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Robert Irving Handin, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K18HL092231 (HANDIN, ROBERT I) May 1, 2008 - Apr 30, 2011
    NIH/NHLBI
    The Biology of Zebrafish Hematopoietic Stem Cells
    Role: Principal Investigator
  2. R01HL054876 (HANDIN, ROBERT I) Aug 1, 1996 - Jun 30, 2000
    NIH/NHLBI
    MOLECULAR BASIS OF PLATELET ADHESION
    Role: Principal Investigator
  3. T32HL007623 (HANDIN, ROBERT I) Jul 1, 1985 - Jun 30, 2012
    NIH/NHLBI
    A Training Program in Molecular Hematology
    Role: Principal Investigator
  4. R37HL034787 (HANDIN, ROBERT I) Dec 1, 1984 - Dec 31, 1997
    NIH/NHLBI
    PLATELET MEMBRANE PROTEINS IN HEMOSTASIS AND THROMBOSIS
    Role: Principal Investigator
  5. P01HL033014 (ROSENBERG, ROBERT D) Dec 1, 1984 - Jun 30, 1996
    NIH/NHLBI
    THROMBOSIS AND ATHEROSCLEROSIS
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gansner JM, Achebe MM, Gray KJ, Yefidoff-Freedman R, Labovitis E, Parnes A, Connors JM, Connell NT, Discenza MN, Handin RI, Berliner N, Shimamura A, Ginsburg ES, Smith NA. Pregnancy outcomes in inherited bone marrow failure syndromes. Blood. 2017 10 05; 130(14):1671-1674. PMID: 28798157.
    Citations: 1     Fields:    Translation:Humans
  2. Gansner JM, Leung AD, Superdock M, Blair MC, Ammerman MB, Durand EM, Barut B, Handin RI, Stachura DL, Lu C, Springer TA, Zon LI. Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 03 09; 129(10):1394-1397. PMID: 28126924.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Bailey E, Cui Y, Casey A, Stoler JM, Ai X, Ma D, Handin R, Sliz P, Vargas SO, El-Chemaly SY. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol. 2017 Jan; 187(1):25-32. PMID: 27846380.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Handin RI. The History of Antithrombotic Therapy: The Discovery of Heparin, the Vitamin K Antagonists, and the Utility of Aspirin. Hematol Oncol Clin North Am. 2016 Oct; 30(5):987-93. PMID: 27637302.
    Citations: 1     Fields:    Translation:Humans
  5. Lin J, Zhang W, Zhao JJ, Kwart AH, Yang C, Ma D, Ren X, Tai YT, Anderson KC, Handin RI, Munshi NC. A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy. Blood. 2016 07 14; 128(2):249-52. PMID: 27207793; PMCID: PMC4946203.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  6. Sacco A, Roccaro AM, Ma D, Shi J, Mishima Y, Moschetta M, Chiarini M, Munshi N, Handin RI, Ghobrial IM. Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model. Cancer Res. 2016 Jan 15; 76(2):463-71. PMID: 26744527.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. PMID: 26211600.
    Citations: 20     Fields:    Translation:Humans
  8. Ma D, Zhang J, Lin HF, Italiano J, Handin RI. The identification and characterization of zebrafish hematopoietic stem cells. Blood. 2011 Jul 14; 118(2):289-97. PMID: 21586750; PMCID: PMC3138684.
    Citations: 30     Fields:    Translation:AnimalsCells
  9. Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 03; 470(7332):95-100. PMID: 21270795; PMCID: PMC3170921.
    Citations: 80     Fields:    Translation:AnimalsCells
  10. Kim J, Wu Q, Zhang Y, Wiens KM, Huang Y, Rubin N, Shimada H, Handin RI, Chao MY, Tuan TL, Starnes VA, Lien CL. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17206-10. PMID: 20858732; PMCID: PMC2951463.
    Citations: 62     Fields:    Translation:AnimalsCells
  11. Amigo JD, Ackermann GE, Cope JJ, Yu M, Cooney JD, Ma D, Langer NB, Shafizadeh E, Shaw GC, Horsely W, Trede NS, Davidson AJ, Barut BA, Zhou Y, Wojiski SA, Traver D, Moran TB, Kourkoulis G, Hsu K, Kanki JP, Shah DI, Lin HF, Handin RI, Cantor AB, Paw BH. The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009 Nov 19; 114(21):4654-63. PMID: 19729519; PMCID: PMC2780302.
    Citations: 24     Fields:    Translation:Animals
  12. Handin R. Escaping the niche. Blood. 2009 Jun 18; 113(25):6271-3. PMID: 19541834.
    Citations:    Fields:    
  13. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. PMID: 17626277.
    Citations: 8     Fields:    Translation:Animals
  14. Paffett-Lugassy N, Hsia N, Fraenkel PG, Paw B, Leshinsky I, Barut B, Bahary N, Caro J, Handin R, Zon LI. Functional conservation of erythropoietin signaling in zebrafish. Blood. 2007 Oct 01; 110(7):2718-26. PMID: 17579187; PMCID: PMC1988930.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  15. Murayama E, Kissa K, Zapata A, Mordelet E, Briolat V, Lin HF, Handin RI, Herbomel P. Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity. 2006 Dec; 25(6):963-75. PMID: 17157041.
    Citations: 138     Fields:    Translation:AnimalsCells
  16. Lin HF, Traver D, Zhu H, Dooley K, Paw BH, Zon LI, Handin RI. Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 2005 Dec 01; 106(12):3803-10. PMID: 16099879; PMCID: PMC1895094.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  17. Handin RI. Inherited platelet disorders. Hematology Am Soc Hematol Educ Program. 2005; 396-402. PMID: 16304410.
    Citations: 2     Fields:    Translation:HumansCells
  18. Levy BD, Katz JT, Wolf MA, Sillman JS, Handin RI, Dzau VJ. An initiative in mentoring to promote residents' and faculty members' careers. Acad Med. 2004 Sep; 79(9):845-50. PMID: 15326007.
    Citations: 19     Fields:    Translation:Humans
  19. Handin RI. A hitchhiker's guide to the galaxy--an H. pylori travel guide. Gastroenterology. 2003 Jun; 124(7):1983-5. PMID: 12806635.
    Citations: 1     Fields:    Translation:HumansCells
  20. Cruz MA, Diacovo TG, Emsley J, Liddington R, Handin RI. Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem. 2000 Jun 23; 275(25):19098-105. PMID: 10764791.
    Citations: 31     Fields:    Translation:HumansCells
  21. Antman EM, Handin R. Low-molecular-weight heparins: an intriguing new twist with profound implications. Circulation. 1998 Jul 28; 98(4):287-9. PMID: 9711931.
    Citations: 4     Fields:    Translation:Humans
  22. Emsley J, Cruz M, Handin R, Liddington R. Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib. J Biol Chem. 1998 Apr 24; 273(17):10396-401. PMID: 9553097.
    Citations: 53     Fields:    Translation:Cells
  23. Bienkowska J, Cruz M, Atiemo A, Handin R, Liddington R. The von willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif. J Biol Chem. 1997 Oct 03; 272(40):25162-7. PMID: 9312128.
    Citations: 17     Fields:    Translation:HumansCells
  24. Handin RI. DAMI cell line. Blood. 1997 Jun 01; 89(11):4238. PMID: 9166871.
    Citations:    Fields:    Translation:HumansCells
  25. Ballen KK, Ritchie AJ, Murphy C, Handin RI, Ewenstein BM. Expression and activation of protein kinase C isoforms in a human megakaryocytic cell line. Exp Hematol. 1996 Nov; 24(13):1501-8. PMID: 8950233.
    Citations: 3     Fields:    Translation:HumansCells
  26. Wu YP, van Breugel HH, Lankhof H, Wise RJ, Handin RI, de Groot PG, Sixma JJ. Platelet adhesion to multimeric and dimeric von Willebrand factor and to collagen type III preincubated with von Willebrand factor. Arterioscler Thromb Vasc Biol. 1996 May; 16(5):611-20. PMID: 8963717.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Handin RI. Platelets and coronary artery disease. N Engl J Med. 1996 Apr 25; 334(17):1126-7. PMID: 8598874.
    Citations: 2     Fields:    Translation:Humans
  28. Cruz MA, Yuan H, Lee JR, Wise RJ, Handin RI. Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF A domain polypeptides. J Biol Chem. 1995 Aug 18; 270(33):19668. PMID: 7642656.
    Citations: 3     Fields:    Translation:Cells
  29. Cruz MA, Yuan H, Lee JR, Wise RJ, Handin RI. Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides. J Biol Chem. 1995 May 05; 270(18):10822-7. PMID: 7738019.
    Citations: 21     Fields:    Translation:HumansCells
  30. Beacham DA, Cruz MA, Handin RI. Glycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum. Thromb Haemost. 1995 Feb; 73(2):309-17. PMID: 7792748.
    Citations: 2     Fields:    Translation:HumansCells
  31. Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem. 1993 Oct 05; 268(28):21238-45. PMID: 8407961.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  32. Wise RJ, Ewenstein BM, Gorlin J, Narins SC, Jesson M, Handin RI. Autosomal recessive transmission of hemophilia A due to a von Willebrand factor mutation. Hum Genet. 1993 May; 91(4):367-72. PMID: 8500791.
    Citations:    Fields:    Translation:HumansCells
  33. Petersen EJ, Handin RI. TaqI and Bsu36I polymorphisms in the human glycoprotein Ib alpha gene (GPIB alpha). Hum Mol Genet. 1992 Sep; 1(6):451. PMID: 1363804.
    Citations: 2     Fields:    Translation:HumansCells
  34. Petersen E, Handin RI. Transient expression of recombinant glycoprotein Ib alpha polypeptides in COS cells that inhibit von Willebrand factor binding to the platelet glycoprotein Ib/IX complex. Thromb Haemost. 1992 Aug 03; 68(2):203-7. PMID: 1412167.
    Citations: 2     Fields:    Translation:HumansCells
  35. Beacham DA, Wise RJ, Turci SM, Handin RI. Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. J Biol Chem. 1992 Feb 15; 267(5):3409-15. PMID: 1737795.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  36. Cruz MA, Petersen E, Turci SM, Handin RI. Functional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen. J Biol Chem. 1992 Jan 15; 267(2):1303-9. PMID: 1730650.
    Citations: 1     Fields:    Translation:Cells
  37. Loscalzo J, Handin RI. Platelet glycocalicin. Methods Enzymol. 1992; 215:289-94. PMID: 1435328.
    Citations:    Fields:    Translation:HumansCells
  38. Adelman B, Carlson P, Handin RI. Evaluation of platelet surface antigens by fluorescence flow cytometry. Methods Enzymol. 1992; 215:420-7. PMID: 1435339.
    Citations: 1     Fields:    Translation:HumansCells
  39. Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. J Clin Invest. 1991 Nov; 88(5):1568-73. PMID: 1939645; PMCID: PMC295673.
    Citations: 41     Fields:    Translation:HumansCells
  40. Inbal A, Handin RI. StuI polymorphisms in the vWF gene. Nucleic Acids Res. 1990 Aug 25; 18(16):4959. PMID: 1975671; PMCID: PMC332024.
    Citations:    Fields:    Translation:HumansCells
  41. Greenberg SM, Chandrasekhar C, Golan DE, Handin RI. Transforming growth factor beta inhibits endomitosis in the Dami human megakaryocytic cell line. Blood. 1990 Aug 01; 76(3):533-7. PMID: 2378984.
    Citations: 3     Fields:    Translation:HumansCells
  42. Finch CN, Miller JL, Lyle VA, Handin RI. Evidence that an abnormality in the glycoprotein Ib alpha gene is not the cause of abnormal platelet function in a family with classic Bernard-Soulier disease. Blood. 1990 Jun 15; 75(12):2357-62. PMID: 1972029.
    Citations: 1     Fields:    Translation:HumansCells
  43. Ewenstein BM, Inbal A, Pober JS, Handin RI. Molecular studies of von Willebrand disease: reduced von Willebrand factor biosynthesis, storage, and release in endothelial cells derived from patients with type I von Willebrand disease. Blood. 1990 Apr 01; 75(7):1466-72. PMID: 2317558.
    Citations: 4     Fields:    Translation:HumansCells
  44. Inbal A, Handin RI. Two TaqI polymorphisms in the 5' region of the von Willebrand factor (vWF) gene. Nucleic Acids Res. 1989 Dec 11; 17(23):10143. PMID: 2574846; PMCID: PMC335278.
    Citations: 1     Fields:    Translation:HumansCells
  45. Rybak ME, Gimbrone MA, Davies PF, Handin RI. Interaction of platelet factor four with cultured vascular endothelial cells. Blood. 1989 May 01; 73(6):1534-9. PMID: 2713492.
    Citations: 8     Fields:    Translation:AnimalsCells
  46. Handin RI, Wagner DD. Molecular and cellular biology of von Willebrand factor. Prog Hemost Thromb. 1989; 9:233-59. PMID: 2643818.
    Citations: 17     Fields:    Translation:HumansCells
  47. Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Handin RI. Characterization of a new megakaryocytic cell line: the Dami cell. Blood. 1988 Dec; 72(6):1968-77. PMID: 3196874.
    Citations: 40     Fields:    Translation:HumansCells
  48. Michelson AD, Adelman B, Barnard MR, Carroll E, Handin RI. Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib. J Clin Invest. 1988 Jun; 81(6):1734-40. PMID: 3384948; PMCID: PMC442618.
    Citations: 8     Fields:    Translation:HumansCells
  49. Wise RJ, Pittman DD, Handin RI, Kaufman RJ, Orkin SH. The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 1988 Jan 29; 52(2):229-36. PMID: 3124962.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  50. Ewenstein BM, Warhol MJ, Handin RI, Pober JS. Composition of the von Willebrand factor storage organelle (Weibel-Palade body) isolated from cultured human umbilical vein endothelial cells. J Cell Biol. 1987 May; 104(5):1423-33. PMID: 3494734; PMCID: PMC2114468.
    Citations: 39     Fields:    Translation:HumansCells
  51. Adelman B, Michelson AD, Greenberg J, Handin RI. Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions. Blood. 1986 Dec; 68(6):1280-4. PMID: 2946332.
    Citations: 3     Fields:    Translation:HumansCells
  52. Bonthron DT, Handin RI, Kaufman RJ, Wasley LC, Orr EC, Mitsock LM, Ewenstein B, Loscalzo J, Ginsburg D, Orkin SH. Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature. 1986 Nov 20-26; 324(6094):270-3. PMID: 3491324.
    Citations: 48     Fields:    Translation:AnimalsCells
  53. Loscalzo J, Inbal A, Handin RI. von Willebrand protein facilitates platelet incorporation in polymerizing fibrin. J Clin Invest. 1986 Oct; 78(4):1112-9. PMID: 3489737; PMCID: PMC423774.
    Citations: 8     Fields:    Translation:HumansCells
  54. Bonthron D, Orr EC, Mitsock LM, Ginsburg D, Handin RI, Orkin SH. Nucleotide sequence of pre-pro-von Willebrand factor cDNA. Nucleic Acids Res. 1986 Sep 11; 14(17):7125-7. PMID: 3489923; PMCID: PMC311723.
    Citations: 25     Fields:    Translation:HumansCells
  55. Bockenstedt P, McDonagh J, Handin RI. Binding and covalent cross-linking of purified von Willebrand factor to native monomeric collagen. J Clin Invest. 1986 Aug; 78(2):551-6. PMID: 2874156; PMCID: PMC423593.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Fay PJ, Kawai Y, Wagner DD, Ginsburg D, Bonthron D, Ohlsson-Wilhelm BM, Chavin SI, Abraham GN, Handin RI, Orkin SH, et al. Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science. 1986 May 23; 232(4753):995-8. PMID: 3486471.
    Citations: 18     Fields:    Translation:HumansCells
  57. Bockenstedt P, Greenberg JM, Handin RI. Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen. Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor. J Clin Invest. 1986 Mar; 77(3):743-9. PMID: 2936763; PMCID: PMC423458.
    Citations: 3     Fields:    Translation:HumansCells
  58. Loscalzo J, Slayter H, Handin RI, Farber D. Subunit structure and assembly of von Willebrand factor polymer: complementary analysis by electron microscopy and quasielastic light scattering. Biophys J. 1986 Jan; 49(1):49-50. PMID: 19431644.
    Citations: 1     Fields:    
  59. Michelson AD, Loscalzo J, Melnick B, Coller BS, Handin RI. Partial characterization of a binding site for von Willebrand factor on glycocalicin. Blood. 1986 Jan; 67(1):19-26. PMID: 3000477.
    Citations: 5     Fields:    Translation:HumansCells
  60. Stemerman MB, Adelman B, Handin RI, Fuhro R. Proliferation of smooth muscle cells in the thoracic aorta after injury to the abdominal aorta: evidence for a humoral mediator in experimental arteriosclerosis. J Lab Clin Med. 1985 Oct; 106(4):369-75. PMID: 3900262.
    Citations: 1     Fields:    Translation:AnimalsCells
  61. Adelman B, Michelson AD, Handin RI, Ault KA. Evaluation of platelet glycoprotein Ib by fluorescence flow cytometry. Blood. 1985 Aug; 66(2):423-7. PMID: 3160414.
    Citations: 2     Fields:    Translation:HumansCells
  62. Loscalzo J, Fisch M, Handin RI. Solution studies of the quaternary structure and assembly of human von Willebrand factor. Biochemistry. 1985 Jul 30; 24(16):4468-75. PMID: 3876847.
    Citations: 4     Fields:    Translation:HumansCells
  63. Slayter H, Loscalzo J, Bockenstedt P, Handin RI. Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering. J Biol Chem. 1985 Jul 15; 260(14):8559-63. PMID: 3874208.
    Citations: 19     Fields:    Translation:HumansCells
  64. Loscalzo J, Melnick B, Handin RI. The interaction of platelet factor four and glycosaminoglycans. Arch Biochem Biophys. 1985 Jul; 240(1):446-55. PMID: 2409923.
    Citations: 21     Fields:    Translation:AnimalsCells
  65. Ginsburg D, Handin RI, Bonthron DT, Donlon TA, Bruns GA, Latt SA, Orkin SH. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science. 1985 Jun 21; 228(4706):1401-6. PMID: 3874428.
    Citations: 90     Fields:    Translation:HumansCells
  66. Adelman B, Michelson AD, Loscalzo J, Greenberg J, Handin RI. Plasmin effect on platelet glycoprotein Ib-von Willebrand factor interactions. Blood. 1985 Jan; 65(1):32-40. PMID: 3155489.
    Citations: 14     Fields:    Translation:Humans
  67. Rosenthal DS, Emerson SE, Rappeport JM, Moloney WC, Handin RI. Long-term survivors of adult acute nonlymphocytic leukemia: fact or fiction? Haematol Blood Transfus. 1985; 29:44-7. PMID: 3896974.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  68. Beardsley DS, Spiegel JE, Jacobs MM, Handin RI, Lux SE. Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin Invest. 1984 Nov; 74(5):1701-7. PMID: 6238978; PMCID: PMC425348.
    Citations: 24     Fields:    Translation:HumansCells
  69. Loscalzo J, Handin RI. Conformational domains and structural transitions of human von Willebrand protein. Biochemistry. 1984 Aug 14; 23(17):3880-6. PMID: 6333249.
    Citations: 4     Fields:    Translation:HumansCells
  70. Stead RB, Schafer AI, Rosenberg RD, Handin RI, Josa M, Khuri SF. Heterogeneity of heparin lots associated with thrombocytopenia and thromboembolism. Am J Med. 1984 Jul; 77(1):185-8. PMID: 6741980.
    Citations: 1     Fields:    Translation:HumansCells
  71. LaMont JT, Turner BS, DiBenedetto D, Handin R, Schafer AI. Arachidonic acid stimulates mucin secretion in prairie dog gallbladder. Am J Physiol. 1983 Jul; 245(1):G92-8. PMID: 6408933.
    Citations: 18     Fields:    Translation:Animals
  72. Adelman B, Stemerman MB, Handin RI. Interaction of platelets and fibrin with injured rabbit aortic neointima. Effect of prostaglandin I2 and heparin. Arteriosclerosis. 1983 Mar-Apr; 3(2):141-8. PMID: 6340650.
    Citations: 3     Fields:    Translation:AnimalsCells
  73. Kowey PR, Verrier RL, Lown B, Handin RI. Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis. Am J Cardiol. 1983 Feb; 51(3):596-602. PMID: 6186137.
    Citations: 5     Fields:    Translation:Animals
  74. Schafer AI, Turner NA, Handin RI. Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. Biochim Biophys Acta. 1982 Sep 14; 712(3):535-41. PMID: 6812645.
    Citations: 3     Fields:    Translation:HumansCells
  75. Curwen KD, Kim HY, Vazquez M, Handin RI, Gimbrone MA. Platelet adhesion to cultured vascular endothelial cells. A quantitative monolayer adhesion assay. J Lab Clin Med. 1982 Sep; 100(3):425-36. PMID: 7108351.
    Citations: 11     Fields:    Translation:HumansCells
  76. Mooney JJ, Horne WC, Handin RI, Schildkraut JJ, Alexander RW. Sodium inhibits both adenylate cyclase and high-affinity 3H-labeled p-aminoclonidine binding to alpha 2-adrenergic receptors in purified human platelet membranes. Mol Pharmacol. 1982 May; 21(3):600-8. PMID: 6287197.
    Citations: 2     Fields:    Translation:HumansCells
  77. Handin RI. Neonatal immune thrombocytopenia--the doctor's dilemma. N Engl J Med. 1981 Oct 15; 305(16):951-3. PMID: 7196992.
    Citations:    Fields:    Translation:Humans
  78. Adler B, Gimbrone MA, Schafer AI, Handin RI. Prostacyclin and beta-adrenergic catecholamines inhibit arachidonate release and PGI2 synthesis by vascular endothelium. Blood. 1981 Sep; 58(3):514-7. PMID: 6167276.
    Citations: 7     Fields:    Translation:Animals
  79. Adelman B, Stemerman MB, Mennell D, Handin RI. The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by prostaglandin I2. Blood. 1981 Aug; 58(2):198-205. PMID: 7018620.
    Citations: 3     Fields:    Translation:AnimalsCells
  80. Rybak ME, Lau HK, Tomkins B, Rosenberg RD, Handin RI. Relationship between platelet secretion and prothrombin cleavage in native whole blood. J Clin Invest. 1981 Aug; 68(2):405-12. PMID: 7263860; PMCID: PMC370812.
    Citations: 1     Fields:    Translation:HumansCells
  81. Handin RI. The evaluation of thromboembolic diseases: what to do now that the radioimmunoassay has arrived. West J Med. 1981 Jul; 135(1):50-1. PMID: 6455013; PMCID: PMC1272920.
    Citations:    Fields:    Translation:Humans
  82. Handin RI, Alexander RW. Humoral heartache -- do platelets have a role? N Engl J Med. 1981 Apr 23; 304(17):1035-6. PMID: 7010170.
    Citations:    Fields:    Translation:HumansAnimalsCells
  83. MacIntyre DE, Handin RI, Rosenberg R, Salzman EW. Heparin opposes prostanoid and non-prostanoid platelet inhibitors by direct enhancement of aggregation. Thromb Res. 1981 Apr 1-15; 22(1-2):167-75. PMID: 6270842.
    Citations: 3     Fields:    Translation:HumansCells
  84. Sobel M, Salzman EW, Davies GC, Handin RI, Sweeney J, Ploetz J, Kurland G. Circulating platelet products in unstable angina pectoris. Circulation. 1981 Feb; 63(2):300-6. PMID: 6450001.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  85. Handin RI, Curwen KD, Gimbrone MA. The interaction of platelets with cultured cells. Ann N Y Acad Sci. 1981; 370:42-50. PMID: 7023324.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  86. Schafer AI, Levine S, Handin RI. Regulation of platelet arachidonic acid oxygenation by cyclic AMP. Blood. 1980 Nov; 56(5):853-8. PMID: 6252992.
    Citations: 4     Fields:    Translation:HumansCells
  87. Schafer AI, Gimbrone MA, Handin RI. Endothelial cell adenylate cyclase: activation by catecholamines and prostaglandin I2+. Biochem Biophys Res Commun. 1980 Oct 31; 96(4):1640-7. PMID: 6255950.
    Citations: 11     Fields:    Translation:HumansCells
  88. Goldberg ID, Stemerman MB, Handin RI. Vascular permeation of platelet factor 4 after endothelial injury. Science. 1980 Aug 01; 209(4456):611-2. PMID: 6994228.
    Citations: 19     Fields:    Translation:Animals
  89. Schafer AI, Alexander RW, Handin RI. Inhibition of platelet function by organic nitrate vasodilators. Blood. 1980 Apr; 55(4):649-54. PMID: 6244016.
    Citations: 23     Fields:    Translation:Humans
  90. Curwen KD, Gimbrone MA, Handin RI. In vitro studies of thromboresistance: the role of prostacyclin (PGI2) in platelet adhesion to cultured normal and virally transformed human vascular endothelial cells. Lab Invest. 1980 Mar; 42(3):366-74. PMID: 6244462.
    Citations: 12     Fields:    Translation:HumansCells
  91. Green LH, Seroppian E, Handin RI. Platelet activation during exercise-induced myocardial ischemia. N Engl J Med. 1980 Jan 24; 302(4):193-7. PMID: 7350460.
    Citations: 11     Fields:    Translation:HumansCells
  92. Scher CD, Farhi JI, Handin RI, Kaplan DR, Lillquist JS, McGovern K, Stiles CD. Initiation of cell replication by cationic polypeptide hormones. Soc Gen Physiol Ser. 1980; 35:39-54. PMID: 7414371.
    Citations:    Fields:    Translation:AnimalsCells
  93. Schafer AI, Handin RI. The role of platelets in thrombotic and vascular disease. Prog Cardiovasc Dis. 1979 Jul-Aug; 22(1):31-52. PMID: 379914.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  94. Adler JR, Handin RI. Solubilization and characterization of a platelet membrane ADP-binding protein. J Biol Chem. 1979 May 25; 254(10):3866-72. PMID: 438164.
    Citations: 3     Fields:    Translation:HumansCells
  95. Schafer AI, Cooper B, O'Hara D, Handin RI. Identification of platelet receptors for prostaglandin I2 and D2. J Biol Chem. 1979 Apr 25; 254(8):2914-7. PMID: 218956.
    Citations: 17     Fields:    Translation:HumansCells
  96. Cooper B, Schafer AI, Puchalsky D, Handin RI. Desensitization of prostaglandin-activated platelet adenylate cyclase. Prostaglandins. 1979 Apr; 17(4):561-71. PMID: 461820.
    Citations: 5     Fields:    Translation:HumansCells
  97. Buchanan GR, Handin RI. Impairment of hemostasis in patients with severe hemophilia. Failure of diphenhydramine, chlorpromazine, and guaifenesin. JAMA. 1978 Nov 10; 240(20):2173-4. PMID: 702728.
    Citations:    Fields:    Translation:HumansCells
  98. Cooper B, Schafer AI, Puchalsky D, Handin RI. Platelet resistance to prostaglandin D2 in patients with myeloproliferative disorders. Blood. 1978 Sep; 52(3):618-26. PMID: 678677.
    Citations: 4     Fields:    Translation:HumansCells
  99. Cooper B, Handin RI, Young LH, Alexander RW. Agonist regulation of the human platelet alpha-adrenergic receptor. Nature. 1978 Aug 17; 274(5672):703-6. PMID: 209342.
    Citations: 12     Fields:    Translation:HumansCells
  100. Handin RI, Stossel TP. Effect of corticosteroid therapy on the phagocytosis of antibody-coated platelets by human leukocytes. Blood. 1978 May; 51(5):771-9. PMID: 565227.
    Citations: 7     Fields:    Translation:HumansCells
  101. Alexander RW, Cooper B, Handin RI. Characterization of the human platelet alpha-adrenergic receptor. Correlation of [3H]dihydroergocryptine binding with aggregation and adenylate cyclase inhibition. J Clin Invest. 1978 May; 61(5):1136-44. PMID: 207726; PMCID: PMC372633.
    Citations: 17     Fields:    Translation:HumansCells
  102. Handin RI, McDonough M, Lesch M. Elevation of platelet factor four in acute myocardial infarction: measurement by radioimmunoassay. J Lab Clin Med. 1978 Feb; 91(2):340-9. PMID: 621432.
    Citations: 14     Fields:    Translation:Humans
  103. Buchanan GR, Martin V, Levine PH, Scoon K, Handin RI. The effects of "anti-platelet" drugs on bleeding time and platelet aggregation in normal human subjects. Am J Clin Pathol. 1977 Sep; 68(3):355-9. PMID: 331937.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  104. Handin RI, Karabin R, Boxer GJ. Enhancement of platelet function by superoxide anion. J Clin Invest. 1977 May; 59(5):959-65. PMID: 192766; PMCID: PMC372304.
    Citations: 20     Fields:    Translation:HumansCells
  105. Buchanan GR, Green DM, Handin RI. Combined von Willebrand disease and Hageman factor deficiency. J Pediatr. 1977 May; 90(5):779-81. PMID: 300792.
    Citations: 1     Fields:    Translation:Humans
  106. Handin RI, Martin V, Moloney WC. Antibody-induced von Willebrand's disease: a newly defined inhibitor syndrome. Blood. 1976 Sep; 48(3):393-405. PMID: 1085186.
    Citations: 6     Fields:    Translation:HumansCells
  107. Handin RI, Cohen HJ. Purification and binding properties of human platelet factor four. J Biol Chem. 1976 Jul 25; 251(14):4273-82. PMID: 819438.
    Citations: 38     Fields:    Translation:HumansCells
  108. Broekman MJ, Handin RI, Derksen A, Cohen P. Distribution of phospholipids, fatty acids, and platelet factor 3 activity among subcellular fractions of human platelets. Blood. 1976 Jun; 47(6):963-71. PMID: 1276478.
    Citations: 9     Fields:    Translation:HumansCells
  109. Buchanan GR, Handin RI. Platelet function in the Chediak-Higashi syndrome. Blood. 1976 Jun; 47(6):941-8. PMID: 1276475.
    Citations: 12     Fields:    Translation:HumansCells
  110. Laks H, Handin RI, Martin V, Pilon RN. The effects of acute normovolemic hemodilution on coagulation and blood utilization in major surgery. J Surg Res. 1976 Mar; 20(3):225-30. PMID: 1263487.
    Citations: 2     Fields:    Translation:HumansCells
  111. Broekman MJ, Handin RI, Cohen P. Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets. Br J Haematol. 1975 Sep; 31(1):51-5. PMID: 1212435.
    Citations: 13     Fields:    Translation:HumansCells
  112. Handin RI, Stossel TP. Phagocytosis of antibody-coated platelets by human granulocytes. N Engl J Med. 1974 May 02; 290(18):989-93. PMID: 4594526.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  113. Handin RI. Editorial: Platelet-phagocyte interactions in idiopathic thrombocytopenic purpura. N Engl J Med. 1974 Jan 31; 290(5):281-2. PMID: 4855569.
    Citations:    Fields:    Translation:HumansAnimalsCells
  114. Handin RI. Thromboembolic complications of pregnancy and oral contraceptives. Prog Cardiovasc Dis. 1974 Jan-Feb; 16(4):395-405. PMID: 4589897.
    Citations: 2     Fields:    Translation:Humans
  115. Rickman FD, Handin R, Howe JP, Alpert JS, Dexter L, Dalen JE. Fibrin split products in acute pulmonary embolism. Ann Intern Med. 1973 Nov; 79(5):664-8. PMID: 4751742.
    Citations: 3     Fields:    Translation:Humans
  116. Handin RI, Piessens WF, Moloney WC. Stimulation of nonimmunized lymphocytes by platelet-antibody complexes in idiopathic thrombocytopenic purpura. N Engl J Med. 1973 Oct 04; 289(14):714-8. PMID: 4199423.
    Citations: 8     Fields:    Translation:HumansCells
  117. Handin RI, Valeri CR. Improved viability of previously frozen platelets. Blood. 1972 Oct; 40(4):509-13. PMID: 4561624.
    Citations: 5     Fields:    Translation:HumansCells
  118. Handin R, Smith AL. Immunoidiopathic or immunogenic thrombocytopenic purpura. N Engl J Med. 1972 Mar 30; 286(13):720-1. PMID: 5062207.
    Citations: 1     Fields:    Translation:HumansCells
  119. Valeri CR, Zaroulis CG, Rogers JC, Handin RI, Marchionni LD. Prostaglandins in the preparation of blood components. Science. 1972 Feb 04; 175(4021):539-42. PMID: 5008596.
    Citations:    Fields:    Translation:HumansCells
  120. Handin RI, Lawler KC, Valeri CR. Automated platelet counting. Am J Clin Pathol. 1971 Nov; 56(5):661-4. PMID: 4941518.
    Citations: 1     Fields:    Translation:HumansCells
  121. Handin RI, Valeri CR. Hemostatic effectiveness of platelets stored at 22 degrees C. N Engl J Med. 1971 Sep 02; 285(10):538-43. PMID: 5560569.
    Citations: 10     Fields:    Translation:HumansCells
  122. Handin RI, Fortier NL, Valeri CR. Platelet response to hypotonic stress after storage at 4 C or 22 C. Transfusion. 1970 Nov-Dec; 10(6):305-9. PMID: 5490097.
    Citations: 1     Fields:    Translation:HumansCells
  123. Dharmamba M, Handin RI, Nandi J, Bern HA. Effect of prolactin on freshwater survival and on plasma osmotic pressure of hypophysectomized Tilapia mossambica. Gen Comp Endocrinol. 1967 Oct; 9(2):295-302. PMID: 6055288.
    Citations: 4     Fields:    Translation:AnimalsCells
  124. HANDIN RI, NANDI J, BERN HA. EFFECT OF HYPOPHYSECTOMY ON SURVIVAL AND ON THYROID AND INTERRENAL HISTOLOGY OF THE CICHLID TELEOST TILAPIA MOSSAMBICA. J Exp Zool. 1964 Dec; 157:339-43. PMID: 14247736.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.