Harvard Catalyst Profiles

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Joyce E. Bischoff, Ph.D.

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Available: 10/01/21, Expires: 04/30/24

Infantile hemangioma (IH) is a common vascular tumor with a unique lifecycle of rapid blood vessel formation over the first 6-9 months of infancy, followed by a slow spontaneous involution of blood vessels over several years. For most children, IH does not pose a serious threat and therapy is unnecessary; however, in about 10% of cases, IH can enlarge dramatically, threaten organs and cause permanent disfigurement. Over the last 10 years, propranolol, a well-known non-selective β-adrenergic receptor antagonist, has emerged as first-line therapy for endangering IH, yet how and why it works so well in reducing the vascular overgrowth in IH has remained a mystery. There is a significant need to improve propranolol therapy because up to 18% of IHs fail to respond, up to 25% resume growth when the drug is stopped, and 37% of propranolol-treated infants require surgery at 5-6 years of age to minimize deformity caused by remaining fibrofatty residua. To improve on propranolol therapy for IH, it is essential to elucidate its mechanism of action against vascular overgrowth in IH. Our lab identified a hemangioma stem cell (HemSC) from human IH surgical specimens that can form hemangioma-like vessels within 7 days when implanted into immune-deficient mice. Subsequent studies from our lab and others validate HemSCs as the IH-initiating cell. Our recent results show that a small molecule inhibitor of the transcription factor SOX18 called Sm4 and propranolol both effectively block HemSC-to-endothelial differentiation. Furthermore, the R(+) enantiomer of propranolol, which lacks β-adrenergic receptor antagonistic activity, is equally effective. R+ propranolol can disrupt SOX18 dimer formation in vitro. This novel discovery identifies a β-adrenergic receptor-independent, SOX18-dependent mechanism by which propranolol reduces vascular overgrowth in IH. We are pursuing this by testing the effect of R+ propranolol on IH vessel formation in vivo, investigating the dimerization status of SOX18 in IH and how propranolol and the R(+) enantiomer might alter SOX18-dependent transcription. In parallel, we are also investigating possible genetic contributors to IH, in particular chromosomal translocations or small copy number variants by deep coverage RNA-Seq on freshly isolated IH cells. We hypothesis that genetic abnormalities may alter SOX18 dimerization and its ability to regulate transcription needed to control vascular growth.

Available: 10/01/21, Expires: 06/30/24

This project focuses on the capillary malformations (CM) that characterize Sturge-Weber syndrome (SWS), a rare neurocutaneous disorder in which CMs ? made up of enlarged capillary-like vessels - occur in the skin (sometimes called ?port-wine stain?), the leptomeninges and in the choroid of the eye. SWS patients suffer from neurological defects and glaucoma, as well as disfigurement from CMs on the face, and unfortunately, medical therapies for CMs do not exist and there is no cure. The 2013 discovery of a somatic activating mutation in GNAQ (p.R183Q) in SWS and non-syndromic CMs set the stage for molecular studies. GNAQ encodes Gαq, the α-subunit of the heterotrimeric Gq protein that activates phospholipase Cβ. Our lab showed the GNAQ R183Q allele is enriched in endothelial cells (EC) sorted from CM specimens. We have created cellular and mouse models to elucidate how the GNAQ mutation affects EC function, how these alterations lead to CM, and how we can prevent the formation or growth of CM. Although the mutation is enriched in EC, our goal is to identify the breadth of cell types that carry the somatic GNAQ R183Q allele. We also aim to develop more refined models of CM in mice and zebrafish to use as platforms for testing candidate drugs. On the molecular level, we are deeply investigating the role of protein kinase C (PKC) and angiopoietin-2 (ANGPT2) as downstream effectors of the constitutively active, mutant Gαq. These projects will help us better understand the pathophysiology of CM and hopefully lead to strategies to minimize the myriad of difficulties CM pose for patients with both non-syndromic and SWS CMs.

Available: 10/01/21, Expires: 04/30/23

We study how the mitral valve endothelium responds after myocardial infarction (MI) and how maladaptive responses in the mitral valve leaflets lead to mitral regurgitation. A myriad of changes occur in the mitral valve leaflets post-MI, including endothelial to mesenchymal transition (EndMT), which we?ve shown with our collaborators, Drs. Robert Levine (MGH) and Elena Aikawa (BWH) in an ovine model of inferior MI. In vitro, valve endothelial cells can be induced to undergo EndMT whereas arterial endothelial cells are resistant. We are studying what factors in the post-MI environment drive EndMT, in particular molecules present in post-MI plasma. We are also using RNA-Seq as an unbiased approach to understand changes in gene expression in mitral valve endothelial cells exposed to post-MI plasma. This work has led to discovery of molecules in plasma that prevent EndMT in mitral valve endothelium but whose levels drop precipitously within days following MI. Along-side this work, we collaborate with Dr. Hong Chen (BCH) to study the role of EndMT in atherosclerosis using mouse models. Our long term goal is to identify ways to modulate EndMT in cardiovascular disease in order to prevent fibrosis and tissue stiffening.

A Murine Model of Hemangioma using Cell-based Strategies
Summer, 03/29/04 - 01/04/04
Myeloid cell recruitment is necessary for bio-engineered vessel formation with ECFCs and MPCs in ischemic muscle
Summer, 06/06/12 - 07/25/12
Analysis of mRNA Expression During Cardiac Valve Epithelial-Mesenchymal Transformation
Summer, 06/19/00 - 08/14/00
Role of NFATcl in Control of Heart Valve Endothelial-mesenchymal Transformation
Part Time/Continuation, 09/01/00 - 12/31/00

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Co-Principal Investigator
  2. R01HL127030 (BISCHOFF, JOYCE E.) Apr 1, 2016 - Jun 30, 2024
    Capillary malformation: From somatic GNAQ mutations to disrupted endothelial biology
    Role: Principal Investigator
  3. R21AR063347 (BISCHOFF, JOYCE E.) Apr 1, 2013 - Mar 31, 2015
    Building Vascularized Skeletal Muscle for Tissue Engineering/Regeneration
    Role: Co-Principal Investigator
  4. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2017
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Co-Principal Investigator
  5. R01HL096384 (BISCHOFF, JOYCE E.) Apr 1, 2009 - Apr 30, 2024
    Blood vessel assembly from multipotent hemangioma-derived stem cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bischoff J. Novel Target for Limiting VEGF-A (Vascular Endothelial Growth Factor A)-Induced Vascular Permeability. Arterioscler Thromb Vasc Biol. 2022 10; 42(10):1242-1243. PMID: 36004641.
    Citations:    Fields:    Translation:Cells
  2. Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J. Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. J Am Heart Assoc. 2022 04 05; 11(7):e023695. PMID: 35348006; PMCID: PMC9075477.
    Citations:    Fields:    Translation:AnimalsCells
  3. Seebauer CT, Graus MS, Huang L, McCann A, Wylie-Sears J, Fontaine F, Karnezis T, Zurakowski D, Staffa SJ, Meunier F, Mulliken JB, Bischoff J, Francois M. Non-beta blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. J Clin Invest. 2022 02 01; 132(3). PMID: 34874911; PMCID: PMC8803322.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Huang L, Bichsel C, Norris AL, Thorpe J, Pevsner J, Alexandrescu S, Pinto A, Zurakowski D, Kleiman RJ, Sahin M, Greene AK, Bischoff J. Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels. Arterioscler Thromb Vasc Biol. 2022 01; 42(1):e27-e43. PMID: 34670408; PMCID: PMC8702487.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E. Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients. Front Cardiovasc Med. 2021; 8:688396. PMID: 34458332; PMCID: PMC8387660.
  6. Alvandi Z, Bischoff J. Endothelial-Mesenchymal Transition in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021 09; 41(9):2357-2369. PMID: 34196216; PMCID: PMC8387428.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Dong Y, Lee Y, Cui K, He M, Wang B, Bhattacharjee S, Zhu B, Yago T, Zhang K, Deng L, Ouyang K, Wen A, Cowan DB, Song K, Yu L, Brophy ML, Liu X, Wylie-Sears J, Wu H, Wong S, Cui G, Kawashima Y, Matsumoto H, Kodera Y, Wojcikiewicz RJH, Srivastava S, Bischoff J, Wang DZ, Ley K, Chen H. Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nat Commun. 2020 08 07; 11(1):3984. PMID: 32770009.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Goss JA, Konczyk DJ, Smits P, Sudduth CL, Bischoff J, Liang MG, Greene AK. Diffuse capillary malformation with overgrowth contains somatic PIK3CA variants. Clin Genet. 2020 05; 97(5):736-740. PMID: 31909475.
    Citations: 5     Fields:    Translation:Humans
  9. Huang L, Bischoff J. Isolation of Stem Cells, Endothelial Cells and Pericytes from Human Infantile Hemangioma. Bio Protoc. 2020 Jan 20; 10(2):e3487. PMID: 33654720; PMCID: PMC7842308.
  10. Overman J, Fontaine F, Wylie-Sears J, Moustaqil M, Huang L, Meurer M, Chiang IK, Lesieur E, Patel J, Zuegg J, Pasquier E, Sierecki E, Gambin Y, Hamdan M, Khosrotehrani K, Andelfinger G, Bischoff J, Francois M. R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. Elife. 2019 07 30; 8. PMID: 31358114; PMCID: PMC6667216.
    Citations: 11     Fields:    Translation:HumansAnimals
  11. Bichsel C, Bischoff J. A somatic missense mutation in GNAQ causes capillary malformation. Curr Opin Hematol. 2019 05; 26(3):179-184. PMID: 30870248.
    Citations: 7     Fields:    Translation:HumansAnimals
  12. Bischoff J. Endothelial-to-Mesenchymal Transition. Circ Res. 2019 04 12; 124(8):1163-1165. PMID: 30973806; PMCID: PMC6540806.
    Citations: 32     Fields:    Translation:AnimalsCells
  13. Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res. 2019 02 15; 124(4):e6-e19. PMID: 30595089.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  14. Bichsel CA, Goss J, Alomari M, Alexandrescu S, Robb R, Smith LE, Hochman M, Greene AK, Bischoff J. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. PMID: 30422215; PMCID: PMC6382586.
    Citations: 12     Fields:    Translation:Humans
  15. Toomer K, Sauls K, Fulmer D, Guo L, Moore K, Glover J, Stairley R, Bischoff J, Levine RA, Norris RA. Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development. Anat Rec (Hoboken). 2019 01; 302(1):117-124. PMID: 30288957; PMCID: PMC6312478.
    Citations: 9     Fields:    Translation:AnimalsCells
  16. Wu H, Rahman HNA, Dong Y, Liu X, Lee Y, Wen A, To KH, Xiao L, Birsner AE, Bazinet L, Wong S, Song K, Brophy ML, Mahamud MR, Chang B, Cai X, Pasula S, Kwak S, Yang W, Bischoff J, Xu J, Bielenberg DR, Dixon JB, D'Amato RJ, Srinivasan RS, Chen H. Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes. J Clin Invest. 2018 08 31; 128(9):4025-4043. PMID: 30102256; PMCID: PMC6118634.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  17. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. PMID: 29766399.
    Citations: 209     Fields:    Translation:HumansAnimals
  18. Bischoff J. PTEN (Phosphatase and Tensin Homolog) Connection in Hereditary Hemorrhagic Telangiectasia 2. Arterioscler Thromb Vasc Biol. 2018 05; 38(5):984-985. PMID: 29695532; PMCID: PMC6636313.
    Citations: 1     Fields:    Translation:HumansAnimals
  19. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642. PMID: 29626080.
    Citations: 1     Fields:    Translation:Humans
  20. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677. PMID: 29248661.
    Citations: 17     Fields:    Translation:Humans
  21. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 19     Fields:    Translation:HumansAnimals
  22. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786; PMCID: PMC5679094.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  23. Kang KT, Lin RZ, Kuppermann D, Melero-Martin JM, Bischoff J. Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle. Sci Rep. 2017 04 10; 7(1):770. PMID: 28396600.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  24. Couto JA, Ayturk UM, Konczyk DJ, Goss JA, Huang AY, Hann S, Reeve JL, Liang MG, Bischoff J, Warman ML, Greene AK. A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth. Angiogenesis. 2017 Aug; 20(3):303-306. PMID: 28120216; PMCID: PMC5511772.
    Citations: 34     Fields:    Translation:HumansCells
  25. Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs YS, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, Bischoff J, Yoon E, Buckanovich RJ. EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res. 2016 11 01; 76(21):6396-6409. PMID: 27803106; PMCID: PMC5120866.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  26. Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017 02; 67:59-63. PMID: 27919468; PMCID: PMC5303551.
    Citations: 20     Fields:    Translation:HumansCells
  27. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208; PMCID: PMC5215059.
    Citations: 38     Fields:    Translation:AnimalsCells
  28. Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HPW, Bischoff J, Greene AK, Warman ML. Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. Am J Hum Genet. 2016 06 02; 98(6):1271. PMID: 27259057; PMCID: PMC4908183.
    Citations: 16     Fields:    
  29. Ye X, Abou-Rayyah Y, Bischoff J, Ritchie A, Sebire NJ, Watts P, Churchill AJ, Bates DO. Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma. J Pathol. 2016 06; 239(2):139-51. PMID: 26957058; PMCID: PMC4869683.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK, Warman ML. Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. Am J Hum Genet. 2016 Apr 07; 98(4):789-95. PMID: 27058448; PMCID: PMC4833432.
    Citations: 39     Fields:    Translation:HumansCells
  31. Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1. PMID: 26976355; PMCID: PMC4829123.
    Citations:    Fields:    Translation:Humans
  32. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87. PMID: 26796392; PMCID: PMC5099077.
    Citations: 35     Fields:    Translation:Animals
  33. Couto JA, Huang L, Vivero MP, Kamitaki N, Maclellan RA, Mulliken JB, Bischoff J, Warman ML, Greene AK. Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations. Plast Reconstr Surg. 2016 Jan; 137(1):77e-82e. PMID: 26368330; PMCID: PMC5242181.
    Citations: 43     Fields:    Translation:HumansCells
  34. Rossi E, Smadja DM, Boscolo E, Langa C, Arevalo MA, Pericacho M, Gamella-Pozuelo L, Kauskot A, Botella LM, Gaussem P, Bischoff J, Lopez-Novoa JM, Bernabeu C. Endoglin regulates mural cell adhesion in the circulatory system. Cell Mol Life Sci. 2016 Apr; 73(8):1715-39. PMID: 26646071; PMCID: PMC4805714.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  35. Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016 Jan; 19(1):95-106. PMID: 26625874.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
    Citations: 95     Fields:    Translation:Humans
  37. Boscolo E, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Natynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J Clin Invest. 2015 Sep; 125(9):3491-504. PMID: 26258417; PMCID: PMC4588237.
    Citations: 55     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  38. Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis. 2015 Sep; 242(1):251-260. PMID: 26232165.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  39. Hofmann NA, Yang J, Trauger SA, Nakayama H, Huang L, Strunk D, Moses MA, Klagsbrun M, Bischoff J, Graier WF. The GPR 55 agonist, L-a-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis. Br J Pharmacol. 2015 Aug; 172(16):4107-18. PMID: 25989290; PMCID: PMC4543616.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  40. Nakayama H, Huang L, Kelly RP, Oudenaarden CR, Dagher A, Hofmann NA, Moses MA, Bischoff J, Klagsbrun M. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins. Biochem Biophys Res Commun. 2015 Aug 14; 464(1):126-32. PMID: 26086095; PMCID: PMC6549231.
    Citations: 4     Fields:    Translation:HumansCells
  41. Smadja DM, Levy M, Huang L, Rossi E, Blandinières A, Israel-Biet D, Gaussem P, Bischoff J. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015 Oct; 114(4):735-47. PMID: 26062754; PMCID: PMC6570989.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Shapero K, Wylie-Sears J, Levine RA, Mayer JE, Bischoff J. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015 Mar; 80:175-85. PMID: 25633835; PMCID: PMC4346432.
    Citations: 31     Fields:    Translation:AnimalsCells
  43. Huang L, Nakayama H, Klagsbrun M, Mulliken JB, Bischoff J. Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells. Stem Cells. 2015 Jan; 33(1):133-45. PMID: 25187207.
    Citations: 28     Fields:    Translation:HumansCells
  44. Jia D, Huang L, Bischoff J, Moses MA. The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells. FASEB J. 2015 Apr; 29(4):1371-82. PMID: 25550468; PMCID: PMC4734806.
    Citations: 7     Fields:    Translation:HumansCells
  45. Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML, Bischoff J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015 Apr; 18(2):151-62. PMID: 25424831; PMCID: PMC4366356.
    Citations: 46     Fields:    Translation:HumansCells
  46. Gelfand MV, Hagan N, Tata A, Oh WJ, Lacoste B, Kang KT, Kopycinska J, Bischoff J, Wang JH, Gu C. Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife. 2014 Sep 22; 3:e03720. PMID: 25244320.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  47. Lee D, Boscolo E, Durham JT, Mulliken JB, Herman IM, Bischoff J. Propranolol targets the contractility of infantile haemangioma-derived pericytes. Br J Dermatol. 2014 Nov; 171(5):1129-37. PMID: 24720697.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  48. Smadja DM, Dorfmüller P, Guerin CL, Bieche I, Badoual C, Boscolo E, Kambouchner M, Cazes A, Mercier O, Humbert M, Gaussem P, Bischoff J, Israël-Biet D. Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway. Thromb Haemost. 2014 Nov; 112(5):1002-13. PMID: 25103869.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  49. Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-ß-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18; 446(4):870-5. PMID: 24632204.
    Citations: 31     Fields:    Translation:AnimalsCells
  50. Smadja DM, Guerin CL, Boscolo E, Bieche I, Mulliken JB, Bischoff J. a6-Integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells. Stem Cells. 2014 Mar; 32(3):684-93. PMID: 24022922.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  51. Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1a mediates vascular dysfunction in diabetes. Cell Metab. 2014 Feb 04; 19(2):246-58. PMID: 24506866.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  52. Allen P, Kang KT, Bischoff J. Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices. J Tissue Eng Regen Med. 2015 May; 9(5):632-6. PMID: 23955835.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  53. Kang KT, Coggins M, Xiao C, Rosenzweig A, Bischoff J. Human vasculogenic cells form functional blood vessels and mitigate adverse remodeling after ischemia reperfusion injury in rats. Angiogenesis. 2013 Oct; 16(4):773-84. PMID: 23666122.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  54. Kolpa HJ, Peal DS, Lynch SN, Giokas AC, Ghatak S, Misra S, Norris RA, Macrae CA, Markwald RR, Ellinor P, Bischoff J, Milan DJ. miR-21 represses Pdcd4 during cardiac valvulogenesis. Development. 2013 May; 140(10):2172-80. PMID: 23578931.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  55. Boscolo E, Mulliken JB, Bischoff J. Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):501-9. PMID: 23288163.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  56. Smadja DM, Mulliken JB, Bischoff J. E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol. 2012 Dec; 181(6):2239-47. PMID: 23041613; PMCID: PMC3509767.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  57. Camci-Unal G, Nichol JW, Bae H, Tekin H, Bischoff J, Khademhosseini A. Hydrogel surfaces to promote attachment and spreading of endothelial progenitor cells. J Tissue Eng Regen Med. 2013 May; 7(5):337-47. PMID: 22223475.
    Citations: 17     Fields:    Translation:HumansCells
  58. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. PMID: 22123981.
    Citations: 69     Fields:    Translation:AnimalsCells
  59. Kang KT, Allen P, Bischoff J. Bioengineered human vascular networks transplanted into secondary mice reconnect with the host vasculature and re-establish perfusion. Blood. 2011 Dec 15; 118(25):6718-21. PMID: 22039257; PMCID: PMC3242724.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  60. Lu L, Bischoff J, Mulliken JB, Bielenberg DR, Fishman SJ, Greene AK. Increased endothelial progenitor cells and vasculogenic factors in higher-staged arteriovenous malformations. Plast Reconstr Surg. 2011 Oct; 128(4):260e-269e. PMID: 21921738; PMCID: PMC4066897.
    Citations: 9     Fields:    Translation:HumansCells
  61. Greenberger S, Yuan S, Walsh LA, Boscolo E, Kang KT, Matthews B, Mulliken JB, Bischoff J. Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma. J Invest Dermatol. 2011 Dec; 131(12):2467-76. PMID: 21938011.
    Citations: 32     Fields:    Translation:HumansCells
  62. Boscolo E, Mulliken JB, Bischoff J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol. 2011 Nov; 179(5):2266-77. PMID: 21945324; PMCID: PMC3204018.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  63. Greenberger S, Bischoff J. Infantile hemangioma-mechanism(s) of drug action on a vascular tumor. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a006460. PMID: 22229118.
    Citations: 32     Fields:    Translation:Humans
  64. Adepoju O, Wong A, Kitajewski A, Tong K, Boscolo E, Bischoff J, Kitajewski J, Wu JK. Expression of HES and HEY genes in infantile hemangiomas. Vasc Cell. 2011 Aug 11; 3:19. PMID: 21834989.
    Citations: 13     
  65. Bischoff J, Aikawa E. Progenitor cells confer plasticity to cardiac valve endothelium. J Cardiovasc Transl Res. 2011 Dec; 4(6):710-9. PMID: 21789724.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  66. Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J. JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2181-92. PMID: 21757656.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  67. Allen P, Melero-Martin J, Bischoff J. Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks. J Tissue Eng Regen Med. 2011 Apr; 5(4):e74-86. PMID: 21413157.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  68. Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J. Mitral valve endothelial cells with osteogenic differentiation potential. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):598-607. PMID: 21164078.
    Citations: 61     Fields:    Translation:AnimalsCells
  69. Greenberger S, Adini I, Boscolo E, Mulliken JB, Bischoff J. Targeting NF-?B in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis. 2010 Dec; 13(4):327-35. PMID: 20872175.
    Citations: 22     Fields:    Translation:HumansCells
  70. Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E. Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue Eng Part C Methods. 2010 Aug; 16(4):597-607. PMID: 19751103.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  71. Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J. Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo. Tissue Eng Part A. 2010 Aug; 16(8):2457-66. PMID: 20218762.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  72. Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med. 2010 Mar 18; 362(11):1005-13. PMID: 20237346; PMCID: PMC2845924.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  73. Wu JK, Adepoju O, De Silva D, Baribault K, Boscolo E, Bischoff J, Kitajewski J. A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. Angiogenesis. 2010 Mar; 13(1):15-23. PMID: 20069356.
    Citations: 24     Fields:    Translation:HumansCells
  74. Jang GH, Park IS, Yang JH, Bischoff J, Lee YM. Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells. FEBS Lett. 2010 Jan 04; 584(1):141-6. PMID: 19914243.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  75. Sales VL, Mettler BA, Engelmayr GC, Aikawa E, Bischoff J, Martin DP, Exarhopoulos A, Moses MA, Schoen FJ, Sacks MS, Mayer JE. Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves. Tissue Eng Part A. 2010 Jan; 16(1):257-67. PMID: 19698056.
    Citations: 25     Fields:    Translation:AnimalsCells
  76. Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince TA, Kozakewich H, Bischoff J, Cataltepe S. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009 Nov; 23(11):3865-73. PMID: 19625659.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  77. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A. Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. Circulation. 2009 Jul 28; 120(4):334-42. PMID: 19597052; PMCID: PMC2752046.
    Citations: 95     Fields:    Translation:Animals
  78. Boscolo E, Bischoff J. Vasculogenesis in infantile hemangioma. Angiogenesis. 2009; 12(2):197-207. PMID: 19430954.
    Citations: 45     Fields:    Translation:HumansCells
  79. Bischoff J. Progenitor cells in infantile hemangioma. J Craniofac Surg. 2009 Mar; 20 Suppl 1:695-7. PMID: 19169153; PMCID: PMC2810465.
    Citations: 10     Fields:    Translation:HumansCells
  80. Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008 Nov; 14(11):1236-46. PMID: 18931684; PMCID: PMC2593632.
    Citations: 126     Fields:    Translation:HumansCells
  81. Dudley AC, Khan ZA, Shih SC, Kang SY, Zwaans BM, Bischoff J, Klagsbrun M. Calcification of multipotent prostate tumor endothelium. Cancer Cell. 2008 Sep 09; 14(3):201-11. PMID: 18772110.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  82. Yang JH, Wylie-Sears J, Bischoff J. Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):512-6. PMID: 18647596.
    Citations: 30     Fields:    Translation:HumansAnimals
  83. Mettler BA, Sales VL, Stucken CL, Anttila V, Mendelson K, Bischoff J, Mayer JE. Stem cell-derived, tissue-engineered pulmonary artery augmentation patches in vivo. Ann Thorac Surg. 2008 Jul; 86(1):132-40; discussion 140-1. PMID: 18573411.
    Citations: 3     Fields:    Translation:AnimalsCells
  84. Khan ZA, Boscolo E, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 2008 Jul; 118(7):2592-9. PMID: 18535669; PMCID: PMC2413184.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  85. Melero-Martin JM, De Obaldia ME, Kang SY, Khan ZA, Yuan L, Oettgen P, Bischoff J. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res. 2008 Jul 18; 103(2):194-202. PMID: 18556575.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  86. Picard A, Boscolo E, Khan ZA, Bartch TC, Mulliken JB, Vazquez MP, Bischoff J. IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma. Pediatr Res. 2008 Mar; 63(3):263-7. PMID: 18287964.
    Citations: 13     Fields:    Translation:Humans
  87. Melero-Martin JM, Bischoff J. Chapter 13. An in vivo experimental model for postnatal vasculogenesis. Methods Enzymol. 2008; 445:303-29. PMID: 19022065.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  88. Bischoff J, Griffioen AW. In memoriam Dr. Judah Folkman. Angiogenesis. 2008; 11(1):1-2. PMID: 18317938.
    Citations: 1     Fields:    Translation:Humans
  89. Mulliken JB, Bischoff J, Kozakewich HP. Multifocal rapidly involuting congenital hemangioma: a link to chorangioma. Am J Med Genet A. 2007 Dec 15; 143A(24):3038-46. PMID: 17937433.
    Citations: 2     Fields:    Translation:Humans
  90. Wu X, Lensch MW, Wylie-Sears J, Daley GQ, Bischoff J. Hemogenic endothelial progenitor cells isolated from human umbilical cord blood. Stem Cells. 2007 Nov; 25(11):2770-6. PMID: 17641248.
    Citations: 12     Fields:    Translation:HumansCells
  91. Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood. 2007 Jun 01; 109(11):4761-8. PMID: 17327403.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  92. Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Circ Res. 2006 Oct 13; 99(8):861-9. PMID: 16973908; PMCID: PMC2810464.
    Citations: 75     Fields:    Translation:HumansCells
  93. Amiel GE, Komura M, Shapira O, Yoo JJ, Yazdani S, Berry J, Kaushal S, Bischoff J, Atala A, Soker S. Engineering of blood vessels from acellular collagen matrices coated with human endothelial cells. Tissue Eng. 2006 Aug; 12(8):2355-65. PMID: 16968175.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  94. Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood. 2006 Aug 01; 108(3):915-21. PMID: 16861344; PMCID: PMC1895853.
    Citations: 44     Fields:    Translation:HumansCells
  95. Yu Y, Fuhr J, Boye E, Gyorffy S, Soker S, Atala A, Mulliken JB, Bischoff J. Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells. 2006 Jun; 24(6):1605-12. PMID: 16456130.
    Citations: 39     Fields:    Translation:HumansCells
  96. Lee YM, Cope JJ, Ackermann GE, Goishi K, Armstrong EJ, Paw BH, Bischoff J. Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev Dyn. 2006 Jan; 235(1):29-37. PMID: 16170785; PMCID: PMC2811314.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  97. Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ, Friedlander SF, Boon L, Chamlin SL, Baselga E, Garzon MC, Nopper AJ, Siegel DH, Mathes EW, Goddard DS, Bischoff J, North PE, Esterly NB. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA. Pediatr Dermatol. 2005 Sep-Oct; 22(5):383-406. PMID: 16190987.
    Citations: 70     Fields:    Translation:Humans
  98. Armstrong EJ, Bischoff J. Heart valve development: endothelial cell signaling and differentiation. Circ Res. 2004 Sep 03; 95(5):459-70. PMID: 15345668; PMCID: PMC2810618.
    Citations: 268     Fields:    Translation:HumansAnimalsCells
  99. Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J. Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H480-7. PMID: 15277191.
    Citations: 52     Fields:    Translation:HumansCells
  100. Yu Y, Wylie-Sears J, Boscolo E, Mulliken JB, Bischoff J. Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression. Mol Med. 2004 Jul-Dec; 10(7-12):117-23. PMID: 15706404; PMCID: PMC1431374.
    Citations: 11     Fields:    Translation:Humans
  101. Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS. E-selectin is required for the antiangiogenic activity of endostatin. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8005-10. PMID: 15148373; PMCID: PMC419547.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  102. Yu Y, Flint AF, Mulliken JB, Wu JK, Bischoff J. Endothelial progenitor cells in infantile hemangioma. Blood. 2004 Feb 15; 103(4):1373-5. PMID: 14576053.
    Citations: 53     Fields:    Translation:HumansCells
  103. Li Q, Yu Y, Bischoff J, Mulliken JB, Olsen BR. Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin. J Pathol. 2003 Oct; 201(2):296-302. PMID: 14517847.
    Citations: 34     Fields:    Translation:HumansCells
  104. Dvorin EL, Jacobson J, Roth SJ, Bischoff J. Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes. J Heart Valve Dis. 2003 Sep; 12(5):617-24. PMID: 14565715; PMCID: PMC2810620.
    Citations: 8     Fields:    Translation:HumansCells
  105. Dvorin EL, Wylie-Sears J, Kaushal S, Martin DP, Bischoff J. Quantitative evaluation of endothelial progenitors and cardiac valve endothelial cells: proliferation and differentiation on poly-glycolic acid/poly-4-hydroxybutyrate scaffold in response to vascular endothelial growth factor and transforming growth factor beta1. Tissue Eng. 2003 Jun; 9(3):487-93. PMID: 12857416.
    Citations: 13     Fields:    Translation:Cells
  106. Perry TE, Kaushal S, Sutherland FW, Guleserian KJ, Bischoff J, Sacks M, Mayer JE. Thoracic Surgery Directors Association Award. Bone marrow as a cell source for tissue engineering heart valves. Ann Thorac Surg. 2003 Mar; 75(3):761-7; discussion 767. PMID: 12645690.
    Citations: 16     Fields:    Translation:AnimalsCells
  107. Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J. NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J Biol Chem. 2003 Jan 17; 278(3):1686-92. PMID: 12427739.
    Citations: 41     Fields:    Translation:HumansCells
  108. Bischoff J. Monoclonal expansion of endothelial cells in hemangioma: an intrinsic defect with extrinsic consequences? Trends Cardiovasc Med. 2002 Jul; 12(5):220-4. PMID: 12161076.
    Citations: 6     Fields:    Translation:Humans
  109. Yu Y, Flint A, Dvorin EL, Bischoff J. AC133-2, a novel isoform of human AC133 stem cell antigen. J Biol Chem. 2002 Jun 07; 277(23):20711-6. PMID: 12042327.
    Citations: 40     Fields:    Translation:HumansCells
  110. Yu Y, Varughese J, Brown LF, Mulliken JB, Bischoff J. Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol. 2001 Dec; 159(6):2271-80. PMID: 11733376; PMCID: PMC1850579.
    Citations: 40     Fields:    Translation:HumansCells
  111. Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J. Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro. Am J Pathol. 2001 Oct; 159(4):1335-43. PMID: 11583961; PMCID: PMC1850524.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  112. Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE. Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med. 2001 Sep; 7(9):1035-40. PMID: 11533707; PMCID: PMC2818999.
    Citations: 189     Fields:    Translation:AnimalsCells
  113. Boye E, Yu Y, Paranya G, Mulliken JB, Olsen BR, Bischoff J. Clonality and altered behavior of endothelial cells from hemangiomas. J Clin Invest. 2001 Mar; 107(6):745-52. PMID: 11254674; PMCID: PMC208946.
    Citations: 68     Fields:    Translation:HumansCells
  114. Luo J, Kato M, Wang H, Bernfield M, Bischoff J. Heparan sulfate and chondroitin sulfate proteoglycans inhibit E-selectin binding to endothelial cells. J Cell Biochem. 2001; 80(4):522-31. PMID: 11169736.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  115. Tomlinson J, Wang JL, Barsky SH, Lee MC, Bischoff J, Nguyen M. Human colon cancer cells express multiple glycoprotein ligands for E-selectin. Int J Oncol. 2000 Feb; 16(2):347-53. PMID: 10639580.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  116. Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med. 1999 Dec; 5(12):1390-5. PMID: 10581081.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  117. Luo J, Paranya G, Bischoff J. Noninflammatory expression of E-selectin is regulated by cell growth. Blood. 1999 Jun 01; 93(11):3785-91. PMID: 10339484.
    Citations: 7     Fields:    Translation:HumansCells
  118. Luo J, Lin J, Paranya G, Bischoff J. Angiostatin upregulates E-selectin in proliferating endothelial cells. Biochem Biophys Res Commun. 1998 Apr 28; 245(3):906-11. PMID: 9588213.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  119. Kräling BM, Bischoff J. A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors. In Vitro Cell Dev Biol Anim. 1998 Apr; 34(4):308-15. PMID: 9590504.
    Citations: 18     Fields:    Translation:HumansCells
  120. Razon MJ, Kräling BM, Mulliken JB, Bischoff J. Increased apoptosis coincides with onset of involution in infantile hemangioma. Microcirculation. 1998; 5(2-3):189-95. PMID: 9789259.
    Citations: 25     Fields:    Translation:Humans
  121. Bischoff J. Cell adhesion and angiogenesis. J Clin Invest. 1997 Dec 01; 100(11 Suppl):S37-9. PMID: 9413399.
    Citations: 9     Fields:    
  122. Bischoff J, Brasel C, Kräling B, Vranovska K. E-selectin is upregulated in proliferating endothelial cells in vitro. Microcirculation. 1997 Jun; 4(2):279-87. PMID: 9219220.
    Citations: 11     Fields:    Translation:AnimalsCells
  123. Bischoff J. Cell adhesion and angiogenesis. J Clin Invest. 1997 Feb 01; 99(3):373-6. PMID: 9022067; PMCID: PMC507807.
    Citations: 25     Fields:    Translation:HumansAnimals
  124. Budson AE, Ko L, Brasel C, Bischoff J. The angiogenesis inhibitor AGM-1470 selectively increases E-selectin. Biochem Biophys Res Commun. 1996 Aug 05; 225(1):141-5. PMID: 8769107.
    Citations: 2     Fields:    Translation:AnimalsCells
  125. Zünd G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, Colgan SP. Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7075-80. PMID: 8692947; PMCID: PMC38938.
    Citations: 10     Fields:    Translation:AnimalsCells
  126. Kräling BM, Razon MJ, Boon LM, Zurakowski D, Seachord C, Darveau RP, Mulliken JB, Corless CL, Bischoff J. E-selectin is present in proliferating endothelial cells in human hemangiomas. Am J Pathol. 1996 Apr; 148(4):1181-91. PMID: 8644859; PMCID: PMC1861523.
    Citations: 37     Fields:    Translation:Humans
  127. Bischoff J, Brasel C. Regulation of P-selectin by tumor necrosis factor-alpha. Biochem Biophys Res Commun. 1995 May 05; 210(1):174-80. PMID: 7537962.
    Citations: 10     Fields:    Translation:AnimalsCells
  128. Bischoff J. Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol. 1995 Feb; 5(2):69-74. PMID: 14731415.
    Citations: 24     Fields:    
  129. Nguyen M, Strubel NA, Bischoff J. A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nature. 1993 Sep 16; 365(6443):267-9. PMID: 7690465.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  130. Strubel NA, Nguyen M, Kansas GS, Tedder TF, Bischoff J. Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. Biochem Biophys Res Commun. 1993 Apr 30; 192(2):338-44. PMID: 7683458.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  131. Nguyen M, Folkman J, Bischoff J. 1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells. J Biol Chem. 1992 Dec 25; 267(36):26157-65. PMID: 1464626.
    Citations: 17     Fields:    Translation:AnimalsCells
  132. Bischoff J, Moremen K, Lodish HF. Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase. J Biol Chem. 1990 Oct 05; 265(28):17110-7. PMID: 2211613.
    Citations: 17     Fields:    Translation:AnimalsCells
  133. Bischoff J, Libresco S, Shia MA, Lodish HF. The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells. J Cell Biol. 1988 Apr; 106(4):1067-74. PMID: 2834401; PMCID: PMC2114991.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.