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Peter Siekmeier, M.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08MH072771 (SIEKMEIER, PETER J) Aug 21, 2007 - Apr 30, 2013
    Computational Modeling of Hippocampus in Schizophrenia
    Role: Principal Investigator
  2. P50MH060450 (COYLE, JOSEPH T) Jul 21, 2006 - May 31, 2011
    Glutamatergic Dysfunction and Schizophrenia
    Role: Investigator
  3. Young Investigator Award (SIEKMEIER, PETER) Jul 1, 2004 - Jun 30, 2006
    National Alliance for Research on Schizophrenia and Depression (NARSAD)
    The Use of a Neurocomputational Model to Examine Hippocampal Etiologies of Schizophrenia and Develop More Effective Pharmacologic Treatments
    Role: Principal Investigator
  4. Young Investigator Award (SIEKMEIER, PETER) Jul 1, 2002 - Jun 30, 2004
    National Alliance for Research on Schizophrenia and Depression (NARSAD)
    Use of a Computational Model of Hippocampus Subfield CA1 to Examine the Neuropathology of Schizophrenia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Siekmeier, P, Lowen, S, and Coyle, JT. Apparatuses and methods for identification and treatment of patients responsive to antipsychotic agent therapy. WO Patent Application No. PCT/US2020/49194. 2020. View Publication.
  2. Siekmeier, P, Lowen, S, and Coyle, JT. Method of increasing cognitive function with glutamate receptor agonist. WO Patent Application No. PCT/US2020/49283. 2020. View Publication.
  3. Siekmeier, P. Systems and methods for modeling and predicting effective treatments for schizophrenia and other disorders. McLean Hospital assignee, U.S. Patent No. 10,720,242. 2020.
  4. Siekmeier, P.J., Lowen, S.B. Neuropsychopharmacology. Novel EEG biomarkers for the a priori identification of responders to the experimental antipsychotic agent pomaglumetad methionil. 2019; 44:486-487.
  5. Siekmeier PJ. An in Silico, Biomarker-Based Method for the Evaluation of Virtual Neuropsychiatric Drug Effects. Neural Comput. 2017 04; 29(4):1021-1052. PMID: 28181877.
    Citations: 1     Fields:    Translation:HumansCells
  6. Siekmeier PJ. Computational modeling of psychiatric illnesses via well-defined neurophysiological and neurocognitive biomarkers. Neurosci Biobehav Rev. 2015 Oct; 57:365-80. PMID: 26432502.
    Citations: 4     Fields:    Translation:HumansAnimals
  7. Siekmeier, PJ, Stufflebeam, SM, Spencer, SK, Hamalainen, M, McCarley, R. Neuropsychopharmacology. Increased beta-gamma power ratio in MEG auditory steady-state responses: A potential biomarker for chronic schizophrenia. 2014; 39(S3):S627.
  8. Siekmeier PJ, vanMaanen DP. Dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study. Neuropsychopharmacology. 2014 Jun; 39(7):1713-21. PMID: 24469592.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Siekmeier, PJ, vanMaanen, DP. Neuropsychopharmacology. Treatment of dopaminergic dysfunction in schizophrenia using non-dopaminergic mechanisms: A computational modeling approach. 2013; 38(S2):S270.
  10. Siekmeier PJ, vanMaanen DP. Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology. PLoS One. 2013; 8(3):e58607. PMID: 23526999.
    Citations: 10     Fields:    Translation:Humans
  11. Siekmeier, PJ, vanMaanen, DP. Neuropsychopharmacology. Computational modeling of hippocampus in schizophrenia and novel antipsychotic development. 2012; 38(S1):S187.
  12. Siekmeier, PJ, vanMaanen, D. Biological Psychiatry. Relating neuropathological findings in hippocampus to schizophrenic symptomatology: A computational modeling approach. 2012; 71(8S):312S.
  13. Siekmeier, P, Matthysse, S. Methods and systems for drug screening and computational modeling based on biologically realistic neurons. McLean Hospital assignee, U.S. Patent No. 7,945,392. 2011.
  14. Siekmeier PJ, Stufflebeam SM. Patterns of spontaneous magnetoencephalographic activity in patients with schizophrenia. J Clin Neurophysiol. 2010 Jun; 27(3):179-90. PMID: 20461010.
    Citations: 20     Fields:    Translation:Humans
  15. Siekmeier PJ. Evidence of multistability in a realistic computer simulation of hippocampus subfield CA1. Behav Brain Res. 2009 Jun 08; 200(1):220-31. PMID: 19378385.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Vierling-Claassen D, Siekmeier P, Stufflebeam S, Kopell N. Modeling GABA alterations in schizophrenia: a link between impaired inhibition and altered gamma and beta range auditory entrainment. J Neurophysiol. 2008 May; 99(5):2656-71. PMID: 18287555.
    Citations: 91     Fields:    Translation:HumansCells
  17. Vierling-Claasen, DL, Siekmeier, PJ, Stufflebeam, S, Kopell, N. Schizophrenia Research. GABA alterations in schizophrenia. 2008; 102(1-3, Sup 2).
  18. Siekmeier PJ, Hasselmo ME, Howard MW, Coyle J. Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia. Schizophr Res. 2007 Jan; 89(1-3):177-90. PMID: 17055702.
    Citations: 17     Fields:    Translation:Humans
  19. Stufflebeam, S, Vierling-Claasen, D, Lin, F-H, Siekmeier, P, Hamalainen, M, Kopell, N, McCarley, R. New Frontiers in Biomagnetism: Proceedings of the 15th International Conference on Biomagnetism. Altered GABA receptor dynamics explains abnormal rhythmic auditory neuromagnetic response in schizophrenia. 2006.
  20. Siekmeier PJ, Hoffman RE. Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex. Br J Psychiatry. 2002 Apr; 180:345-50. PMID: 11925358.
    Citations: 14     Fields:    Translation:Humans
  21. Siekmeier, PJ. The Yale Journal of Biology and Medicine. The use of an attractor neural network model to explore normal brain function and the pathogenesis of schizophrenia. 1997; 3(70):275.
  22. Mori K, Ohya H, Matsumoto K, Furuune H, Isozaki K, Siekmeier P. Design for a bioreactor with sunlight supply and operations systems for use in the space environment. Adv Space Res. 1989; 9(8):161-8. PMID: 11537383.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.