Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileJing Chen, Ph.D.

TitleAssistant Professor of Ophthalmology
InstitutionBoston Children's Hospital
DepartmentOphthalmology
AddressChildrens Hospital
Ophthalmology
300 Longwood Ave
Boston MA 02115
Phone617/355-6000
vCardDownload vCard (login for email)

Collapse Biography 
Collapse education and training
Boston UniversityPhD2004
Boston UniversityPostdoctoral2005
Boston Children's Hospital / Harvard Medical SchoolPostdoctoral2008
Collapse awards and honors
2006Juvenile Diabetes Research Foundation Postdoctoral Fellowship
2007ARVO Foundation for Eye Research/Retina Research Joseph M. and Eula C. Lawrence Travel Scholarship
2008International Society for Eye Research Travel Fellowship
2008Juvenile Diabetes Research Foundation Advanced Postdoctoral Fellowship
2009Knights Templar Eye Foundation Pediatric Ophthalmology Research Award
2009Children’s Hospital Boston Manton Center Junior Faculty Career Development Award
2011Charles H. Hood Foundation Child Health Research Award
2013Boston Children’s Hospital Faculty Career Development Award
2014Alcon Research Institute Young Investigator Award

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Gong Y, Fu Z, Liegl R, Chen J, Hellström A, Smith LE. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. PMID: 28515072.
    View in: PubMed
  2. Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 Jun 05; 214(6):1753-1767. PMID: 28465464.
    View in: PubMed
  3. Liu CH, Wang Z, Sun Y, SanGiovanni JP, Chen J. Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy. Sci Rep. 2016 Sep 22; 6:33947. PMID: 27653551.
    View in: PubMed
  4. Wang Z, Liu CH, Sun Y, Gong Y, Favazza TL, Morss PC, Saba NJ, Fredrick TW, He X, Akula JD, Chen J. Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016 Oct; 186(10):2588-600. PMID: 27524797.
    View in: PubMed
  5. Moran EP, Wang Z, Chen J, Sapieha P, Smith LE, Ma JX. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 Sep 01; 311(3):H738-49. PMID: 27473938.
    View in: PubMed
  6. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Jun 07; 22(6):692. PMID: 27270778.
    View in: PubMed
  7. Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJ, Ridger V, Evans PC. TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res. 2016 Jul 22; 119(3):450-62. PMID: 27245171; PMCID: PMC4959828.
  8. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. PMID: 26974308; PMCID: PMC4823176.
  9. Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. PMID: 26396267; PMCID: PMC4659437.
  10. Liu CH, Sun Y, Li J, Gong Y, Tian KT, Evans LP, Morss PC, Fredrick TW, Saba NJ, Chen J. Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):12163-8. PMID: 26374840; PMCID: PMC4593127.
  11. Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. PMID: 26243880; PMCID: PMC4547221.
  12. Gong Y, Li J, Sun Y, Fu Z, Liu CH, Evans L, Tian K, Saba N, Fredrick T, Morss P, Chen J, Smith LE. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. PMID: 26161975; PMCID: PMC4498645.
  13. SanGiovanni JP, Chen J, Gupta AS, Smith LE, Sapieha P, Lee PH. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. PMID: 25950802; PMCID: PMC4423995.
  14. Wang Z, Cheng R, Lee K, Tyagi P, Ding L, Kompella UB, Chen J, Xu X, Ma JX. Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):855-64. PMID: 25657312; PMCID: PMC4376607.
  15. Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. PMID: 25833984; PMCID: PMC4381778.
  16. Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. PMID: 25414194; PMCID: PMC4541480.
  17. Chen J. Enhancing reliability of the laser-induced choroidal neovascularization mouse model: insights from a new study. Invest Ophthalmol Vis Sci. 2014 Oct 16; 55(10):6535. PMID: 25324347.
    View in: PubMed
  18. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. PMID: 24458713; PMCID: PMC4005334.
  19. Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. PMID: 24416337; PMCID: PMC3885684.
  20. Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One. 2013; 8(9):e73407. PMID: 24023872; PMCID: PMC3759405.
  21. Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. PMID: 23912262; PMCID: PMC4006695.
  22. Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, Evans LP, Juan AM, Tahiri H, Tahir H, Duhamel F, Chen J, Sapieha P, Chemtob S, Joyal JS, Smith LE. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. PMID: 23922736; PMCID: PMC3724908.
  23. Chen J, Smith LE. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. PMID: 23562072; PMCID: PMC3669899.
  24. SanGiovanni JP, Chen J, Sapieha P, Aderman CM, Stahl A, Clemons TE, Chew EY, Smith LE. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. PMID: 23335958; PMCID: PMC3546058.
  25. Chen J, Hellstrom A, Smith LE. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. PMID: 23166302.
    View in: PubMed
  26. Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. PMID: 22848540; PMCID: PMC3404972.
  27. Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ, Tang J, Kern TS, Akula JD, Smith LE. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. PMID: 23448719; PMCID: PMC3408641.
  28. Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. PMID: 22791286; PMCID: PMC3466973.
  29. Chen J, Joyal JS, Hatton CJ, Juan AM, Pei DT, Hurst CG, Xu D, Stahl A, Hellstrom A, Smith LE. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. PMID: 22491401; PMCID: PMC3376075.
  30. Chen J, Smith LE. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. PMID: 22561819; PMCID: PMC3687521.
  31. Chen J, Stahl A, Krah NM, Seaward MR, Joyal JS, Juan AM, Hatton CJ, Aderman CM, Dennison RJ, Willett KL, Sapieha P, Smith LE. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. PMID: 22272305; PMCID: PMC3260226.
  32. Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. PMID: 21969016; PMCID: PMC3326389.
  33. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. PMID: 21896759; PMCID: PMC3174592.
  34. Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. PMID: 21282584; PMCID: PMC3088563.
  35. Chen J, Stahl A, Hellstrom A, Smith LE. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. PMID: 21150442; PMCID: PMC3319383.
  36. Stahl A, Krohne TU, Sapieha P, Chen J, Hellstrom A, Chew E, Holz FG, Smith LE. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. PMID: 21421650; PMCID: PMC3711020.
  37. Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. PMID: 21307302; PMCID: PMC3711031.
  38. Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LE. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. PMID: 21056995; PMCID: PMC2993262.
  39. Stahl A, Buchwald A, Martin G, Junker B, Chen J, Hansen LL, Agostini HT, Smith LE, Feltgen N. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. PMID: 20664492; PMCID: PMC4016716.
  40. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. PMID: 20660252; PMCID: PMC2921958.
  41. Stahl A, Sapieha P, Connor KM, Sangiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. PMID: 20634487; PMCID: PMC2975617.
  42. Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, Hua J, Löfqvist C, Hellström A, Smith LE. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. PMID: 20484600; PMCID: PMC2891451.
  43. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. PMID: 19816419; PMCID: PMC3731997.
  44. Stahl A, Connor KM, Sapieha P, Willett KL, Krah NM, Dennison RJ, Chen J, Guerin KI, Smith LE. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12(3):297-301. PMID: 19757106; PMCID: PMC4005267.
  45. Chen J, Yoshida T, Bitensky MW. Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina. Mol Vis. 2008; 14:2509-17. PMID: 19112528; PMCID: PMC2610287.
  46. Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, Chen J, Hellstrom A, Smith LE. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. PMID: 18997086.
    View in: PubMed
  47. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. PMID: 18952918; PMCID: PMC2892257.
  48. Chen J, Smith LE. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. PMID: 18396079.
    View in: PubMed
  49. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. PMID: 18219389; PMCID: PMC2213374.
  50. Chen J, Connor KM, Smith LE. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. PMID: 17909623; PMCID: PMC1994636.
  51. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LE. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-73. PMID: 17589522; PMCID: PMC4491412.
  52. Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. PMID: 17567756; PMCID: PMC1965557.
  53. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. PMID: 17332988.
    View in: PubMed
  54. Chen J, Yoshida T, Nakano K, Bitensky MW. Subcellular localization of phosducin in rod photoreceptors. Vis Neurosci. 2005 Jan-Feb; 22(1):19-25. PMID: 15842737.
    View in: PubMed
  55. Nakano K, Chen J, Tarr GE, Yoshida T, Flynn JM, Bitensky MW. Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4693-8. PMID: 11287646; PMCID: PMC31896.
  56. Zhang C, Chen J, DeLisi C. Protein-protein recognition: exploring the energy funnels near the binding sites. Proteins. 1999 Feb 01; 34(2):255-67. PMID: 10022360.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Chen's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_