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James Preston Butler, Ph.D.

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My research work is focused primarily on pulmonary physiology, ranging from cellular mechanics to whole organ studies, aerosol transport mechanisms, and imaging with hyperpolarized noble gases. I have recently extended this to human studies of sleep related disorders of breathing, branching into the control of circadian rhythms. I work specifically bridging the gaps between physics, mathematics, and physiology.

At the cellular level, I work with a variety of methodologies that probe specific rheological features of the cytoskeleton, and how these are modulated and influenced by various agonists. My current work focuses on the behavior of migrating epithelial and endothelial monolayers; what controls their mechanical interactions with the microenvironment, what are the consequences to cell/cell interactions and barrier integrity, what is the physics that links motions with forces? These are important to a wide variety of diseases, including asthma and ARDS.

At the organ level, I am engaged in MRI studies of lung function using hyperpolarized noble gases, addressing fundamental questions of what can be quantified through its use in mapping local ventilation, perfusion, oxygen concentration, and airspace dimensions. With others, we have now demonstrated lung growth post pneumonectomy in an adult human, previously thought not possible. Aerosol exposure and the exposure/dose relationships, especially of ultrafine particles that do not have significant impaction or gravitational sedimentation, remain important problems in public health. We have recently proposed a new mechanism, involving irreversible kinematics and chaotic trajectories, that may explain and unify a number of experimental observations. Our theory has been confirmed in a number of initial experiments, and we are extending this work to include variations associated with growth and development from newborns to adults.

Finally, I continue to work in applied mathematics, fluid and continuum mechanics, and comparative physiology from birds to whales to, most recently, penguins and monitor lizards.

I enjoy long standing collaborations with colleagues across a variety of disciplines, which in large measure has been and continues to be an expression of the richness of cross disciplinary studies.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01HL120839 (FREDBERG, JEFFREY J) Aug 1, 2014 - Dec 31, 2019
    Physics of collective cellular migration in lung health and disease
    Role: Co-Principal Investigator
  2. R01HL055569 (BUTLER, JAMES P) Apr 1, 1997 - Mar 31, 2002
    Role: Principal Investigator
  3. R43HL055032 (BUTLER, JAMES P) Apr 1, 1996 - Mar 31, 1997
    Role: Principal Investigator
  4. R41CA064964 (BUTLER, JAMES P) Sep 1, 1994 - Aug 31, 1996
    Role: Principal Investigator
  5. R01HL036427 (BUTLER, JAMES P) Aug 1, 1988 - Jul 31, 1992
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ. A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation. iScience. 2021 Nov 19; 24(11):103252. PMID: 34755092; PMCID: PMC8564056.
    Citations: 9     
  2. Maeda Y, Fukushima K, Kyoutani S, Butler JP, Fujii M, Sasaki H. Dramatic Performance by a Professional Actor for the Treatment of Patients with Behavioral and Psychological Symptoms of Dementia. Tohoku J Exp Med. 2020 11; 252(3):263-267. PMID: 33177265.
    Citations:    Fields:    Translation:Humans
  3. DeCamp SJ, Tsuda VMK, Ferruzzi J, Koehler SA, Giblin JT, Roblyer D, Zaman MH, Weiss ST, Kiliç A, De Marzio M, Park CY, Ogassavara NC, Mitchel JA, Butler JP, Fredberg JJ. Epithelial layer unjamming shifts energy metabolism toward glycolysis. Sci Rep. 2020 10 27; 10(1):18302. PMID: 33110128.
    Citations: 13     Fields:    Translation:AnimalsCells
  4. Mitchel JA, Das A, O'Sullivan MJ, Stancil IT, DeCamp SJ, Koehler S, Ocaña OH, Butler JP, Fredberg JJ, Nieto MA, Bi D, Park JA. In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition. Nat Commun. 2020 10 07; 11(1):5053. PMID: 33028821.
    Citations: 34     Fields:    Translation:HumansCells
  5. Green Y, Fredberg JJ, Butler JP. Relationship between velocities, tractions, and intercellular stresses in the migrating epithelial monolayer. Phys Rev E. 2020 Jun; 101(6-1):062405. PMID: 32688543.
    Citations: 1     Fields:    Translation:Cells
  6. Fukushima K, Aita E, Butler JP, Fujii M, Sasaki H. Emotional therapy using Internet of Things for behavioral and psychological symptoms of dementia. Geriatr Gerontol Int. 2020 May; 20(5):502-503. PMID: 32358878.
    Citations:    Fields:    Translation:Humans
  7. Kim JH, Pegoraro AF, Das A, Koehler SA, Ujwary SA, Lan B, Mitchel JA, Atia L, He S, Wang K, Bi D, Zaman MH, Park JA, Butler JP, Lee KH, Starr JR, Fredberg JJ. Unjamming and collective migration in MCF10A breast cancer cell lines. Biochem Biophys Res Commun. 2020 01 15; 521(3):706-715. PMID: 31699371.
    Citations: 12     Fields:    Translation:HumansCells
  8. Fujii M, Butler JP, Sasaki H. Antipsychotic drug use and favourable natures of emotional functions in patients with dementia. Psychogeriatrics. 2019 Jul; 19(4):320-324. PMID: 30784147.
    Citations:    Fields:    Translation:Humans
  9. He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ. The tumor suppressor p53 can promote collective cellular migration. PLoS One. 2019; 14(2):e0202065. PMID: 30707705; PMCID: PMC6358060.
    Citations: 4     Fields:    Translation:HumansCells
  10. Butler JP, Malhotra A, Loring SH. Revisiting atelectasis in lung units with low ventilation/perfusion ratios. J Appl Physiol (1985). 2019 03 01; 126(3):782-786. PMID: 30571287; PMCID: PMC6734073.
    Citations: 1     Fields:    Translation:Humans
  11. Sands SA, Edwards BA, Terrill PI, Butler JP, Owens RL, Taranto-Montemurro L, Azarbarzin A, Marques M, Hess LB, Smales ET, de Melo CM, White DP, Malhotra A, Wellman A. Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy. Eur Respir J. 2018 09; 52(3). PMID: 30139771; PMCID: PMC6232193.
    Citations: 48     Fields:    Translation:Humans
  12. Lan B, Mitchel JA, O'Sullivan MJ, Park CY, Kim JH, Cole WC, Butler JP, Park JA. Airway epithelial compression promotes airway smooth muscle proliferation and contraction. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L645-L652. PMID: 30070589; PMCID: PMC6295502.
    Citations: 16     Fields:    Translation:HumansCells
  13. Fujii M, Butler JP, Sasaki H. Core symptoms and peripheral symptoms of dementia. Geriatr Gerontol Int. 2018 06; 18(6):979-980. PMID: 29924491.
    Citations:    Fields:    Translation:Humans
  14. Atia L, Bi D, Sharma Y, Mitchel JA, Gweon B, Koehler S, DeCamp SJ, Lan B, Kim JH, Hirsch R, Pegoraro AF, Lee KH, Starr JR, Weitz DA, Martin AC, Park JA, Butler JP, Fredberg JJ. Geometric constraints during epithelial jamming. Nat Phys. 2018 Jun; 14:613-620. PMID: 30151030; PMCID: PMC6108541.
    Citations: 58     
  15. Fujii M, Butler JP, Sasaki H. Gamma-oryzanol for behavioural and psychological symptoms of dementia. Psychogeriatrics. 2018 03; 18(2):151-152. PMID: 29417716.
    Citations: 2     Fields:    Translation:Humans
  16. Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L799-L807. PMID: 29345194; PMCID: PMC6008132.
    Citations: 10     Fields:    Translation:HumansCells
  17. Sands SA, Terrill PI, Edwards BA, Taranto Montemurro L, Azarbarzin A, Marques M, de Melo CM, Loring SH, Butler JP, White DP, Wellman A. Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea. Sleep. 2018 01 01; 41(1). PMID: 29228393.
    Citations: 51     Fields:    Translation:Humans
  18. Hardin CC, Chattoraj J, Manomohan G, Colombo J, Nguyen T, Tambe D, Fredberg JJ, Birukov K, Butler JP, Del Gado E, Krishnan R. Long-range stress transmission guides endothelial gap formation. Biochem Biophys Res Commun. 2018 01 01; 495(1):749-754. PMID: 29137986; PMCID: PMC5761675.
    Citations: 11     Fields:    Translation:HumansCells
  19. Phillips AJK, Klerman EB, Butler JP. Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery. PLoS Comput Biol. 2017 Oct; 13(10):e1005759. PMID: 29073206.
    Citations: 8     Fields:    Translation:Humans
  20. Lee G, Atia L, Lan B, Sharma Y, Nissim L, Wu MR, Pery E, Lu TK, Park CY, Butler JP, Fredberg JJ. Contact guidance and collective migration in the advancing epithelial monolayer. Connect Tissue Res. 2018 07; 59(4):309-315. PMID: 28945485; PMCID: PMC5867268.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. de Melo CM, Taranto-Montemurro L, Butler JP, White DP, Loring SH, Azarbarzin A, Marques M, Berger PJ, Wellman A, Sands SA. Stable Breathing in Patients With Obstructive Sleep Apnea Is Associated With Increased Effort but Not Lowered Metabolic Rate. Sleep. 2017 10 01; 40(10). PMID: 28977669.
    Citations: 5     Fields:    Translation:Humans
  22. Genta PR, Sands SA, Butler JP, Loring SH, Katz ES, Demko BG, Kezirian EJ, White DP, Wellman A. Airflow Shape Is Associated With the Pharyngeal Structure Causing OSA. Chest. 2017 09; 152(3):537-546. PMID: 28651794; PMCID: PMC5812772.
    Citations: 43     Fields:    Translation:Humans
  23. Butler JP, Green Y. Forces, Flows, Fluorescence, and µFluidics. Biophys J. 2017 04 11; 112(7):1293-1294. PMID: 28402872; PMCID: PMC5389959.
    Citations:    Fields:    
  24. Sands SA, Mebrate Y, Edwards BA, Nemati S, Manisty CH, Desai AS, Wellman A, Willson K, Francis DP, Butler JP, Malhotra A. Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure. Am J Respir Crit Care Med. 2017 01 15; 195(2):237-246. PMID: 27559818; PMCID: PMC5394785.
    Citations: 9     Fields:    Translation:Humans
  25. Alencar AM, Ferraz MS, Park CY, Millet E, Trepat X, Fredberg JJ, Butler JP. Non-equilibrium cytoquake dynamics in cytoskeletal remodeling and stabilization. Soft Matter. 2016 Oct 19; 12(41):8506-8511. PMID: 27722665.
    Citations: 7     Fields:    Translation:HumansCells
  26. Park JA, Atia L, Mitchel JA, Fredberg JJ, Butler JP. Collective migration and cell jamming in asthma, cancer and development. J Cell Sci. 2016 09 15; 129(18):3375-83. PMID: 27550520; PMCID: PMC5047682.
    Citations: 52     Fields:    Translation:HumansAnimals
  27. Notbohm J, Banerjee S, Utuje KJC, Gweon B, Jang H, Park Y, Shin J, Butler JP, Fredberg JJ, Marchetti MC. Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophys J. 2016 Jun 21; 110(12):2729-2738. PMID: 27332131; PMCID: PMC4919426.
    Citations: 43     Fields:    Translation:AnimalsCells
  28. Lippincott MF, Chan YM, Delaney A, Rivera-Morales D, Butler JP, Seminara SB. Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty. J Clin Endocrinol Metab. 2016 08; 101(8):3061-9. PMID: 27214398; PMCID: PMC4971332.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  29. Park JA, Mitchel JA, Qazvini NT, Kim JH, Park CY, Butler JP, Israel E, Randell SH, Shore SA, Drazen JM, Fredberg JJ. Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S102. PMID: 27027941.
    Citations: 3     Fields:    
  30. Genta PR, Edwards BA, Sands SA, Owens RL, Butler JP, Loring SH, White DP, Wellman A. Tube Law of the Pharyngeal Airway in Sleeping Patients with Obstructive Sleep Apnea. Sleep. 2016 Feb 01; 39(2):337-43. PMID: 26446124.
    Citations: 8     Fields:    Translation:Humans
  31. Park JA, Kim JH, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R, Burger S, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater. 2015 Oct; 14(10):1040-8. PMID: 26237129.
    Citations: 148     Fields:    Translation:HumansCells
  32. Owens RL, Edwards BA, Eckert DJ, Jordan AS, Sands SA, Malhotra A, White DP, Loring SH, Butler JP, Wellman A. An Integrative Model of Physiological Traits Can be Used to Predict Obstructive Sleep Apnea and Response to Non Positive Airway Pressure Therapy. Sleep. 2015 Jun 01; 38(6):961-70. PMID: 25515107.
    Citations: 64     Fields:    Translation:Humans
  33. Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R. High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb). 2015 Oct; 7(10):1318-24. PMID: 25953078.
    Citations: 30     Fields:    Translation:HumansCells
  34. Fujii M, Butler JP, Sasaki H. A Japanese fairy tale, Urashima Taro, and dementia. Psychogeriatrics. 2015 Dec; 15(4):279-80. PMID: 25918858.
    Citations:    Fields:    Translation:Humans
  35. Shaw ND, Butler JP, Nemati S, Kangarloo T, Ghassemi M, Malhotra A, Hall JE. Accumulated deep sleep is a powerful predictor of LH pulse onset in pubertal children. J Clin Endocrinol Metab. 2015 Mar; 100(3):1062-70. PMID: 25490277; PMCID: PMC4333042.
    Citations: 10     Fields:    Translation:Humans
  36. Chan YM, Lippincott MF, Butler JP, Sidhoum VF, Li CX, Plummer L, Seminara SB. Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2762-71. PMID: 25226293; PMCID: PMC4255107.
    Citations: 15     Fields:    Translation:HumansCells
  37. Zhou EH, Watson C, Pizzo R, Cohen J, Dang Q, Ferreira de Barros PM, Park CY, Chen C, Brain JD, Butler JP, Ruberti JW, Fredberg JJ, Demokritou P. Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay. Nanomedicine (Lond). 2014 Dec; 9(18):2803-15. PMID: 24823434.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  38. Wellman A, Genta PR, Owens RL, Edwards BA, Sands SA, Loring SH, White DP, Jackson AC, Pedersen OF, Butler JP. Test of the Starling resistor model in the human upper airway during sleep. J Appl Physiol (1985). 2014 Dec 15; 117(12):1478-85. PMID: 25324514.
    Citations: 9     Fields:    Translation:Humans
  39. Terrill PI, Edwards BA, Nemati S, Butler JP, Owens RL, Eckert DJ, White DP, Malhotra A, Wellman A, Sands SA. Quantifying the ventilatory control contribution to sleep apnoea using polysomnography. Eur Respir J. 2015 Feb; 45(2):408-18. PMID: 25323235.
    Citations: 87     Fields:    Translation:Humans
  40. Sands SA, Eckert DJ, Jordan AS, Edwards BA, Owens RL, Butler JP, Schwab RJ, Loring SH, Malhotra A, White DP, Wellman A. Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):930-7. PMID: 25191791; PMCID: PMC4299579.
    Citations: 50     Fields:    Translation:Humans
  41. Fujii M, Butler JP, Sasaki H. Emotional function in dementia patients. Psychogeriatrics. 2014 Sep; 14(3):202-9. PMID: 25250479.
    Citations: 3     Fields:    Translation:Humans
  42. Tambe DT, Butler JP, Fredberg JJ. Comment on "Intracellular stresses in patterned cell assemblies" by M. Moussus et al., Soft Matter, 2014, 10, 2414. Soft Matter. 2014 Oct 21; 10(39):7681-2. PMID: 25186230.
    Citations: 1     Fields:    Translation:HumansCells
  43. Greenblatt EE, Butler JP, Venegas JG, Winkler T. Pendelluft in the bronchial tree. J Appl Physiol (1985). 2014 Nov 01; 117(9):979-88. PMID: 25170072.
    Citations: 20     Fields:    Translation:Humans
  44. Edwards BA, Sands SA, Owens RL, White DP, Genta PR, Butler JP, Malhotra A, Wellman A. Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea. J Physiol. 2014 Oct 15; 592(20):4523-35. PMID: 25085887.
    Citations: 24     Fields:    Translation:Humans
  45. Genta PR, Owens RL, Edwards BA, Sands SA, Eckert DJ, Butler JP, Loring SH, Malhotra A, Jackson AC, White DP, Wellman A. Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway. Respir Physiol Neurobiol. 2014 Sep 15; 201:55-9. PMID: 25020212.
    Citations: 11     Fields:    Translation:Humans
  46. Fujii M, Butler JP, Hirazakura A, Sasaki H. Mini-Emotional State Examination for dementia patients. Geriatr Gerontol Int. 2014 Apr; 14(2):508-13. PMID: 24467673.
    Citations:    Fields:    Translation:Humans
  47. Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway. J Appl Physiol (1985). 2014 Apr 15; 116(8):1105-12. PMID: 24458746.
    Citations: 13     Fields:    Translation:Humans
  48. Washko GR, Diaz AA, Kim V, Barr RG, Dransfield MT, Schroeder J, Reilly JJ, Ramsdell JW, McKenzie A, Van Beek EJ, Lynch DA, Butler JP, Han MK. Computed tomographic measures of airway morphology in smokers and never-smoking normals. J Appl Physiol (1985). 2014 Mar 15; 116(6):668-73. PMID: 24436301.
    Citations: 30     Fields:    Translation:Humans
  49. Schachner ER, Cieri RL, Butler JP, Farmer CG. Unidirectional pulmonary airflow patterns in the savannah monitor lizard. Nature. 2014 Feb 20; 506(7488):367-70. PMID: 24336209.
    Citations: 20     Fields:    Translation:Animals
  50. Deyoung PN, Bakker JP, Sands SA, Batool-Anwar S, Connolly JG, Butler JP, Malhotra A. Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea. J Clin Sleep Med. 2013 Nov 15; 9(11):1161-4. PMID: 24235897.
    Citations: 13     Fields:    Translation:Humans
  51. Tsuda A, Henry FS, Butler JP. Particle transport and deposition: basic physics of particle kinetics. Compr Physiol. 2013 Oct; 3(4):1437-71. PMID: 24265235.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  52. Kaneko Y, Butler JP, Saitoh E, Horie T, Fujii M, Sasaki H. Efficacy of white noise therapy for dementia patients with schizophrenia. Geriatr Gerontol Int. 2013 Jul; 13(3):808-10. PMID: 23819634.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  53. Nemati S, Edwards BA, Lee J, Pittman-Polletta B, Butler JP, Malhotra A. Respiration and heart rate complexity: effects of age and gender assessed by band-limited transfer entropy. Respir Physiol Neurobiol. 2013 Oct 01; 189(1):27-33. PMID: 23811194.
    Citations: 16     Fields:    Translation:Humans
  54. Kim JH, Serra-Picamal X, Tambe DT, Zhou EH, Park CY, Sadati M, Park JA, Krishnan R, Gweon B, Millet E, Butler JP, Trepat X, Fredberg JJ. Propulsion and navigation within the advancing monolayer sheet. Nat Mater. 2013 Sep; 12(9):856-63. PMID: 23793160; PMCID: PMC3750079.
    Citations: 87     Fields:    Translation:AnimalsCells
  55. Hardin C, Rajendran K, Manomohan G, Tambe DT, Butler JP, Fredberg JJ, Martinelli R, Carman CV, Krishnan R. Glassy dynamics, cell mechanics, and endothelial permeability. J Phys Chem B. 2013 Oct 24; 117(42):12850-6. PMID: 23638866.
    Citations: 11     Fields:    Translation:HumansCells
  56. Macdonell MM, Haroun LA, Teuschler LK, Rice GE, Hertzberg RC, Butler JP, Chang YS, Clark SL, Johns AP, Perry CS, Garcia SS, Jacobi JH, Scofield MA. Cumulative risk assessment toolbox: methods and approaches for the practitioner. J Toxicol. 2013; 2013:310904. PMID: 23762048.
    Citations: 10     
  57. Butler JP, Owens RL, Malhotra A, Wellman A. Rebuttal from James P. Butler, Robert L. Owens, Atul Malhotra and Andrew Wellman. J Physiol. 2013 May 01; 591(9):2237. PMID: 23740882.
    Citations:    Fields:    Translation:HumansAnimals
  58. Butler JP, Owens RL, Malhotra A, Wellman A. CrossTalk opposing view: the human upper airway during sleep does not behave like a Starling resistor. J Physiol. 2013 May 01; 591(9):2233-4. PMID: 23740880.
    Citations: 8     Fields:    Translation:Humans
  59. Bhadelia RA, Madan N, Zhao Y, Wagshul ME, Heilman C, Butler JP, Patz S. Physiology-based MR imaging assessment of CSF flow at the foramen magnum with a valsalva maneuver. AJNR Am J Neuroradiol. 2013 Sep; 34(9):1857-62. PMID: 23620074.
    Citations: 13     Fields:    Translation:Humans
  60. Butler JP. Looking back and looking forward: normal lung growth and the pathophysiological consequences of 'misplaced' growth in disease. Eur J Radiol. 2014 Jan; 83(1):2-5. PMID: 23583296.
    Citations:    Fields:    Translation:Humans
  61. Campana LM, Owens RL, Butler JP, Suki B, Malhotra A. Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma. Respir Physiol Neurobiol. 2013 May 01; 186(3):290-5. PMID: 23473922.
    Citations: 2     Fields:    Translation:Humans
  62. Tambe DT, Croutelle U, Trepat X, Park CY, Kim JH, Millet E, Butler JP, Fredberg JJ. Monolayer stress microscopy: limitations, artifacts, and accuracy of recovered intercellular stresses. PLoS One. 2013; 8(2):e55172. PMID: 23468843.
    Citations: 76     Fields:    
  63. Wellman A, Edwards BA, Sands SA, Owens RL, Nemati S, Butler J, Passaglia CL, Jackson AC, Malhotra A, White DP. A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. J Appl Physiol (1985). 2013 Apr; 114(7):911-22. PMID: 23349453.
    Citations: 90     Fields:    Translation:Humans
  64. Sun Y, Butler JP, Ferrigno M, Albert MS, Loring SH. "Ventilatory alternans": a left-right alternation of inspiratory airflow in humans. Respir Physiol Neurobiol. 2013 Jan 15; 185(2):468-71. PMID: 23142365.
    Citations: 2     Fields:    Translation:Humans
  65. Muradyan I, Butler JP, Dabaghyan M, Hrovat M, Dregely I, Ruset I, Topulos GP, Frederick E, Hatabu H, Hersman WF, Patz S. Single-breath xenon polarization transfer contrast (SB-XTC): implementation and initial results in healthy humans. J Magn Reson Imaging. 2013 Feb; 37(2):457-70. PMID: 23011916.
    Citations: 14     Fields:    Translation:Humans
  66. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. PMID: 23028423.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  67. Shaw ND, Butler JP, McKinney SM, Nelson SA, Ellenbogen JM, Hall JE. Insights into puberty: the relationship between sleep stages and pulsatile LH secretion. J Clin Endocrinol Metab. 2012 Nov; 97(11):E2055-62. PMID: 22948756; PMCID: PMC3485602.
    Citations: 18     Fields:    Translation:Humans
  68. Butler JP, Loring SH, Patz S, Tsuda A, Yablonskiy DA, Mentzer SJ. Evidence for adult lung growth in humans. N Engl J Med. 2012 Jul 19; 367(3):244-7. PMID: 22808959; PMCID: PMC3422892.
    Citations: 93     Fields:    Translation:Humans
  69. Butler JP, Fujii M, Sasaki H. New lessons of nurturing life for geriatric patients. Tohoku J Exp Med. 2012 07; 227(3):203-10. PMID: 22790875.
    Citations:    Fields:    Translation:Humans
  70. Strohl KP, Butler JP, Malhotra A. Mechanical properties of the upper airway. Compr Physiol. 2012 Jul; 2(3):1853-72. PMID: 23723026.
    Citations: 34     Fields:    Translation:HumansAnimals
  71. Krishnan R, Canovic EP, Iordan AL, Rajendran K, Manomohan G, Pirentis AP, Smith ML, Butler JP, Fredberg JJ, Stamenovic D. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C368-75. PMID: 22700796.
    Citations: 28     Fields:    Translation:HumansCells
  72. Malhotra A, Butler JP, Wellman A. The pharyngeal airway: is bigger really better? Chest. 2012 Jun; 141(6):1372-1375. PMID: 22670014.
    Citations: 5     Fields:    Translation:Humans
  73. Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume. J Appl Physiol (1985). 2012 Sep 01; 113(5):691-9. PMID: 22628372.
    Citations: 15     Fields:    Translation:Humans
  74. Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB. Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. J Clin Endocrinol Metab. 2012 Aug; 97(8):E1458-67. PMID: 22577171; PMCID: PMC3410261.
    Citations: 29     Fields:    Translation:Humans
  75. Lee J, Nemati S, Silva I, Edwards BA, Butler JP, Malhotra A. Transfer entropy estimation and directional coupling change detection in biomedical time series. Biomed Eng Online. 2012 Apr 13; 11:19. PMID: 22500692.
    Citations: 28     Fields:    
  76. Koch TM, Münster S, Bonakdar N, Butler JP, Fabry B. 3D Traction forces in cancer cell invasion. PLoS One. 2012; 7(3):e33476. PMID: 22479403.
    Citations: 116     Fields:    Translation:HumansCells
  77. Semmler-Behnke M, Kreyling WG, Schulz H, Takenaka S, Butler JP, Henry FS, Tsuda A. Nanoparticle delivery in infant lungs. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5092-7. PMID: 22411799.
    Citations: 28     Fields:    Translation:HumansAnimals
  78. Mizrahi N, Zhou EH, Lenormand G, Krishnan R, Weihs D, Butler JP, Weitz DA, Fredberg JJ, Kimmel E. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter. 2012 Feb 28; 8(8):2438-2443. PMID: 23646063.
    Citations: 30     Fields:    
  79. Engelberts D, Malhotra A, Butler JP, Topulos GP, Loring SH, Kavanagh BP. Relative effects of negative versus positive pressure ventilation depend on applied conditions. Intensive Care Med. 2012 May; 38(5):879-85. PMID: 22349427.
    Citations: 9     Fields:    Translation:Animals
  80. Mamata H, Tokuda J, Gill RR, Padera RF, Lenkinski RE, Sugarbaker DJ, Butler JP, Hatabu H. Clinical application of pharmacokinetic analysis as a biomarker of solitary pulmonary nodules: dynamic contrast-enhanced MR imaging. Magn Reson Med. 2012 Nov; 68(5):1614-22. PMID: 22231729.
    Citations: 6     Fields:    Translation:Humans
  81. Edwards BA, Sands SA, Eckert DJ, White DP, Butler JP, Owens RL, Malhotra A, Wellman A. Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea. J Physiol. 2012 Mar 01; 590(5):1199-211. PMID: 22219335.
    Citations: 100     Fields:    Translation:HumansCTClinical Trials
  82. Kojic M, Butler JP, Vlastelica I, Stojanovic B, Rankovic V, Tsuda A. Geometric hysteresis of alveolated ductal architecture. J Biomech Eng. 2011 Nov; 133(11):111005. PMID: 22168737.
    Citations: 9     Fields:    Translation:Animals
  83. Pedersen OF, Butler JP. Expiratory flow limitation. Compr Physiol. 2011 Oct; 1(4):1861-82. PMID: 23733691.
    Citations: 12     Fields:    Translation:HumansAnimals
  84. Kim JH, Butler JP, Loring SH. Probing softness of the parietal pleural surface at the micron scale. J Biomech. 2011 Sep 23; 44(14):2558-64. PMID: 21820660.
    Citations: 2     Fields:    Translation:Animals
  85. Butler JP, Tsuda A. Transport of gases between the environment and alveoli--theoretical foundations. Compr Physiol. 2011 Jul; 1(3):1301-16. PMID: 23733643.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  86. Lenormand G, Millet E, Park CY, Hardin CC, Butler JP, Moldovan NI, Fredberg JJ. Dynamics of the cytoskeleton: how much does water matter? Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jun; 83(6 Pt 1):061918. PMID: 21797414.
    Citations: 2     Fields:    Translation:HumansCells
  87. Tambe DT, Hardin CC, Angelini TE, Rajendran K, Park CY, Serra-Picamal X, Zhou EH, Zaman MH, Butler JP, Weitz DA, Fredberg JJ, Trepat X. Collective cell guidance by cooperative intercellular forces. Nat Mater. 2011 Jun; 10(6):469-75. PMID: 21602808.
    Citations: 365     Fields:    Translation:AnimalsCells
  88. Zitterbart DP, Wienecke B, Butler JP, Fabry B. Coordinated movements prevent jamming in an Emperor penguin huddle. PLoS One. 2011; 6(6):e20260. PMID: 21673816.
    Citations: 11     Fields:    Translation:Animals
  89. Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. J Appl Physiol (1985). 2011 Jul; 111(1):55-67. PMID: 21474696.
    Citations: 18     Fields:    Translation:AnimalsCells
  90. Chan YM, Butler JP, Pinnell NE, Pralong FP, Crowley WF, Ren C, Chan KK, Seminara SB. Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab. 2011 Jun; 96(6):E908-15. PMID: 21470997; PMCID: PMC3100758.
    Citations: 41     Fields:    Translation:Humans
  91. Kim JH, Butler JP, Loring SH. Influence of the softness of the parietal pleura on respiratory sliding mechanisms. Respir Physiol Neurobiol. 2011 Jul 31; 177(2):114-9. PMID: 21473935.
    Citations: 2     Fields:    Translation:Animals
  92. Butler JP, Fujii M, Sasaki H. Balanced aging, or successful aging? Geriatr Gerontol Int. 2011 Jan; 11(1):1-2. PMID: 21166964.
    Citations: 3     Fields:    Translation:Humans
  93. Lin YC, Tambe DT, Park CY, Wasserman MR, Trepat X, Krishnan R, Lenormand G, Fredberg JJ, Butler JP. Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct; 82(4 Pt 1):041918. PMID: 21230324.
    Citations: 26     Fields:    Translation:HumansCells
  94. Oliver M, Kováts T, Mijailovich SM, Butler JP, Fredberg JJ, Lenormand G. Remodeling of integrated contractile tissues and its dependence on strain-rate amplitude. Phys Rev Lett. 2010 Oct 08; 105(15):158102. PMID: 21230941.
    Citations: 11     Fields:    Translation:Animals
  95. Muradyan I, Loring SH, Ferrigno M, Lindholm P, Topulos GP, Patz S, Butler JP. Inhalation heterogeneity from subresidual volumes in elite divers. J Appl Physiol (1985). 2010 Dec; 109(6):1969-73. PMID: 20864566.
    Citations: 7     Fields:    Translation:Humans
  96. Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C146-54. PMID: 20861463.
    Citations: 101     Fields:    Translation:HumansCells
  97. Gregg C, Zhang J, Butler JE, Haig D, Dulac C. Sex-specific parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 06; 329(5992):682-5. PMID: 20616234; PMCID: PMC2997643.
    Citations: 171     Fields:    Translation:AnimalsCells
  98. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010 Jun 06; 7 Suppl 3:S331-40. PMID: 20356875.
    Citations: 15     Fields:    Translation:HumansCells
  99. Park CY, Tambe D, Alencar AM, Trepat X, Zhou EH, Millet E, Butler JP, Fredberg JJ. Mapping the cytoskeletal prestress. Am J Physiol Cell Physiol. 2010 May; 298(5):C1245-52. PMID: 20164383.
    Citations: 30     Fields:    Translation:HumansCells
  100. Sun Y, Butler JP, Lindholm P, Walvick RP, Loring SH, Gereige J, Ferrigno M, Albert MS. Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond. Respir Physiol Neurobiol. 2009 Oct 31; 169(1):44-9. PMID: 19664729.
    Citations: 2     Fields:    Translation:Humans
  101. Loring SH, Butler JP, Patz S. Science to practice: how do we interpret the transfer of hyperpolarized 129Xe from blood into alveolar gas? Radiology. 2009 Aug; 252(2):319-21. PMID: 19703872.
    Citations:    Fields:    
  102. Zhou EH, Trepat X, Park CY, Lenormand G, Oliver MN, Mijailovich SM, Hardin C, Weitz DA, Butler JP, Fredberg JJ. Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10632-7. PMID: 19520830.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  103. Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One. 2009; 4(5):e5486. PMID: 19424501.
    Citations: 124     Fields:    Translation:HumansCells
  104. Tokuda Y, Doba N, Butler JP, Paasche-Orlow MK. Health literacy and physical and psychological wellbeing in Japanese adults. Patient Educ Couns. 2009 Jun; 75(3):411-7. PMID: 19403259.
    Citations: 24     Fields:    Translation:Humans
  105. Moghani T, Butler JP, Loring SH. Determinants of friction in soft elastohydrodynamic lubrication. J Biomech. 2009 May 29; 42(8):1069-74. PMID: 19358993.
    Citations: 4     Fields:    
  106. Alencar AM, Butler JP, Mijailovich SM. Thermodynamic origin of cooperativity in actomyosin interactions: the coupling of short-range interactions with actin bending stiffness in an Ising-like model. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Apr; 79(4 Pt 1):041906. PMID: 19518255.
    Citations: 1     Fields:    Translation:Cells
  107. Freeman S, Ebihara S, Ebihara T, Niu K, Kohzuki M, Arai H, Butler JP. Olfactory stimuli and enhanced postural stability in older adults. Gait Posture. 2009 Jun; 29(4):658-60. PMID: 19286382.
    Citations: 5     Fields:    Translation:HumansAnimals
  108. Butler JP, Loring SH. A Potential Elastohydrodynamic Origin of Load-Support and Coulomb-Like Friction in Lung/Chest Wall Lubrication. J Tribol. 2008 Oct; 130(4):41201. PMID: 20890380.
    Citations: 2     
  109. Marinkovic M, Diez-Silva M, Pantic I, Fredberg JJ, Suresh S, Butler JP. Febrile temperature leads to significant stiffening of Plasmodium falciparum parasitized erythrocytes. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C59-64. PMID: 18596215.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  110. Patz S, Muradian I, Hrovat MI, Ruset IC, Topulos G, Covrig SD, Frederick E, Hatabu H, Hersman FW, Butler JP. Human pulmonary imaging and spectroscopy with hyperpolarized 129Xe at 0.2T. Acad Radiol. 2008 Jun; 15(6):713-27. PMID: 18486008.
    Citations: 51     Fields:    Translation:Humans
  111. Lin JL, Moghani T, Fabry B, Butler JP, Loring SH. Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissues. J Biomech. 2008; 41(6):1197-205. PMID: 18367193.
    Citations: 2     Fields:    Translation:Animals
  112. Tsuda A, Henry FS, Butler JP. Gas and aerosol mixing in the acinus. Respir Physiol Neurobiol. 2008 Nov 30; 163(1-3):139-49. PMID: 18396469.
    Citations: 27     Fields:    Translation:HumansAnimals
  113. Dickie R, Wang YT, Butler JP, Schulz H, Tsuda A. Distribution and quantity of contractile tissue in postnatal development of rat alveolar interstitium. Anat Rec (Hoboken). 2008 Jan; 291(1):83-93. PMID: 18085624.
    Citations: 12     Fields:    Translation:Animals
  114. Lenormand G, Bursac P, Butler JP, Fredberg JJ. Out-of-equilibrium dynamics in the cytoskeleton of the living cell. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Oct; 76(4 Pt 1):041901. PMID: 17995020.
    Citations: 11     Fields:    Translation:HumansCells
  115. Patz S, Hersman FW, Muradian I, Hrovat MI, Ruset IC, Ketel S, Jacobson F, Topulos GP, Hatabu H, Butler JP. Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality? Eur J Radiol. 2007 Dec; 64(3):335-44. PMID: 17890035.
    Citations: 51     Fields:    Translation:HumansAnimals
  116. Lenormand G, Chopin J, Bursac P, Fredberg JJ, Butler JP. Directional memory and caged dynamics in cytoskeletal remodelling. Biochem Biophys Res Commun. 2007 Sep 07; 360(4):797-801. PMID: 17631276; PMCID: PMC2394503.
    Citations: 11     Fields:    Translation:HumansCells
  117. Moghani T, Butler JP, Lin JL, Loring SH. Finite Element Simulation of Elastohydrodynamic Lubrication of Soft Biological Tissues. Comput Struct. 2007 Jun; 85(11-14):1114-1120. PMID: 18037975.
    Citations: 6     
  118. Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, Fredberg JJ. Universal physical responses to stretch in the living cell. Nature. 2007 May 31; 447(7144):592-5. PMID: 17538621.
    Citations: 260     Fields:    Translation:HumansAnimalsCells
  119. Oliver MN, Fabry B, Marinkovic A, Mijailovich SM, Butler JP, Fredberg JJ. Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason? Am J Respir Cell Mol Biol. 2007 Sep; 37(3):264-72. PMID: 17463392; PMCID: PMC1994228.
    Citations: 49     Fields:    Translation:HumansAnimals
  120. Puig-de-Morales-Marinkovic M, Turner KT, Butler JP, Fredberg JJ, Suresh S. Viscoelasticity of the human red blood cell. Am J Physiol Cell Physiol