Harvard Catalyst Profiles

The scope of our research includes basic, translational and clinical projects focused on human circuit neuroscience across the borders of neurology and psychiatry. Our questions address the anatomy and physiology of disease-relevant networks, the investigation of pathophysiological mechanisms at the circuit level (with an emphasis on transdiagnostic processes and the role of plasticity) and the translational development of tools to support clinical care and decision-making (e.g. biomarkers, predictors of response, treatment development). Critical efforts are geared towards applying the paradigms and methods of human systems neuroscience to discover treatment targets that support the development of new individualized precision therapeutics, with a focus on image-guided device-based neuromodulation. Methodologically, our lab uses multimodal combinations of brain stimulation, neuroimaging/neurophysiology and behavior to investigate neural circuitry and plasticity in a translational manner. We work with a wide range of noninvasive and invasive neuromodulation techniques including transcranial current stimulation (tCS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT) and deep brain stimulation (DBS). We also use functional and structural MRI, EEG and innovative simultaneous combinations of TMS and tDCS with neuroimaging.