Harvard Catalyst Profiles

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Agnes Shuk Yee Lo, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Davis SM, Hariharan VN, Lo A, Turanov AA, Echeverria D, Sousa J, McHugh N, Biscans A, Alterman JF, Karumanchi SA, Moore MJ, Khvorova A. Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1. Mol Ther Nucleic Acids. 2022 Sep 13; 29:135-149. PMID: 35847173; PMCID: PMC9263991.
  2. Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca CC, Han F, Barse L, Henning SW, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack SR, Ramesh P, Jaishankar D, Lo AS, Moss J, Picken MM, Darling TN, Scholtens DM, Dilling DF, Junghans RP, Le Poole IC. Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice. JCI Insight. 2021 11 22; 6(22). PMID: 34806651; PMCID: PMC8663788.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Berg AH, Tavasoli M, Lo AS, Burnett-Bowie SM, Bhan I, Karumanchi SA, Kalim S, Zhang D, Zhao S, Thadhani RI. Development and analytical validation of a novel bioavailable 25-hydroxyvitamin D assay. PLoS One. 2021; 16(7):e0254158. PMID: 34242315.
    Citations:    Fields:    Translation:Humans
  4. Thomas A, Dellacecca E, Shivde R, Lanki N, Barse L, Lo AS, Scholtens DM, Dilling D, Junghans RP, Le Poole C. Journal of ImmunoTherapy of Cancer. 97 Polyfunctional activity of GD3CAR T-cells against tumors in tuberous sclerosis complex. 2020; 3(8):A108.
  5. Lecarpentier E, Zsengellér ZK, Salahuddin S, Covarrubias AE, Lo A, Haddad B, Thadhani RI, Karumanchi SA. Total Versus Free Placental Growth Factor Levels in the Pathogenesis of Preeclampsia. Hypertension. 2020 09; 76(3):875-883. PMID: 32654553.
    Citations: 3     Fields:    Translation:Humans
  6. Johnson N, Wu C, Mostrom M, Yu S, Lo AS, Li H, Gathum S, Marx PA, von Laer D, Skowron G, Shaw G, Kaur A, Junghans RP, Braun SE. South Central Branch of the American Society for Microbiology. In Vivo Expansion of CMV-Specific anti-HIV CAR T cells following CMV Superinfection. 2019; November 2019.
  7. Zsengellér ZK, Lo A, Tavasoli M, Pernicone E, Karumanchi SA, Rosen S. Soluble fms-Like Tyrosine Kinase 1 Localization in Renal Biopsies of CKD. Kidney Int Rep. 2019 Dec; 4(12):1735-1741. PMID: 31844810; PMCID: PMC6895657.
    Citations: 3     
  8. Johnson N, Wu C, Mostrom M, Yu S, Lo AS, Li H, Gathum S, Marx PA, von Laer D, Skowron G, Shaw G, Kaur A, Junghans RP, Braun SE. American Society of Gene and Cell Therapy. In Vivo Expansion of CMV-Specific anti-HIV CAR T cells following CMV Superinfection. 2019; May 2019.
  9. Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho BMDC, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A. RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nat Biotechnol. 2018 Nov 19. PMID: 30451990; PMCID: PMC6526074.
    Citations: 38     Fields:    
  10. Covarrubias AE, Lecarpentier E, Lo A, Salahuddin S, Gray KJ, Karumanchi SA, Zsengellér ZK. AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis. Am J Pathol. 2019 01; 189(1):104-114. PMID: 30315766; PMCID: PMC6854435.
    Citations: 16     Fields:    Translation:HumansCells
  11. Prete A, Lo AS, Sadow PM, Bhasin SS, Antonello ZA, Vodopivec DM, Ullas S, Sims JN, Clohessy J, Dvorak AM, Sciuto T, Bhasin M, Murphy-Ullrich JE, Lawler J, Karumanchi SA, Nucera C. Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFß1 Axis. Clin Cancer Res. 2018 12 01; 24(23):6078-6097. PMID: 30076136; PMCID: PMC6279578.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  12. Antonello ZA, Hsu N, Bhasin M, Roti G, Joshi M, Van Hummelen P, Ye E, Lo AS, Karumanchi SA, Bryke CR, Nucera C. Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAFV600E. Oncotarget. 2017 Oct 17; 8(49):84743-84760. PMID: 29156680; PMCID: PMC5689570.
    Citations: 23     Fields:    
  13. Rita Horvath, Manish Maski, Zsuzsanna Zsengeller, Agnes Lo, Elizabeth Pernicone, Janos Rigo, S. Ananth Karumanchi. Pregnancy Hypertension. 15 Follistatin-Like 3 Protein (FSTL3) is upregulated in preeclampsia: Biomarkers, prediction of preeclampsia. 2016; 6(3):144. View Publication.
  14. Junghans RP, Ma Q, Rathore R, Gomes EM, Bais AJ, Lo AS, Abedi M, Davies RA, Cabral HJ, Al-Homsi AS, Cohen SI. Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response. Prostate. 2016 10; 76(14):1257-70. PMID: 27324746.
    Citations: 87     Fields:    Translation:HumansCellsCTClinical Trials
  15. Lo AS, Mao X, Mukherjee EM, Ellebrecht CT, Yu X, Posner MR, Payne AS, Cavacini LA. Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris. PLoS One. 2016; 11(6):e0156800. PMID: 27304671.
    Citations: 10     Fields:    Translation:HumansCells
  16. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 07 01; 126(7):2561-74. PMID: 27270170; PMCID: PMC4922717.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  17. Lo AS, Xu C, Murakami A, Marasco WA. Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor. Mol Ther Oncolytics. 2014; 1:14003. PMID: 27119093; PMCID: PMC4782938.
    Citations: 8     
  18. Cho MJ, Lo AS, Mao X, Nagler AR, Ellebrecht CT, Mukherjee EM, Hammers CM, Choi EJ, Sharma PM, Uduman M, Li H, Rux AH, Farber SA, Rubin CB, Kleinstein SH, Sachais BS, Posner MR, Cavacini LA, Payne AS. Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients. Nat Commun. 2014 Jun 19; 5:4167. PMID: 24942562.
    Citations: 28     Fields:    Translation:HumansCells
  19. Ma Q, Gomes EM, Lo AS, Junghans RP. Advanced generation anti-prostate specific membrane antigen designer T cells for prostate cancer immunotherapy. Prostate. 2014 Feb; 74(3):286-96. PMID: 24174378.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  20. Cerdeira AS, Rajakumar A, Royle CM, Lo A, Husain Z, Thadhani RI, Sukhatme VP, Karumanchi SA, Kopcow HD. Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors. J Immunol. 2013 Apr 15; 190(8):3939-48. PMID: 23487420; PMCID: PMC3742368.
    Citations: 83     Fields:    Translation:HumansCells
  21. Junghans RP, Gomes E, Bais A, Lo AS, Davies R, Abedi M, Cohen S, Rathore R. Journal of Immunotherapy. On a Critical Role for IL2 Adjunctive Co-Therapy for Successful Suppression of Solid Tumor With Designer T Cells. November 2012. 2012; 35.
  22. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61. PMID: 22869555.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  23. Ma Q, Wang Y, Lo AS, Gomes EM, Junghans RP. Cell density plays a critical role in ex vivo expansion of T cells for adoptive immunotherapy. J Biomed Biotechnol. 2010; 2010:386545. PMID: 20625484.
    Citations: 19     Fields:    Translation:HumansCells
  24. Lo AS, Ma Q, Liu DL, Junghans RP. Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors. Clin Cancer Res. 2010 May 15; 16(10):2769-80. PMID: 20460472.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  25. Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One. 2010 Mar 10; 5(3):e9625. PMID: 20224781.
    Citations: 19     Fields:    Translation:HumansCells
  26. Emtage PC, Lo AS, Gomes EM, Liu DL, Gonzalo-Daganzo RM, Junghans RP. Second-generation anti-carcinoembryonic antigen designer T cells resist activation-induced cell death, proliferate on tumor contact, secrete cytokines, and exhibit superior antitumor activity in vivo: a preclinical evaluation. Clin Cancer Res. 2008 Dec 15; 14(24):8112-22. PMID: 19088026.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  27. Lo AS, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Handb Exp Pharmacol. 2008; (181):343-73. PMID: 18071953.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  28. Lo AS, Taylor JR, Farzaneh F, Kemeny DM, Dibb NJ, Maher J. Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation. Mol Immunol. 2008 Mar; 45(5):1276-87. PMID: 17950877.
    Citations: 18     Fields:    Translation:HumansCells
  29. Lo AS, Gorak-Stolinska P, Bachy V, Ibrahim MA, Kemeny DM, Maher J. Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3'-kinase and delayed caspase activation. J Leukoc Biol. 2007 Dec; 82(6):1446-54. PMID: 17855501.
    Citations: 7     Fields:    Translation:HumansCells
  30. Lo AS, Liew CT, Ngai SM, Tsui SK, Fung KP, Lee CY, Waye MM. Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1). J Cell Biochem. 2005 Mar 01; 94(4):763-73. PMID: 15565635.
    Citations: 26     Fields:    Translation:Humans
  31. Lo AS, Liew CT, Law PT, Garcia-Barceló M, Tsui SK, Fung KP, Lee CY, Waye MM. Radiation hybrid mapping of human cytosolic malate dehydrogenase (hcMDH) to the short arm of chromosome 2. Somat Cell Mol Genet. 1999 Mar; 25(2):109-13. PMID: 11225055.
    Citations:    Fields:    Translation:HumansCells
  32. Lau JY, Lo SY, Ng EK, Lee DW, Lam YH, Chung SC. A randomized comparison of acute phase response and endotoxemia in patients with perforated peptic ulcers receiving laparoscopic or open patch repair. Am J Surg. 1998 Apr; 175(4):325-7. PMID: 9568663.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  33. Waye M, Cheung HKY, Lam WY, Law PTW, Lo AS, Lui VWY, Luk SCW, Tsui SKW, Tung CKC, Yam NYH, Liew CC, Lee CY. Protein Engineering. Gene-expression of adult human heart as revealed by random sequencing of cDNA library. 1995; 8:January 1995.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.