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Changhong Xing, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS094392 (XING, CHANGHONG) Jul 1, 2016 - Jun 30, 2021
    Comparative Gene Expression in Human vs Rodent Stroke Models
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Deng W, Xing C, David R, Mastroeni D, Ning M, Lo EH, Coleman PD. AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging Dis. 2019 Dec; 10(6):1146-1158. PMID: 31788328.
  2. Du Y, Li W, Lin L, Lo EH, Xing C. Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One. 2019; 14(7):e0218965. PMID: 31269059.
  3. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X. HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPAR? activity in vitro. J Neurochem. 2019 Apr; 149(2):298-310. PMID: 30347434.
    Citations:    Fields:    
  4. Guo S, Tjärnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH. Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab. 2018 12; 38(12):2236-2250. PMID: 30152713.
  5. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y. From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res. 2018 09; 135:201-211. PMID: 30103000.
    Citations:    Fields:    
  6. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH. Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis. 2019 06; 126:117-123. PMID: 30031157.
    Citations:    Fields:    
  7. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 07; 146(2):160-172. PMID: 29570780.
    Citations: 1     Fields:    
  8. Xing C, Li W, Deng W, Ning M, Lo EH. A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation. 2018 May 15; 15(1):143. PMID: 29764475.
    Citations:    Fields:    
  9. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res. 2018 Oct; 34(3):477-488. PMID: 29728920.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y. Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets. 2018; 17(5):338-347. PMID: 29895257.
    Citations:    Fields:    
  11. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X. Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci. 2017; 14(10):927-936. PMID: 28924363.
    Citations:    Fields:    Translation:AnimalsCells
  12. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 07 15; 26(14):1078-1085. PMID: 28446066.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y. Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B. 2017 Jul; 7(4):470-478. PMID: 28752032.
    Citations: 1     
  14. Lin L, Desai R, Wang X, Lo EH, Xing C. Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation. 2017 05 08; 14(1):101. PMID: 28482909.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 02; 8(1):1-2. PMID: 27714670.
    Citations: 4     Fields:    Translation:Humans
  16. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Corrigendum: Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 11 03; 539(7627):123. PMID: 27629516.
    Citations: 3     Fields:    
  18. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5. PMID: 27466127.
    Citations: 71     Fields:    Translation:AnimalsCells
  19. Xing C, Lo EH. Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol. 2017 05; 152:181-199. PMID: 27079786.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 07 15; 33(14):1303-16. PMID: 26528928.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C. Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1425-1434. PMID: 27328691.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem. 2016 Feb; 136(4):851-858. PMID: 26603372.
    Citations: 3     Fields:    
  23. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X. Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res. 2015 Dec; 6(6):478-84. PMID: 26449616.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  24. Wu L, Du Y, Lok J, Lo EH, Xing C. Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem. 2015 Mar; 132(6):622-8. PMID: 25557118.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  26. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  27. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402. PMID: 24510881.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH. Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest. 2013 Aug; 123(8):3373-7. PMID: 23867621.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  29. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847.
    Citations: 26     Fields:    Translation:HumansCells
  30. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH. The vasculome of the mouse brain. PLoS One. 2012; 7(12):e52665. PMID: 23285140.
    Citations: 13     Fields:    Translation:AnimalsCells
  31. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45. PMID: 23070608.
    Citations: 10     Fields:    Translation:AnimalsCells
  32. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85. PMID: 22712739.
    Citations: 35     Fields:    Translation:HumansCells
  33. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  34. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  35. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH. Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab. 2012 Jun; 32(6):983-8. PMID: 22491155.
    Citations: 8     Fields:    Translation:HumansCells
  36. Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J. 2012 Apr 01; 443(1):153-64. PMID: 22239089.
    Citations: 14     Fields:    Translation:AnimalsCells
  37. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  38. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7. PMID: 20364320.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  39. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol. 2009 Oct 25; 621(1-3):38-45. PMID: 19737553.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res. 2009 Aug 15; 87(11):2571-7. PMID: 19360900.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  41. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke. 2009 Aug; 40(8):2836-42. PMID: 19556529.
    Citations: 37     Fields:    Translation:AnimalsCells
  42. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol. 2009 May; 217(1):165-70. PMID: 19233173.
    Citations: 27     Fields:    Translation:Animals
  43. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728.
    Citations: 42     Fields:    Translation:AnimalsCells
  44. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem. 2009 Jan; 108(2):430-6. PMID: 19012741.
    Citations: 18     Fields:    Translation:AnimalsCells
  45. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett. 2008 Mar 28; 434(2):224-9. PMID: 18328624.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  46. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z. Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol. 2007 May; 205(1):222-9. PMID: 17335809.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Xing C, Yin Y, He X, Xie Z. Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res. 2006 Feb 09; 1072(1):30-5. PMID: 16438944.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Xing C, Yin Y, Chang R, He X, Xie Z. A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett. 2005 Aug 12-19; 384(1-2):93-7. PMID: 15885901.
    Citations: 5     Fields:    Translation:AnimalsCells
  49. Gong H, Shen P, Jin L, Xing C, Tang F. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm. 2005 Apr; 20(2):155-62. PMID: 15869449.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  50. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y. [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi. 2002 Apr 10; 82(7):481-3. PMID: 12133521.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.