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Donna Louise McPhie, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia. Nat Commun. 2022 06 27; 13(1):3690. PMID: 35760976; PMCID: PMC9237031.
    Citations:    Fields:    Translation:HumansCells
  2. Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry. 2020 Nov; 25(11):3103-3104. PMID: 31366918.
    Citations: 1     Fields:    
  3. Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nat Neurosci. 2020 11; 23(11):1352-1364. PMID: 33097921.
    Citations: 8     Fields:    Translation:HumansCells
  4. Kathuria A, Lopez-Lengowski K, Jagtap SS, McPhie D, Perlis RH, Cohen BM, Karmacharya R. Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. JAMA Psychiatry. 2020 07 01; 77(7):745-754. PMID: 32186681; PMCID: PMC7081156.
    Citations: 22     Fields:    Translation:HumansCells
  5. Kathuria A, Lopez-Lengowski K, Vater M, McPhie D, Cohen BM, Karmacharya R. Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder. Genome Med. 2020 04 19; 12(1):34. PMID: 32306996; PMCID: PMC7168850.
    Citations: 20     Fields:    Translation:HumansCells
  6. Kathuria A, Lopez-Lengowski K, Watmuff B, McPhie D, Cohen BM, Karmacharya R. Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine. Transl Psychiatry. 2019 11 28; 9(1):321. PMID: 31780643.
    Citations: 19     Fields:    Translation:HumansCells
  7. Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry. 2020 11; 25(11):2873-2888. PMID: 31019265.
    Citations: 18     Fields:    Translation:HumansCells
  8. Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 02; 22(2):229-242. PMID: 30664768; PMCID: PMC6373728.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  9. McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM. Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Transl Psychiatry. 2018 10 23; 8(1):230. PMID: 30352993.
    Citations: 17     Fields:    Translation:HumansCells
  10. Robicsek O, Ene HM, Karry R, Ytzhaki O, Asor E, McPhie D, Cohen BM, Ben-Yehuda R, Weiner I, Ben-Shachar D. Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder. Schizophr Bull. 2018 02 15; 44(2):432-442. PMID: 28586483.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  11. Sonntag KC, Ryu WI, Amirault KM, Healy RA, Siegel AJ, McPhie DL, Forester B, Cohen BM. Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles. Sci Rep. 2017 10 25; 7(1):14038. PMID: 29070876.
    Citations: 49     Fields:    Translation:HumansCells
  12. Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017 02 03; 16(2):481-493. PMID: 28152600.
    Citations: 7     Fields:    Translation:HumansCells
  13. Cameron LA, McPhie DL. Hardware Technologies and Probe Development in Light Microscopy Help Drive Discoveries in Cell Biology: Introduction to a Virtual Symposium in The Biological Bulletin. Biol Bull. 2016 Aug; 231(1):2-4. PMID: 27682179.
    Citations:    Fields:    
  14. Cameron LA, McPhie DL. Hardware Technologies and Probe Development in Light Microscopy Help Drive Discoveries in Cell Biology: Introduction to a Virtual Symposium in The Biological Bulletin. Biol Bull. 2016 08; 231(1):3-4. PMID: 27638690.
    Citations:    Fields:    
  15. Huang JH, Berkovitch SS, Iaconelli J, Watmuff B, Park H, Chattopadhyay S, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates a-Aminoadipate as a Potential Biomarker for Bipolar Disorder. Mol Neuropsychiatry. 2016 Jul; 2(2):97-106. PMID: 27606323; PMCID: PMC4996006.
    Citations: 5     
  16. Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll AT, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA. Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats. PLoS One. 2015; 10(3):e0120693. PMID: 25822989.
    Citations:    Fields:    Translation:AnimalsCells
  17. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):284. PMID: 25623946.
    Citations: 14     Fields:    
  18. Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie DL, Kim KS, Cohen BM, Seo H, Sonntag KC. MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016 Jan; 53(1):95-108. PMID: 25407931; PMCID: PMC4437970.
    Citations: 21     Fields:    Translation:AnimalsCells
  19. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):162-9. PMID: 25403839; PMCID: PMC4394050.
    Citations: 64     Fields:    Translation:HumansCells
  20. McCarthy MJ, Wei H, Marnoy Z, Darvish RM, McPhie DL, Cohen BM, Welsh DK. Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients. Transl Psychiatry. 2013 Oct 22; 3:e318. PMID: 24150227.
    Citations: 45     Fields:    Translation:HumansCells
  21. Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BM. Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report. Stem Cells Int. 2011; 2011:586586. PMID: 22190964.
    Citations: 9     
  22. Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ, Froimowitz MP, Hassinger LC, Menesale EB, Sargent LW, Logan DJ, Carpenter AE, Cohen BM. Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol. 2010 Aug; 177(2):575-85. PMID: 20566748; PMCID: PMC2913344.
    Citations: 89     Fields:    Translation:HumansCells
  23. Laifenfeld D, Patzek LJ, McPhie DL, Chen Y, Levites Y, Cataldo AM, Neve RL. Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. J Neurosci. 2007 Jul 04; 27(27):7141-53. PMID: 17611268; PMCID: PMC6794581.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  24. Chen Y, Bodles AM, McPhie DL, Neve RL, Mrak RE, Griffin WS. APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1. Mol Neurodegener. 2007 Feb 07; 2:3. PMID: 17286867.
    Citations: 13     Fields:    
  25. Neve RL, McPhie DL. Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis. Biochim Biophys Acta. 2007 Apr; 1772(4):430-7. PMID: 17113271; PMCID: PMC1862818.
    Citations: 13     Fields:    Translation:Cells
  26. McPhie DL, Miller MW. Biological Bulletin Virtual Symposium: Marine Invertebrate Models of Learning and Memory. Biol Bull. 2006 Jun; 210(3):171-173. PMID: 27690542.
    Citations:    Fields:    
  27. Neve RL, McPhie DL. The cell cycle as a therapeutic target for Alzheimer's disease. Pharmacol Ther. 2006 Jul; 111(1):99-113. PMID: 16274748.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  28. Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J Cell Biol. 2003 Oct 13; 163(1):27-33. PMID: 14557245; PMCID: PMC2173435.
    Citations: 36     Fields:    Translation:HumansAnimals
  29. McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J Neurosci. 2003 Jul 30; 23(17):6914-27. PMID: 12890786; PMCID: PMC6740729.
    Citations: 49     Fields:    Translation:AnimalsCells
  30. Suhara T, Magrané J, Rosen K, Christensen R, Kim HS, Zheng B, McPhie DL, Walsh K, Querfurth H. Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism. Neurobiol Aging. 2003 May-Jun; 24(3):437-51. PMID: 12600720.
    Citations: 26     Fields:    Translation:HumansCells
  31. McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. Brain Res Mol Brain Res. 2001 Dec 16; 97(1):103-13. PMID: 11744168.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  32. Carlezon WA, Todtenkopf MS, McPhie DL, Pimentel P, Pliakas AM, Stellar JR, Trzcinska M. Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area. Neuropsychopharmacology. 2001 Aug; 25(2):234-41. PMID: 11425507.
    Citations: 11     Fields:    Translation:AnimalsCells
  33. Querfurth HW, Suhara T, Rosen KM, McPhie DL, Fujio Y, Tejada G, Neve RL, Adelman LS, Walsh K. Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy. Mol Cell Neurosci. 2001 May; 17(5):793-810. PMID: 11358479.
    Citations: 18     Fields:    Translation:HumansCells
  34. Neve RL, McPhie DL, Chen Y. Alzheimer's disease: dysfunction of a signalling pathway mediated by the amyloid precursor protein? Biochem Soc Symp. 2001; (67):37-50. PMID: 11447838.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  35. Neve RL, McPhie DL, Chen Y. Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). Brain Res. 2000 Dec 15; 886(1-2):54-66. PMID: 11119687.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  36. Chen Y, McPhie DL, Hirschberg J, Neve RL. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem. 2000 Mar 24; 275(12):8929-35. PMID: 10722740.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  37. Pascale A, Bhagavan S, Nelson TJ, Neve RL, McPhie DL, Etcheberrigaray R. Enhanced BK-induced calcium responsiveness in PC12 cells expressing the C100 fragment of the amyloid precursor protein. Brain Res Mol Brain Res. 1999 Oct 01; 72(2):205-13. PMID: 10529479.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  38. Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Brain Res Mol Brain Res. 1999 Mar 20; 66(1-2):150-62. PMID: 10095087.
    Citations: 31     Fields:    Translation:Animals
  39. Bursztajn S, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, Neve RL. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J Neurosci. 1998 Dec 01; 18(23):9790-9. PMID: 9822738; PMCID: PMC6793279.
    Citations: 19     Fields:    Translation:HumansCells
  40. Neve RL, Coopersmith R, McPhie DL, Santeufemio C, Pratt KG, Murphy CJ, Lynn SD. The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis. J Neurosci. 1998 Oct 01; 18(19):7757-67. PMID: 9742146; PMCID: PMC6793001.
    Citations: 27     Fields:    Translation:HumansCells
  41. McPhie DL, Lee RK, Eckman CB, Olstein DH, Durham SP, Yager D, Younkin SG, Wurtman RJ, Neve RL. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains. J Biol Chem. 1997 Oct 03; 272(40):24743-6. PMID: 9312066.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  42. Nelson TJ, Cavallaro S, Yi CL, McPhie D, Schreurs BG, Gusev PA, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon DL. Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):13808-13. PMID: 8943017; PMCID: PMC19433.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  43. Oster-Granite ML, McPhie DL, Greenan J, Neve RL. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci. 1996 Nov 01; 16(21):6732-41. PMID: 8824314; PMCID: PMC6579256.
    Citations: 55     Fields:    Translation:AnimalsCells
  44. Neve RL, Boyce FM, McPhie DL, Greenan J, Oster-Granite ML. Transgenic mice expressing APP-C100 in the brain. Neurobiol Aging. 1996 Mar-Apr; 17(2):191-203. PMID: 8744400.
    Citations: 15     Fields:    Translation:HumansAnimals
  45. Lester DS, Olds JL, Schreurs BG, McPhie D, Bramham CR, Alkon DL. Incorporation of fluorescent lipids into living rabbit hippocampal and cerebellar slices. Neuroimage. 1994 Nov; 1(4):264-75. PMID: 9343576.
    Citations:    Fields:    Translation:AnimalsCells
  46. Olds JL, Bhalla US, McPhie DL, Lester DS, Bower JM, Alkon DL. Lateralization of membrane-associated protein kinase C in rat piriform cortex: specific to operant training cues in the olfactory modality. Behav Brain Res. 1994 Mar 31; 61(1):37-46. PMID: 8031495.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Ito E, Oka K, Etcheberrigaray R, Nelson TJ, McPhie DL, Tofel-Grehl B, Gibson GE, Alkon DL. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):534-8. PMID: 8290560; PMCID: PMC42983.
    Citations: 120     Fields:    Translation:HumansCells
  48. McPhie DL, Matzel LD, Olds JL, Lester DS, Kuzirian AM, Alkon DL. Cell specificity of molecular changes during memory storage. J Neurochem. 1993 Feb; 60(2):646-51. PMID: 8419542.
    Citations: 6     Fields:    Translation:AnimalsCells
  49. Connor JH, Olds JL, Lester DS, McPhie DL, Senft SL, Johnston JA, Alkon DL. Heterogenous Distribution of Fluorescent Phorbol Ester Signal in Living Sea Urchin Embryos. Biol Bull. 1992 Oct; 183(2):365-366. PMID: 29300655.
    Citations:    Fields:    
  50. Olds JL, Golski S, McPhie DL, Olton D, Mishkin M, Alkon DL. Discrimination learning alters the distribution of protein kinase C in the hippocampus of rats. J Neurosci. 1990 Nov; 10(11):3707-13. PMID: 2230955; PMCID: PMC6570097.
    Citations: 14     Fields:    Translation:Animals
  51. Alkon DL, Ikeno H, Dworkin J, McPhie DL, Olds JL, Lederhendler I, Matzel L, Schreurs BG, Kuzirian A, Collin C, et al. Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1611-4. PMID: 2304920; PMCID: PMC53525.
    Citations: 8     Fields:    Translation:AnimalsCells
  52. Olds JL, Anderson ML, McPhie DL, Staten LD, Alkon DL. Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus. Science. 1989 Aug 25; 245(4920):866-9. PMID: 2772638.
    Citations: 51     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.