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Linda Valeri, Ph.D.

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Overview
Dr. Linda Valeri has primary responsibility for the statistical consulting service of McLean’s Laboratory for Psychiatric Biostatistics.
Prior to joining McLean and Harvard Medical School, she earned a PhD in Biostatistics at Harvard University with a dissertation on causal mediation analysis. This method of causal inference is relevant for comparative effectiveness research, evaluating and improving policy recommendations, and explaining biological mechanisms. She then completed a two-year post-doctoral fellowship at the Harvard T.H. Chan School of Public Health, collaborating with multidisciplinary teams of researchers on studies of the social determinants of health disparities and of the effect of complex mixtures of environmental exposures on child neurodevelopment. The main focus of Dr. Valeri statistical research is on modeling mediation mechanisms characterized by continuous, discrete, and time-to-event measurements in the presence of interactions and when factors such as missing data and measurement error complicate estimation.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vesterinen HM, Dutcher TV, Errecaborde KM, Mahero MW, Macy KW, Prasarnphanich OO, Kassenborg H, Yulizar E, Fauzi RP, Budayanti NS, Suwandono A, Artama WT, Valeri L, Pelican KM. Strengthening multi-sectoral collaboration on critical health issues: One Health Systems Mapping and Analysis Resource Toolkit (OH-SMART) for operationalizing One Health. PLoS One. 2019; 14(7):e0219197. PMID: 31276535.
    Citations:    
  2. VanderWeele TJ, Valeri L, Ananth CV. Counterpoint: Mediation Formulas With Binary Mediators and Outcomes and the "Rare Outcome Assumption". Am J Epidemiol. 2019 Jul 01; 188(7):1204-1205. PMID: 30590417.
    Citations:    Fields:    
  3. Andersen MP, Valeri L, Starkopf L, Mortensen RN, Sessa M, Kragholm KH, Vardinghus-Nielsen H, Bøggild H, Lange T, Torp-Pedersen C. The Mediating Effect of Pupils' Physical Fitness on the Relationship Between Family Socioeconomic Status and Academic Achievement in a Danish School Cohort. Sports Med. 2019 May 20. PMID: 31111445.
    Citations:    
  4. Fasanelli F, Giraudo MT, Ricceri F, Valeri L, Zugna D. Marginal Time-Dependent Causal Effects in Mediation Analysis With Survival Data. Am J Epidemiol. 2019 May 01; 188(5):967-974. PMID: 30689682.
    Citations:    Fields:    
  5. Chouinard VA, Shinn AK, Valeri L, Chouinard PA, Gardner ME, Asan AE, Cohen BM, Öngür D. Visual hallucinations associated with multimodal hallucinations, suicide attempts and morbidity of illness in psychotic disorders. Schizophr Res. 2019 Jun; 208:196-201. PMID: 30842029.
    Citations:    
  6. Petimar J, Tabung FK, Valeri L, Rosner B, Chan AT, Smith-Warner SA, Giovannucci EL. Mediation of associations between adiposity and colorectal cancer risk by inflammatory and metabolic biomarkers. Int J Cancer. 2019 Jun 15; 144(12):2945-2953. PMID: 30521066.
    Citations:    Fields:    
  7. Bellavia A, Centorrino F, Jackson JW, Fitzmaurice G, Valeri L. The role of weight gain in explaining the effects of antipsychotic drugs on positive and negative symptoms: An analysis of the CATIE schizophrenia trial. Schizophr Res. 2019 Apr; 206:96-102. PMID: 30584025.
    Citations:    Fields:    
  8. Discacciati A, Bellavia A, Lee JJ, Mazumdar M, Valeri L. Med4way: a Stata command to investigate mediating and interactive mechanisms using the four-way effect decomposition. Int J Epidemiol. 2018 Nov 16. PMID: 30452641.
    Citations:    Fields:    
  9. Valeri L, Sugarman DE, Reilly ME, McHugh RK, Fitzmaurice GM, Greenfield SF. Group therapy for women with substance use disorders: In-session affiliation predicts women's substance use treatment outcomes. J Subst Abuse Treat. 2018 Nov; 94:60-68. PMID: 30243419.
    Citations:    Fields:    
  10. Bobb JF, Claus Henn B, Valeri L, Coull BA. Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health. 2018 08 20; 17(1):67. PMID: 30126431.
    Citations:    Fields:    Translation:PHPublic Health
  11. Votaw VR, Witkiewitz K, Valeri L, Bogunovic O, McHugh RK. Nonmedical prescription sedative/tranquilizer use in alcohol and opioid use disorders. Addict Behav. 2019 Jan; 88:48-55. PMID: 30142484.
    Citations:    Fields:    
  12. Rahman ML, Liang L, Valeri L, Su L, Zhu Z, Gao S, Mostofa G, Qamruzzaman Q, Hauser R, Baccarelli A, Christiani DC. Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh. Epigenetics. 2018; 13(6):573-590. PMID: 30099960.
    Citations:    Fields:    
  13. Hughes KC, Gao X, Baker JM, Stephen C, Kim IY, Valeri L, Schwarzschild MA, Ascherio A. Non-motor features of Parkinson's disease in a nested case-control study of US men. J Neurol Neurosurg Psychiatry. 2018 Dec; 89(12):1288-1295. PMID: 30076266.
    Citations:    Fields:    
  14. Lee JJ, Valeri L, Kapur K, Ibne Hasan MOS, Quamruzzaman Q, Wright RO, Bellinger DC, Christiani DC, Mazumdar M. Growth parameters at birth mediate the relationship between prenatal manganese exposure and cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. Int J Epidemiol. 2018 08 01; 47(4):1169-1179. PMID: 29733356.
    Citations:    Fields:    
  15. Blakely T, Disney G, Valeri L, Atkinson J, Teng A, Wilson N, Gurrin L. Socioeconomic and Tobacco Mediation of Ethnic Inequalities in Mortality over Time: Repeated Census-mortality Cohort Studies, 1981 to 2011. Epidemiology. 2018 07; 29(4):506-516. PMID: 29642084.
    Citations:    Fields:    
  16. Zou X, Zhu Y, Jackson JW, Bellavia A, Fitzmaurice GM, Centorrino F, Valeri L. The role of PANSS symptoms and adverse events in explaining the effects of paliperidone on social functioning: a causal mediation analysis approach. NPJ Schizophr. 2018 Jun 27; 4(1):13. PMID: 29950691.
    Citations:    
  17. Wilcox MA, Savitz AJ, Addington AM, Gray GS, Guinan EC, Jackson JW, Lehner T, Normand SL, Ranu H, Senthil G, Spertus J, Valeri L, Ross JS. The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data. NPJ Schizophr. 2018 Jun 27; 4(1):14. PMID: 29950580.
    Citations:    
  18. Bellavia A, Valeri L. Decomposition of the Total Effect in the Presence of Multiple Mediators and Interactions. Am J Epidemiol. 2018 Jun 01; 187(6):1311-1318. PMID: 29140421.
    Citations: 3     Fields:    
  19. Luque-Fernandez MA, Belot A, Valeri L, Cerulli G, Maringe C, Rachet B. Data-Adaptive Estimation for Double-Robust Methods in Population-Based Cancer Epidemiology: Risk Differences for Lung Cancer Mortality by Emergency Presentation. Am J Epidemiol. 2018 04 01; 187(4):871-878. PMID: 29020131.
    Citations:    Fields:    
  20. Stewart JG, Valeri L, Esposito EC, Auerbach RP. Peer Victimization and Suicidal Thoughts and Behaviors in Depressed Adolescents. J Abnorm Child Psychol. 2018 04; 46(3):581-596. PMID: 28444481.
    Citations:    Fields:    
  21. Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2018 Mar 09. PMID: 29523870.
    Citations:    Fields:    
  22. Lai PS, Bebell LM, Meney C, Valeri L, White MC. Epidemiology of antibiotic-resistant wound infections from six countries in Africa. BMJ Glob Health. 2017; 2(Suppl 4):e000475. PMID: 29588863.
    Citations: 1     
  23. Chiu YH, Bellavia A, James-Todd T, Correia KF, Valeri L, Messerlian C, Ford JB, Mínguez-Alarcón L, Calafat AM, Hauser R, Williams PL. Evaluating effects of prenatal exposure to phthalate mixtures on birth weight: A comparison of three statistical approaches. Environ Int. 2018 04; 113:231-239. PMID: 29453090.
    Citations:    Fields:    Translation:HumansPHPublic Health
  24. Rahman ML, Kile ML, Rodrigues EG, Valeri L, Raj A, Mazumdar M, Mostofa G, Quamruzzaman Q, Rahman M, Hauser R, Baccarelli A, Liang L, Christiani DC. Prenatal arsenic exposure, child marriage, and pregnancy weight gain: Associations with preterm birth in Bangladesh. Environ Int. 2018 03; 112:23-32. PMID: 29245039.
    Citations:    Fields:    Translation:HumansPHPublic Health
  25. Rahman ML, Valeri L, Kile ML, Mazumdar M, Mostofa G, Qamruzzaman Q, Rahman M, Baccarelli A, Liang L, Hauser R, Christiani DC. Investigating causal relation between prenatal arsenic exposure and birthweight: Are smaller infants more susceptible? Environ Int. 2017 11; 108:32-40. PMID: 28787626.
    Citations:    Fields:    Translation:HumansPHPublic Health
  26. Admon R, Treadway MT, Valeri L, Mehta M, Douglas S, Pizzagalli DA. Distinct Trajectories of Cortisol Response to Prolonged Acute Stress Are Linked to Affective Responses and Hippocampal Gray Matter Volume in Healthy Females. J Neurosci. 2017 08 16; 37(33):7994-8002. PMID: 28739584.
    Citations:    Fields:    Translation:Humans
  27. Valeri L, Mazumdar MM, Bobb JF, Claus Henn B, Rodrigues E, Sharif OIA, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect. 2017 06 26; 125(6):067015. PMID: 28669934.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  28. North CM, Valeri L, Hunt PW, Mocello AR, Martin JN, Boum Y, Haberer JE, Bangsberg DR, Christiani DC, Siedner MJ. Cooking fuel and respiratory symptoms among people living with HIV in rural Uganda. ERJ Open Res. 2017 Apr; 3(2). PMID: 28534032.
    Citations: 1     
  29. Chouinard VA, Kim SY, Valeri L, Yuksel C, Ryan KP, Chouinard G, Cohen BM, Du F, Öngür D. Brain bioenergetics and redox state measured by 31P magnetic resonance spectroscopy in unaffected siblings of patients with psychotic disorders. Schizophr Res. 2017 09; 187:11-16. PMID: 28258794.
    Citations: 3     Fields:    Translation:HumansCells
  30. Valeri L, Reese SL, Zhao S, Page CM, Nystad W, Coull BA, London SJ. Misclassified exposure in epigenetic mediation analyses. Does DNA methylation mediate effects of smoking on birthweight? Epigenomics. 2017 03; 9(3):253-265. PMID: 28234025.
    Citations: 4     Fields:    Translation:HumansCells
  31. Errecaborde KM, Pelican KM, Kassenborg H, Prasarnphanich OO, Valeri L, Yuuzar E, Fauzi RP, Budayanti NS, Suwandono A, Artama WT, Adisasmito W, Dutcher T. Piloting the One Health Systems Mapping and Analysis Resource Toolkit in Indonesia. Ecohealth. 2017 03; 14(1):178-181. PMID: 28180995.
    Citations:    Fields:    Translation:HumansPHPublic Health
  32. Gleason KM, Valeri L, Shankar AH, Hasan MO, Quamruzzaman Q, Rodrigues EG, Christiani DC, Wright RO, Bellinger DC, Mazumdar M. Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health. 2016 11 04; 15(1):103. PMID: 27809911.
    Citations:    Fields:    Translation:HumansPHPublic Health
  33. Valeri L, Patterson-Lomba O, Gurmu Y, Ablorh A, Bobb J, Townes FW, Harling G. Predicting Subnational Ebola Virus Disease Epidemic Dynamics from Sociodemographic Indicators. PLoS One. 2016; 11(10):e0163544. PMID: 27732614.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  34. Frankson R, Hueston W, Christian K, Olson D, Lee M, Valeri L, Hyatt R, Annelli J, Rubin C. One Health Core Competency Domains. Front Public Health. 2016; 4:192. PMID: 27679794.
    Citations: 4     
  35. Valeri L, Coull BA. Estimating causal contrasts involving intermediate variables in the presence of selection bias. Stat Med. 2016 11 20; 35(26):4779-4793. PMID: 27411847.
    Citations: 1     Fields:    Translation:Humans
  36. Rodrigues EG, Bellinger DC, Valeri L, Hasan MO, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health. 2016 Mar 12; 15:44. PMID: 26968381.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  37. Valeri L, Chen JT, Garcia-Albeniz X, Krieger N, VanderWeele TJ, Coull BA. The Role of Stage at Diagnosis in Colorectal Cancer Black-White Survival Disparities: A Counterfactual Causal Inference Approach. Cancer Epidemiol Biomarkers Prev. 2016 Jan; 25(1):83-9. PMID: 26503034.
    Citations: 6     Fields:    Translation:Humans
  38. Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol. 2015 Sep; 103(9):754-62. PMID: 26250961.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  39. Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, Rodrigues EG, Silva F, Mia S, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Environ Health. 2015 Apr 10; 14:34. PMID: 25885259.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  40. Valeri L, VanderWeele TJ. SAS macro for causal mediation analysis with survival data. Epidemiology. 2015 Mar; 26(2):e23-4. PMID: 25643116.
    Citations: 18     Fields:    Translation:Humans
  41. Pieters N, Janssen BG, Valeri L, Cox B, Cuypers A, Dewitte H, Plusquin M, Smeets K, Nawrot TS. Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: a candidate gene approach. Mech Ageing Dev. 2015 Jan; 145:51-7. PMID: 25736869.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  42. Lai PS, Hang JQ, Valeri L, Zhang FY, Zheng BY, Mehta AJ, Shi J, Su L, Brown D, Eisen EA, Christiani DC. Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study. Occup Environ Med. 2015 Aug; 72(8):546-552. PMID: 25666844.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  43. Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics. 2015 Jul; 16(3):493-508. PMID: 25532525.
    Citations: 17     Fields:    Translation:HumansAnimals
  44. Valeri L, Lin X, VanderWeele TJ. Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model. Stat Med. 2014 Dec 10; 33(28):4875-90. PMID: 25220625.
    Citations: 6     Fields:    
  45. Valeri L, Vanderweele TJ. The estimation of direct and indirect causal effects in the presence of misclassified binary mediator. Biostatistics. 2014 Jul; 15(3):498-512. PMID: 24671909.
    Citations: 5     Fields:    Translation:Humans
  46. Hueston W, Appert J, Denny T, King L, Umber J, Valeri L. Assessing global adoption of one health approaches. Ecohealth. 2013 Sep; 10(3):228-33. PMID: 23835604.
    Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
  47. Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. J Am Heart Assoc. 2013 Jun 19; 2(3):e000212. PMID: 23782920.
    Citations: 46     Fields:    Translation:HumansCellsPHPublic Health
  48. Valeri L, Vanderweele TJ. Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros. Psychol Methods. 2013 Jun; 18(2):137-50. PMID: 23379553.
    Citations: 168     Fields:    Translation:Humans
  49. Garcia-Albeniz X, Nan H, Valeri L, Morikawa T, Kuchiba A, Phipps AI, Hutter CM, Peters U, Newcomb PA, Fuchs CS, Giovannucci EL, Ogino S, Chan AT. Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival. Carcinogenesis. 2013 Feb; 34(2):292-8. PMID: 23104301.
    Citations: 14     Fields:    Translation:HumansCells
  50. VanderWeele TJ, Valeri L, Ogburn EL. The role of measurement error and misclassification in mediation analysis: mediation and measurement error. Epidemiology. 2012 Jul; 23(4):561-4. PMID: 22659547.
    Citations: 18     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.