnimalsCells
  132. Berberat PO, Katori M, Kaczmarek E, Anselmo D, Lassman C, Ke B, Shen X, Busuttil RW, Yamashita K, Csizmadia E, Tyagi S, Otterbein LE, Brouard S, Tobiasch E, Bach FH, Kupiec-Weglinski JW, Soares MP. Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury. FASEB J. 2003 Sep; 17(12):1724-6. PMID: 12958189.
    Citations: 53     Fields:    Translation:AnimalsCells
  133. Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem. 2003 Sep 26; 278(39):36993-8. PMID: 12857751.
    Citations: 77     Fields:    Translation:AnimalsCells
  134. Song R, Kubo M, Morse D, Zhou Z, Zhang X, Dauber JH, Fabisiak J, Alber SM, Watkins SC, Zuckerbraun BS, Otterbein LE, Ning W, Oury TD, Lee PJ, McCurry KR, Choi AM. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol. 2003 Jul; 163(1):231-42. PMID: 12819027.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  135. Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. . 2003 Jul; 285(1):L250-7. PMID: 12651633.
    Citations: 13     Fields:    Translation:AnimalsCells
  136. Moore BA, Otterbein LE, Türler A, Choi AM, Bauer AJ. Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology. 2003 Feb; 124(2):377-91. PMID: 12557144.
    Citations: 45     Fields:    Translation:Animals
  137. Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003 Feb; 9(2):183-90. PMID: 12539038.
    Citations: 112     Fields:    Translation:AnimalsCells
  138. Sarady JK, Otterbein SL, Liu F, Otterbein LE, Choi AM. Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages. Am J Respir Cell Mol Biol. 2002 Dec; 27(6):739-45. PMID: 12444034.
    Citations: 34     Fields:    Translation:AnimalsCells
  139. Song R, Mahidhara RS, Liu F, Ning W, Otterbein LE, Choi AM. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol. 2002 Nov; 27(5):603-10. PMID: 12397020.
    Citations: 24     Fields:    Translation:HumansCells
  140. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003 Jan 10; 278(2):1248-58. PMID: 12399465.
    Citations: 59     Fields:    Translation:AnimalsCells
  141. Song R, Ning W, Liu F, Ameredes BT, Calhoun WJ, Otterbein LE, Choi AM. Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide. . 2003 Jan; 284(1):L50-6. PMID: 12388337.
    Citations: 8     Fields:    Translation:HumansCells
  142. Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem. 2002 May-Jun; 234-235(1-2):249-63. PMID: 12162441.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  143. Otterbein LE. Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule. Antioxid Redox Signal. 2002 Apr; 4(2):309-19. PMID: 12006182.
    Citations: 29     Fields:    Translation:HumansAnimals
  144. Sethi JM, Otterbein LE, Choi AM. Differential modulation by exogenous carbon monoxide of TNF-alpha stimulated mitogen-activated protein kinases in rat pulmonary artery endothelial cells. Antioxid Redox Signal. 2002 Apr; 4(2):241-8. PMID: 12006175.
    Citations: 7     Fields:    Translation:AnimalsCells
  145. Choi AM, Otterbein LE. Emerging role of carbon monoxide in physiologic and pathophysiologic states. Antioxid Redox Signal. 2002 Apr; 4(2):227-8. PMID: 12006173.
    Citations: 13     Fields:    Translation:Humans
  146. Otterbein LE, Choi AM. The saga of leucine zippers continues: in response to oxidative stress. Am J Respir Cell Mol Biol. 2002 Feb; 26(2):161-3. PMID: 11804863.
    Citations: 5     Fields:    Translation:AnimalsCells
  147. Chapman JT, Otterbein LE, Elias JA, Choi AM. Carbon monoxide attenuates aeroallergen-induced inflammation in mice. . 2001 Jul; 281(1):L209-16. PMID: 11404264.
    Citations: 34     Fields:    Translation:AnimalsCells
  148. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 2001 Mar 15; 166(6):4185-94. PMID: 11238670.
    Citations: 93     Fields:    Translation:AnimalsCellsPHPublic Health
  149. Lu Y, Parkyn L, Otterbein LE, Kureishi Y, Walsh K, Ray A, Ray P. Activated Akt protects the lung from oxidant-induced injury and delays death of mice. J Exp Med. 2001 Feb 19; 193(4):545-49. PMID: 11181705.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  150. Otterbein LE, Choi AM. Heme oxygenase: colors of defense against cellular stress. . 2000 Dec; 279(6):L1029-37. PMID: 11076792.
    Citations: 160     Fields:    Translation:HumansAnimals
  151. Brouard S, Otterbein LE, Anrather J, Tobiasch E, Bach FH, Choi AM, Soares MP. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med. 2000 Oct 02; 192(7):1015-26. PMID: 11015442.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  152. Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000 Apr; 6(4):422-8. PMID: 10742149.
    Citations: 416     Fields:    Translation:HumansAnimalsCells
  153. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AM. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. . 2000 Feb; 278(2):L312-9. PMID: 10666115.
    Citations: 54     Fields:    Translation:AnimalsCells
  154. Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, Choi AM. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol. 1999 09; 277(3):L589-95. PMID: 10484467.
    Citations: 20     Fields:    Translation:AnimalsCells
  155. Otterbein LE, Lee PJ, Chin BY, Petrache I, Camhi SL, Alam J, Choi AM. Protective effects of heme oxygenase-1 in acute lung injury. Chest. 1999 Jul; 116(1 Suppl):61S-63S. PMID: 10424595.
    Citations: 19     Fields:    Translation:HumansAnimals
  156. Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, Choi AM. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Invest. 1999 Apr; 103(7):1047-54. PMID: 10194478.
    Citations: 92     Fields:    Translation:AnimalsCells
  157. Otterbein LE, Mantell LL, Choi AM. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 1999 04; 276(4):L688-94. PMID: 10198367.
    Citations: 104     Fields:    Translation:Animals
  158. Gaine SP, Booth G, Otterbein L, Flavahan NA, Choi AM, Wiener CM. Induction of heme oxygenase-1 with hemoglobin depresses vasoreactivity in rat aorta. J Vasc Res. 1999 Mar-Apr; 36(2):114-9. PMID: 10213906.
    Citations: 2     Fields:    Translation:Animals
  159. Otterbein LE, Chin BY, Mantell LL, Stansberry L, Horowitz S, Choi AM. Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia. Am J Physiol. 1998 07; 275(1):L14-20. PMID: 9688930.
    Citations: 12     Fields:    Translation:Animals
  160. Otterbein L, Chin BY, Otterbein SL, Lowe VC, Fessler HE, Choi AM. Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway. Am J Physiol. 1997 Feb; 272(2 Pt 1):L268-75. PMID: 9124378.
    Citations: 11     Fields:    Translation:Animals
  161. Fessler HE, Otterbein L, Chung HS, Choi AM. Alpha-2 adrenoceptor blockade protects rats against lipopolysaccharide. Am J Respir Crit Care Med. 1996 Dec; 154(6 Pt 1):1689-93. PMID: 8970356.
    Citations: 1     Fields:    Translation:AnimalsCells
  162. Kotanidou A, Choi AM, Winchurch RA, Otterbein L, Fessler HE. Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release. J Appl Physiol (1985). 1996 Nov; 81(5):2305-11. PMID: 8941558.
    Citations: 5     Fields:    Translation:Animals
  163. Lee PJ, Alam J, Sylvester SL, Inamdar N, Otterbein L, Choi AM. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury. Am J Respir Cell Mol Biol. 1996 Jun; 14(6):556-68. PMID: 8652184.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  164. Otterbein L, Sylvester SL, Choi AM. Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am J Respir Cell Mol Biol. 1995 Nov; 13(5):595-601. PMID: 7576696.
    Citations: 53     Fields:    Translation:Animals
  165. Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi AM. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol. 1995 Oct; 13(4):387-98. PMID: 7546768.
    Citations: 50     Fields:    Translation:AnimalsCells
  166. Choi AM, Sylvester S, Otterbein L, Holbrook NJ. Molecular responses to hyperoxia in vivo: relationship to increased tolerance in aged rats. Am J Respir Cell Mol Biol. 1995 Jul; 13(1):74-82. PMID: 7598940.
    Citations: 14     Fields:    Translation:AnimalsCells
  167. Bassett DJ, Elbon CL, Ishii Y, Yang H, Otterbein L, Boswell GA, Kerr JS. EDU pretreatment decreases polymorphonuclear leukocyte migration into rat lung airways. Toxicol Appl Pharmacol. 1994 Jul; 127(1):76-82. PMID: 8048056.
    Citations:    Fields:    Translation:AnimalsCells
  168. Noronha-Blob L, Lowe VC, Otterbein L, Steranka L, Burch RM. NPC 15669 reduces mortality associated with sepsis in rats. J Pharmacol Exp Ther. 1993 Nov; 267(2):664-9. PMID: 8246139.
    Citations: 5     Fields:    Translation:AnimalsCells
  169. Otterbein L, Lowe VC, Kyle DJ, Noronha-Blob L. Additive effects of a bradykinin antagonist, NPC 17761, and a leumedin, NPC 15669, on survival in animal models of sepsis. Agents Actions. 1993; 39 Spec No:C125-7. PMID: 8273550.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.