Harvard Catalyst Profiles

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Daniel Geoffrey Tenen, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA197697 (TENEN, DANIEL G) Aug 1, 2015 - Jul 31, 2022
    NIH/NCI
    Mechanisms of regulation by RNA in acute myeloid leukemia
    Role: Principal Investigator
  2. R01DK103858 (TENEN, DANIEL G) Jun 15, 2015 - May 31, 2018
    NIH/NIDDK
    Noncoding RNA-DNMT1 interactions in hematopoiesis
    Role: Principal Investigator
  3. R01CA138211 (TENEN, DANIEL G) Sep 25, 2008 - Jul 31, 2014
    NIH/NCI
    Targeting Leukemic Stem Cells
    Role: Principal Investigator
  4. P01DK080665 (TENEN, DANIEL G) Sep 1, 2008 - Jul 31, 2014
    NIH/NIDDK
    Hematopoietic stem cell commitment
    Role: Principal Investigator
  5. R01CA118316 (TENEN, DANIEL G) Apr 12, 2007 - Jan 31, 2014
    NIH/NCI
    Distinct acute myeloid leukemia subclasses with CEBPA mutations
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis. Cancer Cell. 2019 Jan 14; 35(1):156. PMID: 30645972.
    Citations:    Fields:    
  2. Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M. Correction to: EVI2B is a C/EBPa target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. Cell Death Differ. 2019 Jan; 26(1):198. PMID: 29991745.
    Citations:    Fields:    
  3. Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L. Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer. Nucleic Acids Res. 2018 Sep 06; 46(15):7953-7969. PMID: 29796672.
    Citations:    Fields:    
  4. Sridhar R, Takei H, Syed R, Kobayashi IS, Hui LB, Kamal A, Tenen DG, Kobayashi SS. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPa. Molecules. 2018 Aug 03; 23(8). PMID: 30081475.
    Citations:    Fields:    
  5. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 Oct 02; 28(4):631-643.e3. PMID: 30078553.
    Citations:    Fields:    
  6. Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG. Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):E7119-E7128. PMID: 29976840.
    Citations:    Fields:    Translation:HumansCells
  7. Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis. Cancer Cell. 2018 Jun 11; 33(6):1111-1127.e5. PMID: 29894694.
    Citations:    Fields:    
  8. Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018 04 24; 9(1):1622. PMID: 29692408.
    Citations:    Fields:    
  9. Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 01; 27(5):1121-1137.e5. PMID: 29657031.
    Citations: 3     Fields:    
  10. Ngoc PCT, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG, Sanda T. Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. Leukemia. 2018 Oct; 32(10):2138-2151. PMID: 29654272.
    Citations:    Fields:    
  11. Kardosova M, Zjablovskaja P, Danek P, Angelisova P, de Figueiredo-Pontes LL, Welner RS, Brdicka T, Lee S, Tenen DG, Alberich-Jorda M. C/EBP? is dispensable for steady-state and emergency granulopoiesis. Haematologica. 2018 Aug; 103(8):e331-e335. PMID: 29567783.
    Citations:    Fields:    
  12. Ali A, Levantini E, Teo JT, Goggi J, Clohessy JG, Wu CS, Chen L, Yang H, Krishnan I, Kocher O, Zhang J, Soo RA, Bhakoo K, Chin TM, Tenen DG. Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. EMBO Mol Med. 2018 03; 10(3). PMID: 29449326.
    Citations: 2     Fields:    
  13. Cusan M, Cai SF, Mohammad HP, Krivtsov A, Chramiec A, Loizou E, Witkin MD, Smitheman KN, Tenen DG, Ye M, Will B, Steidl U, Kruger RG, Levine RL, Rienhoff HY, Koche RP, Armstrong SA. LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPa-dependent enhancers in AML. Blood. 2018 Apr 12; 131(15):1730-1742. PMID: 29453291.
    Citations: 5     Fields:    
  14. Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T. ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes Dev. 2017 12 01; 31(23-24):2343-2360. PMID: 29326336.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S. TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLoS Pathog. 2017 Oct; 13(10):e1006681. PMID: 29045464.
    Citations: 3     Fields:    Translation:HumansCells
  16. Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer. Nucleic Acids Res. 2017 Oct 13; 45(18):10436-10451. PMID: 28985428.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG. ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa. J Biol Chem. 2017 11 17; 292(46):18924-18936. PMID: 28900037.
    Citations:    Fields:    Translation:HumansCells
  18. Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, Maekawa T. C/EBPß is required for survival of Ly6C- monocytes. Blood. 2017 10 19; 130(16):1809-1818. PMID: 28807982.
    Citations:    Fields:    Translation:AnimalsCells
  19. Pulikkan JA, Tenen DG, Behre G. C/EBPa deregulation as a paradigm for leukemogenesis. Leukemia. 2017 11; 31(11):2279-2285. PMID: 28720765.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Wurm AA, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Benoukraf T, Fricke S, Hilger N, Müller AM, Bill M, Schwind S, Tenen DG, Niederwieser D, Alberich-Jorda M, Behre G. Disruption of the C/EBPa-miR-182 balance impairs granulocytic differentiation. Nat Commun. 2017 06 29; 8(1):46. PMID: 28663557.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  21. Cao F, Fang Y, Tan HK, Goh Y, Choy JYH, Koh BTH, Hao Tan J, Bertin N, Ramadass A, Hunter E, Green J, Salter M, Akoulitchev A, Wang W, Chng WJ, Tenen DG, Fullwood MJ. Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions. Sci Rep. 2017 05 19; 7(1):2186. PMID: 28526829.
    Citations: