Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Changhong Xing, Ph.D.

Title
Institution
Department
Address

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS094392 (XING, CHANGHONG) Jul 1, 2016 - Jun 30, 2021
    NIH/NINDS
    Comparative Gene Expression in Human vs Rodent Stroke Models
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X. HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPAR? activity in vitro. J Neurochem. 2019 Apr; 149(2):298-310. PMID: 30347434.
    Citations:    Fields:    
  2. Guo S, Tjärnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH. Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab. 2018 Dec; 38(12):2236-2250. PMID: 30152713.
    Citations:    
  3. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y. From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res. 2018 09; 135:201-211. PMID: 30103000.
    Citations:    Fields:    
  4. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH. Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis. 2019 06; 126:117-123. PMID: 30031157.
    Citations:    Fields:    
  5. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 Jul; 146(2):160-172. PMID: 29570780.
    Citations: 1     Fields:    
  6. Xing C, Li W, Deng W, Ning M, Lo EH. A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation. 2018 May 15; 15(1):143. PMID: 29764475.
    Citations:    Fields:    
  7. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res. 2018 Oct; 34(3):477-488. PMID: 29728920.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y. Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets. 2018; 17(5):338-347. PMID: 29895257.
    Citations:    Fields:    
  9. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X. Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci. 2017; 14(10):927-936. PMID: 28924363.
    Citations:    Fields:    Translation:AnimalsCells
  10. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 07 15; 26(14):1078-1085. PMID: 28446066.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y. Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B. 2017 Jul; 7(4):470-478. PMID: 28752032.
    Citations: 1     
  12. Lin L, Desai R, Wang X, Lo EH, Xing C. Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation. 2017 05 08; 14(1):101. PMID: 28482909.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 02; 8(1):1-2. PMID: 27714670.
    Citations: 4     Fields:    Translation:Humans
  14. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  15. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Corrigendum: Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 11 03; 539(7627):123. PMID: 27629516.
    Citations: 3     Fields:    
  16. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5. PMID: 27466127.
    Citations: 71     Fields:    Translation:AnimalsCells
  17. Xing C, Lo EH. Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol. 2017 05; 152:181-199. PMID: 27079786.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 07 15; 33(14):1303-16. PMID: 26528928.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C. Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1425-1434. PMID: 27328691.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem. 2016 Feb; 136(4):851-858. PMID: 26603372.
    Citations: 3     Fields:    
  21. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X. Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res. 2015 Dec; 6(6):478-84. PMID: 26449616.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  22. Wu L, Du Y, Lok J, Lo EH, Xing C. Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem. 2015 Mar; 132(6):622-8. PMID: 25557118.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  25. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402. PMID: 24510881.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH. Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest. 2013 Aug; 123(8):3373-7. PMID: 23867621.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847.
    Citations: 26     Fields:    Translation:HumansCells
  28. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH. The vasculome of the mouse brain. PLoS One. 2012; 7(12):e52665. PMID: 23285140.
    Citations: 13     Fields:    Translation:AnimalsCells
  29. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45. PMID: 23070608.
    Citations: 10     Fields:    Translation:AnimalsCells
  30. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85. PMID: 22712739.
    Citations: 35     Fields:    Translation:HumansCells
  31. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  32. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  33. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH. Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab. 2012 Jun; 32(6):983-8. PMID: 22491155.
    Citations: 8     Fields:    Translation:HumansCells
  34. Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J. 2012 Apr 01; 443(1):153-64. PMID: 22239089.
    Citations: 14     Fields:    Translation:AnimalsCells
  35. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  36. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7. PMID: 20364320.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  37. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol. 2009 Oct 25; 621(1-3):38-45. PMID: 19737553.
    Citations: 11     Fields:    Translation:AnimalsCells
  38. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res. 2009 Aug 15; 87(11):2571-7. PMID: 19360900.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  39. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke. 2009 Aug; 40(8):2836-42. PMID: 19556529.
    Citations: 37     Fields:    Translation:AnimalsCells
  40. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol. 2009 May; 217(1):165-70. PMID: 19233173.
    Citations: 27     Fields:    Translation:Animals
  41. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728.
    Citations: 42     Fields:    Translation:AnimalsCells
  42. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem. 2009 Jan; 108(2):430-6. PMID: 19012741.
    Citations: 18     Fields:    Translation:AnimalsCells
  43. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett. 2008 Mar 28; 434(2):224-9. PMID: 18328624.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  44. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z. Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol. 2007 May; 205(1):222-9. PMID: 17335809.
    Citations: 10     Fields:    Translation:AnimalsCells
  45. Xing C, Yin Y, He X, Xie Z. Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res. 2006 Feb 09; 1072(1):30-5. PMID: 16438944.
    Citations: 4     Fields:    Translation:AnimalsCells
  46. Xing C, Yin Y, Chang R, He X, Xie Z. A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett. 2005 Aug 12-19; 384(1-2):93-7. PMID: 15885901.
    Citations: 5     Fields:    Translation:AnimalsCells
  47. Gong H, Shen P, Jin L, Xing C, Tang F. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm. 2005 Apr; 20(2):155-62. PMID: 15869449.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  48. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y. [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi. 2002 Apr 10; 82(7):481-3. PMID: 12133521.
    Citations: 1     Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Xing's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (237)
Explore
_
Co-Authors (15)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.