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Jason Dearling, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dammes N, Goldsmith M, Ramishetti S, Dearling JLJ, Veiga N, Packard AB, Peer D. Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics. Nat Nanotechnol. 2021 09; 16(9):1030-1038. PMID: 34140675.
    Citations: 6     Fields:    Translation:HumansAnimals
  2. Dearling JLJ, van Dam EM, Harris MJ, Packard AB. Detection and therapy of neuroblastoma minimal residual disease using [64/67Cu]Cu-SARTATE in a preclinical model of hepatic metastases. EJNMMI Res. 2021 Feb 25; 11(1):20. PMID: 33630166.
    Citations: 2     
  3. Woodham AW, Zeigler SH, Zeyang EL, Kolifrath SC, Cheloha RW, Rashidian M, Chaparro RJ, Seidel RD, Garforth SJ, Dearling JL, Mesyngier M, Duddempudi PK, Packard AB, Almo SC, Ploegh HL. In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography. Nat Methods. 2020 10; 17(10):1025-1032. PMID: 32929269.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  4. Butch ER, Mead PE, Amador Diaz V, Tillman H, Stewart E, Mishra JK, Kim J, Bahrami A, Dearling JLJ, Packard AB, Stoddard SV, Vavere AL, Han Y, Shulkin BL, Snyder SE. Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma. Cancer Res. 2019 06 15; 79(12):3112-3124. PMID: 31015228.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  5. Dearling JLJ, Packard AB. Molecular imaging in nanomedicine - A developmental tool and a clinical necessity. J Control Release. 2017 09 10; 261:23-30. PMID: 28624600.
    Citations: 7     Fields:    Translation:HumansAnimals
  6. Dearling JLJ, Packard AB. A Sensitive Method for the Measurement of Copper at Trace Levels Using an HPLC-Based Assay. Curr Radiopharm. 2017; 10(1):59-64. PMID: 28124595.
    Citations:    Fields:    Translation:Cells
  7. Dearling JL, Daka A, Veiga N, Peer D, Packard AB. Colitis ImmunoPET: Defining Target Cell Populations and Optimizing Pharmacokinetics. Inflamm Bowel Dis. 2016 Mar; 22(3):529-38. PMID: 26841223.
    Citations: 12     Fields:    Translation:Animals
  8. Daly KP, Dearling JL, Seto T, Dunning P, Fahey F, Packard AB, Briscoe DM. Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection. Transplantation. 2015 Sep; 99(9):e132-9. PMID: 25675207.
    Citations: 9     Fields:    Translation:Animals
  9. Dearling JL, Paterson BM, Akurathi V, Betanzos-Lara S, Treves ST, Voss SD, White JM, Huston JS, Smith SV, Donnelly PS, Packard AB. The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjug Chem. 2015 Apr 15; 26(4):707-17. PMID: 25719414.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Dearling JL, Packard AB. On the destiny of (copper) species. J Nucl Med. 2014 Jan; 55(1):7-8. PMID: 24337607.
    Citations: 3     Fields:    Translation:HumansAnimals
  11. O'Neill AF, Dearling JL, Wang Y, Tupper T, Sun Y, Aster JC, Calicchio ML, Perez-Atayde AR, Packard AB, Kung AL. Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res. 2014 Feb 01; 20(3):678-87. PMID: 24218512.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Dearling JL, Barnes JW, Panigrahy D, Zimmerman RE, Fahey F, Treves ST, Morrison MS, Kieran MW, Packard AB. Specific uptake of 99mTc-NC100692, an avß3-targeted imaging probe, in subcutaneous and orthotopic tumors. Nucl Med Biol. 2013 Aug; 40(6):788-94. PMID: 23701702.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Vavere AL, Butch ER, Dearling JL, Packard AB, Navid F, Shulkin BL, Barfield RC, Snyder SE. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. J Nucl Med. 2012 Nov; 53(11):1772-8. PMID: 23064212.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  14. Dearling JL, Packard AB. PET-radioimmunodetection of integrins: imaging acute colitis using a 64Cu-labeled anti-ß7 integrin antibody. Methods Mol Biol. 2012; 757:487-96. PMID: 21909929.
    Citations: 1     Fields:    Translation:Animals
  15. Rajkumar V, Dearling JL, Packard A, Pedley RB. Radioimmunotherapy: optimizing delivery to solid tumors. Ther Deliv. 2011 May; 2(5):567-72. PMID: 22833974.
    Citations: 2     Fields:    Translation:Humans
  16. Dearling JL, Voss SD, Dunning P, Snay E, Fahey F, Smith SV, Huston JS, Meares CF, Treves ST, Packard AB. Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody. Nucl Med Biol. 2011 Jan; 38(1):29-38. PMID: 21220127.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  17. Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 Sep; 16(9):1458-66. PMID: 20186943.
    Citations: 11     Fields:    Translation:Animals
  18. Dearling JL, Packard AB. Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM. Nucl Med Biol. 2010 Apr; 37(3):237-43. PMID: 20346863.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  19. Dearling JL, Flynn AA, Qureshi U, Whiting S, Boxer GM, Green A, Begent RH, Pedley RB. Localization of radiolabeled anti-CEA antibody in subcutaneous and intrahepatic colorectal xenografts: influence of tumor size and location within host organ on antibody uptake. Nucl Med Biol. 2009 Nov; 36(8):883-94. PMID: 19875045.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Violet JA, Dearling JL, Green AJ, Begent RH, Pedley RB. Fractionated 131I anti-CEA radioimmunotherapy: effects on xenograft tumour growth and haematological toxicity in mice. Br J Cancer. 2008 Aug 19; 99(4):632-8. PMID: 18682714.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Fidarova EF, El-Emir E, Boxer GM, Qureshi U, Dearling JL, Robson MP, Begent RH, Trott KR, Pedley RB. Microdistribution of targeted, fluorescently labeled anti-carcinoembryonic antigen antibody in metastatic colorectal cancer: implications for radioimmunotherapy. Clin Cancer Res. 2008 May 01; 14(9):2639-46. PMID: 18451227.
    Citations: 13     Fields:    Translation:HumansAnimals
  22. El Emir E, Qureshi U, Dearling JL, Boxer GM, Clatworthy I, Folarin AA, Robson MP, Nagl S, Konerding MA, Pedley RB. Predicting response to radioimmunotherapy from the tumor microenvironment of colorectal carcinomas. Cancer Res. 2007 Dec 15; 67(24):11896-905. PMID: 18089820.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  23. Voss SD, Smith SV, DiBartolo N, McIntosh LJ, Cyr EM, Bonab AA, Dearling JL, Carter EA, Fischman AJ, Treves ST, Gillies SD, Sargeson AM, Huston JS, Packard AB. Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17489-93. PMID: 17954911.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  24. Dearling JL, Pedley RB. Technological advances in radioimmunotherapy. Clin Oncol (R Coll Radiol). 2007 Aug; 19(6):457-69. PMID: 17537620.
    Citations: 6     Fields:    Translation:Humans
  25. El-Emir E, Dearling JL, Huhalov A, Robson MP, Boxer G, Neri D, van Dongen GA, Trachsel E, Begent RH, Pedley RB. Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models. Br J Cancer. 2007 Jun 18; 96(12):1862-70. PMID: 17519905.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  26. Dearling JL, Qureshi U, Begent RH, Pedley RB. Combining radioimmunotherapy with antihypoxia therapy 2-deoxy-D-glucose results in reduction of therapeutic efficacy. Clin Cancer Res. 2007 Mar 15; 13(6):1903-10. PMID: 17363547.
    Citations: 7     Fields:    Translation:HumansAnimals
  27. Lankester KJ, Maxwell RJ, Pedley RB, Dearling JL, Qureshi UA, El-Emir E, Hill SA, Tozer GM. Combretastatin A-4-phosphate effectively increases tumor retention of the therapeutic antibody, 131I-A5B7, even at doses that are sub-optimal for vascular shut-down. Int J Oncol. 2007 Feb; 30(2):453-60. PMID: 17203228.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  28. El-Emir E, Boxer GM, Petrie IA, Boden RW, Dearling JL, Begent RH, Pedley RB. Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice. Eur J Cancer. 2005 Mar; 41(5):799-806. PMID: 15763657.
    Citations: 14     Fields:    Translation:HumansAnimals
  29. Green A, Flynn A, Pedley RB, Dearling J, Begent R. Nonuniform absorbed dose distribution in the kidney: the influence of organ architecture. Cancer Biother Radiopharm. 2004 Jun; 19(3):371-7. PMID: 15285885.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Dearling JL, Flynn AA, Sutcliffe-Goulden J, Petrie IA, Boden R, Green AJ, Boxer GM, Begent RH, Pedley RB. Analysis of the regional uptake of radiolabeled deoxyglucose analogs in human tumor xenografts. J Nucl Med. 2004 Jan; 45(1):101-7. PMID: 14734681.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  31. Mayer A, Tsiompanou E, Flynn AA, Pedley RB, Dearling J, Boden R, Begent RH. Higher dose and dose-rate in smaller tumors result in improved tumor control. Cancer Invest. 2003 Jun; 21(3):382-8. PMID: 12901284.
    Citations: 2     Fields:    Translation:HumansAnimals
  32. Flynn AA, Pedley RB, Green AJ, Dearling JL, El-Emir E, Boxer GM, Boden R, Begent RH. The nonuniformity of antibody distribution in the kidney and its influence on dosimetry. Radiat Res. 2003 Feb; 159(2):182-9. PMID: 12537523.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  33. Pedley RB, El-Emir E, Flynn AA, Boxer GM, Dearling J, Raleigh JA, Hill SA, Stuart S, Motha R, Begent RH. Synergy between vascular targeting agents and antibody-directed therapy. Int J Radiat Oncol Biol Phys. 2002 Dec 01; 54(5):1524-31. PMID: 12459381.
    Citations: 11     Fields:    Translation:AnimalsCells
  34. Petrie IA, Flynn AA, Pedley RB, Green AJ, El-Emir E, Dearling JL, Boxer GM, Boden R, Begent RH. Spatial accuracy of 3D reconstructed radioluminographs of serial tissue sections and resultant absorbed dose estimates. Phys Med Biol. 2002 Oct 21; 47(20):3651-61. PMID: 12433126.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Southworth R, Dearling JL, Medina RA, Flynn AA, Pedley RB, Garlick PB. Dissociation of glucose tracer uptake and glucose transporter distribution in the regionally ischaemic isolated rat heart: application of a new autoradiographic technique. Eur J Nucl Med Mol Imaging. 2002 Oct; 29(10):1334-41. PMID: 12271416.
    Citations: 6     Fields:    Translation:Animals
  36. Flynn AA, Green AJ, Pedley RB, Boxer GM, Dearling J, Watson R, Boden R, Begent RH. A model-based approach for the optimization of radioimmunotherapy through antibody design and radionuclide selection. Cancer. 2002 Feb 15; 94(4 Suppl):1249-57. PMID: 11877753.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  37. Dearling JL, Lewis JS, Mullen GE, Welch MJ, Blower PJ. Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships. J Biol Inorg Chem. 2002 Mar; 7(3):249-59. PMID: 11935349.
    Citations: 56     Fields:    Translation:AnimalsCells
  38. Pedley RB, Hill SA, Boxer GM, Flynn AA, Boden R, Watson R, Dearling J, Chaplin DJ, Begent RH. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate. Cancer Res. 2001 Jun 15; 61(12):4716-22. PMID: 11406542.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  39. Flynn AA, Pedley RB, Green AJ, Boxer GM, Boden R, Dearling J, Bhatia J, Begent RH. Effectiveness of radiolabelled antibodies for radio-immunotherapy in a colorectal xenograft model: a comparative study using the linear--quadratic formulation. Int J Radiat Biol. 2001 Apr; 77(4):507-17. PMID: 11304442.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  40. Lewis JS, Dearling JL, Sosabowski JK, Zweit J, Carnochan P, Kelland LR, Coley HM, Blower PJ. Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET. Eur J Nucl Med. 2000 Jun; 27(6):638-46. PMID: 10901449.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  41. Dearling JL, Lewis JS, Mullen GE, Rae MT, Zweit J, Blower PJ. Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro. Eur J Nucl Med. 1998 Jul; 25(7):788-92. PMID: 9662602.
    Citations: 28     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.