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Elisabeth M. Battinelli, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA200748 (ITALIANO, JOSEPH E) Dec 16, 2016 - Nov 30, 2021
    NIH/NCI
    How does malignancy subvert platelet and megakaryocytic biology?
    Role: Principal Investigator
  2. K08HL097070 (BATTINELLI, ELISABETH M) Sep 1, 2009 - Jun 30, 2014
    NIH/NHLBI
    Defining the Mechanisms by Which Plateletes Regulate Angiogenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE, Battinelli EM. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019 Jan 22; 3(2):198-211. PMID: 30670536.
    Citations:    
  2. Hall KT, Buring JE, Mukamal KJ, Vinayaga Moorthy M, Wayne PM, Kaptchuk TJ, Battinelli EM, Ridker PM, Sesso HD, Weinstein SJ, Albanes D, Cook NR, Chasman DI. COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. J Natl Cancer Inst. 2019 Jan 08. PMID: 30624689.
    Citations:    Fields:    
  3. Simmons DP, Herskovits AZ, Battinelli EM, Schur PH, Lemire SJ, Dorfman DM. Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity. Clin Chem Lab Med. 2018 Jul 26; 56(8):1289-1296. PMID: 27305702.
    Citations: 1     Fields:    
  4. Takagi S, Tsukamoto S, Park J, Johnson KE, Kawano Y, Moschetta M, Liu CJ, Mishima Y, Kokubun K, Manier S, Salem KZ, Huynh D, Sacco A, Forward J, Roccaro AM, Battinelli EM, Ghobrial IM. Platelets Enhance Multiple Myeloma Progression via IL-1ß Upregulation. Clin Cancer Res. 2018 May 15; 24(10):2430-2439. PMID: 29440174.
    Citations:    Fields:    
  5. Machlus KR, Battinelli EM. RBCs pin platelets against the (thrombus) wall. Blood. 2017 05 04; 129(18):2460-2461. PMID: 28473411.
    Citations: 1     Fields:    Translation:HumansCells
  6. Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arterioscler Thromb Vasc Biol. 2017 04; 37(4):664-674. PMID: 28153880.
    Citations: 8     Fields:    Translation:HumansCells
  7. Hollenhorst MA, Battinelli EM. Thrombosis, Hypercoagulable States, and Anticoagulants. Prim Care. 2016 Dec; 43(4):619-635. PMID: 27866581.
    Citations: 2     Fields:    Translation:Humans
  8. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6. PMID: 26647394; PMCID: PMC4760093.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Battinelli EM. Procoagulant Platelets: Not Just Full of Hot Air. Circulation. 2015 Oct 13; 132(15):1374-6. PMID: 26330410.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Battinelli EM. TTP and pregnancy. Blood. 2014 Mar 13; 123(11):1624-5. PMID: 24627517.
    Citations: 1     Fields:    Translation:Humans
  11. Battinelli EM, Marshall A, Connors JM. The role of thrombophilia in pregnancy. Thrombosis. 2013; 2013:516420. PMID: 24455235; PMCID: PMC3880751.
    Citations: 4     
  12. Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood. 2014 Jan 02; 123(1):101-12. PMID: 24065244; PMCID: PMC3879901.
    Citations: 26     Fields:    Translation:HumansCells
  13. Kuznetsov HS, Marsh T, Markens BA, Castaño Z, Greene-Colozzi A, Hay SA, Brown VE, Richardson AL, Signoretti S, Battinelli EM, McAllister SS. Identification of luminal breast cancers that establish a tumor-supportive macroenvironment defined by proangiogenic platelets and bone marrow-derived cells. Cancer Discov. 2012 Dec; 2(12):1150-65. PMID: 22896036; PMCID: PMC3517696.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  14. Battinelli EM, Murphy DL, Connors JM. Venous thromboembolism overview. Hematol Oncol Clin North Am. 2012 Apr; 26(2):345-67, ix. PMID: 22463831.
    Citations: 2     Fields:    Translation:Humans
  15. Battinelli EM. Reversal of new oral anticoagulants. Circulation. 2011 Oct 04; 124(14):1508-10. PMID: 21969317.
    Citations: 9     Fields:    Translation:Humans
  16. Battinelli EM, Markens BA, Italiano JE. Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood. 2011 Aug 04; 118(5):1359-69. PMID: 21680800; PMCID: PMC3152500.
    Citations: 71     Fields:    Translation:HumansCells
  17. Battinelli EM, Bauer KA. Thrombophilias in pregnancy. Hematol Oncol Clin North Am. 2011 Apr; 25(2):323-33, viii. PMID: 21444033.
    Citations: 2     Fields:    Translation:Humans
  18. Italiano JE, Battinelli EM. Selective sorting of alpha-granule proteins. J Thromb Haemost. 2009 Jul; 7 Suppl 1:173-6. PMID: 19630794; PMCID: PMC3004150.
    Citations: 21     Fields:    Translation:HumansCells
  19. Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE. Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood. 2009 Jan 29; 113(5):1112-21. PMID: 18802008; PMCID: PMC2635076.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  20. Italiano JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood. 2008 Feb 01; 111(3):1227-33. PMID: 17962514; PMCID: PMC2214735.
    Citations: 205     Fields:    Translation:HumansCells
  21. Battinelli EM, Hartwig JH, Italiano JE. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007 Sep; 14(5):419-26. PMID: 17934346.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  22. Battinelli, E.M. and Garnick, M.B. Complications of Chemotherapy for Urologic Cancer. Complications of Urologic Surgery and Practice K. Loughlin. 2007; 513.
  23. Battinelli EM, Ansell J. Cancer and thrombosis. Curr Hematol Rep. 2005 Sep; 4(5):378-84. PMID: 16131439.
    Citations:    Fields:    Translation:Humans
  24. Loscalzo, J. and Battinelli, E.M. Compositions and Methods for Producing Platelets and/or Proplatelets from Megakaryocytes. 2003.
  25. Battinelli E, Willoughby SR, Foxall T, Valeri CR, Loscalzo J. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14458-63. PMID: 11734646; PMCID: PMC64703.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  26. Battinelli E, Loscalzo J. Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood. 2000 Jun 01; 95(11):3451-9. PMID: 10828028.
    Citations: 17     Fields:    Translation:HumansCells
  27. Battinelli, E.M. and Loscalzo, J. Nitric Oxide and Platelet-Derived Hemostasis. Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. Vita. 2000; 123.
  28. Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res. 1999 Jun 25; 84(12):1416-21. PMID: 10381894.
    Citations: 50     Fields:    Translation:AnimalsCells
  29. Zhang, Y-Y, Prystupa, J., Battinelli, E.M., Loscalzo, J. Suppression of Human Pulmonary Artery Endothelial Cell Growth by 5-Lipoxygenase Inhibitors. Circulation. 1999; 100:I-1253.
  30. Battinelli, E.M., and Loscalzo, J. . Nitric Oxide Induces Platelet Formation from Megakaryocytes. Circulation. 1999; 100:I-3221.
  31. Battinelli, E.M. The Role of Nitric Oxide in Megakaryocyte Apoptosis and Thrombopoiesis. 1999.
  32. Battinelli, E.M., Trolliet, M.R., and Loscalzo, J. . Nitric Oxide and its role in hemostasis. The Pathophysiology and Clinical Applications of Nitric Oxide. G. Rubanyi,. 1998; 229.
  33. Battinelli, E.M., and Loscalzo, J. . Growth and maturation factors modulate nitric oxide-induced apoptosis in megakaryocytes. Circulation. 1998; 98:I-522.
  34. Freedman, J., Sauter, R., Battinelli, E., Ault, K., Knowles, C., Huang, P.L., and Loscalzo, J. . Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOS3 gene. Circulation. 1998; 98:I-4.
  35. Battinelli, E.M., and Loscalzo, J. Nitric oxide induces apoptosis in human megakaryocytes. Circulation. 1997; 96:I-724.
  36. Battinelli EM, Boyd Y, Craig IW, Breakefield XO, Chen ZY. Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp). Mamm Genome. 1996 Feb; 7(2):93-7. PMID: 8835523.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  37. Battinelli, E.M., Breakefield, X.O., and Chen, Z-Y . Characterization of the mouse NDP (Norrie disease ) locus. American Journal of Human Genetics. 1995; 747.
  38. Chen, Z-Y., Kramm, C.M., Battinelli, E.M., Li, F., Schuback, D.E., and Corey, D.P. . Neuron-specific expression of the Norrie Disease Gene (NDP) in the Central Nervous System. American Journal of Human Genetics. 1994; 747.
  39. Schuback, D.E., Adams, J.C., Chen, Z-Y., Battinelli, E.M., Craig, I.W., Corey, D.P., Breakefield, X.O., and Sims, K. . Identification of mutations in the Norrie Disease Gene and Further Elucidation of the Norrie location and function. American Journal of Human Genetics. 1994; 665.
  40. Bergen, A-A.B., Berger, W., Chen Z-Y., Diergaarde, P., Battinelli, E.M., Warburg, M., Bleeker-Wagemakers, L.M., Ropers, H-H., and Craig, I.W. . Norrie disease. Molecular Genetics of Inherited Eye Disorders. AF Wright and B. Jay. 1994; 321.
  41. Chen ZY, Battinelli EM, Fielder A, Bundey S, Sims K, Breakefield XO, Craig IW. A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy. Nat Genet. 1993 Oct; 5(2):180-3. PMID: 8252044.
    Citations: 63     Fields:    Translation:HumansCells
  42. Chen ZY, Battinelli EM, Woodruff G, Young I, Breakefield XO, Craig IW. Characterization of a mutation within the NDP gene in a family with a manifesting female carrier. Hum Mol Genet. 1993 Oct; 2(10):1727-9. PMID: 8268931.
    Citations: 6     Fields:    Translation:HumansCells
  43. Chen ZY, Battinelli EM, Hendriks RW, Powell JF, Middleton-Price H, Sims KB, Breakefield XO, Craig IW. Norrie disease gene: characterization of deletions and possible function. Genomics. 1993 May; 16(2):533-5. PMID: 8314592.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  44. Chen, Z-Y., Battinelli, E.M., Fielder, A., Bundey, S., Sims, K.B., Breakefield, X.O., and Craig, I.W. . Identification of a mutation in the Norrie Disease Gene (NDP) in affected members of a family with X-linked Familial Exudative Vitreoretinopathy. American Journal of Human Genetics. 1993; 1140.
  45. Battinelli, E.M. Molecular Characterisation of the Norrie Disease Gene. 1992.
  46. Battinelli, E.M. Characterization of the RNA Splicing Pattern of psbA in the chloroplast of Chlamydomonas reinhardtii. 1991.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.