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Sidharth Venkata Puram, M.D.,Ph.D.

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Overview
My scientific background includes training in biochemistry, neurobiology, drug delivery, cancer biology, and residency training in otolaryngology (head and neck surgery). My research began as an undergraduate in the laboratory of Robert Langer at MIT, where I identified novel methods for DNA vaccine delivery using pH-sensitive, biocompatible polymer microspheres (Choleris et al, PNAS 2007; Little et al, Journal of Controlled Release 2005; Little et al, PNAS 2004). Following my undergraduate degrees in Biology and Neuroscience, I entered the Medical Scientist Training Program at Harvard Medical School where I graduated Magna Cum Laude (M.D.) with a PhD in Pathology from the Biology and Biomedical Sciences program. Working in the laboratory of Azad Bonni, I was able to define mechanisms that drive dendrite growth and retraction, including a centrosomal signaling pathway linking calcium signaling at the membrane to the ubiquitin proteasome system (Kim et al., Cell 2009; Puram et al, Nature Neuroscience 2011; Puram et al, Genes and Development, 2011; Puram et al., Cell Reports 2013). These studies identified an entirely novel function for the abundant protein CaMKIIß, which represents 1-2% of protein in the brain, together establishing a major area of research into the homeostatic mechanisms orchestrating dendrite pruning and remodeling (Valnegri*, Puram* et al, Trends in Neuroscience 2015; Puram et al, Development 2015; Puram and Bonni, Seminars in Cell and Developmental Biology 2011; Puram et al, Cell Cycle 2010). I was able to apply skills in biochemistry and cell biology to additional graduate studies on the context-dependent, dual role of the transcription factor STAT3 as an oncogene and tumor suppressor in human glioma models (de la Igelesia et al, Genes and Development 2008; Puram et al, Journal of Neuroscience 2012; Jahani-Asl et al, Nature Neuroscience 2016). These studies challenged the traditional view of transcription factors as unidirectional drivers in oncology, while identifying genetic context-specific pathways that may regulate glioma tumorigenesis (de la Iglesia et al, Current Molecular Medicine 2009). Together, these experiences stimulated a deep interest in tumor biology and the mechanisms that drive growth, invasion, and metastasis, while providing a rich skill set to complete further studies. I am now applying this experience to a post-doctoral project in Brad Bernstein’s laboratory at Massachusetts General Hospital where we are leveraging single cell RNA sequencing to define intratumoral heterogeneity in head and neck squamous cell carcinoma. I have successfully mentored trainees and developed collaborative efforts related to this project, while pursuing additional studies ranging from genomic analyses of adenoid cystic carcinoma, esthesioneuroblastoma, and cutaneous squamous cell carcinoma to basic biological studies of squamous cell differentiation. We hope that our efforts will provide an advanced understanding of diverse cellular populations and the genetic mechanisms governing cancers of the head and neck (Puram et al, Hematology Oncology Clinics of North America 2015). My clinical interests include electrophysiologic parameters defining intraoperative injury to the recurrent laryngeal nerve, transfusion outcomes following head and neck free and pedicled flap reconstruction, and national health care metrics after head and neck cancer surgery.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DE031072 (PURAM, SIDHARTH VENKATA) Aug 1, 2021 - Jul 31, 2023
    NIH
    RNA modification and the regulation of partial EMT in head and neck cancer
    Role: Principal Investigator
  2. K08CA237732 (PURAM, SIDHARTH VENKATA) Sep 1, 2019 - Aug 31, 2024
    NIH
    Understanding programs of invasion and metastasis in head and neck cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Awan M, Akakpo KE, Shukla M, Graboyes EM, Pipkorn P, Puram SV, Zenga J. The Substantial Omission of Indicated Postoperative Radiotherapy in Patients With Advanced-Stage Oral Cancer in the US-A Call to Action. JAMA Otolaryngol Head Neck Surg. 2021 10 01; 147(10):907-909. PMID: 34383035.
    Citations:    Fields:    
  2. Bulbul MG, Tarabichi O, Parikh AS, Yoon BC, Juliano A, Sadow PM, Faquin W, Gropler M, Walker R, Puram SV, Varvares MA. The utility of intra-oral ultrasound in improving deep margin clearance of oral tongue cancer resections. Oral Oncol. 2021 11; 122:105512. PMID: 34564016.
    Citations:    Fields:    
  3. Walia A, Lee JJ, Jackson RS, Hardi AC, Bollig CA, Graboyes EM, Zenga J, Puram SV, Pipkorn P. Management of Flap Failure After Head and Neck Reconstruction: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2021 Sep 07; 1945998211044683. PMID: 34491852.
    Citations:    Fields:    
  4. Sun H, Cao S, Mashl RJ, Mo CK, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, Mudd JL, Dean DA, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM, Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX, Aft R, Fuh KC, Schwarz JK, Zevallos JP, Puram SV, Dipersio JF, Davis-Dusenbery B, Ellis MJ, Lewis MT, Davies MA, Herlyn M, Fang B, Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Chuang JH, Raphael BJ, Ding L. Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment. Nat Commun. 2021 08 24; 12(1):5086. PMID: 34429404.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Li MM, Zhao S, Eskander A, Rygalski C, Brock G, Parikh AS, Haring CT, Swendseid B, Zhan KY, Bradford CR, Teknos TN, Carrau RL, VanKoevering KK, Seim NB, Old MO, Rocco JW, Puram SV, Kang SY. ASO Visual Abstract: Stage Migration and Survival Trends in Laryngeal Cancer. Ann Surg Oncol. 2021 Aug 03. PMID: 34346018.
    Citations:    Fields:    
  6. Bollig CA, Wang K, Llerena P, Puram SV, Pipkorn PJ, Jackson RS, Stubbs VC. National Analysis of Oropharyngeal Salivary Gland Malignancies Treated With Transoral Robotic Surgery. Otolaryngol Head Neck Surg. 2021 Jul 27; 1945998211031161. PMID: 34311621.
    Citations:    Fields:    
  7. Li MM, Zhao S, Eskander A, Rygalski C, Brock G, Parikh AS, Haring CT, Swendseid B, Zhan KY, Bradford CR, Teknos TN, Carrau RL, VanKoevering KK, Seim NB, Old MO, Rocco JW, Puram SV, Kang SY. Stage Migration and Survival Trends in Laryngeal Cancer. Ann Surg Oncol. 2021 Nov; 28(12):7300-7309. PMID: 34263369.
    Citations:    Fields:    Translation:Humans
  8. Pal A, Barrett TF, Paolini R, Parikh A, Puram SV. Partial EMT in head and neck cancer biology: a spectrum instead of a switch. Oncogene. 2021 Aug; 40(32):5049-5065. PMID: 34239045.
    Citations:    Fields:    
  9. Koss K, Massey B, Graboyes EM, Pipkorn P, Varvares MA, Puram SV, Zenga J. Anastomosis to the Internal Jugular Vein Stump: A Highly Reliable Technique in Head and Neck Reconstruction. Facial Plast Surg Aesthet Med. 2021 Jul 01. PMID: 34197217.
    Citations:    
  10. Massa ST, Mazul AL, Puram SV, Pipkorn P, Zevallos JP, Piccirillo JF. Association of Demographic and Geospatial Factors With Treatment Selection for Laryngeal Cancer. JAMA Otolaryngol Head Neck Surg. 2021 07 01; 147(7):590-598. PMID: 33885716.
    Citations: 1     Fields:    Translation:Humans
  11. Stabenau KA, Akakpo KE, Richmon JD, McMullen C, Holcomb AJ, Graboyes EM, Gross J, Pipkorn P, Puram SV, Zenga J. Postoperative wound infections in head and neck surgery: The current state of antiseptic and antibiotic practices. Oral Oncol. 2021 07; 118:105361. PMID: 34083128.
    Citations:    Fields:    Translation:Humans
  12. Barrett TF, Mazul AL, Stepan KO, Wood CB, Paniello RC, Zevallos JP, Massa S, Jackson RS, Schmitt NC, Zenga J, Kang SY, Pipkorn P, Rich JT, Puram SV. The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database. Oral Oncol. 2021 07; 118:105330. PMID: 33991757.
    Citations:    Fields:    
  13. Bulbul MG, Wu M, Lin D, Emerick K, Deschler D, Richmon J, Goldsmith T, Zenga J, Puram SV, Varvares MA. Prediction of Speech, Swallowing, and Quality of Life in Oral Cavity Cancer Patients: A Pilot Study. Laryngoscope. 2021 11; 131(11):2497-2504. PMID: 33881173.
    Citations:    Fields:    
  14. Abt NB, Miller LE, Mokhtari TE, Lin DT, Richmon JD, Deschler DG, Varvares MA, Puram SV. Nasal and paranasal sinus mucosal melanoma: Long-term survival outcomes and prognostic factors. Am J Otolaryngol. 2021 Nov-Dec; 42(6):103070. PMID: 33930681.
    Citations:    Fields:    
  15. Lee JJ, Wood CB, Puram SV, Zenga J, Bollig CA, Pipkorn P. Free vascularized parascapular fat flap for parotidectomy reconstruction. Am J Otolaryngol. 2021 Sep-Oct; 42(5):103028. PMID: 33848769.
    Citations:    Fields:    
  16. Akakpo KE, Varvares MA, Richmon JD, McMullen C, Holcomb AJ, Rezaee R, Tamaki A, Curry J, Old MO, Kang SY, Graboyes EM, Gross J, Pipkorn P, Puram SV, Zenga J. The tipping point in oral cavity reconstruction: A multi-institutional survey of choice between flap and non-flap reconstruction. Oral Oncol. 2021 09; 120:105267. PMID: 33810989.
    Citations: 1     Fields:    
  17. Campbell DA, Pipkorn P, Divi V, Stadler M, Massey B, Campbell B, Richmon JD, Graboyes E, Puram S, Zenga J. The effect of reconstruction on positive margin rates in oral cancer: Using length of stay as a proxy measure for flap reconstruction in a national database. Am J Otolaryngol. 2021 Sep-Oct; 42(5):103012. PMID: 33857781.
    Citations:    Fields:    
  18. Jackson RS, Stepan K, Bollig C, Sharma RK, Patel M, Massa S, Puram SV, Zevallos JP, Pipkorn P, Zenga J. Outcomes of HPV-Negative Oropharyngeal Cancer Treated With Transoral Robotic Surgery. Otolaryngol Head Neck Surg. 2021 11; 165(5):682-689. PMID: 33752484.
    Citations:    Fields:    
  19. Qi Z, Liu Y, Mints M, Mullins R, Sample R, Law T, Barrett T, Mazul AL, Jackson RS, Kang SY, Pipkorn P, Parikh AS, Tirosh I, Dougherty J, Puram SV. Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2021 Mar 11; 13(6). PMID: 33799782.
    Citations: 3     
  20. Stepan KO, Mazul AL, Skillington SA, Paniello RC, Rich JT, Zevallos JP, Jackson RS, Pipkorn P, Massa S, Puram SV. The prognostic significance of race in nasopharyngeal carcinoma by histological subtype. Head Neck. 2021 06; 43(6):1797-1811. PMID: 33620125.
    Citations:    Fields:    Translation:Humans
  21. Sample RA, Wood CB, Mazul AL, Barrett TF, Paniello RC, Rich JT, Kang SY, Zevallos J, Daly MD, Thorstad WL, Chen SY, Pipkorn P, Jackson RS, Puram SV. Low-risk human papilloma virus positive oropharyngeal cancer with one positive lymph node: Equivalent outcomes in patients treated with surgery and radiation therapy versus surgery alone. Head Neck. 2021 06; 43(6):1759-1768. PMID: 33586842.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  22. Walia A, Mendoza J, Bollig CA, Craig EJ, Jackson RS, Rich JT, Puram SV, Massa ST, Pipkorn P. A Comprehensive Analysis of Complications of Free Flaps for Oromandibular Reconstruction. Laryngoscope. 2021 09; 131(9):1997-2005. PMID: 33571385.
    Citations:    Fields:    Translation:Humans
  23. Chen SY, Sinha P, Last A, Ettyreddy A, Kallogjeri D, Pipkorn P, Rich JT, Zevallos JP, Paniello R, Puram SV, Van Abel K, Moore EJ, Oppelt P, Palka K, Adkins D, Daly M, Gay H, Thorstad WL, Jackson RS. Outcomes of Patients With Single-Node Metastasis of Human Papillomavirus-Related Oropharyngeal Cancer Treated With Transoral Surgery. JAMA Otolaryngol Head Neck Surg. 2021 01 01; 147(1):16-22. PMID: 33151273.
    Citations:    Fields:    Translation:Humans
  24. Lee DS, Ramirez RJ, Lee JJ, Valenzuela CV, Zevallos JP, Mazul AL, Puram SV, Doering MM, Pipkorn P, Jackson RS. Survival of Young Versus Old Patients With Oral Cavity Squamous Cell Carcinoma: A Meta-Analysis. Laryngoscope. 2021 06; 131(6):1310-1319. PMID: 33264444.
    Citations: 1     Fields:    Translation:Humans
  25. Mazul AL, Naik AN, Zhan KY, Stepan KO, Old MO, Kang SY, Nakken ER, Puram SV. Gender and race interact to influence survival disparities in head and neck cancer. Oral Oncol. 2021 01; 112:105093. PMID: 33232879.
    Citations: 2     Fields:    Translation:HumansCells
  26. Andruska N, Mahapatra L, Brenneman RJ, Huang Y, Paniello RC, Puram SV, Mansour M, Rich JT, Baumann BC, Thorstad WL, Daly MD. Regional lymph node irradiation in locally advanced Merkel cell carcinoma reduces regional and distant relapse and improves disease-specific survival. Radiother Oncol. 2021 02; 155:246-253. PMID: 33212121.
    Citations: 2     Fields:    Translation:Humans
  27. Rygalski CJ, Zhao S, Eskander A, Zhan KY, Mroz EA, Brock G, Silverman DA, Blakaj D, Bonomi MR, Carrau RL, Old MO, Rocco JW, Seim NB, Puram SV, Kang SY. Time to Surgery and Survival in Head and Neck Cancer. Ann Surg Oncol. 2021 Feb; 28(2):877-885. PMID: 33188461.
    Citations: 1     Fields:    Translation:Humans
  28. Rygalski CJ, Zhao S, Eskander A, Puram SV, Kang SY. ASO Author Reflections: Head and Neck Cancer Surgery-How Long Can it Wait? Ann Surg Oncol. 2021 Feb; 28(2):886-887. PMID: 33185735.
    Citations:    Fields:    Translation:Humans
  29. Bahethi RR, Stepan KO, Pinotti R, Li R, Agrawal N, Puram SV, Miles BA, Barber B. Genetic Mutations in Young Nonsmoking Patients With Oral Cavity Cancer: A Systematic Review. OTO Open. 2020 Oct-Dec; 4(4):2473974X20970181. PMID: 33210069.
    Citations:    
  30. Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I. Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nat Genet. 2020 11; 52(11):1208-1218. PMID: 33128048.
    Citations: 13     Fields:    Translation:HumansCells
  31. Bollig CA, Lee DS, Mazul AL, Stepan K, Puram SV, Massa ST, Zenga J, Faden DL, Doering MM, Jackson RS, Pipkorn P. Systematic Review of Second Primary Oropharyngeal Cancers in Patients With p16+ Oropharyngeal Cancer. Otolaryngol Head Neck Surg. 2021 04; 164(4):733-740. PMID: 32928026.
    Citations:    Fields:    Translation:Humans
  32. Parikh A, Shin J, Faquin W, Lin DT, Tirosh I, Sunwoo JB, Puram SV. Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. J Immunother Cancer. 2020 09; 8(2). PMID: 32958684.
    Citations: 3     Fields:    Translation:HumansCells
  33. Bauer E, Mazul A, Zenga J, Graboyes EM, Jackson R, Puram SV, Doering M, Pipkorn P. Complications After Soft Tissue With Plate vs Bony Mandibular Reconstruction: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2021 03; 164(3):501-511. PMID: 32838614.
    Citations: 1     Fields:    Translation:Humans
  34. Bulbul MG, Zenga J, Tarabichi O, Parikh AS, Sethi RK, Robbins KT, Puram SV, Varvares MA. Margin Practices in Oral Cavity Cancer Resections: Survey of American Head and Neck Society Members. Laryngoscope. 2021 04; 131(4):782-787. PMID: 32827312.
    Citations: 1     Fields:    Translation:Humans
  35. Stepan KO, Li MM, Kang SY, Puram SV. Molecular margins in head and neck cancer: Current techniques and future directions. Oral Oncol. 2020 11; 110:104893. PMID: 32702629.
    Citations: 3     Fields:    Translation:HumansCells
  36. Silverman DA, Zhan KY, Puram SV, Eskander A, Teknos TN, Rocco JW, Old MO, Kang SY. Predictors of Postoperative Radiation Following Laser Resection in Early-Stage Glottic Cancer. Otolaryngol Head Neck Surg. 2020 12; 163(6):1218-1225. PMID: 32631147.
    Citations:    Fields:    Translation:Humans
  37. Mazul AL, Stepan KO, Barrett TF, Thorstad WL, Massa S, Adkins DR, Daly MD, Rich JT, Paniello RC, Pipkorn P, Zevallos JP, Jackson RS, Kang SY, Puram SV. Duration of radiation therapy is associated with worse survival in head and neck cancer. Oral Oncol. 2020 09; 108:104819. PMID: 32485609.
    Citations: 2     Fields:    Translation:Humans
  38. Lindeborg MM, Sethi RKV, Puram SV, Parikh A, Yarlagadda B, Varvares M, Emerick K, Lin D, Durand ML, Deschler DG. Predicting length of stay in head and neck patients who undergo free flap reconstruction. Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):461-467. PMID: 32596488.
    Citations:    
  39. Silverman DA, Lin C, Tamaki A, Puram SV, Carrau RL, Seim NB, Eskander A, Rocco JW, Old MO, Kang SY. Respiratory and pulmonary complications in head and neck cancer patients: Evidence-based review for the COVID-19 era. Head Neck. 2020 06; 42(6):1218-1226. PMID: 32343013.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  40. Abt NB, Puram SV, Kamani D, Modi R, Randolph GW. Neuromonitored Thyroid Surgery: Optimal Stimulation Based on Intraoperative EMG Response Features. Laryngoscope. 2020 12; 130(12):E970-E975. PMID: 32176321.
    Citations: 2     Fields:    Translation:Humans
  41. Lindeborg MM, Puram SV, Sethi RKV, Abt N, Emerick KS, Lin D, Deschler DG. Predictive factors for prolonged operative time in head and neck patients undergoing free flap reconstruction. Am J Otolaryngol. 2020 Mar - Apr; 41(2):102392. PMID: 31918856.
    Citations: 2     Fields:    Translation:Humans
  42. Zhan KY, Puram SV, Li MM, Silverman DA, Agrawal AA, Ozer E, Old MO, Carrau RL, Rocco JW, Higgins KM, Enepekides DJ, Husain Z, Kang SY, Eskander A. National treatment trends in human papillomavirus-positive oropharyngeal squamous cell carcinoma. Cancer. 2020 03 15; 126(6):1295-1305. PMID: 31825543.
    Citations: 2     Fields:    Translation:Humans
  43. Parikh AS, Khawaja A, Puram SV, Srikanth P, Tjoa T, Lee H, Sethi RKV, Bulbul M, Varvares MA, Rocco JW, Emerick KS, Deschler DG, Lin DT. Outcomes and prognostic factors in parotid gland malignancies: A 10-year single center experience. Laryngoscope Investig Otolaryngol. 2019 Dec; 4(6):632-639. PMID: 31890881.
    Citations: 5     
  44. Parikh AS, Puram SV, Faquin WC, Richmon JD, Emerick KS, Deschler DG, Varvares MA, Tirosh I, Bernstein BE, Lin DT. Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis. Oral Oncol. 2019 12; 99:104458. PMID: 31704557.
    Citations: 11     Fields:    Translation:Humans
  45. Qi Z, Barrett T, Parikh AS, Tirosh I, Puram SV. Single-cell sequencing and its applications in head and neck cancer. Oral Oncol. 2019 12; 99:104441. PMID: 31689639.
    Citations: 15     Fields:    Translation:Humans
  46. Bulbul MG, Zenga J, Puram SV, Tarabichi O, Parikh AS, Varvares MA. Understanding approaches to measurement and impact of depth of invasion of oral cavity cancers: A survey of American Head and Neck Society Membership. Oral Oncol. 2019 12; 99:104461. PMID: 31678765.
    Citations: 2     Fields:    Translation:Humans
  47. Sethia R, Allarakhia Z, Puram S, Kang S, Ozer E, Agrawal A, Carrau R, Rocco J, Old M. Free flap salvage from venous thrombosis by creation of a venocutaneous fistula: Case report and review of the literature. Head Neck. 2019 12; 41(12):E159-E162. PMID: 31512798.
    Citations:    Fields:    Translation:Humans
  48. Varvares MA, McIntyre J, Bulbul MG, Puram SV. Letter to the Editor "Stage II Oral Tongue Cancer: Survival Impact of Adjuvant Radiation Based on Depth of Invasion". Otolaryngol Head Neck Surg. 2019 09; 161(3):543. PMID: 31478474.
    Citations:    Fields:    Translation:Humans
  49. Silverman DA, Li MM, Puram SV, Kang SY. ASO Author Reflections: Margin Analysis in Head and Neck Cancer-State of the Art and Future Directions. Ann Surg Oncol. 2019 Nov; 26(12):4081-4082. PMID: 31471843.
    Citations:    Fields:    Translation:Humans
  50. Li MM, Puram SV, Silverman DA, Old MO, Rocco JW, Kang SY. Margin Analysis in Head and Neck Cancer: State of the Art and Future Directions. Ann Surg Oncol. 2019 Nov; 26(12):4070-4080. PMID: 31385128.
    Citations: 6     Fields:    Translation:Humans
  51. Feng AL, Puram SV, Singer MC, Modi R, Kamani D, Randolph GW. Increased prevalence of neural monitoring during thyroidectomy: Global surgical survey. Laryngoscope. 2020 04; 130(4):1097-1104. PMID: 31361342.
    Citations: 3     Fields:    Translation:Humans
  52. Davis-Marcisak EF, Sherman TD, Orugunta P, Stein-O'Brien GL, Puram SV, Roussos Torres ET, Hopkins AC, Jaffee EM, Favorov AV, Afsari B, Goff LA, Fertig EJ. Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data. Cancer Res. 2019 10 01; 79(19):5102-5112. PMID: 31337651.
    Citations: 8     Fields:    Translation:Humans
  53. Lin C, Puram SV, Bulbul MG, Sethi RK, Rocco JW, Old MO, Kang SY. Elective neck dissection for salvage laryngectomy: A systematic review and meta-analysis. Oral Oncol. 2019 09; 96:97-104. PMID: 31422220.
    Citations: 2     Fields:    Translation:Humans
  54. Abt NB, Tarabanis C, Miller AL, Puram SV, Varvares MA. Preoperative anemia displays a dose-dependent effect on complications in head and neck oncologic surgery. Head Neck. 2019 09; 41(9):3033-3040. PMID: 31034668.
    Citations: 1     Fields:    Translation:Humans
  55. Barbarite E, Puram SV, Derakhshan A, Rossi ED, Faquin WC, Varvares MA. A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology. Laryngoscope. 2020 01; 130(1):80-85. PMID: 30848480.
    Citations: 7     Fields:    Translation:Humans
  56. Puram SV, Bhattacharyya N. Surgery versus radiation for T1 glottic carcinoma: Second primary considerations. Laryngoscope. 2019 12; 129(12):2713-2715. PMID: 30767222.
    Citations: 1     Fields:    Translation:Humans
  57. Silverman DA, Puram SV, Rocco JW, Old MO, Kang SY. Salvage laryngectomy following organ-preservation therapy - An evidence-based review. Oral Oncol. 2019 01; 88:137-144. PMID: 30616784.
    Citations: 7     Fields:    Translation:Humans
  58. Yu PK, Sethi RKV, Rathi V, Puram SV, Lin DT, Emerick KS, Durand ML, Deschler DG. Postoperative care in an intermediate-level medical unit after head and neck microvascular free flap reconstruction. Laryngoscope Investig Otolaryngol. 2019 Feb; 4(1):39-42. PMID: 30828617.
    Citations: 1     
  59. Holbrook EH, Puram SV, See RB, Tripp AG, Nair DG. Induction of smell through transethmoid electrical stimulation of the olfactory bulb. Int Forum Allergy Rhinol. 2019 02; 9(2):158-164. PMID: 30480384.
    Citations: 4     Fields:    Translation:Humans
  60. Abt NB, Puram SV, Sinha S, Sethi RKV, Goyal N, Emerick KS, Lin DT, Deschler DG. Transfusion in Head and Neck Cancer Patients Undergoing Pedicled Flap Reconstruction. Laryngoscope. 2018 12; 128(12):E409-E415. PMID: 30247764.
    Citations: 3     Fields:    Translation:Humans
  61. Sethi RKV, Panth N, Puram SV, Varvares MA. Opioid Prescription Patterns Among Patients With Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2018 Apr 01; 144(4):382-383. PMID: 29522065.
    Citations: 3     Fields:    Translation:Humans
  62. Puram SV, Parikh AS, Tirosh I. Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer. Mol Cell Oncol. 2018; 5(3):e1448244. PMID: 30250901.
    Citations: 25     
  63. Abt NB, Sethi RK, Puram SV, Varvares MA. Preoperative laboratory data are associated with complications and surgical site infection in composite head and neck surgical resections. Am J Otolaryngol. 2018 May - Jun; 39(3):261-265. PMID: 29398185.
    Citations:    Fields:    Translation:Humans
  64. Puram SV, Bhattacharyya N. Identifying Metrics before and after Readmission following Head and Neck Surgery and Factors Affecting Readmission Rate. Otolaryngol Head Neck Surg. 2018 05; 158(5):860-866. PMID: 29336226.
    Citations: 1     Fields:    Translation:Humans
  65. Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell. 2017 Dec 14; 171(7):1611-1624.e24. PMID: 29198524.
    Citations: 413     Fields:    Translation:HumansCells
  66. Barber SR, Kozin ED, Remenschneider AK, Puram SV, Smith M, Herrmann BS, Cunnane ME, Brown MC, Lee DJ. Auditory Brainstem Implant Array Position Varies Widely Among Adult and Pediatric Patients and Is Associated With Perception. Ear Hear. 2017 Nov/Dec; 38(6):e343-e351. PMID: 28700445.
    Citations: 5     Fields:    Translation:Humans
  67. Rathi VK, Gadkaree SK, Ross JS, Kozin ED, Sethi RK, Naunheim MR, Puram SV, Gray ST. US Food and Drug Administration Clearance of Moderate-Risk Otolaryngologic Devices via the 510(k) Process, 1997-2016. Otolaryngol Head Neck Surg. 2017 10; 157(4):608-617. PMID: 28786317.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  68. Abt NB, Xie Y, Puram SV, Richmon JD, Varvares MA. Frailty index: Intensive care unit complications in head and neck oncologic regional and free flap reconstruction. Head Neck. 2017 08; 39(8):1578-1585. PMID: 28449296.
    Citations: 6     Fields:    Translation:Humans
  69. Puram SV, Doody J, Cunningham MJ. A Young Boy With Progressive Dysphonia. JAMA Otolaryngol Head Neck Surg. 2017 03 01; 143(3):313-314. PMID: 28097294.
    Citations:    Fields:    Translation:Humans
  70. Abt NB, Srikanth P, Puram SV, Deschler DG. Repair of complex pharyngocutaneous fistula using a staged temporoparietal fascial flap. Am J Otolaryngol. 2017 Mar - Apr; 38(2):254-256. PMID: 27916282.
    Citations:    Fields:    Translation:Humans
  71. Sinha S, Puram SV, Sethi RK, Goyal N, Emerick KS, Lin D, Durand ML, Deschler DG. Perioperative Deep Vein Thrombosis Risk Stratification. Otolaryngol Head Neck Surg. 2017 01; 156(1):118-121. PMID: 27600631.
    Citations: 1     Fields:    Translation:Humans
  72. Puram SV, Bhattacharyya N. Quality Indicators for Head and Neck Oncologic Surgery: Academic versus Nonacademic Outcomes. Otolaryngol Head Neck Surg. 2016 11; 155(5):733-739. PMID: 27329425.
    Citations: 3     Fields:    Translation:Humans
  73. Puram SV, Chow H, Wu CW, Heaton JT, Kamani D, Gorti G, Chiang FY, Dionigi G, Barczynski M, Schneider R, Dralle H, Lorenz K, Randolph GW. Posterior cricoarytenoid muscle electrophysiologic changes are predictive of vocal cord paralysis with recurrent laryngeal nerve compressive injury in a canine model. Laryngoscope. 2016 12; 126(12):2744-2751. PMID: 27113438.
    Citations: 6     Fields:    Translation:Animals
  74. Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci. 2016 06; 19(6):798-806. PMID: 27110918.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  75. Puram SV, Barber SR, Kozin ED, Shah P, Remenschneider A, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. Outcomes following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center. Otolaryngol Head Neck Surg. 2016 07; 155(1):133-8. PMID: 27095049.
    Citations: 10     Fields:    Translation:Humans
  76. Puram SV, Lee DJ. Pediatric Auditory Brainstem Implant Surgery. Otolaryngol Clin North Am. 2015 Dec; 48(6):1117-48. PMID: 26553310.
    Citations: 4     Fields:    Translation:Humans
  77. Puram SV, Rocco JW. Molecular Aspects of Head and Neck Cancer Therapy. Hematol Oncol Clin North Am. 2015 Dec; 29(6):971-92. PMID: 26568543.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  78. Puram SV, Chow H, Wu CW, Heaton JT, Kamani D, Gorti G, Chiang FY, Dionigi G, Barczynski M, Schneider R, Dralle H, Lorenz K, Randolph GW. Vocal cord paralysis predicted by neural monitoring electrophysiologic changes with recurrent laryngeal nerve compressive neuropraxic injury in a canine model. Head Neck. 2016 04; 38 Suppl 1:E1341-50. PMID: 26348472.
    Citations: 7     Fields:    Translation:Animals
  79. Valnegri P, Puram SV, Bonni A. Regulation of dendrite morphogenesis by extrinsic cues. Trends Neurosci. 2015 Jul; 38(7):439-47. PMID: 26100142.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  80. Puram SV, Herrmann B, Barker FG, Lee DJ. Retrosigmoid Craniotomy for Auditory Brainstem Implantation in Adult Patients with Neurofibromatosis Type 2. J Neurol Surg B Skull Base. 2015 Dec; 76(6):440-50. PMID: 27054058.
    Citations: 2     
  81. Puram SV, Carter MS, Deschler D. Maggot infestation of an ulcerated neck wound. Ear Nose Throat J. 2015 Jun; 94(6):E47-8. PMID: 26053993.
    Citations:    Fields:    Translation:Humans
  82. Mohan S, Puram SV, Yarlagadda B, Nosé V, Deschler DG. Ossifying Parotid Carcinoma ex Pleomorphic Adenoma. Case Rep Otolaryngol. 2015; 2015:395358. PMID: 26075129.
    Citations: 2     
  83. Puram SV, Tward AD, Jung DH, Dilger AE, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. Auditory brainstem implantation in a 16-month-old boy with cochlear hypoplasia. Otol Neurotol. 2015 Apr; 36(4):618-24. PMID: 25473959.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  84. Noij KS, Remenschneider AK, Kozin ED, Puram S, Herrmann B, Cohen M, Cunnane MB, Lee DJ. Direct parasagittal magnetic resonance imaging of the internal auditory canal to determine cochlear or auditory brainstem implant candidacy in children. Laryngoscope. 2015 Oct; 125(10):2382-5. PMID: 25778542.
    Citations: 1     Fields:    Translation:Humans
  85. Puram SV, Yarlagadda BB, Sethi R, Muralidhar V, Chambers KJ, Emerick KS, Rocco JW, Lin DT, Deschler DG. Transfusion in head and neck free flap patients: practice patterns and a comparative analysis by flap type. Otolaryngol Head Neck Surg. 2015 Mar; 152(3):449-57. PMID: 25628368.
    Citations: 7     Fields:    Translation:Humans
  86. Kaplan AB, Kozin ED, Puram SV, Owoc MS, Shah PV, Hight AE, Sethi RKV, Remenschneider AK, Lee DJ. Auditory brainstem implant candidacy in the United States in children 0-17 years old. Int J Pediatr Otorhinolaryngol. 2015 Mar; 79(3):310-315. PMID: 25577282.
    Citations: 8     Fields:    Translation:Humans
  87. Puram SV, Kozin ED, Sethi RK, Hight AE, Shrime MG, Gray ST, Cohen MS, Lee DJ. Influence of trainee participation on operative times for adult and pediatric cochlear implantation. Cochlear Implants Int. 2015 May; 16(3):175-9. PMID: 25387322.
    Citations:    Fields:    Translation:Humans
  88. Puram SV, Kozin ED, Sethi R, Alkire B, Lee DJ, Gray ST, Shrime MG, Cohen M. Impact of resident surgeons on procedure length based on common pediatric otolaryngology cases. Laryngoscope. 2015 Apr; 125(4):991-7. PMID: 25251257.
    Citations: 8     Fields:    Translation:Humans
  89. Puram SV, Bonni A. Cell-intrinsic drivers of dendrite morphogenesis. Development. 2013 Dec; 140(23):4657-71. PMID: 24255095.
    Citations: 48     Fields:    Translation:AnimalsCells
  90. Puram SV, Roberts DS, Niesten ME, Dilger AE, Lee DJ. Cochlear implant outcomes in patients with superior canal dehiscence. Cochlear Implants Int. 2015 Jul; 16(4):213-21. PMID: 24074366.
    Citations: 2     Fields:    Translation:Humans
  91. Puram SV, Kim AH, Park HY, Anckar J, Bonni A. The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Cell Rep. 2013 Jul 11; 4(1):19-30. PMID: 23831032.
    Citations: 20     Fields:    Translation:AnimalsCells
  92. Puram SV, Hasserjian RP, Faquin WC, Lin HW, Rocco JW. Castleman disease presenting in the neck: report of a case and review of the literature. Am J Otolaryngol. 2013 May-Jun; 34(3):239-44. PMID: 23375540.
    Citations: 3     Fields:    Translation:Humans
  93. Puram SV, Yeung CM, Jahani-Asl A, Lin C, de la Iglesia N, Konopka G, Jackson-Grusby L, Bonni A. STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation. J Neurosci. 2012 Jun 06; 32(23):7806-18. PMID: 22674257.
    Citations: 21     Fields:    Translation:AnimalsCells
  94. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A. A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev. 2011 Dec 15; 25(24):2659-73. PMID: 22135323.
    Citations: 27     Fields:    Translation:AnimalsCells
  95. Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIß signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci. 2011 Jul 03; 14(8):973-83. PMID: 21725312.
    Citations: 42     Fields:    Translation:AnimalsCells
  96. Puram SV, Bonni A. Novel functions for the anaphase-promoting complex in neurobiology. Semin Cell Dev Biol. 2011 Aug; 22(6):586-94. PMID: 21439392.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  97. Puram SV, Kim AH, Bonni A. An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle. 2010 Feb 01; 9(3):482-5. PMID: 20195072.
    Citations: 6     Fields:    Translation:AnimalsCells
  98. de la Iglesia N, Puram SV, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med. 2009 Jun; 9(5):580-90. PMID: 19601808.
    Citations: 52     Fields:    Translation:HumansAnimals
  99. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009 Jan 23; 136(2):322-36. PMID: 19167333.
    Citations: 107     Fields:    Translation:AnimalsCells
  100. de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15; 22(4):449-62. PMID: 18258752.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  101. Choleris E, Little SR, Mong JA, Puram SV, Langer R, Pfaff DW. Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4670-5. PMID: 17360582.
    Citations: 43     Fields:    Translation:Animals
  102. Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Control Release. 2005 Oct 20; 107(3):449-62. PMID: 16112767.
    Citations: 24     Fields:    Translation:AnimalsCells
  103. Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9534-9. PMID: 15210954.
    Citations: 70     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.