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Vetrivelan Ramalingam, Ph.D.

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Available: 02/18/22, Expires: 03/01/24

Rapid eye movement (REM) sleep is a distinct state of sleep during which vivid dreams occur. This stage of sleep is severely dysregulated in several neuropsychiatric disorders including major depression, bipolar disorder, post-traumatic stress disorder. The major goal of the project is to identify the neural elements responsible for REM sleep abnormalities in such disorders. The student will be able to learn and apply several modern genetic tools such as calcium imaging, optogenetics and chemogenetic methods and behavioral techniques in animal models to study this problem.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS119223 (RAMALINGAM, VETRIVELAN) Jul 1, 2021 - Apr 30, 2026
    Neural mechanisms underlying cataplexy control by MCH neurons
    Role: Principal Investigator
  2. R01NS088482 (RAMALINGAM, VETRIVELAN) Apr 1, 2015 - Mar 31, 2020
    Neural mechanisms underlying REM sleep regulation by MCH neurons
    Role: Principal Investigator
  3. R21NS074205 (RAMALINGAM, VETRIVELAN) Apr 1, 2012 - Mar 31, 2015
    Genetic dissection of sleep regulation by ventrolateral preoptic area
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wen YJ, Yang WJ, Guo CN, Qiu MH, Kroeger D, Niu JG, Zhan SQ, Yang XF, Gisabella B, Vetrivelan R, Lu J. Pontine control of rapid eye movement sleep and fear memory. CNS Neurosci Ther. 2023 Feb 16. PMID: 36794544.
    Citations:    Fields:    
  2. Kroeger D, Vetrivelan R. To sleep or not to sleep - Effects on memory in normal aging and disease. Aging Brain. 2023; 3:100068. PMID: 36911260.
  3. Fan FF, Vetrivelan R, Yang Y, Guo ZN, Lu J. Role of pontine sub-laterodorsal tegmental nucleus (SLD) in rapid eye movement (REM) sleep, cataplexy, and emotion. CNS Neurosci Ther. 2022 Dec 30. PMID: 36585816.
    Citations:    Fields:    
  4. Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CA. Chronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158. PMID: 35150732.
    Citations:    Fields:    Translation:HumansAnimals
  5. Bandaru SS, Khanday MA, Ibrahim N, Naganuma F, Vetrivelan R. Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings. Curr Neurol Neurosci Rep. 2020 10 02; 20(12):55. PMID: 33006677.
    Citations: 3     Fields:    Translation:HumansCells
  6. Wen Y, Lv Y, Niu J, Xin C, Cui L, Vetrivelan R, Lu J. Roles of motor and cortical activity in sleep rebound in rat. Eur J Neurosci. 2020 11; 52(9):4100-4114. PMID: 32588491.
    Citations:    Fields:    Translation:Animals
  7. Negro A, Seidel JL, Houben T, Yu ES, Rosen I, Arreguin AJ, Yalcin N, Shorser-Gentile L, Pearlman L, Sadhegian H, Vetrivelan R, Chamberlin NL, Ayata C, Martelletti P, Moskowitz MA, Eikermann-Haerter K. Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization. J Headache Pain. 2020 Jul 06; 21(1):86. PMID: 32631251.
    Citations: 5     Fields:    Translation:Animals
  8. Lombardi F, Gómez-Extremera M, Bernaola-Galván P, Vetrivelan R, Saper CB, Scammell TE, Ivanov PC. Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake. J Neurosci. 2020 01 02; 40(1):171-190. PMID: 31694962.
    Citations: 9     Fields:    Translation:Animals
  9. Naganuma F, Kroeger D, Bandaru SS, Absi G, Madara JC, Vetrivelan R. Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia. PLoS Biol. 2019 03; 17(3):e3000172. PMID: 30893297; PMCID: PMC6426208.
    Citations: 13     Fields:    Translation:AnimalsCells
  10. Kroeger D, Bandaru SS, Madara JC, Vetrivelan R. Ventrolateral periaqueductal gray mediates rapid eye movement sleep regulation by melanin-concentrating hormone neurons. Neuroscience. 2019 05 15; 406:314-324. PMID: 30890480.
    Citations: 7     Fields:    Translation:AnimalsCells
  11. Vetrivelan R., Lu J. Rapid-Eye-Movement Sleep Behavior Disorder; Schenck C., Högl B., Videnovic A. (eds). Neural Circuitry Regulating REM Sleep and Its Implication in REM Sleep Behavior Disorder. 2019; 559-577.
  12. Leise TL, Goldberg A, Michael J, Montoya G, Solow S, Molyneux P, Vetrivelan R, Harrington ME. Recurring circadian disruption alters circadian clock sensitivity to resetting. Eur J Neurosci. 2020 06; 51(12):2343-2354. PMID: 30269396.
    Citations: 8     Fields:    Translation:Animals
  13. Kroeger D, Absi G, Gagliardi C, Bandaru SS, Madara JC, Ferrari LL, Arrigoni E, Münzberg H, Scammell TE, Saper CB, Vetrivelan R. Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun. 2018 10 08; 9(1):4129. PMID: 30297727.
    Citations: 58     Fields:    Translation:AnimalsCells
  14. Naganuma F, Bandaru SS, Absi G, Chee MJ, Vetrivelan R. Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release. Brain Struct Funct. 2019 Jan; 224(1):99-110. PMID: 30284033; PMCID: PMC6369018.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Naganuma F, Bandaru SS, Absi G, Mahoney CE, Scammell TE, Vetrivelan R. Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis. 2018 12; 120:12-20. PMID: 30149182; PMCID: PMC6195361.
    Citations: 10     Fields:    Translation:AnimalsCells
  16. Chen MC, Vetrivelan R, Guo CN, Chang C, Fuller PM, Lu J. Ventral medullary control of rapid eye movement sleep and atonia. Exp Neurol. 2017 04; 290:53-62. PMID: 28077261; PMCID: PMC5844261.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. 2016 Nov 12; 336:102-113. PMID: 27595887.
    Citations: 34     Fields:    Translation:AnimalsCells
  18. Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 08 18; 536(7616):360. PMID: 27281219.
    Citations: 6     Fields:    
  19. Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 04 07; 532(7597):112-6. PMID: 27027295; PMCID: PMC5549630.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  20. Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55. PMID: 26496606.
    Citations: 275     Fields:    Translation:HumansAnimalsCells
  21. Qiu MH, Yao QL, Vetrivelan R, Chen MC, Lu J. Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep. Cereb Cortex. 2016 Apr; 26(4):1430-9. PMID: 25316334.
    Citations: 24     Fields:    Translation:AnimalsCells
  22. Vetrivelan R, Saper CB, Fuller PM. Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep. 2014; 6:57-63. PMID: 24833927.
    Citations: 7     
  23. Ramaligam V, Chen MC, Saper CB, Lu J. Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder. Sleep Med. 2013 Aug; 14(8):707-13. PMID: 23768838.
    Citations: 5     Fields:    Translation:HumansAnimals
  24. Anaclet C, Lin JS, Vetrivelan R, Krenzer M, Vong L, Fuller PM, Lu J. Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. J Neurosci. 2012 Dec 12; 32(50):17970-6. PMID: 23238713.
    Citations: 45     Fields:    Translation:AnimalsCells
  25. Vetrivelan R, Fuller PM, Yokota S, Lu J, Saper CB. Metabolic effects of chronic sleep restriction in rats. Sleep. 2012 Nov 01; 35(11):1511-20. PMID: 23115400.
    Citations: 26     Fields:    Translation:Animals
  26. Vetrivelan R, Chang C, Lu J. Muscle tone regulation during REM sleep: neural circuitry and clinical significance. Arch Ital Biol. 2011 Dec; 149(4):348-66. PMID: 22205588.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  27. Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS One. 2011; 6(10):e24998. PMID: 22043278.
    Citations: 57     Fields:    Translation:AnimalsCells
  28. Eikermann M, Vetrivelan R, Grosse-Sundrup M, Henry ME, Hoffmann U, Yokota S, Saper CB, Chamberlin NL. The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia. Brain Res. 2011 Dec 02; 1426:30-7. PMID: 22041226.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. Vetrivelan R, Qiu MH, Chang C, Lu J. Role of Basal Ganglia in sleep-wake regulation: neural circuitry and clinical significance. Front Neuroanat. 2010; 4:145. PMID: 21151379.
    Citations: 21     
  30. Qiu MH, Vetrivelan R, Fuller PM, Lu J. Basal ganglia control of sleep-wake behavior and cortical activation. Eur J Neurosci. 2010 Feb; 31(3):499-507. PMID: 20105243.
    Citations: 70     Fields:    Translation:Animals
  31. Arrigoni E, Lu J, Vetrivelan R, Saper CB. Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus. Eur J Neurosci. 2009 Dec 03; 30(11):2112-20. PMID: 20128848.
    Citations: 8     Fields:    Translation:AnimalsCells
  32. Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci. 2009 Jul 22; 29(29):9361-9. PMID: 19625526.
    Citations: 46     Fields:    Translation:AnimalsCells
  33. Kumar VM, Vetrivelan R, Mallick HN. Noradrenergic afferents and receptors in the medial preoptic area: neuroanatomical and neurochemical links between the regulation of sleep and body temperature. Neurochem Int. 2007 May; 50(6):783-90. PMID: 17403554.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  34. Kumar VM, Vetrivelan R, Mallick HN. Alpha-1 adrenergic receptors in the medial preoptic area are involved in the induction of sleep. Neurochem Res. 2006 Aug; 31(8):1095-102. PMID: 16933152.
    Citations: 6     Fields:    Translation:Animals
  35. Vetrivelan R, Mallick HN, Kumar VM. Tonic activity of alpha1 adrenergic receptors of the medial preoptic area contributes towards increased sleep in rats. Neuroscience. 2006; 139(3):1141-51. PMID: 16533567.
    Citations: 4     Fields:    Translation:Animals
  36. Vetrivelan R, Mallick HN, Kumar VM. Sleep induction and temperature lowering by medial preoptic alpha(1) adrenergic receptors. Physiol Behav. 2006 Apr 15; 87(4):707-13. PMID: 16529782.
    Citations: 8     Fields:    Translation:AnimalsCells
  37. Vetrivelan R, Mallick HN, Kumar VM. Unmasking of alpha1 adrenoceptor induced hypnogenic response from medial preoptic area. Physiol Behav. 2005 Mar 31; 84(4):641-50. PMID: 15811400.
    Citations: 6     Fields:    Translation:Animals
  38. Vetrivelan R, Mallick HN, Kumar VM. Repeated intracerebral microinjections: efficacy in studying brain functions. Indian J Physiol Pharmacol. 2004 Oct; 48(4):471-5. PMID: 15907057.
    Citations: 1     Fields:    Translation:Animals
  39. Vetrivelan R, Mallick HN, Kumar VM. Changes in body temperature and sleep-wakefulness after intrapreoptic injection of methoxamine in rats. Neural Plast. 2003; 10(4):267-78. PMID: 15152981; PMCID: PMC2565433.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.