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James T. McKenna, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McKenna JT, Thankachan S, Uygun DS, Shukla C, McNally JM, Schiffino FL, Cordeira J, Katsuki F, Zant JC, Gamble MC, Deisseroth K, McCarley RW, Brown RE, Strecker RE, Basheer R. Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli. Curr Biol. 2020 Jun 22; 30(12):2379-2385.e4. PMID: 32413301.
    Citations:    
  2. Gamble MC, Katsuki F, McCoy JG, Strecker RE, McKenna JT. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020 Mar 12; 43(3). PMID: 31595304.
    Citations:    
  3. Zielinski MR, Atochin DN, McNally JM, McKenna JT, Huang PL, Strecker RE, Gerashchenko D. Somatostatin+/nNOS+ neurons are involved in delta electroencephalogram activity and cortical-dependent recognition memory. Sleep. 2019 10 09; 42(10). PMID: 31328777.
    Citations:    
  4. Thankachan S, Katsuki F, McKenna JT, Yang C, Shukla C, Deisseroth K, Uygun DS, Strecker RE, Brown RE, McNally JM, Basheer R. Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice. Sci Rep. 2019 03 05; 9(1):3607. PMID: 30837664.
    Citations:    
  5. Hwang E, Brown RE, Kocsis B, Kim T, McKenna JT, McNally JM, Han HB, Choi JH. Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses. Brain Struct Funct. 2019 May; 224(4):1505-1518. PMID: 30826928.
    Citations:    
  6. Uygun DS, Katsuki F, Bolortuya Y, Aguilar DD, McKenna JT, Thankachan S, McCarley RW, Basheer R, Brown RE, Strecker RE, McNally JM. Validation of an automated sleep spindle detection method for mouse electroencephalography. Sleep. 2019 02 01; 42(2). PMID: 30476300.
    Citations:    Fields:    
  7. McKenna JT, Gamble MC, Anderson-Chernishof MB, Shah SR, McCoy JG, Strecker RE. A rodent cage change insomnia model disrupts memory consolidation. J Sleep Res. 2019 04; 28(2):e12792. PMID: 30461100.
    Citations:    Fields:    
  8. Yang C, Larin A, McKenna JT, Jacobson KA, Winston S, Strecker RE, Kalinchuk A, Basheer R, Brown RE. Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice. Sci Rep. 2018 Jul 16; 8(1):10730. PMID: 30013200.
    Citations:    Fields:    
  9. McCoy JG, Yu HJ, Niznikiewicz M, McKenna JT, Strecker RE. Partnerships in Neuroscience Research Between Small Colleges and Large Institutions: A Case Study. J Undergrad Neurosci Educ. 2018; 16(2):A159-A167. PMID: 30057498.
    Citations:    
  10. Yang C, McKenna JT, Brown RE. Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro. Neuroscience. 2017 06 03; 352:249-261. PMID: 28411158.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Zielinski MR, McKenna JT, McCarley RW. Functions and Mechanisms of Sleep. AIMS Neurosci. 2016; 3(1):67-104. PMID: 28413828.
    Citations: 2     
  12. Zant JC, Kim T, Prokai L, Szarka S, McNally J, McKenna JT, Shukla C, Yang C, Kalinchuk AV, McCarley RW, Brown RE, Basheer R. Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study. J Neurosci. 2016 Feb 10; 36(6):2057-67. PMID: 26865627.
    Citations: 19     Fields:    Translation:AnimalsCells
  13. Brown RE, McKenna JT. Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal. Front Neurol. 2015; 6:135. PMID: 26124745.
    Citations: 14     
  14. Kim T, Thankachan S, McKenna JT, McNally JM, Yang C, Choi JH, Chen L, Kocsis B, Deisseroth K, Strecker RE, Basheer R, Brown RE, McCarley RW. Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3535-40. PMID: 25733878.
    Citations: 44     Fields:    Translation:AnimalsCells
  15. Yang C, McKenna JT, Zant JC, Winston S, Basheer R, Brown RE. Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons. J Neurosci. 2014 Feb 19; 34(8):2832-44. PMID: 24553925.
    Citations: 24     Fields:    Translation:AnimalsCells
  16. Mietzsch U, McKenna J, Reith RM, Way SW, Gambello MJ. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013 Nov; 521(16):3817-31. PMID: 23749404.
    Citations:    
  17. McKenna JT, Kocsis B, McCarley RW. Aberrant cortical neuroplasticity in the OSA patient (Commentary on Opie et al.). Eur J Neurosci. 2013 Jun; 37(11):1843. PMID: 23725099.
    Citations:    Fields:    Translation:Humans
  18. McKenna JT, Yang C, Franciosi S, Winston S, Abarr KK, Rigby MS, Yanagawa Y, McCarley RW, Brown RE. Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse. J Comp Neurol. 2013 Apr 15; 521(6):1225-50. PMID: 23254904.
    Citations: 23     Fields:    Translation:AnimalsCells
  19. Chen L, McKenna JT, Bolortuya Y, Brown RE, McCarley RW. Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep. Eur J Neurosci. 2013 Mar; 37(6):957-63. PMID: 23282008.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012 Jul; 92(3):1087-187. PMID: 22811426.
    Citations: 210     Fields:    Translation:HumansAnimalsCells
  21. McKenna JT, Christie MA, Jeffrey BA, McCoy JG, Lee E, Connolly NP, Ward CP, Strecker RE. Chronic ramelteon treatment in a mouse model of Alzheimer's disease. Arch Ital Biol. 2012 Mar; 150(1):5-14. PMID: 22786833.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. McNally JM, McCarley RW, McKenna JT, Yanagawa Y, Brown RE. Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophrenia. Neuroscience. 2011 Dec 29; 199:51-63. PMID: 22027237.
    Citations: 28     Fields:    Translation:AnimalsCells
  23. Chen L, McKenna JT, Bolortuya Y, Winston S, Thakkar MM, Basheer R, Brown RE, McCarley RW. Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period. Eur J Neurosci. 2010 Nov; 32(9):1528-36. PMID: 21089218.
    Citations: 14     Fields:    Translation:Animals
  24. Chen L, McKenna JT, Leonard MZ, Yanagawa Y, McCarley RW, Brown RE. GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis. Neuroreport. 2010 Feb 17; 21(3):216-20. PMID: 20051926.
    Citations: 8     Fields:    Translation:AnimalsCells
  25. McCoy JG, McKenna JT, Connolly NP, Poeta DL, Ling L, McCarley RW, Strecker RE. One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats. Behav Brain Res. 2010 Jun 26; 210(1):123-6. PMID: 20122971.
    Citations: 10     Fields:    Translation:Animals
  26. Tartar JL, McKenna JT, Ward CP, McCarley RW, Strecker RE, Brown RE. Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine. Neurosci Lett. 2010 Jan 18; 469(1):1-5. PMID: 19914331.
    Citations: 14     Fields:    Translation:AnimalsCells
  27. McKenna JT, Cordeira JW, Jeffrey BA, Ward CP, Winston S, McCarley RW, Strecker RE. c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness. Brain Res Bull. 2009 Dec 16; 80(6):382-8. PMID: 19716862.
    Citations: 9     Fields:    Translation:AnimalsCells
  28. Chen L, Brown RE, McKenna JT, McCarley RW. Animal models of narcolepsy. CNS Neurol Disord Drug Targets. 2009 Aug; 8(4):296-308. PMID: 19689311.
    Citations: 9     Fields:    Translation:HumansAnimals
  29. Ward CP, McCoy JG, McKenna JT, Connolly NP, McCarley RW, Strecker RE. Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea. Brain Res. 2009 Oct 19; 1294:128-37. PMID: 19643093.
    Citations: 21     Fields:    Translation:Animals
  30. Basheer R, McKenna JT, McCarley RW. Encyclopedia of Neuroscience, Squire LR (ed.). Pharmacology of Sleep: Adenosine. 2009; 7:601-610.
  31. Christie MA, McKenna JT, Connolly NP, McCarley RW, Strecker RE. 24 hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat-psychomotor vigilance task. J Sleep Res. 2008 Dec; 17(4):376-84. PMID: 19021853.
    Citations: 16     Fields:    Translation:Animals
  32. Christie MA, Bolortuya Y, Chen LC, McKenna JT, McCarley RW, Strecker RE. Microdialysis elevation of adenosine in the basal forebrain produces vigilance impairments in the rat psychomotor vigilance task. Sleep. 2008 Oct; 31(10):1393-8. PMID: 18853936.
    Citations: 16     Fields:    Translation:Animals
  33. McKenna JT, Cordeira JW, Christie MA, Tartar JL, McCoy JG, Lee E, McCarley RW, Strecker RE. Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness. J Sleep Res. 2008 Dec; 17(4):365-75. PMID: 18823428.
    Citations: 5     Fields:    Translation:HumansAnimals
  34. Brown RE, McKenna JT, Winston S, Basheer R, Yanagawa Y, Thakkar MM, McCarley RW. Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice. Eur J Neurosci. 2008 Jan; 27(2):352-63. PMID: 18215233.
    Citations: 33     Fields:    Translation:AnimalsCells
  35. McKenna JT, Tartar JL, Ward CP, Thakkar MM, Cordeira JW, McCarley RW, Strecker RE. Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness. Neuroscience. 2007 Jun 08; 146(4):1462-73. PMID: 17442498.
    Citations: 37     Fields:    Translation:Animals
  36. McCoy JG, Tartar JL, Bebis AC, Ward CP, McKenna JT, Baxter MG, McGaughy J, McCarley RW, Strecker RE. Experimental sleep fragmentation impairs attentional set-shifting in rats. Sleep. 2007 Jan; 30(1):52-60. PMID: 17310865.
    Citations: 24     Fields:    Translation:Animals
  37. Tao R, Ma Z, McKenna JT, Thakkar MM, Winston S, Strecker RE, McCarley RW. Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats. Neuroscience. 2006 Sep 01; 141(3):1101-5. PMID: 16820265.
    Citations: 15     Fields:    Translation:Animals
  38. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006 May; 23(10):2739-48. PMID: 16817877.
    Citations: 66     Fields:    Translation:Animals
  39. Strecker RE, Basheer R, McKenna JT, McCarley RW. Another chapter in the adenosine story. Sleep. 2006 Apr; 29(4):426-8. PMID: 16676774.
    Citations: 4     Fields:    Translation:Humans
  40. Ma Z, Strecker RE, McKenna JT, Thakkar MM, McCarley RW, Tao R. Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats. Neuroscience. 2005; 135(3):949-58. PMID: 16154286.
    Citations: 9     Fields:    Translation:Animals
  41. McKenna JT, Vertes RP. Afferent projections to nucleus reuniens of the thalamus. J Comp Neurol. 2004 Dec 06; 480(2):115-42. PMID: 15514932.
    Citations: 44     Fields:    Translation:Animals
  42. McKenna JT, Dauphin LJ, Mulkern KJ, Stronge AM, McCarley RE, Strecker RE. Sleep Research Online. Nocturnal elevation of extracellular adenosine in the rat basal forebrain. 2003; (5):155-160.
  43. McKenna JT, Vertes RP. Collateral projections from the median raphe nucleus to the medial septum and hippocampus. Brain Res Bull. 2001 Apr; 54(6):619-30. PMID: 11403988.
    Citations: 11     Fields:    Translation:AnimalsCells
  44. McKenna JT. Doctoral dissertation - A Neuroanatomical Investigation of the Median Raphe Nucleus, Supramammillary Nucleus, and Nucleus Reuniens: Possible Implications for the Modulation of the Hippocampal EEG - Vertes RP, advisor. 2001.
  45. Vertes RP, McKenna JT. Collateral projections from the supramammillary nucleus to the medial septum and hippocampus. Synapse. 2000 Dec 01; 38(3):281-93. PMID: 11020231.
    Citations: 18     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.